Elston D’Souza
@elstondsouza.com
DPhil Student and RA at the CRDG Lab, University of Oxford
Reposted by Elston D’Souza
Re:science, an issue is that ppl don't have a great grasp of stats. Even those w/quant bkgds.
Populations & systems aren't the same as a person. If you have X% risk, you don't get only X% of the outcome.
Also, diff in risk is not always a meaningful diff. A person is not a system to be optimized!
Populations & systems aren't the same as a person. If you have X% risk, you don't get only X% of the outcome.
Also, diff in risk is not always a meaningful diff. A person is not a system to be optimized!
Ethical/moral arguments aren't effective w/them bc so many of these people simply do not care. Bring back bullying and shame, specifically of being suckers.
We mock women ruthlessly for astrology. Time to bring some of that energy to eugenicists.
After all, eugenics is just astrology for bigots.
We mock women ruthlessly for astrology. Time to bring some of that energy to eugenicists.
After all, eugenics is just astrology for bigots.
The tech bro fascination with eugenics is so on brand. The idea that you could make accurate, actionable predictions from individual genotypes (with all their complex, non-linear interactions) from averaged, linearly modeled population-level genomic statistics is just another big data fantasy
December 12, 2024 at 7:32 PM
Re:science, an issue is that ppl don't have a great grasp of stats. Even those w/quant bkgds.
Populations & systems aren't the same as a person. If you have X% risk, you don't get only X% of the outcome.
Also, diff in risk is not always a meaningful diff. A person is not a system to be optimized!
Populations & systems aren't the same as a person. If you have X% risk, you don't get only X% of the outcome.
Also, diff in risk is not always a meaningful diff. A person is not a system to be optimized!
Reposted by Elston D’Souza
Reposted by Elston D’Souza
Honoured to be recognised by @gensocuk.bsky.social and humbled to be named alongside so many incredible geneticists 🤯🧬
But science is a team sport: this is really down to, and for, my absolutely incredible team who inspire, drive, and motivate me every day 🌟 #teamWork #youGuysRock
1/2
But science is a team sport: this is really down to, and for, my absolutely incredible team who inspire, drive, and motivate me every day 🌟 #teamWork #youGuysRock
1/2
Congratulations to @nickywhiffin.bsky.social on being awarded the Balfour Lecturer! Her innovative contributions on the role of genetic variants in rare diseases are shaping the future of research and discovery. We look forward to her inspiring lecture!
genetics.org.uk/medals-and-p...
genetics.org.uk/medals-and-p...
November 22, 2024 at 11:46 AM
Honoured to be recognised by @gensocuk.bsky.social and humbled to be named alongside so many incredible geneticists 🤯🧬
But science is a team sport: this is really down to, and for, my absolutely incredible team who inspire, drive, and motivate me every day 🌟 #teamWork #youGuysRock
1/2
But science is a team sport: this is really down to, and for, my absolutely incredible team who inspire, drive, and motivate me every day 🌟 #teamWork #youGuysRock
1/2
Reposted by Elston D’Souza
Offering a free bowl of gummy bears is the best value-for-money to make your guests/co-workers feel pampered
November 20, 2024 at 7:11 AM
Offering a free bowl of gummy bears is the best value-for-money to make your guests/co-workers feel pampered
Reposted by Elston D’Souza
I wrote about Eric Turkheimer's recent book on "the nature-nurture debate", which should be of interest to people thinking not just about the genetics of behavior but complex traits more broadly. A 🧵:
Book Review: Eric Turkheimer's "Understanding the Nature-Nurture Debate"
Or, some thoughts on The Gloomy Prospect and the Gloomy Present
open.substack.com
November 16, 2024 at 6:40 PM
I wrote about Eric Turkheimer's recent book on "the nature-nurture debate", which should be of interest to people thinking not just about the genetics of behavior but complex traits more broadly. A 🧵:
Reposted by Elston D’Souza
I couldn't spot a starter pack for rare disease / clinical genomics, so I started one: go.bsky.app/SUWZ9Hw
Very much a work in progress, and biased by who I have already found here, so please suggest people to add! Self-nominations encouraged.
#ClinicalInformatics #genomics #bioinformatics 🖥️🧬
Very much a work in progress, and biased by who I have already found here, so please suggest people to add! Self-nominations encouraged.
#ClinicalInformatics #genomics #bioinformatics 🖥️🧬
November 15, 2024 at 10:30 AM
I couldn't spot a starter pack for rare disease / clinical genomics, so I started one: go.bsky.app/SUWZ9Hw
Very much a work in progress, and biased by who I have already found here, so please suggest people to add! Self-nominations encouraged.
#ClinicalInformatics #genomics #bioinformatics 🖥️🧬
Very much a work in progress, and biased by who I have already found here, so please suggest people to add! Self-nominations encouraged.
