In reading reports of clinical trials, I mainly limit myself to trials that are controlled, usually placebo-controlled, and while I've seen MID, etc a lot, this is the first time I've seen this distinction made.

Are you aware of an SWD for MDD, perhaps in terms of points on the HAMD?

Is there a difference between smallest worthwhile difference (SWD) and minimum clinically important difference (MCID)?

Of possible future (or present) interest to @retractionwatch.com

Leucovorin devotee PI seems to have continuous difficulty w/trials. See pp.4-5 from FDA
www.thetransmitter.org/wp-content/u...

The technical term for enrolling subjects in a trial that FDA says you may not initiate is BAD.

"To clarify, while Dr. Oz doesn't necessarily have a stake in the forthcoming FDA-approved Leucovorin manufacturer, he does have a financial stake in a non-prescription alternative."

Such a conflict of interest would be very much on brand for this administration.

...but what's likely to happen is that hype will circulate among parents of kids w autism about a new treatment for autism–the nuance about CFD will be overshadowed. Then they'll be asking their doctors if their kids shdn't B treated w this exciting new treatment. I've already had 1 such inquiry.

And the news release title is misleading with its "treatment for autism symptoms". The text of the release clarifies that the treatment is not for autism per se but rather for cerebral folate deficiency (CFD), which, as @akesselheim.bsky.social pointed out, requires a lumbar puncture to diagnose...

Secret photo shows that Portland has already established an autonomous free zone! They're going to call it the Portland Saturday Market!
#WarRavagedPortland
#Portland

War-ravaged Portland, 5 minutes ago

War ravaged Portland.

Blog post about the article by the lead author, Stephen Curry (no, not the basketball player!)

occamstypewriter.org/scurry/2025/...