Erik Van Dis
@erikvandis.bsky.social
Immunologist and Damon Runyon fellow in the Stetson lab at UW, interested in innate immunity and cell death.
Previously at Berkeley, Carleton College and Rocky Mountain Labs
Previously at Berkeley, Carleton College and Rocky Mountain Labs
Reposted by Erik Van Dis
Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-kB https://www.biorxiv.org/content/10.1101/2025.11.09.687461v1
November 10, 2025 at 9:17 PM
Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-kB https://www.biorxiv.org/content/10.1101/2025.11.09.687461v1
Reposted by Erik Van Dis
Can we improve peer review? We think we can! Check out an experiment I helped with as part of @solvingforsci.bsky.social 's mission to make science better.
And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings:
solvingfor.org/news-posts-d...
And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings:
solvingfor.org/news-posts-d...
November 5, 2025 at 11:25 PM
Can we improve peer review? We think we can! Check out an experiment I helped with as part of @solvingforsci.bsky.social 's mission to make science better.
And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings:
solvingfor.org/news-posts-d...
And if you don't want to read the whole bioRxiv manuscript, here's an overview of the main findings:
solvingfor.org/news-posts-d...
Very cool work from my former mentor elucidating differential control of HIV by IFN alpha subtypes 🦠🧫🧬
Differential Control of HIV-1 Replication by IFN-α14 Compared to IFN-α2 Relates to Differences in the Modulation of Host Antiretroviral Restriction Factors https://www.biorxiv.org/content/10.1101/2025.11.01.685890v1
November 4, 2025 at 3:37 AM
Very cool work from my former mentor elucidating differential control of HIV by IFN alpha subtypes 🦠🧫🧬
Reposted by Erik Van Dis
Sphingolipid sensor degrades cGAMP to suppress antiviral host defense- #virus #lipids #hostdefense #innateImmunity
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation
Wang et al. find that cell membrane stress upon viral infection induces expression
and stabilization of host sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B),
which, in turn, degrades cGAMP to s...
www.cell.com
November 2, 2025 at 6:52 PM
Sphingolipid sensor degrades cGAMP to suppress antiviral host defense- #virus #lipids #hostdefense #innateImmunity
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Erik Van Dis
#Cytokines2025 will kick off with two special symposia! Check in early, get your badges, to attend these sessions.
November 2, 2025 at 5:19 PM
#Cytokines2025 will kick off with two special symposia! Check in early, get your badges, to attend these sessions.
Reposted by Erik Van Dis
Sad day for the folks who staked their reputations on lab leak conspiracy theories.
www.telegraph.co.uk/global-healt...
www.telegraph.co.uk/global-healt...
October 31, 2025 at 3:51 PM
Sad day for the folks who staked their reputations on lab leak conspiracy theories.
www.telegraph.co.uk/global-healt...
www.telegraph.co.uk/global-healt...
Reposted by Erik Van Dis
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 14, 2025 at 6:45 PM
Super excited about first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to the brilliant Chase Suiter (not here) & @greenahn.bsky.social on the work! Preprint here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Erik Van Dis
When 2 life science discoveries converge: solving a ~3 decade mystery of extraordinary longevity and healthspan + an essential cell danger sensor
And related ongoing clinical trials!
erictopol.substack.com/p/a-long-awa...
And related ongoing clinical trials!
erictopol.substack.com/p/a-long-awa...
A Long-Awaited Longevity Mystery Solved
Spotlighting an essential human biologic pathway targeted by drugs in clinical trials
erictopol.substack.com
October 12, 2025 at 12:32 PM
When 2 life science discoveries converge: solving a ~3 decade mystery of extraordinary longevity and healthspan + an essential cell danger sensor
And related ongoing clinical trials!
erictopol.substack.com/p/a-long-awa...
And related ongoing clinical trials!
erictopol.substack.com/p/a-long-awa...
