@draashish.bsky.social
Internist, Educator, EBM enthusiast, photography hobbyist. #FOAMed #Medsky #IMSky
Reposted
MASSIVE RCT from Kenya showing that steroids reduce mortality in CAP
Mortality benefit easier to demonstrate w/ less resources available to salvage pts
Should allay the hype that the negative REMAP-CAP steroid RCT received (despite being woefully underpowered)
www.nejm.org/doi/pdf/10.1... #EMIMCC
Mortality benefit easier to demonstrate w/ less resources available to salvage pts
Should allay the hype that the negative REMAP-CAP steroid RCT received (despite being woefully underpowered)
www.nejm.org/doi/pdf/10.1... #EMIMCC
October 29, 2025 at 3:37 PM
MASSIVE RCT from Kenya showing that steroids reduce mortality in CAP
Mortality benefit easier to demonstrate w/ less resources available to salvage pts
Should allay the hype that the negative REMAP-CAP steroid RCT received (despite being woefully underpowered)
www.nejm.org/doi/pdf/10.1... #EMIMCC
Mortality benefit easier to demonstrate w/ less resources available to salvage pts
Should allay the hype that the negative REMAP-CAP steroid RCT received (despite being woefully underpowered)
www.nejm.org/doi/pdf/10.1... #EMIMCC
Reposted
The BICAR-ICU-2 trial just dropped!
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
October 29, 2025 at 2:59 PM
The BICAR-ICU-2 trial just dropped!
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
RCT involving IV bicarb in metabolic acidosis among patients with mod-severe AKI
Bicarb didn't affect mortality but it reduced the need for dialysis & risk of bacteremia
VERY similar conclusions to BICAR-ICU-1
🧵 #1/
jamanetwork.com/journals/jam... #EMIMCC
@gradydoctor.bsky.social What an inspiring talk by Dr. Manning at APDIM! #APDIM
October 17, 2025 at 7:40 PM
@gradydoctor.bsky.social What an inspiring talk by Dr. Manning at APDIM! #APDIM
Reposted
AQUATIC: More Than 6 Months After PCI, Don’t Use Aspirin With OAC
AQUATIC: More Than 6 Months After PCI, Don’t Use Aspirin With OAC
AQUATIC: More Than 6 Months After PCI, Don’t Use Aspirin With OAC
ccox@crf.org
Mon, 09/01/2025 - 06:22
Todd Neale
The “antithrombotic sweet spot” means continuing with oral anticoagulation alone in the chronic phase, Renato Lopes says.
www.tctmd.com
September 1, 2025 at 10:32 AM
AQUATIC: More Than 6 Months After PCI, Don’t Use Aspirin With OAC
Reposted
HI-PRO: Oral Apixaban for 1 Year Protective, Safe in Provoked VTE Patients
HI-PRO: Oral Apixaban for 1 Year Protective, Safe in Provoked VTE Patients
HI-PRO: Oral Apixaban for 1 Year Protective, Safe in Provoked VTE Patients
ccox@crf.org
Mon, 09/01/2025 - 06:36
Caitlin E. Cox
While the anticoagulant didn’t raise the odds of major bleeding, nonmajor clinically relevant bleeds did trend higher.
www.tctmd.com
September 1, 2025 at 10:46 AM
HI-PRO: Oral Apixaban for 1 Year Protective, Safe in Provoked VTE Patients
Reposted
Ticagrelor wasn’t superior to BID clopidogrel at 1 month post-#PCI, with similar bleeding, but reduced #MACE in the first 2 weeks. https://bit.ly/46eOmcU
#ESCCongress #WCCardio #JACC #CardioSky #MedSky
#ESCCongress #WCCardio #JACC #CardioSky #MedSky
August 30, 2025 at 9:25 AM
Ticagrelor wasn’t superior to BID clopidogrel at 1 month post-#PCI, with similar bleeding, but reduced #MACE in the first 2 weeks. https://bit.ly/46eOmcU
#ESCCongress #WCCardio #JACC #CardioSky #MedSky
#ESCCongress #WCCardio #JACC #CardioSky #MedSky
Reposted
Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction.
www.nejm.org/doi/full/10....
@nejm.org @escardio.bsky.social
#CardioSky #ESCCongress #WCCardio
www.nejm.org/doi/full/10....
