Muhammad Zaman Assir
@dr-assir.bsky.social
Clinician-Scientist interested in early human brain development and neurodevelopmental disorders | Stem cells | Microglia | Maternal inflammation | 3D tissue culture | Neuroimmunology | Extracellular matrix | University of Aberdeen, UK
Pinned
IL-17A Alters Human Cortical Development in a 3D Ex Vivo Model of Maternal Immune Activation
Human brain development depends on the coordinated interaction of diverse cell types and extracellular matrix (ECM) components, which are essential for proper neurogenesis and cortical organization. E...
www.biorxiv.org
🚨 Maternal inflammation doesn’t just change the cellular makeup of the developing human cortex—it extensively remodels its extracellular matrix.
In this preprint, we report the effects of IL-17A, key cytokine in maternal inflammation, on developing human 🧠.
www.biorxiv.org/content/10.1...
In this preprint, we report the effects of IL-17A, key cytokine in maternal inflammation, on developing human 🧠.
www.biorxiv.org/content/10.1...
Reposted by Muhammad Zaman Assir
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
November 15, 2025 at 9:53 AM
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
Reposted by Muhammad Zaman Assir
For the first time, ISSCR, Society for Developmental Biology and Allen Institute are collaborating to present a three-day scientific symposium led by early-career scientists. Learn more: https://ow.ly/bBQ250XrhtO
November 13, 2025 at 6:27 PM
For the first time, ISSCR, Society for Developmental Biology and Allen Institute are collaborating to present a three-day scientific symposium led by early-career scientists. Learn more: https://ow.ly/bBQ250XrhtO
Pleased to see our work out in @natcomms.nature.com showing extracellular matrix genes display cell-type specific signatures in developing human cortex!
New research from University of Aberdeen neuroscientists shows how matrisome genes guide brain development and relate to neurodevelopmental disorders. @eunchaikang.bsky.social @uniofaberdeen.bsky.social
Read more: www.nature.com/articles/s41...
Read more: www.nature.com/articles/s41...
Deciphering cell-type-and temporally specific matrisome expression signatures in human cortical development and neurodevelopmental disorders via scRNA-seq meta-analysis - Nature Communications
Human cortical development involves dynamic changes in matrisome gene expression across cell types and developmental stages. Here, authors show that these changes reveal links to neurodevelopmental di...
www.nature.com
November 13, 2025 at 8:30 PM
Pleased to see our work out in @natcomms.nature.com showing extracellular matrix genes display cell-type specific signatures in developing human cortex!
Reposted by Muhammad Zaman Assir
Register now for the joint BSDB and Genesis Research Trust (GRT) symposium on Environmental and Metabolic Control of Stem Cells & Development!
4th of December 2025 at the MRC Laboratory of Medical Sciences, London.
Register here: www.symposia.org.uk/courses/stem...
4th of December 2025 at the MRC Laboratory of Medical Sciences, London.
Register here: www.symposia.org.uk/courses/stem...
July 4, 2025 at 9:33 AM
Register now for the joint BSDB and Genesis Research Trust (GRT) symposium on Environmental and Metabolic Control of Stem Cells & Development!
4th of December 2025 at the MRC Laboratory of Medical Sciences, London.
Register here: www.symposia.org.uk/courses/stem...
4th of December 2025 at the MRC Laboratory of Medical Sciences, London.
Register here: www.symposia.org.uk/courses/stem...
🎓 Incredibly proud to have graduated today from the @uniofaberdeen.bsky.social University of Aberdeen.
Back in 2021, as a Clinical Assistant Professor on the verge of promotion to Associate—and then Full Professor within a few years—I faced a pivotal choice:
Back in 2021, as a Clinical Assistant Professor on the verge of promotion to Associate—and then Full Professor within a few years—I faced a pivotal choice:
June 30, 2025 at 8:17 PM
🎓 Incredibly proud to have graduated today from the @uniofaberdeen.bsky.social University of Aberdeen.
Back in 2021, as a Clinical Assistant Professor on the verge of promotion to Associate—and then Full Professor within a few years—I faced a pivotal choice:
Back in 2021, as a Clinical Assistant Professor on the verge of promotion to Associate—and then Full Professor within a few years—I faced a pivotal choice:
Grateful to see our RCT shape STRONG guidelines published @jama.com for restrictive platelet transfusion in dengue without major bleeding. Proud to contribute as lead author of one trial & reviewer of the other—impacting safety & cost-effectiveness in global health.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
June 22, 2025 at 12:42 PM
Grateful to see our RCT shape STRONG guidelines published @jama.com for restrictive platelet transfusion in dengue without major bleeding. Proud to contribute as lead author of one trial & reviewer of the other—impacting safety & cost-effectiveness in global health.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Looking forward to join online.