Reposted by Erik Van Dis
Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells
Tissue-resident memory CD4+ T cells (TRM) are key sentinels of the adaptive immune response that provide a rapid, robust inflammatory response upon reactivation in non-lymphoid tissues. While CD4+ TRM...
www.biorxiv.org
October 10, 2025 at 7:22 PM
Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Erik Van Dis
@biorxivpreprint.bsky.social Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells @marionpepper.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 7, 2025 at 3:02 PM
@biorxivpreprint.bsky.social Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells @marionpepper.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Erik Van Dis
How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription
Molecular determinants underlying functional divergence of TBP homologs
The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...
www.biorxiv.org
October 7, 2025 at 7:43 PM
How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.
Read it here 👉
www.biorxiv.org/content/10.1...
#MolecularEvolution #Transcription
Reposted by Erik Van Dis
Impaired IFNγ responsiveness of lung monocyte-derived cells limits immunity to Mycobacterium tuberculosis https://www.biorxiv.org/content/10.1101/2025.10.06.680719v1
October 7, 2025 at 2:16 AM
Impaired IFNγ responsiveness of lung monocyte-derived cells limits immunity to Mycobacterium tuberculosis https://www.biorxiv.org/content/10.1101/2025.10.06.680719v1
Reposted by Erik Van Dis
Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells https://www.biorxiv.org/content/10.1101/2025.10.03.680350v1
October 6, 2025 at 2:16 AM
Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells https://www.biorxiv.org/content/10.1101/2025.10.03.680350v1
Timely piece on the importance and safety of “gain-of-function” research, from my brilliant PhD advisor Sarah Stanley www.statnews.com/2025/10/06/g...
The NIH ordered me to stop my ‘dangerous’ gain-of-function research. It isn’t dangerous at all
Safe gain-of-function research is necessary to identify new treatments for diseases like for tuberculosis — but the NIH has imposed unfounded stops.
www.statnews.com
October 6, 2025 at 6:46 PM
Timely piece on the importance and safety of “gain-of-function” research, from my brilliant PhD advisor Sarah Stanley www.statnews.com/2025/10/06/g...
Reposted by Erik Van Dis
“The job of teaching is not just to provide something worth noticing, but to protect students from everything that isn’t.”
Interesting article by @carlhendrick.substack.com
substack.com/@carlhendric...
Interesting article by @carlhendrick.substack.com
substack.com/@carlhendric...
Carl Hendrick (@carlhendrick)
Attention is a filter not a spotlight, and noisy classrooms assault that filter from every direction. Today's students rarely suffer from boredom or attention shortages, they suffer from attention sur...
substack.com
October 4, 2025 at 11:34 AM
“The job of teaching is not just to provide something worth noticing, but to protect students from everything that isn’t.”
Interesting article by @carlhendrick.substack.com
substack.com/@carlhendric...
Interesting article by @carlhendrick.substack.com
substack.com/@carlhendric...
Reposted by Erik Van Dis
I'm thrilled to announce I'll be joining the Department of Molecular Genetics & Microbiology at the University of Florida in January 2026! My lab will study RNA virus-host interactions with a particular focus on the spatial regulation of viral replication and innate immune activation. genoyerlab.com
Genoyer Lab
genoyerlab.com
October 3, 2025 at 6:10 PM
I'm thrilled to announce I'll be joining the Department of Molecular Genetics & Microbiology at the University of Florida in January 2026! My lab will study RNA virus-host interactions with a particular focus on the spatial regulation of viral replication and innate immune activation. genoyerlab.com
Reposted by Erik Van Dis
Reposted by Erik Van Dis
This is the official communication from the FDA to physicians on acetaminophen use in pregnancy.
- They acknowledge the lack of a causal link with autism
- Essentially tell physicians to keep doing what we've been doing anyway
It's very different from the press conference.
Pass it on.
- They acknowledge the lack of a causal link with autism
- Essentially tell physicians to keep doing what we've been doing anyway
It's very different from the press conference.
Pass it on.
September 25, 2025 at 1:59 PM
This is the official communication from the FDA to physicians on acetaminophen use in pregnancy.
- They acknowledge the lack of a causal link with autism
- Essentially tell physicians to keep doing what we've been doing anyway
It's very different from the press conference.
Pass it on.
