Esben Svenningsen
@esbensv.bsky.social
Senior Scientist with Novo Nordisk | Process Optimization and Automation
PhD in Chemical Biology from TBP lab @ Aarhus University, Denmark.
Covalent modifiers, chemoproteomics, morphological profiling / cell painting
ORCID: 0000-0001-5118-6499
PhD in Chemical Biology from TBP lab @ Aarhus University, Denmark.
Covalent modifiers, chemoproteomics, morphological profiling / cell painting
ORCID: 0000-0001-5118-6499
Reposted by Esben Svenningsen
I am excited to share that the latest project from the @tbpoulsen.bsky.social group, detailing the syntheses and biological evaluation of the four natural products cyclohelminthol I-IV is now available in Chemical Science!
doi.org/10.1039/D4SC...
A short "Bluetorial" below #ChemSky #ChemBio 1/7
doi.org/10.1039/D4SC...
A short "Bluetorial" below #ChemSky #ChemBio 1/7
January 30, 2025 at 9:12 PM
I am excited to share that the latest project from the @tbpoulsen.bsky.social group, detailing the syntheses and biological evaluation of the four natural products cyclohelminthol I-IV is now available in Chemical Science!
doi.org/10.1039/D4SC...
A short "Bluetorial" below #ChemSky #ChemBio 1/7
doi.org/10.1039/D4SC...
A short "Bluetorial" below #ChemSky #ChemBio 1/7
Reposted by Esben Svenningsen
Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! www.nature.com/articles/s41...
C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature
SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.
www.nature.com
January 30, 2025 at 12:30 PM
Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! www.nature.com/articles/s41...
Reposted by Esben Svenningsen
A Christmas present to all of the lasso peptide connoisseurs out there. The next chapter in our work is on triculamin is ready on bioRxiv. Great work by two incredibly talented graduate students @amerrild.bsky.social and @tizianasvenningsen.bsky.social.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Convergent Evolution of the Antimycobacterial Lasso Peptide Triculamin
Triculamin is a ribosomally synthesized and post-translationally modified peptide (RiPP) lasso peptide with potent antimycobacterial activity, produced by an unusual, non-canonical biosynthetic gene c...
www.biorxiv.org
December 22, 2024 at 9:52 AM
A Christmas present to all of the lasso peptide connoisseurs out there. The next chapter in our work is on triculamin is ready on bioRxiv. Great work by two incredibly talented graduate students @amerrild.bsky.social and @tizianasvenningsen.bsky.social.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Esben Svenningsen
Reposted by Esben Svenningsen
In a new preprint @chemrxiv.bsky.social, work from @bgless.bsky.social and Sabrina Schmied investigate the mechanism of a rearrangement that can lead to peptide/protein backbone cleavage.
Thanks to #LEOFondet for funding the project that led to this discovery.
chemrxiv.org/engage/chemr...
Thanks to #LEOFondet for funding the project that led to this discovery.
chemrxiv.org/engage/chemr...
Peptide Backbone Cleavage and trans-Amidation via Thioester-to-Imide Acyl Transfer
Cysteine thioesters are involved in a myriad of cen-tral biological transformations because of their unique reactivity. Despite their well-studied proper-ties, we discovered an unexpected trans-amidat...
chemrxiv.org
December 6, 2024 at 12:52 PM
In a new preprint @chemrxiv.bsky.social, work from @bgless.bsky.social and Sabrina Schmied investigate the mechanism of a rearrangement that can lead to peptide/protein backbone cleavage.
Thanks to #LEOFondet for funding the project that led to this discovery.
chemrxiv.org/engage/chemr...
Thanks to #LEOFondet for funding the project that led to this discovery.
chemrxiv.org/engage/chemr...
Reposted by Esben Svenningsen
Job alert: fully funded postdoc position in chemical biology in beautiful Geneva! Do you have a PhD in Chemical Biology or related field with organic synthetic experience? Apply now! Details on how to apply can be found here: www.hoogendoornlab.org/joinus #chemsky #ChemBio
Join us! | Hoogendoorn Lab
Openings for PhD students and postdocs will be advertized here
www.hoogendoornlab.org
December 3, 2024 at 11:26 AM
Job alert: fully funded postdoc position in chemical biology in beautiful Geneva! Do you have a PhD in Chemical Biology or related field with organic synthetic experience? Apply now! Details on how to apply can be found here: www.hoogendoornlab.org/joinus #chemsky #ChemBio
Reposted by Esben Svenningsen
Little Reminder: tomorrow 2pm. We are excited 😉
Next STAMMTISCH will be very exciting.