Thank you to everyone who has registered to attend YEN 2025!
You can still register for online attendence to hear talks and look at online posters.
We have sent out a programme to our attendees so if you haven't heard from us just email us or reach out on social media.
#yen2025
You can still register for online attendence to hear talks and look at online posters.
We have sent out a programme to our attendees so if you haven't heard from us just email us or reach out on social media.
#yen2025
May 9, 2025 at 3:50 PM
Looking forward to join online.
Excited to attend this upcoming meeting on cortical development and hear from some of the leading voices in the field. I’ll also be presenting our work from @kangberglab.bsky.social on how maternal inflammation impacts early human cortical development.
Still time to register—don’t miss it!
Still time to register—don’t miss it!
Please keep the date for HUMAN CEREBRAL CORTEX DEVELOPMENT III - Anatomical Society Meeting 14-16th July 2025, St John’s College, Oxford
Follow up to two meetings in 2010 and in 2018 issues of the Journal of Anatomy onlinelibrary.wiley.com/doi/10.1111/... and onlinelibrary.wiley.com/toc/14697580...
Follow up to two meetings in 2010 and in 2018 issues of the Journal of Anatomy onlinelibrary.wiley.com/doi/10.1111/... and onlinelibrary.wiley.com/toc/14697580...
May 8, 2025 at 7:42 PM
Excited to attend this upcoming meeting on cortical development and hear from some of the leading voices in the field. I’ll also be presenting our work from @kangberglab.bsky.social on how maternal inflammation impacts early human cortical development.
Still time to register—don’t miss it!
Still time to register—don’t miss it!
Reposted by Muhammad Zaman Assir
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
May 8, 2025 at 10:12 AM
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
Reposted by Muhammad Zaman Assir
We indeed got many entries!
May 2, 2025 at 6:09 PM
We indeed got many entries!
Reposted by Muhammad Zaman Assir
Come to Lund! We are looking for a postdoc to join the team. #transposons #epigenetics
April 17, 2025 at 12:29 PM
Come to Lund! We are looking for a postdoc to join the team. #transposons #epigenetics
Reposted by Muhammad Zaman Assir
Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons.
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
December 26, 2024 at 5:31 PM
Human cortical pyramidal neurons are larger, with more elaborate branching, and distinct nonlinear biophysical properties compared to rat cortical pyramidal neurons.
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
Are they more functionally complex? Could that boost the human brain’s computational power? and is that what makes us human? (1/11)
Reposted by Muhammad Zaman Assir
We are seeking a new colleague to join us at the Vienna BioCenter, specifically at my beloved home institution, IMBA @imbavienna.bsky.social
we value collegiality and a passion for curiosity driven science. Being a great and fun human being also helps!
we value collegiality and a passion for curiosity driven science. Being a great and fun human being also helps!
IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.
March 29, 2025 at 1:22 PM
We are seeking a new colleague to join us at the Vienna BioCenter, specifically at my beloved home institution, IMBA @imbavienna.bsky.social
we value collegiality and a passion for curiosity driven science. Being a great and fun human being also helps!
we value collegiality and a passion for curiosity driven science. Being a great and fun human being also helps!
Reposted by Muhammad Zaman Assir
Our review "Measuring and manipulating mechanical forces during development" is now published in Nature Cell Biology!
#Mechanobiology #DevelopmentalBiology
#Mechanobiology #DevelopmentalBiology
Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...
Measuring and manipulating mechanical forces during development - Nature Cell Biology
This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...
www.nature.com
March 12, 2025 at 12:39 PM
Our review "Measuring and manipulating mechanical forces during development" is now published in Nature Cell Biology!
#Mechanobiology #DevelopmentalBiology
#Mechanobiology #DevelopmentalBiology
Reposted by Muhammad Zaman Assir
Multiple group leader positions in developmental biology in @ibdm.bsky.social Marseille, at an institute that produces some great work.
