Elizabeth McFadden
@elizabeth-mcfadden.bsky.social
Structural virology, protein engineering, cryo-EM 👩🏻🔬 | Ph.D. Candidate in McLellan Lab at UT Austin seeking post-doctoral roles
Reposted by Elizabeth McFadden
Now online! Generation of antigen-specific paired-chain antibodies using large language models
Generation of antigen-specific paired-chain antibodies using large language models
MAGE is a sequence-based protein language model designed to generate diverse human antibody sequences targeting various pathogens, including SARS-CoV-2, H5N1, and RSV-A. This AI-driven approach addresses traditional limitations by enabling efficient, target-agnostic antibody design with experimentally validated binding specificity.
dlvr.it
November 4, 2025 at 11:38 PM
Now online! Generation of antigen-specific paired-chain antibodies using large language models
Reposted by Elizabeth McFadden
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
September 23, 2025 at 5:08 PM
I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪
Reposted by Elizabeth McFadden
Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.
August 19, 2025 at 6:24 PM
Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.
Reposted by Elizabeth McFadden
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
June 18, 2025 at 6:32 AM
Latest preprint from the lab, many years in the making!
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase.
This could have big implications for our understanding of viral replication & assembly (🧵)
www.biorxiv.org/content/10.1...
Grateful to be a part of such a fun project led by my labmate @luqiang.bsky.social!
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
June 18, 2025 at 10:37 PM
Grateful to be a part of such a fun project led by my labmate @luqiang.bsky.social!
Reposted by Elizabeth McFadden
Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...
May 20, 2025 at 6:19 PM
Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...
Reposted by Elizabeth McFadden
Happy to finally see this study published, a great collaboration between academic, government and industry labs! We show that CCHFV GP38 can induce vascular leak and that this can be prevented by protective but not virus-neutralizing antibodies! www.science.org/doi/10.1126/...
Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread
Glycoprotein GP38-specific antibodies reduce viral dissemination and GP38-mediated vascular leak in Crimean-Congo hemorrhagic fever virus infection.
www.science.org
February 19, 2025 at 11:31 PM
Happy to finally see this study published, a great collaboration between academic, government and industry labs! We show that CCHFV GP38 can induce vascular leak and that this can be prevented by protective but not virus-neutralizing antibodies! www.science.org/doi/10.1126/...
Reposted by Elizabeth McFadden
Wow! UT Austin’s Jason McLellan will be inducted into the National Inventors Hall of Fame for his work on structure-based vaccine design that led to development of vaccines to fight COVID-19 & RSV.
@mclellanlab.bsky.social @utaustin.bsky.social #COVIDVaccine
cns.utexas.edu/news/announc...
@mclellanlab.bsky.social @utaustin.bsky.social #COVIDVaccine
cns.utexas.edu/news/announc...
UT Vaccine Scientist Will Be Inducted Into National Inventors Hall of Fame
McLellan, who will be inducted in Washington, D.C. on May 8, is among the youngest new inductees in hall of fame history.
cns.utexas.edu
January 17, 2025 at 4:00 PM
Wow! UT Austin’s Jason McLellan will be inducted into the National Inventors Hall of Fame for his work on structure-based vaccine design that led to development of vaccines to fight COVID-19 & RSV.
@mclellanlab.bsky.social @utaustin.bsky.social #COVIDVaccine
cns.utexas.edu/news/announc...
@mclellanlab.bsky.social @utaustin.bsky.social #COVIDVaccine
cns.utexas.edu/news/announc...
Reposted by Elizabeth McFadden
I’m super excited to see this work out from my lab/PhD-cohort-mate @elizabeth-mcfadden.bsky.social. By engineering and structurally analyzing a soluble gp38-Gn-Gc complex, she develops new insights for CCHFV and other type II viral fusion proteins alike. Definitely worth the read!
I'm happy to announce that our paper is now online in Cell! This study was the result of a highly collaborative effort from many scientists. Please read it here: www.cell.com/cell/fulltex...
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Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes
Crimean-Congo hemorrhagic fever virus is a widespread tickborne virus that infects humans. Engineering-based structural studies of the viral glycoprotein complexes GP38-Gn and GP38-Gn-Gc provide insights to their function in the viral life cycle. GP38-Gn-Gc confers partial protection against lethal viral challenge in mice, showing promise as a vaccine antigen for further development.
www.cell.com
December 21, 2024 at 7:13 PM
I’m super excited to see this work out from my lab/PhD-cohort-mate @elizabeth-mcfadden.bsky.social. By engineering and structurally analyzing a soluble gp38-Gn-Gc complex, she develops new insights for CCHFV and other type II viral fusion proteins alike. Definitely worth the read!
Reposted by Elizabeth McFadden
Congratulations Elizabeth! Great collaborative effort with our colleagues Kartik Chandran, Andrew Herbert, Stephanie Monticelli and more!
This is my first, first-author paper of my PhD and is a reminder of my growth over the last several years and the excellent training and mentorship I've received from
@mclellanlab.bsky.social. Thanks to all who contributed to this work!
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@mclellanlab.bsky.social. Thanks to all who contributed to this work!
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December 20, 2024 at 8:43 PM
Congratulations Elizabeth! Great collaborative effort with our colleagues Kartik Chandran, Andrew Herbert, Stephanie Monticelli and more!
I'm happy to announce that our paper is now online in Cell! This study was the result of a highly collaborative effort from many scientists. Please read it here: www.cell.com/cell/fulltex...
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Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes
Crimean-Congo hemorrhagic fever virus is a widespread tickborne virus that infects humans. Engineering-based structural studies of the viral glycoprotein complexes GP38-Gn and GP38-Gn-Gc provide insights to their function in the viral life cycle. GP38-Gn-Gc confers partial protection against lethal viral challenge in mice, showing promise as a vaccine antigen for further development.
www.cell.com
December 20, 2024 at 8:01 PM
I'm happy to announce that our paper is now online in Cell! This study was the result of a highly collaborative effort from many scientists. Please read it here: www.cell.com/cell/fulltex...
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