Erick Turner
@eturnermd1.bsky.social
Advocate for and researcher on transparency in medical research. Former FDA reviewer of psychotropic drugs back when the FDA was a tougher gatekeeper.
Pinned
Erick Turner
@eturnermd1.bsky.social
· Dec 10
Leveraging Registered Reports to increase transparency in trial publication – Open Pharma - Innovations in medical publishing
Publication bias undermines the credibility of clinical trial reporting and negatively affects the reputation of pharma sponsors. Registered Reports (RR) is a peer review process designed to eradicate...
www.openpharma.blog
Wouldn't it be nice if u could read a published pharma-sponsored clinical trial about some new drug & be confident that the results are what they appear to be?
@chrisdc77 & I think it's very achievable using the @RegReports peer review model.
Our proposal ⬇️ www.openpharma.blog/blog/transpa...
@chrisdc77 & I think it's very achievable using the @RegReports peer review model.
Our proposal ⬇️ www.openpharma.blog/blog/transpa...
Maybe I should start numbering these soap opera "episodes".
Pazdur JUST turned down the offer to be CDER Director. Now he accepts. Negotiating tactic?
Pazdur JUST turned down the offer to be CDER Director. Now he accepts. Negotiating tactic?
November 12, 2025 at 6:30 PM
Maybe I should start numbering these soap opera "episodes".
Pazdur JUST turned down the offer to be CDER Director. Now he accepts. Negotiating tactic?
Pazdur JUST turned down the offer to be CDER Director. Now he accepts. Negotiating tactic?
Today's episode of the FDA soap opera. First, Tidmarsh leaves, then Pazdur and Thanh Hai say no thanks to the "opportunity" to be CDER Director, and now they're asking for "anyone interested" to apply. 🙄 @akesselheim.bsky.social
November 10, 2025 at 7:44 PM
Today's episode of the FDA soap opera. First, Tidmarsh leaves, then Pazdur and Thanh Hai say no thanks to the "opportunity" to be CDER Director, and now they're asking for "anyone interested" to apply. 🙄 @akesselheim.bsky.social
I like what the authors have done here...apply EBM principles to a specific drug class. This brings it to the attention of specialty physicians whose radar screens don't normally cover 'meta' topics like EBM.
pubmed.ncbi.nlm.nih.gov/41198383/
pubmed.ncbi.nlm.nih.gov/41198383/
November 9, 2025 at 8:20 PM
I like what the authors have done here...apply EBM principles to a specific drug class. This brings it to the attention of specialty physicians whose radar screens don't normally cover 'meta' topics like EBM.
pubmed.ncbi.nlm.nih.gov/41198383/
pubmed.ncbi.nlm.nih.gov/41198383/
Latest episode of the FDA soap opera
www.nytimes.com/2025/11/02/h...
www.nytimes.com/2025/11/02/h...
F.D.A. Drug Unit Chief Resigns, and Is Sued by Drug Company
www.nytimes.com
November 3, 2025 at 5:58 PM
Latest episode of the FDA soap opera
www.nytimes.com/2025/11/02/h...
www.nytimes.com/2025/11/02/h...
New JAMA Psychiatry report on clinical trial of ketamine vs midazolam (aka. Versed, a short-acting benzo mainly used as an anesthetic). No difference in efficacy found. High rates of AEs in both gps.
@floriannaudet.bsky.social @chrisaikenmd.bsky.social
watermark02.silverchair.com/jamapsychiat...
@floriannaudet.bsky.social @chrisaikenmd.bsky.social
watermark02.silverchair.com/jamapsychiat...
November 2, 2025 at 7:01 PM
New JAMA Psychiatry report on clinical trial of ketamine vs midazolam (aka. Versed, a short-acting benzo mainly used as an anesthetic). No difference in efficacy found. High rates of AEs in both gps.
@floriannaudet.bsky.social @chrisaikenmd.bsky.social
watermark02.silverchair.com/jamapsychiat...
@floriannaudet.bsky.social @chrisaikenmd.bsky.social
watermark02.silverchair.com/jamapsychiat...
Positions available to work with @akesselheim.bsky.social and his colleagues at PORTAL. Fellowship positions in Pharmaceutical Law and Policy Research.
Physician Fellowship: form.jotform.com/252916841579...