Our 3 guests give an "Introduction to the #open #laboratory #communication standard #SiLA and the scientific data standard #AnIML - with a practical demonstration of its #FAIR #data capabilities"
29.11.2024, 14 - 15 CET
bit.ly/486Rgzt
#chemsky #chemistry
Our 3 guests give an "Introduction to the #open #laboratory #communication standard #SiLA and the scientific data standard #AnIML - with a practical demonstration of its #FAIR #data capabilities"
29.11.2024, 14 - 15 CET
bit.ly/486Rgzt
#chemsky #chemistry
November 28, 2024 at 1:34 PM
Little Reminder: tomorrow 2pm. We are excited 😉
Reposted by Esben Svenningsen
Opportunity in chemical biology & #proteomics at Pfizer (Groton CT USA) ref: 4924293 | closing: 06-Dec-2024 #ChemBiol #biochem #chemsky 🧪
pfizer.wd1.myworkdayjobs.com/PfizerCareer...
pfizer.wd1.myworkdayjobs.com/PfizerCareer...
Senior Scientist, Chemical Biology and Proteomics
Would you like to discover the medicines of the future? At Pfizer we deliver Breakthroughs That Change Patients Lives. In the Chemical Biology and Proteomics group, we play a vital role in this missio...
pfizer.wd1.myworkdayjobs.com
November 27, 2024 at 7:08 AM
Opportunity in chemical biology & #proteomics at Pfizer (Groton CT USA) ref: 4924293 | closing: 06-Dec-2024 #ChemBiol #biochem #chemsky 🧪
pfizer.wd1.myworkdayjobs.com/PfizerCareer...
pfizer.wd1.myworkdayjobs.com/PfizerCareer...
Reposted by Esben Svenningsen
I want to write a paper titled “the sky is blue, the ocean is deep and trees are green”
"Non-White scientists appear on fewer editorial boards, spend more time under review, and receive fewer citations"
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Non-White scientists appear on fewer editorial boards, spend more time under review, and receive fewer citations | PNAS
Disparities continue to pose major challenges in various aspects of science. One such
aspect is editorial board composition, which has been shown t...
www.pnas.org
November 26, 2024 at 3:13 AM
I want to write a paper titled “the sky is blue, the ocean is deep and trees are green”
Reposted by Esben Svenningsen
ChemBio fans please repost the #ChemicalBiology Feed bsky.app/profile/thor...
@carolynbertozzi.bsky.social @ritastrack.bsky.social @stephanhacker2.bsky.social @stuartcantrill.bsky.social @laurahowes.bsky.social @dirktrauner.bsky.social @chemjobber.bsky.social @dereklowe.bsky.social
#chemsky
@carolynbertozzi.bsky.social @ritastrack.bsky.social @stephanhacker2.bsky.social @stuartcantrill.bsky.social @laurahowes.bsky.social @dirktrauner.bsky.social @chemjobber.bsky.social @dereklowe.bsky.social
#chemsky
November 25, 2024 at 1:02 AM
Reposted by Esben Svenningsen
Great to see them apply the proteome-wide profiling method for electrophile reactivity and selectivity that we developed together with @nesvilab.bsky.social in Fragpipe in this exciting system. chemrxiv.org/engage/chemr...
Profiling the proteome-wide selectivity of diverse electrophiles
Targeted covalent inhibitors are powerful entities in drug discovery, but their application has so far mainly been limited to addressing cysteine residues. The development of cysteine-directed covalen...
chemrxiv.org
November 21, 2024 at 9:28 AM
Great to see them apply the proteome-wide profiling method for electrophile reactivity and selectivity that we developed together with @nesvilab.bsky.social in Fragpipe in this exciting system. chemrxiv.org/engage/chemr...
In my first #bsky post, I am very happy and proud to share the new(ish) preprint of my post doc project on N-terminal cysteine (NCys) chemoprotomics using the oxSTEF probes!
Preprint at 👉 www.doi.org/10.26434/chemrxiv-2024-4w549
Skeeturial (??) below ⬇️ #ChemSky #ChemBio
Preprint at 👉 www.doi.org/10.26434/chemrxiv-2024-4w549
Skeeturial (??) below ⬇️ #ChemSky #ChemBio
November 20, 2024 at 3:37 PM
In my first #bsky post, I am very happy and proud to share the new(ish) preprint of my post doc project on N-terminal cysteine (NCys) chemoprotomics using the oxSTEF probes!
Preprint at 👉 www.doi.org/10.26434/chemrxiv-2024-4w549
Skeeturial (??) below ⬇️ #ChemSky #ChemBio
Preprint at 👉 www.doi.org/10.26434/chemrxiv-2024-4w549
Skeeturial (??) below ⬇️ #ChemSky #ChemBio