#ClinicalInformatics #genomics #bioinformatics 🖥️🧬
Reposted by Elston D’Souza
Back home and reflecting on a fantastic week at #ASHG24.
It was wonderful to reconnect with friends, make new connections, and be surrounded by amazing science! 🧬
This was my first time attending ASHG with many of my amazing team (see below). They did an incredible job representing the group 🥰 1/2
It was wonderful to reconnect with friends, make new connections, and be surrounded by amazing science! 🧬
This was my first time attending ASHG with many of my amazing team (see below). They did an incredible job representing the group 🥰 1/2
November 11, 2024 at 2:57 PM
Back home and reflecting on a fantastic week at #ASHG24.
It was wonderful to reconnect with friends, make new connections, and be surrounded by amazing science! 🧬
This was my first time attending ASHG with many of my amazing team (see below). They did an incredible job representing the group 🥰 1/2
It was wonderful to reconnect with friends, make new connections, and be surrounded by amazing science! 🧬
This was my first time attending ASHG with many of my amazing team (see below). They did an incredible job representing the group 🥰 1/2
Reposted by Elston D’Souza
A starter pack of starter packs 😛 Love it!
My fav starter packs so far, a thread:
stats: go.bsky.app/Ki7PjpS
stats: go.bsky.app/7TBN5rX
causal inference: go.bsky.app/FdemGAZ
package devs: go.bsky.app/N1569Qh
data peeps: go.bsky.app/8TdEfdK
medical stats: go.bsky.app/ArqEz36
bioinformatics: go.bsky.app/Ha64Gmv
r-ladies: go.bsky.app/Vgxwa2F
stats: go.bsky.app/Ki7PjpS
stats: go.bsky.app/7TBN5rX
causal inference: go.bsky.app/FdemGAZ
package devs: go.bsky.app/N1569Qh
data peeps: go.bsky.app/8TdEfdK
medical stats: go.bsky.app/ArqEz36
bioinformatics: go.bsky.app/Ha64Gmv
r-ladies: go.bsky.app/Vgxwa2F
October 27, 2024 at 8:53 PM
A starter pack of starter packs 😛 Love it!
Reposted by Elston D’Souza
Your periodic reminder that ChatGPT is not a research tool.
(The purification theorem was presented in Harsanyi's 1973 Int J Game Theory paper, not in the famous Management Science trilogy.)
(The purification theorem was presented in Harsanyi's 1973 Int J Game Theory paper, not in the famous Management Science trilogy.)
October 25, 2024 at 4:04 AM
Your periodic reminder that ChatGPT is not a research tool.
(The purification theorem was presented in Harsanyi's 1973 Int J Game Theory paper, not in the famous Management Science trilogy.)
(The purification theorem was presented in Harsanyi's 1973 Int J Game Theory paper, not in the famous Management Science trilogy.)
Hope not Hate as well as the Guardian doing an amazing job of exposing crap science and the con men behind it.
www.theguardian.com/science/2024...
www.theguardian.com/science/2024...
US startup charging couples to ‘screen embryos for IQ’
Heliospect’s services were marketed at up to $50,000 for 100 embryos, undercover footage shows
www.theguardian.com
October 18, 2024 at 5:32 PM
Hope not Hate as well as the Guardian doing an amazing job of exposing crap science and the con men behind it.
www.theguardian.com/science/2024...
www.theguardian.com/science/2024...
Reposted by Elston D’Souza
Wow, the Guardian journalists who just yesterday published about the network of race scientists getting funding from tech CEOs just broke another story that this group has accessed UK Biobank data without authorization. This is seriously bad for the integrity of science & a massive failure by UKBB
‘Race science’ group say they accessed sensitive UK health data
Exclusive: Fringe network recorded boasting of securing data from UK Biobank trove donated by 500,000 volunteers
www.theguardian.com
October 17, 2024 at 3:40 PM
Wow, the Guardian journalists who just yesterday published about the network of race scientists getting funding from tech CEOs just broke another story that this group has accessed UK Biobank data without authorization. This is seriously bad for the integrity of science & a massive failure by UKBB
Reposted by Elston D’Souza
I wrote a bit about the two very interesting studies of siblings/families from last week. Tan et al. family GWAS (medrxiv.org/content/10.1...) and Sidorenko et al. sibling heritability estimates (nature.com/articles/s41...).
What are we learning from the genes of siblings?
Family-based genetic analyses come of age
open.substack.com
October 13, 2024 at 4:19 PM
I wrote a bit about the two very interesting studies of siblings/families from last week. Tan et al. family GWAS (medrxiv.org/content/10.1...) and Sidorenko et al. sibling heritability estimates (nature.com/articles/s41...).
Cats were never domesticated so much as they live symbiotically next to us lesser mortals 😂
October 11, 2024 at 9:04 PM
Cats were never domesticated so much as they live symbiotically next to us lesser mortals 😂
Reposted by Elston D’Souza
Meanwhile. Elsewhere and Elsewhen...
