Dr Scott J. Roberts
@drsjroberts.bsky.social
Reader and Musculoskeletal Drug Hunter
👏 Wonderful to see our research featured on the cover of @natureportfolio.nature.com journal Bone Research (@brjournal.bsky.social)! Congratulations to my co-authors from the @royalvetcollege.bsky.social and UCB .
#sclerosteosis #raredisease #drugdiscovery
#sclerosteosis #raredisease #drugdiscovery
Cover image showing pseudo-colored trabeculae of the Sost -/- proximal tibiae, highlighting how bone thickness varies, measured by µCT. This cover image was contributed by @Scott Roberts, the Royal Veterinary College, London, UK.
@brjournal.bsky.social
www.nature.com/articles/s41...
@brjournal.bsky.social
www.nature.com/articles/s41...
August 29, 2025 at 8:46 AM
👏 Wonderful to see our research featured on the cover of @natureportfolio.nature.com journal Bone Research (@brjournal.bsky.social)! Congratulations to my co-authors from the @royalvetcollege.bsky.social and UCB .
#sclerosteosis #raredisease #drugdiscovery
#sclerosteosis #raredisease #drugdiscovery
Reposted by Dr Scott J. Roberts
📢 New Publication: I am delighted to share our most recent paper, published in @natureportfolio.nature.com Journal Bone Research "Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies".
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies - Bone Research
Bone Research - Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies
www.nature.com
April 22, 2025 at 5:18 PM
📢 New Publication: I am delighted to share our most recent paper, published in @natureportfolio.nature.com Journal Bone Research "Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies".
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Dr Scott J. Roberts
Excited to share the latest chapter of our work on fat-joint interorgan crosstalk in knee OA, featuring the role of complement factor D secreted by fat in knee pain. Link here: bit.ly/42Og5hJ
Thanks to @farsh-g.bsky.social for all of your support - @thehopefulscie1.bsky.social and all coauthors!
Thanks to @farsh-g.bsky.social for all of your support - @thehopefulscie1.bsky.social and all coauthors!
April 25, 2025 at 6:13 PM
Excited to share the latest chapter of our work on fat-joint interorgan crosstalk in knee OA, featuring the role of complement factor D secreted by fat in knee pain. Link here: bit.ly/42Og5hJ
Thanks to @farsh-g.bsky.social for all of your support - @thehopefulscie1.bsky.social and all coauthors!
Thanks to @farsh-g.bsky.social for all of your support - @thehopefulscie1.bsky.social and all coauthors!
Reposted by Dr Scott J. Roberts
Annemarie’s latest paper is out today!
CYR61 delivery promotes angiogenesis during bone fracture repair.
www.nature.com/articles/s41...
@amilangscience.bsky.social @madhura0327.bsky.social @cpane94.bsky.social @eseidlscience.bsky.social @ricgottardi.bsky.social et al.
CYR61 delivery promotes angiogenesis during bone fracture repair.
www.nature.com/articles/s41...
@amilangscience.bsky.social @madhura0327.bsky.social @cpane94.bsky.social @eseidlscience.bsky.social @ricgottardi.bsky.social et al.
CYR61 delivery promotes angiogenesis during bone fracture repair - npj Regenerative Medicine
npj Regenerative Medicine - CYR61 delivery promotes angiogenesis during bone fracture repair
www.nature.com
April 24, 2025 at 3:15 AM
Annemarie’s latest paper is out today!
CYR61 delivery promotes angiogenesis during bone fracture repair.
www.nature.com/articles/s41...
@amilangscience.bsky.social @madhura0327.bsky.social @cpane94.bsky.social @eseidlscience.bsky.social @ricgottardi.bsky.social et al.
CYR61 delivery promotes angiogenesis during bone fracture repair.
www.nature.com/articles/s41...
@amilangscience.bsky.social @madhura0327.bsky.social @cpane94.bsky.social @eseidlscience.bsky.social @ricgottardi.bsky.social et al.
Reposted by Dr Scott J. Roberts
Enzyme Porcupine inhibition of Wnt signaling-a promising treatment forsclerosteosis - rare Dz caused by SOST mutations & loss of functional sclerostin. Results in high bone mass & skeletal overgrowth (Sxs of facial paralysis, hearing loss, incr intracranial pressure www.nature.com/articles/s41...
Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies - Bone Research
Bone Research - Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies
www.nature.com
April 17, 2025 at 3:02 PM
Enzyme Porcupine inhibition of Wnt signaling-a promising treatment forsclerosteosis - rare Dz caused by SOST mutations & loss of functional sclerostin. Results in high bone mass & skeletal overgrowth (Sxs of facial paralysis, hearing loss, incr intracranial pressure www.nature.com/articles/s41...
Reposted by Dr Scott J. Roberts
This study was published in Bone Research, the team investigates the impact of LGK974, a Porcupine inhibitor, on bone mass regulation in a sclerosteosis mouse model.
#Bone #Sclerosteosis
Details: doi.org/10.1038/s414...
#Bone #Sclerosteosis
Details: doi.org/10.1038/s414...
April 16, 2025 at 11:57 AM
This study was published in Bone Research, the team investigates the impact of LGK974, a Porcupine inhibitor, on bone mass regulation in a sclerosteosis mouse model.
#Bone #Sclerosteosis
Details: doi.org/10.1038/s414...
#Bone #Sclerosteosis
Details: doi.org/10.1038/s414...
Reposted by Dr Scott J. Roberts
Porcupine inhibition, targeting the Wnt signaling pathway, shows promise as a treatment for sclerosteosis, potentially reducing the need for high-risk surgeries in this rare genetic disorder. doi.org/g9fm67
Porcupine inhibition represents a promising treatment for sclerosteosis patients
New research from the Royal Veterinary College (RVC) has identified porcupine inhibition—a strategy that blocks a key bone-related signaling pathway (Wnt)—as a promising pharmacological treatment for severe sclerosteosis.
medicalxpress.com
April 15, 2025 at 7:04 PM
Porcupine inhibition, targeting the Wnt signaling pathway, shows promise as a treatment for sclerosteosis, potentially reducing the need for high-risk surgeries in this rare genetic disorder. doi.org/g9fm67
📢 New Publication: I am delighted to share our most recent paper, published in @natureportfolio.nature.com Journal Bone Research "Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies".
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies - Bone Research
Bone Research - Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies
www.nature.com
April 22, 2025 at 5:18 PM
📢 New Publication: I am delighted to share our most recent paper, published in @natureportfolio.nature.com Journal Bone Research "Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies".
www.nature.com/articles/s41...
www.nature.com/articles/s41...