Postdoctoral Fellowship: form.jotform.com/252916475545...
Physician Fellowship: form.jotform.com/252916841579...
Postdoctoral Fellowship: form.jotform.com/252916475545...
PORTAL Postdoctoral Fellowship Application (2026)
Please click the link to complete this form.
form.jotform.com
October 28, 2025 at 5:30 PM
Positions available to work with @akesselheim.bsky.social and his colleagues at PORTAL. Fellowship positions in Pharmaceutical Law and Policy Research.
Physician Fellowship: form.jotform.com/252916841579...
Postdoctoral Fellowship: form.jotform.com/252916475545...
Physician Fellowship: form.jotform.com/252916841579...
Postdoctoral Fellowship: form.jotform.com/252916475545...
I remember reading that FDA Advisory Committee meetings were in jeopardy but didn't realize they were on their deathbed.
(Screenshot from the Pink Sheet. I can't share the article b/c I don't subscribe ($$$!!!).)
(Screenshot from the Pink Sheet. I can't share the article b/c I don't subscribe ($$$!!!).)
October 17, 2025 at 7:27 PM
I remember reading that FDA Advisory Committee meetings were in jeopardy but didn't realize they were on their deathbed.
(Screenshot from the Pink Sheet. I can't share the article b/c I don't subscribe ($$$!!!).)
(Screenshot from the Pink Sheet. I can't share the article b/c I don't subscribe ($$$!!!).)
Reposted by Erick Turner
Leucovorin devotee PI seems to have continuous difficulty w/trials. See pp.4-5 from FDA
www.thetransmitter.org/wp-content/u...
The technical term for enrolling subjects in a trial that FDA says you may not initiate is BAD.
www.thetransmitter.org/wp-content/u...
The technical term for enrolling subjects in a trial that FDA says you may not initiate is BAD.
Exclusive: Meet Richard Frye, who studies leucovorin for autism
Frye has led two placebo-controlled trials of the folate supplement in autistic people; the first was suspended by regulators, and the other has yet to be published.
www.thetransmitter.org
October 6, 2025 at 2:07 AM
Leucovorin devotee PI seems to have continuous difficulty w/trials. See pp.4-5 from FDA
www.thetransmitter.org/wp-content/u...
The technical term for enrolling subjects in a trial that FDA says you may not initiate is BAD.
www.thetransmitter.org/wp-content/u...
The technical term for enrolling subjects in a trial that FDA says you may not initiate is BAD.
This still feels strange. Drugs have always been approved on the initiative of drug companies. Here, the FDA is saying *it* initiated the approval. It's as if Makary did this to placate RFK Jr and his odd beliefs about autism. @akesselheim.bsky.social
FDA news release www.fda.gov/news-events/... says:
"The FDA is working with GSK, the innovator of Wellcovorin (leucovorin calcium), on a process to include the essential scientific information needed for the safe and effective use of these drug products for adults and pediatric patients with CFD."
"The FDA is working with GSK, the innovator of Wellcovorin (leucovorin calcium), on a process to include the essential scientific information needed for the safe and effective use of these drug products for adults and pediatric patients with CFD."
October 6, 2025 at 12:01 AM
This still feels strange. Drugs have always been approved on the initiative of drug companies. Here, the FDA is saying *it* initiated the approval. It's as if Makary did this to placate RFK Jr and his odd beliefs about autism. @akesselheim.bsky.social
Reposted by Erick Turner
Every single one of these clips was taken today in downtown Portland. Portland doesn’t want or need a federal takeover. If Trump insists on sending federal “resources” he can start with funding health care, bridges, affordable housing, and wildfire protection to name a few.
September 27, 2025 at 9:35 PM
Every single one of these clips was taken today in downtown Portland. Portland doesn’t want or need a federal takeover. If Trump insists on sending federal “resources” he can start with funding health care, bridges, affordable housing, and wildfire protection to name a few.
Reposted by Erick Turner
Portland declares ICE facility out of compliance, demands its clearance. www.portland.gov/mayor/keith-...
City of Portland will issue land use violation notice for ICE facility, triggering process to determine next steps at the site
The City of Portland believes the federal government violated detention conditions of its land use approval 25 times in a 10-month period, according to federal records. Next steps could include fines ...
www.portland.gov
September 27, 2025 at 10:18 PM
Portland declares ICE facility out of compliance, demands its clearance. www.portland.gov/mayor/keith-...
