Ethan Hollingsworth
@ewholling.bsky.social
MD/PhD Student in the Kvon Lab at UC Irvine
Gene regulation in development and disease.
Gene regulation in development and disease.
Pinned
How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/
Main story of my PhD with @evgenykvon.bsky.social in preprint! See thread and link for all the details!
A call to arms for research universities
"We need to get up from under our desks and persuade our fellow citizens that the institutions that they have helped create with their tax dollars are incredibly precious and important."
"We need to get up from under our desks and persuade our fellow citizens that the institutions that they have helped create with their tax dollars are incredibly precious and important."
September 9, 2025 at 1:53 AM
A call to arms for research universities
"We need to get up from under our desks and persuade our fellow citizens that the institutions that they have helped create with their tax dollars are incredibly precious and important."
"We need to get up from under our desks and persuade our fellow citizens that the institutions that they have helped create with their tax dollars are incredibly precious and important."
Reposted by Ethan Hollingsworth
The @NYTimes has done a fantastic job on explaining what the Trump administration’s savage
cuts to biomedical research mean: cures that won’t happen. Please share this widely. This is a catastrophe. www.nytimes.com/2025/08/24/o...
cuts to biomedical research mean: cures that won’t happen. Please share this widely. This is a catastrophe. www.nytimes.com/2025/08/24/o...
Opinion | America First? Not When It Comes to Your Health.
www.nytimes.com
August 24, 2025 at 4:10 PM
The @NYTimes has done a fantastic job on explaining what the Trump administration’s savage
cuts to biomedical research mean: cures that won’t happen. Please share this widely. This is a catastrophe. www.nytimes.com/2025/08/24/o...
cuts to biomedical research mean: cures that won’t happen. Please share this widely. This is a catastrophe. www.nytimes.com/2025/08/24/o...
Reposted by Ethan Hollingsworth
Please RP.
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
August 16, 2025 at 7:15 AM
Please RP.
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”
We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...
Reposted by Ethan Hollingsworth
Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...
August 10, 2025 at 1:19 PM
Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...
Reposted by Ethan Hollingsworth
Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....
August 7, 2025 at 4:20 PM
Excited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....
Reposted by Ethan Hollingsworth
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
August 6, 2025 at 6:27 PM
🚨 Our parent-of-origin study is out in Nature! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗 www.nature.com/articles/s41...
Highlights below!
Exactly 7 years (to the day) after packing my car up and leaving for California, I successfully defended my PhD in the the lab of @evgenykvon.bsky.social!
Incredibly grateful to Evgeny, the lab, my family, and many more whose support made this possible
Incredibly grateful to Evgeny, the lab, my family, and many more whose support made this possible
July 24, 2025 at 6:45 PM
Exactly 7 years (to the day) after packing my car up and leaving for California, I successfully defended my PhD in the the lab of @evgenykvon.bsky.social!
Incredibly grateful to Evgeny, the lab, my family, and many more whose support made this possible
Incredibly grateful to Evgeny, the lab, my family, and many more whose support made this possible
Reposted by Ethan Hollingsworth
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
July 9, 2025 at 10:05 AM
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Huge congrats to @gracebower.bsky.social & @evgenykvon.bsky.social on the lab's recent Nature paper! A lot of fun to contribute to this project and watch the story develop over the past several years
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 3, 2025 at 12:57 PM
Huge congrats to @gracebower.bsky.social & @evgenykvon.bsky.social on the lab's recent Nature paper! A lot of fun to contribute to this project and watch the story develop over the past several years
Main story of my PhD with @evgenykvon.bsky.social in preprint! See thread and link for all the details!
How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/
June 23, 2025 at 1:14 PM
Main story of my PhD with @evgenykvon.bsky.social in preprint! See thread and link for all the details!