Felix Pahmeier
@fpahmeier.bsky.social
PhD Candidate - Infectious Diseases and Immunity
Reposted by Felix Pahmeier
Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...
May 20, 2025 at 6:19 PM
Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...
Happy to finally see this study published, a great collaboration between academic, government and industry labs! We show that CCHFV GP38 can induce vascular leak and that this can be prevented by protective but not virus-neutralizing antibodies! www.science.org/doi/10.1126/...
Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread
Glycoprotein GP38-specific antibodies reduce viral dissemination and GP38-mediated vascular leak in Crimean-Congo hemorrhagic fever virus infection.
www.science.org
February 19, 2025 at 11:31 PM
Happy to finally see this study published, a great collaboration between academic, government and industry labs! We show that CCHFV GP38 can induce vascular leak and that this can be prevented by protective but not virus-neutralizing antibodies! www.science.org/doi/10.1126/...
Reposted by Felix Pahmeier
I'm happy to announce that our paper is now online in Cell! This study was the result of a highly collaborative effort from many scientists. Please read it here: www.cell.com/cell/fulltex...
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Engineering and structures of Crimean-Congo hemorrhagic fever virus glycoprotein complexes
Crimean-Congo hemorrhagic fever virus is a widespread tickborne virus that infects humans. Engineering-based structural studies of the viral glycoprotein complexes GP38-Gn and GP38-Gn-Gc provide insights to their function in the viral life cycle. GP38-Gn-Gc confers partial protection against lethal viral challenge in mice, showing promise as a vaccine antigen for further development.
www.cell.com
December 20, 2024 at 8:01 PM
I'm happy to announce that our paper is now online in Cell! This study was the result of a highly collaborative effort from many scientists. Please read it here: www.cell.com/cell/fulltex...
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Reposted by Felix Pahmeier
"A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice"
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice
The continued emergence of SARS-CoV-2 variants and the threat of future Sarbecovirus zoonoses have spurred the design of vaccines that can induce broa…
www.sciencedirect.com
November 18, 2024 at 7:07 PM
"A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice"
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...