Reposted by Erick Turner
Secret photo shows that Portland has already established an autonomous free zone! They're going to call it the Portland Saturday Market!
#WarRavagedPortland
#Portland
#WarRavagedPortland
#Portland
September 27, 2025 at 5:42 PM
Secret photo shows that Portland has already established an autonomous free zone! They're going to call it the Portland Saturday Market!
#WarRavagedPortland
#Portland
#WarRavagedPortland
#Portland
Reposted by Erick Turner
War-ravaged Portland, 5 minutes ago
September 27, 2025 at 4:29 PM
War-ravaged Portland, 5 minutes ago
Reposted by Erick Turner
War ravaged Portland.
September 27, 2025 at 3:07 PM
War ravaged Portland.
Reposted by Erick Turner
War-ravaged Portland
September 27, 2025 at 2:44 PM
War-ravaged Portland
FDA news release www.fda.gov/news-events/... says:
"The FDA is working with GSK, the innovator of Wellcovorin (leucovorin calcium), on a process to include the essential scientific information needed for the safe and effective use of these drug products for adults and pediatric patients with CFD."
"The FDA is working with GSK, the innovator of Wellcovorin (leucovorin calcium), on a process to include the essential scientific information needed for the safe and effective use of these drug products for adults and pediatric patients with CFD."
September 24, 2025 at 8:00 PM
FDA news release www.fda.gov/news-events/... says:
"The FDA is working with GSK, the innovator of Wellcovorin (leucovorin calcium), on a process to include the essential scientific information needed for the safe and effective use of these drug products for adults and pediatric patients with CFD."
"The FDA is working with GSK, the innovator of Wellcovorin (leucovorin calcium), on a process to include the essential scientific information needed for the safe and effective use of these drug products for adults and pediatric patients with CFD."
"Ending publication bias: A values-based approach to surface null and negative results"
Paper out today in PLoS Medicine by many of us who would like to see publication bias reduced or eliminated.
Especially happy that Registered Reports got shout-outs.
journals.plos.org/plosbiology/...
Paper out today in PLoS Medicine by many of us who would like to see publication bias reduced or eliminated.
Especially happy that Registered Reports got shout-outs.
journals.plos.org/plosbiology/...
Ending publication bias: A values-based approach to surface null and negative results
Sharing knowledge is a fundamental principle within the scientific community, yet null and negative results are still being underreported. This Consensus View discusses the problem of such publication...
journals.plos.org
September 24, 2025 at 7:46 PM
"Ending publication bias: A values-based approach to surface null and negative results"
Paper out today in PLoS Medicine by many of us who would like to see publication bias reduced or eliminated.
Especially happy that Registered Reports got shout-outs.
journals.plos.org/plosbiology/...
Paper out today in PLoS Medicine by many of us who would like to see publication bias reduced or eliminated.
Especially happy that Registered Reports got shout-outs.
journals.plos.org/plosbiology/...
Dr. Kesselheim @akesselheim.bsky.social
also noted that the study cited by the F.D.A. showed only small improvements in autism symptoms among people with certain folate levels in their spinal fluid.
also noted that the study cited by the F.D.A. showed only small improvements in autism symptoms among people with certain folate levels in their spinal fluid.
Before prescribing leucovorin, doctors would first need to determine whether a patient suffered from the deficiency, Dr. Kesselheim said. How they would arrive at that diagnosis short of a risky, expensive spinal tap was not clear, he said.
www.nytimes.com/2025/09/23/h...
www.nytimes.com/2025/09/23/h...
F.D.A.’s Approval of a Drug for Autism Upends Review Process
www.nytimes.com
September 24, 2025 at 3:45 AM
Dr. Kesselheim @akesselheim.bsky.social
also noted that the study cited by the F.D.A. showed only small improvements in autism symptoms among people with certain folate levels in their spinal fluid.
also noted that the study cited by the F.D.A. showed only small improvements in autism symptoms among people with certain folate levels in their spinal fluid.
Reposted by Erick Turner
Before prescribing leucovorin, doctors would first need to determine whether a patient suffered from the deficiency, Dr. Kesselheim said. How they would arrive at that diagnosis short of a risky, expensive spinal tap was not clear, he said.
www.nytimes.com/2025/09/23/h...
www.nytimes.com/2025/09/23/h...