@nejm.org @escardio.bsky.social
#CardioSky #ESCCongress #WCCardio
August 30, 2025 at 9:32 AM
Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction.
www.nejm.org/doi/full/10....
@nejm.org @escardio.bsky.social
#CardioSky #ESCCongress #WCCardio
www.nejm.org/doi/full/10....
@nejm.org @escardio.bsky.social
#CardioSky #ESCCongress #WCCardio
Reposted
In patients undergoing #PCI, a personalized #DAPT duration from 3 to 24 months based on a clinical risk score led to a lowered risk of net adverse clinical events than standard care consisting of 12 months of DAPT. https://bit.ly/47pBB0l
#JACC #ESCCongress #WCCardio #CardioSky
#JACC #ESCCongress #WCCardio #CardioSky
August 30, 2025 at 9:05 AM
In patients undergoing #PCI, a personalized #DAPT duration from 3 to 24 months based on a clinical risk score led to a lowered risk of net adverse clinical events than standard care consisting of 12 months of DAPT. https://bit.ly/47pBB0l
#JACC #ESCCongress #WCCardio #CardioSky
#JACC #ESCCongress #WCCardio #CardioSky
10K is popular but this study shows; there may not much more gain beyond 7k. Easier to achieve for some folks.
Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis - The Lancet Public Health www.thelancet.com/journals/lan...
Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis - The Lancet Public Health www.thelancet.com/journals/lan...
Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis
Although 10 000 steps per day can still be a viable target for those who are more
active, 7000 steps per day is associated with clinically meaningful improvements in
health outcomes and might be a mor...
www.thelancet.com
August 16, 2025 at 8:40 PM
10K is popular but this study shows; there may not much more gain beyond 7k. Easier to achieve for some folks.
Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis - The Lancet Public Health www.thelancet.com/journals/lan...
Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis - The Lancet Public Health www.thelancet.com/journals/lan...
April 20, 2025 at 2:23 AM
Reposted
In fiscal year 2024, the report found, NIH awarded more than $36.9 billion to researchers, supporting more than 408,000 jobs and generating over $94.5 billion in new economic activity nationwide.
news.harvard.edu/gazette/stor...
news.harvard.edu/gazette/stor...
NIH funding delivers exponential economic returns — Harvard Gazette
Report finds all 50 states reap gains in patient health, job creation, research resources, business development.
news.harvard.edu
March 12, 2025 at 11:49 PM
In fiscal year 2024, the report found, NIH awarded more than $36.9 billion to researchers, supporting more than 408,000 jobs and generating over $94.5 billion in new economic activity nationwide.
news.harvard.edu/gazette/stor...
news.harvard.edu/gazette/stor...
Reposted
99% of new medicines developed by the pharmaceutical industry depend on NIH research jamanetwork.com/journals/jam...
Comparison of Research Spending on New Drug Approvals by the NIH vs the Pharmaceutical Industry
This cross-sectional study examines National Institutes of Health and pharmaceutical industry investments in recent drug approvals.
jamanetwork.com
March 10, 2025 at 2:15 PM
99% of new medicines developed by the pharmaceutical industry depend on NIH research jamanetwork.com/journals/jam...
Reposted
Rep John Larson - Connecticut:
March 12, 2025 at 8:15 PM
Rep John Larson - Connecticut:
IDSA-"There have been no deaths shown to be related to the MMR vaccine in healthy people. There have been rare cases of deaths from vaccine side effects among children who are immune compromised, which is why it is recommended that they don’t get the vaccine."#IDsky
www.idsociety.org/public-healt...
www.idsociety.org/public-healt...
March 12, 2025 at 2:15 PM
IDSA-"There have been no deaths shown to be related to the MMR vaccine in healthy people. There have been rare cases of deaths from vaccine side effects among children who are immune compromised, which is why it is recommended that they don’t get the vaccine."#IDsky
www.idsociety.org/public-healt...
www.idsociety.org/public-healt...