- They acknowledge the lack of a causal link with autism
- Essentially tell physicians to keep doing what we've been doing anyway
It's very different from the press conference.
Pass it on.
Reposted by Erik Van Dis
@biorxivpreprint.bsky.social Endogenous retroelements promote tolerance to dietary antigens @belkaidlab.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 11, 2025 at 3:43 AM
@biorxivpreprint.bsky.social Endogenous retroelements promote tolerance to dietary antigens @belkaidlab.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Erik Van Dis
#Tuberculosis severity varies widely between people; why is this? This study uses the #CollaborativeCross mouse panel to identify the protease #cathepsin Z (CTSZ) as a conserved regulator of #TB outcomes via its influence on CXCL1 in mice & in humans @plosbiology.org 🧪 plos.io/4phwRA8
September 10, 2025 at 5:35 PM
#Tuberculosis severity varies widely between people; why is this? This study uses the #CollaborativeCross mouse panel to identify the protease #cathepsin Z (CTSZ) as a conserved regulator of #TB outcomes via its influence on CXCL1 in mice & in humans @plosbiology.org 🧪 plos.io/4phwRA8
Reposted by Erik Van Dis
Join us at the amazing Midwinter Conference of Immunologists in January 2025 in beautiful Asilomar!
🚨There is a travel grant for underrepresented trainees, apply now! www.cvent.com/c/abstracts/...
#blackinImmuno #BlackinMicro #Sacnas
🚨There is a travel grant for underrepresented trainees, apply now! www.cvent.com/c/abstracts/...
#blackinImmuno #BlackinMicro #Sacnas
September 8, 2025 at 3:59 PM
Join us at the amazing Midwinter Conference of Immunologists in January 2025 in beautiful Asilomar!
🚨There is a travel grant for underrepresented trainees, apply now! www.cvent.com/c/abstracts/...
#blackinImmuno #BlackinMicro #Sacnas
🚨There is a travel grant for underrepresented trainees, apply now! www.cvent.com/c/abstracts/...
#blackinImmuno #BlackinMicro #Sacnas
Reposted by Erik Van Dis
A choanoflagellate cGLR-STING pathway reveals evolutionary links between bacterial and animal immunity https://www.biorxiv.org/content/10.1101/2025.09.04.674280v1
September 5, 2025 at 5:16 AM
A choanoflagellate cGLR-STING pathway reveals evolutionary links between bacterial and animal immunity https://www.biorxiv.org/content/10.1101/2025.09.04.674280v1
Reposted by Erik Van Dis
SMURF2 inhibits autophagic control of Mycobacterium tuberculosis in macrophages https://www.biorxiv.org/content/10.1101/2025.09.02.673599v1
September 5, 2025 at 10:17 AM
SMURF2 inhibits autophagic control of Mycobacterium tuberculosis in macrophages https://www.biorxiv.org/content/10.1101/2025.09.02.673599v1
Reposted by Erik Van Dis
Yes, it was carefully hidden in the New England Journal of Medicine.
Pfizer/BioNTech vaccine (www.nejm.org/doi/pdf/10.1... )
1/2
Pfizer/BioNTech vaccine (www.nejm.org/doi/pdf/10.1... )
1/2
September 1, 2025 at 4:08 PM
Yes, it was carefully hidden in the New England Journal of Medicine.
Pfizer/BioNTech vaccine (www.nejm.org/doi/pdf/10.1... )
1/2
Pfizer/BioNTech vaccine (www.nejm.org/doi/pdf/10.1... )
1/2
Reposted by Erik Van Dis
9 CDC Directors going back to 1977 speak out. What RFK Jr has done to our nation’s public health system "should alarm every American."
It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...
It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...
Opinion | We Ran the C.D.C.: Kennedy Is Endangering Every American’s Health
www.nytimes.com
September 1, 2025 at 11:23 AM
9 CDC Directors going back to 1977 speak out. What RFK Jr has done to our nation’s public health system "should alarm every American."
It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...
It "is unlike anything we have ever seen at the agency, and unlike anything our country has ever experienced." www.nytimes.com/2025/09/01/o...