F.D.A.’s Approval of a Drug for Autism Upends Review Process
www.nytimes.com
September 24, 2025 at 2:11 AM
Before prescribing leucovorin, doctors would first need to determine whether a patient suffered from the deficiency, Dr. Kesselheim said. How they would arrive at that diagnosis short of a risky, expensive spinal tap was not clear, he said.
www.nytimes.com/2025/09/23/h...
www.nytimes.com/2025/09/23/h...
A couple of new articles on the current FDA leadership's crackdown on Direct-to-Consumer (DTC) advertising.
Excerpt: "...all three of Boehringer’s letters concern a different one of the company’s musical theater-themed Jardiance ads."
I must admit those commercials are very irritating.
Excerpt: "...all three of Boehringer’s letters concern a different one of the company’s musical theater-themed Jardiance ads."
I must admit those commercials are very irritating.
September 20, 2025 at 12:28 AM
A couple of new articles on the current FDA leadership's crackdown on Direct-to-Consumer (DTC) advertising.
Excerpt: "...all three of Boehringer’s letters concern a different one of the company’s musical theater-themed Jardiance ads."
I must admit those commercials are very irritating.
Excerpt: "...all three of Boehringer’s letters concern a different one of the company’s musical theater-themed Jardiance ads."
I must admit those commercials are very irritating.
Now Tidmarsh is saying he "never said" he'd abandon Advisory Committee meetings.
www.biospace.com/fda/fda-flip...
www.biospace.com/fda/fda-flip...
September 20, 2025 at 12:21 AM
Now Tidmarsh is saying he "never said" he'd abandon Advisory Committee meetings.
www.biospace.com/fda/fda-flip...
www.biospace.com/fda/fda-flip...
Reposted by Erick Turner
For #PeerReviewWeek, I just published my BlueSky posts and notes from the 10th International Peer Review Congress, held 2 weeks ago in Chicago.
#PRC10 @peerreviewcongress.bsky.social
Part 1 is here: scienceintegritydigest.com/2025/09/16/p...
#PRC10 @peerreviewcongress.bsky.social
Part 1 is here: scienceintegritydigest.com/2025/09/16/p...
Peer Review Congress Chicago – Day 1
It’s Peer Review Week! A perfect time to post my notes from the 10th International Congress on Peer Review and Scientific Publication, which was held at the Swissôtel in Chicago, two weeks ag…
scienceintegritydigest.com
September 18, 2025 at 1:31 AM
For #PeerReviewWeek, I just published my BlueSky posts and notes from the 10th International Peer Review Congress, held 2 weeks ago in Chicago.
#PRC10 @peerreviewcongress.bsky.social
Part 1 is here: scienceintegritydigest.com/2025/09/16/p...
#PRC10 @peerreviewcongress.bsky.social
Part 1 is here: scienceintegritydigest.com/2025/09/16/p...
Can't think of any but will repost.
(Might there be a starter pack for child shrinks?)
(Might there be a starter pack for child shrinks?)
@eturnermd1.bsky.social Any child psychiatrists on Bluesky?
I'm not an expert but I can't see how a child with an undiagosed eating disorder or depression, for example, can participate in physical activity or make good food choices. Cart before horse.
I'm not an expert but I can't see how a child with an undiagosed eating disorder or depression, for example, can participate in physical activity or make good food choices. Cart before horse.
September 17, 2025 at 7:42 PM
Can't think of any but will repost.
(Might there be a starter pack for child shrinks?)
(Might there be a starter pack for child shrinks?)
Reposted by Erick Turner
Reprint of my Substack with @ylepidemiologist.bsky.social today in @statnews.com. Check it out if you’re interested in recent “moves” the FDA is making on drug ads. As with most claims this admin makes … IBIWISI: www.statnews.com/2025/09/13/p...
9 answers to burning questions about pharmaceutical ads
Got questions about the FDA’s new plans around pharmaceutical ads? We’ve got answers.
www.statnews.com
September 13, 2025 at 7:55 PM
Reprint of my Substack with @ylepidemiologist.bsky.social today in @statnews.com. Check it out if you’re interested in recent “moves” the FDA is making on drug ads. As with most claims this admin makes … IBIWISI: www.statnews.com/2025/09/13/p...