Eric Strobel
@estrobel.bsky.social
Transcriptional acrobatics. Assistant Professor at the University at Buffalo.
Check out our new preprint in which we teamed up with the Walter and Chen labs to determine how transcription coordinates the folding and function of a tandem aptamer glycine riboswitch from B. subtilis: www.biorxiv.org/content/10.1...
Co-transcriptional folding orchestrates sequential multi-effector sensing by a glycine tandem riboswitch
Riboswitches are non-coding RNA motifs that regulate gene expression in response to ligand binding. The glycine tandem riboswitch (GTR) is notable because it comprises two distinct glycine aptamers th...
www.biorxiv.org
June 6, 2025 at 2:24 PM
Check out our new preprint in which we teamed up with the Walter and Chen labs to determine how transcription coordinates the folding and function of a tandem aptamer glycine riboswitch from B. subtilis: www.biorxiv.org/content/10.1...
Our paper describing a method for measuring cotranscriptional RNA folding using high-throughput RNA chemical probing is out @natcomms.nature.com!
June 5, 2025 at 2:32 PM
Our paper describing a method for measuring cotranscriptional RNA folding using high-throughput RNA chemical probing is out @natcomms.nature.com!
Tool - 10,000 Days and Fear Inoculum both qualify.
here's a fun game if you're a music dork: what is the best album released by a music act at least 15 years after its debut album?
May 1, 2025 at 10:21 PM
Tool - 10,000 Days and Fear Inoculum both qualify.
Reposted by Eric Strobel
Here is our paper showing in vivo folding of nascent RNA right after synthesis, published now in @cp-molcell.bsky.social!
With @karlaneugebauer.bsky.social, @isaac-vock.bsky.social, @mattdsimon.bsky.social
www.cell.com/molecular-ce...
With @karlaneugebauer.bsky.social, @isaac-vock.bsky.social, @mattdsimon.bsky.social
www.cell.com/molecular-ce...
Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis
Schärfen et al. develop a method to measure the structure of nascent RNAs during their
synthesis by RNA polymerases. Base pairing occurs rapidly in cells, revealing the
strong regulatory potential of ...
www.cell.com
March 26, 2025 at 1:39 PM
Here is our paper showing in vivo folding of nascent RNA right after synthesis, published now in @cp-molcell.bsky.social!
With @karlaneugebauer.bsky.social, @isaac-vock.bsky.social, @mattdsimon.bsky.social
www.cell.com/molecular-ce...
With @karlaneugebauer.bsky.social, @isaac-vock.bsky.social, @mattdsimon.bsky.social
www.cell.com/molecular-ce...
Reposted by Eric Strobel
I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social
Take a peek here authors.elsevier.com/a/1kpxo_Oylr...
Take a peek here authors.elsevier.com/a/1kpxo_Oylr...
authors.elsevier.com
March 26, 2025 at 12:12 PM
I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social
Take a peek here authors.elsevier.com/a/1kpxo_Oylr...
Take a peek here authors.elsevier.com/a/1kpxo_Oylr...
Reposted by Eric Strobel
I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social
Here is the link that works! authors.elsevier.com/a/1kpxo_Oylr...
Here is the link that works! authors.elsevier.com/a/1kpxo_Oylr...
authors.elsevier.com
March 26, 2025 at 1:07 PM
I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social
Here is the link that works! authors.elsevier.com/a/1kpxo_Oylr...
Here is the link that works! authors.elsevier.com/a/1kpxo_Oylr...
Yup. I use SABIAN cymbals and inquired about getting some prototypes through SABIAN's Sound Check program in January. I was told that the program was on hold for the US until the uncertainty regarding tariffs is resolved. Glad I'm already set up with all the catalog cymbals I want for now...
BOOM! US tariffs could crash the market for North American drummers, writes PIIE's Cullen Hendrix www.piie.com/blogs/realti...
US tariffs could crash the market for North American drummers
North America’s two largest cymbal producers share a family lineage and approaches to cymbal making. What they don’t share is a country of origin. One is US-based, the other Canadian. The similarities...
www.piie.com
March 14, 2025 at 4:10 PM
Yup. I use SABIAN cymbals and inquired about getting some prototypes through SABIAN's Sound Check program in January. I was told that the program was on hold for the US until the uncertainty regarding tariffs is resolved. Glad I'm already set up with all the catalog cymbals I want for now...
Reposted by Eric Strobel
BOOM! US tariffs could crash the market for North American drummers, writes PIIE's Cullen Hendrix www.piie.com/blogs/realti...
US tariffs could crash the market for North American drummers
North America’s two largest cymbal producers share a family lineage and approaches to cymbal making. What they don’t share is a country of origin. One is US-based, the other Canadian. The similarities...
www.piie.com
March 13, 2025 at 7:09 PM
BOOM! US tariffs could crash the market for North American drummers, writes PIIE's Cullen Hendrix www.piie.com/blogs/realti...
Our paper describing our Transcription Elongation Complex Display platform for high-throughput cotranscriptional RNA functional assays is now online at @naturecomms.bsky.social: www.nature.com/articles/s41.... We used TECdisplay to assess the activity of >1M ZTP riboswitch variants!
Systematic analysis of cotranscriptional RNA folding using transcription elongation complex display - Nature Communications
Understanding how RNA folds into functional structures requires methods that can systematically assess how sequence perturbations affect RNA structure and function. Here, the authors develop a broadly...
www.nature.com
March 10, 2025 at 2:04 PM
Our paper describing our Transcription Elongation Complex Display platform for high-throughput cotranscriptional RNA functional assays is now online at @naturecomms.bsky.social: www.nature.com/articles/s41.... We used TECdisplay to assess the activity of >1M ZTP riboswitch variants!
Reposted by Eric Strobel
It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture.
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
November 21, 2024 at 1:27 AM
It's my great pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture.
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
Reposted by Eric Strobel
I haven't seen a nucleic acids starter pack yet, so I started one! Please reach out if I missed you! go.bsky.app/NxKgUY5
November 18, 2024 at 3:53 PM
I haven't seen a nucleic acids starter pack yet, so I started one! Please reach out if I missed you! go.bsky.app/NxKgUY5
Our latest preprint, led by Skyler Kelly: we developed a platform for high-throughput cotranscriptional RNA biochemistry called Transcription Elongation Complex display. www.biorxiv.org/content/10.1...
Systematic analysis of cotranscriptional RNA folding using transcription elongation complex display
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
December 26, 2023 at 3:57 PM
Our latest preprint, led by Skyler Kelly: we developed a platform for high-throughput cotranscriptional RNA biochemistry called Transcription Elongation Complex display. www.biorxiv.org/content/10.1...
The final version of our article describing a modernized procedure for cotranscriptional RNA structure probing is online! www.nature.com/articles/s41...
Observation of coordinated RNA folding events by systematic cotranscriptional RNA structure probing ...
RNA begins to fold as the nascent transcript emerges from a transcribing RNA polymerase. Here, the authors develop a concise method for mapping RNA folding pathways that couples in vitro transcription...
www.nature.com
November 29, 2023 at 2:46 PM
The final version of our article describing a modernized procedure for cotranscriptional RNA structure probing is online! www.nature.com/articles/s41...
Paper data for an assay I dreamed up in 2018 👀
September 19, 2023 at 6:55 PM
Paper data for an assay I dreamed up in 2018 👀