Reposted
Remembering a lot of people saying stuff like “I don’t agree with RFK Jr. on everything but at least he’s going to do something about the food that’s making us sick”
USDA has eliminated two food safety advisory committees for microbiological contamination and meat inspection. Most recently, they had been reviewing regulatory approaches in response to the fatal Listeria outbreak from Boar’s Head meats and fatal Cronobacter contamination in powdered infant formula
USDA eliminates two food safety advisory committees
The U.S. Department of Agriculture has eliminated two committees that advise it on food safety, the agency said on Friday, raising concerns about government oversight of the food supply as the Trump administration seeks to downsize the federal bureaucracy and slash costs.
www.reuters.com
March 8, 2025 at 10:27 PM
Remembering a lot of people saying stuff like “I don’t agree with RFK Jr. on everything but at least he’s going to do something about the food that’s making us sick”
Saw a surprising semi-heated debate,on ✓ing Fe panel in a pt w/ ↑MCV anemia (PMH:↓Thyroid,HFrEF, Congestive hepatopathy). Sm against ✓ing 2° ↑MCV~103.Rest in favor as ↓Fe can be present on an ↑MCV too.Thoughts? @shematologist.medsky.social @hannahrabrams.bsky.social @amarkelkar.bsky.social #Hemesky
March 9, 2025 at 7:19 AM
Saw a surprising semi-heated debate,on ✓ing Fe panel in a pt w/ ↑MCV anemia (PMH:↓Thyroid,HFrEF, Congestive hepatopathy). Sm against ✓ing 2° ↑MCV~103.Rest in favor as ↓Fe can be present on an ↑MCV too.Thoughts? @shematologist.medsky.social @hannahrabrams.bsky.social @amarkelkar.bsky.social #Hemesky
Just a reminder for people who say things like; "old days", "natural ways in the past", "previous generations..", etc.
www.statista.com/statistics/1...
www.statista.com/statistics/1...
March 3, 2025 at 4:30 AM
Just a reminder for people who say things like; "old days", "natural ways in the past", "previous generations..", etc.
www.statista.com/statistics/1...
www.statista.com/statistics/1...
Reposted
It is a full fledge assault on medical research. Turning off funding, canceling grants, and disabling the tools we use. It is a complete dismantling of the infrastructure.
March 2, 2025 at 1:16 AM
It is a full fledge assault on medical research. Turning off funding, canceling grants, and disabling the tools we use. It is a complete dismantling of the infrastructure.
Reposted
JUDGE COLLEEN KOLLAR-KOTELLY: Is there an administrator of DOGE at the present time?
GOVERNMENT COUNSEL: I don’t know the answer to that
GOVERNMENT COUNSEL: I don’t know the answer to that
Preliminary injunction hearing at 2 p.m. today on DOGE access to Treasury records
Will Judge Colleen Kollar-Kotelly accept the challenge????
Will we finally learn the identity of the DOGE administrator?????
Stay tuned
Will Judge Colleen Kollar-Kotelly accept the challenge????
Will we finally learn the identity of the DOGE administrator?????
Stay tuned
February 24, 2025 at 8:32 PM
JUDGE COLLEEN KOLLAR-KOTELLY: Is there an administrator of DOGE at the present time?
GOVERNMENT COUNSEL: I don’t know the answer to that
GOVERNMENT COUNSEL: I don’t know the answer to that
Reposted
Government funds account for more than *half* the R&D budget that US universities spend each year—in 2023, that was $60B out of $109B. The gov also does a lot of its own research at national labs like Oak Ridge & Los Alamos and agencies like NOAA and DoD.
What are the returns on that investment? 3/
What are the returns on that investment? 3/
February 21, 2025 at 1:01 PM
Government funds account for more than *half* the R&D budget that US universities spend each year—in 2023, that was $60B out of $109B. The gov also does a lot of its own research at national labs like Oak Ridge & Los Alamos and agencies like NOAA and DoD.
What are the returns on that investment? 3/
What are the returns on that investment? 3/
Reposted
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine had no signs of relapse after three years.
Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.
Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.
A Vaccine For Pancreatic Cancer Continues To Show Promise
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine for the disease had no relapse three years later.
buff.ly
February 21, 2025 at 7:41 PM
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine had no signs of relapse after three years.
Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.
Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.
Reposted
Just a reminder that the HPV vaccine literally PREVENTS CANCER and the series can be started as early as 9 years of age.
February 21, 2025 at 8:29 PM
Just a reminder that the HPV vaccine literally PREVENTS CANCER and the series can be started as early as 9 years of age.