Cefidericol was not inferior for mortality but was the source of all the serious adverse events in this study comparing cefiderocol to standard of care for healthcare-associated GNR blood stream infections.

For CRE subset, verdict less clear… #IDSky

www.thelancet.com/journals/lan...

What the DOTS trial of Staph bacteremia tells us:
• Dalbavancin d1 and d8 vs daily IVs for WEEKS
• No left-sided IE/CNS/prosthetics
• Dalba not superior by DOOR endpoint, but similar clinical outcomes.
Big implications for inpt care. More here! #IDSky tinyurl.com/3hjzkt96

To change or not to change?

Clinicians please consider this quick (<2 min!!) survey regarding your catheter-associated UTI practice patterns.

My collaborators in 🇳🇱 are exploring practice variations across different countries and medical specialties worldwide.

forms.office.com/e/MRCMwUb2UK

Daily CRP vs daily PCT - which one can help reduce the duration of antibiotic therapy?
Caveat: daily PCT = expensive in LMICs!

A new "paper highlight" on our MAMSIG website
antibiotic-ninja.com/paper-highli...

Would you choose cefta-avi or ceftolozane-tazo to treat pneumonia by MDR P. aeruginosa?
We highlighted the CACTUS study published a few weeks ago

www.antibiotic-ninja.com/paper-highli...

New research article in The Lancet Microbe

Prevalence, misclassification, and clinical consequences of the heteroresistant phenotype in Escherichia coli bloodstream infections in patients in Uppsala, Sweden: a retrospective cohort study

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #AMR

In our winter issue: The choice between debridement and implant exchange affects treatment outcomes for Candida-related prosthetic joint infections, highlighting the need for standardized guidelines and research. Yingsi Fang, PharmD and Michael Vala, PharmD offer insights on the topic. #IDsky

WHERE WAS THIS 6 MONTHS AGO WHEN I WAS RESEARCHING OUR TETRACYCLINES EPISODE??!!

Wotevs. Check out this awesome review

Unless u r driving or hate reading; then our episode is here: podcasts.apple.com/gb/podcast/i...

And the episode on the newer agents here: podcasts.apple.com/gb/podcast/i...

Study shows how zinc deprivation makes VIM-2-expressing bacteria more susceptible to azithromycin, offering new treatment options for multidrug-resistant infections. #IDsky #MEDsky

Read more including insights from investigator Meghan Tu: www.contagionlive.com/view/exploit...

Tetracyclines always been a fascinating antibiotic class. So many different evolutions, and antimicrobial activity that variably spans across Gram pos & neg bacteria, as well as malaria!

Cool review in @cmicomms.bsky.social by @jeffpears0n.bsky.social @bwdionne.bsky.social

#IDSky #clinmicro #AMR

🔗 References:
1. CLSI M100 ED34:2024, Table 2A-1, Table 2D, Appendix E, Table 2 Dosages
2. Rationale document clsi.org/standards/pr...

Who is still using metronidazole q8h for most indications? There’s definitely an opportunity for less frequent dosing most of the time!

I’ve attached my proposal from last year - feel free to take a look, and hopefully it can save you some trouble and doses for you too!

1drv.ms/w/s!AurvlEJP...

Malaysia's MOH and university hospitals report high inpatient antibiotic prescription rates of 45%, mainly in ICUs, outpatient rates are ~5%. Despite concerns, 98% of prescriptions align with national guidelines, reflecting efforts to ensure appropriate use.

codeblue.galencentre.org/2025/01/up-t...

Has anyone seen NTM infections or difficult-to-diagnose splenic abscesses, presenting as PUO following mesenchymal cell therapy?

The 2025 Infection Prevention and Control Workshop is here!
🖐️🦠👩‍⚕️👨‍⚕️
Grab your seats now and learn from the experts about the latest infection control strategies and best practices.
Don’t miss out!
#InfectionPrevention #IPCW2025

Click here to know more: ummctrainings.onpay.my/order/form/i...

New year, new paper! 🎉

We’ve summarized the findings from the BALANCE trial, the largest study on BSI to date
#BSI #BALANCETrial

Check it out on the MAMSIG website!
www.antibiotic-ninja.com/paper-highli...