October 9, 2024 at 3:07 PM
Meanwhile. Elsewhere and Elsewhen...
Reposted by Elston D’Souza
Chem Nobel for protein structure prediction and de novo design! While she writes up the news, please enjoy @laurahowes.bsky.social 's deep dive into David Baker's brain:
cen.acs.org/biological-c...
cen.acs.org/biological-c...
Protein wrangler, serial entrepreneur, and community builder: Inside David Baker’s brain
Institute for Protein Design leader believes success lies in building a team and research community interconnected like a nerve center
cen.acs.org
October 9, 2024 at 10:40 AM
Chem Nobel for protein structure prediction and de novo design! While she writes up the news, please enjoy @laurahowes.bsky.social 's deep dive into David Baker's brain:
cen.acs.org/biological-c...
cen.acs.org/biological-c...
Expect the next Nobel Prize in Physics to be a biologist because biology is applied chemistry and chemistry is applied physics.
October 8, 2024 at 3:27 PM
Expect the next Nobel Prize in Physics to be a biologist because biology is applied chemistry and chemistry is applied physics.
Reposted by Elston D’Souza
Applied Statistics
August 25, 2024 at 6:30 PM
Applied Statistics
Oldpassword+n had been my go to until my Twitter got hacked.
I seriously wish institution-wide password managers were implemented rather than this outdated and ineffective policy.
I seriously wish institution-wide password managers were implemented rather than this outdated and ineffective policy.
"the requirement to periodically change [passwords] can diminish security because the added burden incentivizes weaker passwords that are easier to remember....[R]equired use of certain characters [also] often does more harm than good" arstechnica.com/security/202...
NIST proposes barring some of the most nonsensical password rules
Proposed guidelines aim to inject badly needed common sense into password hygiene.
arstechnica.com
September 26, 2024 at 4:56 PM
Oldpassword+n had been my go to until my Twitter got hacked.
I seriously wish institution-wide password managers were implemented rather than this outdated and ineffective policy.
I seriously wish institution-wide password managers were implemented rather than this outdated and ineffective policy.
The one thing I really love about Rstudio and hate about Python IDEs is the line by line evaluation in Rstudio as opposed to the block evaluation in something like Jupyter.
Its so useful in data analysis when playing around with data frames.
I cant wait to try this out.
Its so useful in data analysis when playing around with data frames.
I cant wait to try this out.
The newest RStudio release lets you toggle between R and Python in the Console by clicking the language’s logo in the Console pane header. #Rstats
September 26, 2024 at 2:12 PM
The one thing I really love about Rstudio and hate about Python IDEs is the line by line evaluation in Rstudio as opposed to the block evaluation in something like Jupyter.
Its so useful in data analysis when playing around with data frames.
I cant wait to try this out.
Its so useful in data analysis when playing around with data frames.
I cant wait to try this out.
Consumer genetics has been along for a while but I really now worry retailers are promising that the results of some out-of-date GWAS result is make changes to diet to improve skincare.
National dietary guidelines have been made for a reason. They work for nearly* all of us.
National dietary guidelines have been made for a reason. They work for nearly* all of us.
September 26, 2024 at 10:59 AM
Consumer genetics has been along for a while but I really now worry retailers are promising that the results of some out-of-date GWAS result is make changes to diet to improve skincare.
National dietary guidelines have been made for a reason. They work for nearly* all of us.
National dietary guidelines have been made for a reason. They work for nearly* all of us.
Reposted by Elston D’Souza
My lab read this paper www.biorxiv.org/content/10.1... for journal club, and had some thoughts on the strong claims made about the number of signals of selection found.
Pervasive findings of directional selection realize the promise of ancient DNA to elucidate human adaptation
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
September 21, 2024 at 6:57 PM
My lab read this paper www.biorxiv.org/content/10.1... for journal club, and had some thoughts on the strong claims made about the number of signals of selection found.
Reposted by Elston D’Souza
Calling all science/tech folks: Do you have thoughts about xkcd? Parker Bach & I are trying to understand the role that xkcd plays in the scientific/technical community. Will you share your thoughts? forms.office.com/pages/respon... And since we are doing a snowball sample, please pass the word!
Microsoft Forms
forms.office.com
September 19, 2024 at 5:12 PM
Calling all science/tech folks: Do you have thoughts about xkcd? Parker Bach & I are trying to understand the role that xkcd plays in the scientific/technical community. Will you share your thoughts? forms.office.com/pages/respon... And since we are doing a snowball sample, please pass the word!
Reposted by Elston D’Souza
We need to be honest with people who want to get PhDs and not just about the job market lucris.lub.lu.se/ws/portalfil...
September 19, 2024 at 4:37 PM
We need to be honest with people who want to get PhDs and not just about the job market lucris.lub.lu.se/ws/portalfil...