Nature Metabolism, Published online: 24 September 2025; doi:10.1038/s42255-025-01360-4The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

Bloating, abdominal pain, constipation? You might have diverticular disease — a condition that affects nearly 7 in 10 people over 80. Here’s what you need to know.

In people with overweight or obesity, regular exercise even without weight loss or vitamin D supplementation completely prevents the usual winter decline in the vitamin D metabolite that maintains health at a cellular level, 1,25(OH) 2 D 3 , and ameliorates the decline in the vitamin D status marker 25(OH)D. Abstract Many adults become vitamin D deficient or insufficient during winter at northerly latitudes when cutaneous vitamin D synthesis does not occur. Vitamin D accumulates in adipose tissue and people with overweight or obesity are more likely to have low systemic vitamin D. This randomized controlled trial demonstrates that regular exercise completely maintains serum concentrations of the active vitamin D metabolite 1,25(OH) 2 D 3 over winter and may ameliorate the decline in 25(OH)D status in overweight men and women, even without weight loss. The binding of 1,25(OH) 2 D 3 to the vitamin D receptor mediates the crucial role for vitamin D in the healthy function of multiple organ systems and vitamin D supplementation does not impact circulating 1,25(OH) 2 D 3 . Thus, the VitaDEx study provides causal evidence that exercise plays an important role in vitamin D metabolism that is distinct from the effects of oral supplementation.

In people with overweight or obesity, regular exercise even without weight loss or vitamin D supplementation completely prevents the usual winter decline in the vitamin D metabolite that maintains he...

In people with overweight or obesity, regular exercise even without weight loss or vitamin D supplementation completely prevents the usual winter decline in the vitamin D metabolite that maintains he...

Researchers describe how they are using skills honed in the laboratory in their creative pursuits.