We Are Recruiting Group Leaders - IBDM | Institut de Biologie du Développement de Marseille
The Institut de Biologie du Développement de Marseille (IBDM) is inviting applications for group leader positions. We are seeking innovative researchers who aim to address fundamental questions in bio...
staging.ibdm.univ-amu.fr
March 4, 2025 at 10:15 AM
Multiple group leader positions in developmental biology in @ibdm.bsky.social Marseille, at an institute that produces some great work.
Reposted by Muhammad Zaman Assir
Join the Department of Developmental & Molecular Biology @einsteinmededu.bsky.social ! 🧬✨
Are you passionate about cutting-edge research and collaborative science? We are looking for you😉
Come be part of a department where curiosity meets impact! 🚀
Learn more and join us👇
#ResearchExcellence #JoinUs
Are you passionate about cutting-edge research and collaborative science? We are looking for you😉
Come be part of a department where curiosity meets impact! 🚀
Learn more and join us👇
#ResearchExcellence #JoinUs
Faculty-Tenure Track, Department of Developmental and Molecular Biology - Bronx, New York job with Albert Einstein College of Medicine | 12835514
Faculty-Tenure Track, Department of Developmental and Molecular Biology US-NY-Bronx Job ID: 2025-17126 Type: Research # of Openings: 1 Category: F...
www.nature.com
February 26, 2025 at 3:31 AM
Join the Department of Developmental & Molecular Biology @einsteinmededu.bsky.social ! 🧬✨
Are you passionate about cutting-edge research and collaborative science? We are looking for you😉
Come be part of a department where curiosity meets impact! 🚀
Learn more and join us👇
#ResearchExcellence #JoinUs
Are you passionate about cutting-edge research and collaborative science? We are looking for you😉
Come be part of a department where curiosity meets impact! 🚀
Learn more and join us👇
#ResearchExcellence #JoinUs
Reposted by Muhammad Zaman Assir
Want to work in another country?
The HFSP postdoc fellowship supports proposals for frontier, potentially transformative research in the life sciences and cross-disciplinary. high-risk projects are encouraged
LOI opens March 13, 2025
#neuroskyence #academicsky 🧪🧠🪰🌱🧬
www.hfsp.org/funding/hfsp...
The HFSP postdoc fellowship supports proposals for frontier, potentially transformative research in the life sciences and cross-disciplinary. high-risk projects are encouraged
LOI opens March 13, 2025
#neuroskyence #academicsky 🧪🧠🪰🌱🧬
www.hfsp.org/funding/hfsp...
Postdoctoral Fellowships | Human Frontier Science Program
www.hfsp.org
March 1, 2025 at 10:11 PM
Want to work in another country?
The HFSP postdoc fellowship supports proposals for frontier, potentially transformative research in the life sciences and cross-disciplinary. high-risk projects are encouraged
LOI opens March 13, 2025
#neuroskyence #academicsky 🧪🧠🪰🌱🧬
www.hfsp.org/funding/hfsp...
The HFSP postdoc fellowship supports proposals for frontier, potentially transformative research in the life sciences and cross-disciplinary. high-risk projects are encouraged
LOI opens March 13, 2025
#neuroskyence #academicsky 🧪🧠🪰🌱🧬
www.hfsp.org/funding/hfsp...
Reposted by Muhammad Zaman Assir
Spearheaded by Do Hyeon. Thanks to authors who are on bluesky: @dr-assir.bsky.social @mdmorgan.bsky.social @eunchaikang.bsky.social @daniel-berg.bsky.social
February 25, 2025 at 4:17 PM
Spearheaded by Do Hyeon. Thanks to authors who are on bluesky: @dr-assir.bsky.social @mdmorgan.bsky.social @eunchaikang.bsky.social @daniel-berg.bsky.social
Interested in how expression patterns of extracellular matrix related genes evolve across early human cortical development! This recent preprint @biorxiv-neursci.bsky.social from our lab shows ECM signatures of diverse cell types of developing cortex and their link to neurodevelopmental disorders.
🧠 New preprint! Our meta-analysis of scRNA-seq data (37 donors, GWs 8–26) maps ECM dynamics in human cortical development, linking many genes to NDDs.
📄 Read more:https://www.biorxiv.org/content/10.1101/2025.02.24.639826v1
#Neuroscience #scRNAseq #ECM #Neurodevelopment #Preprint #metaanalysis
📄 Read more:https://www.biorxiv.org/content/10.1101/2025.02.24.639826v1
#Neuroscience #scRNAseq #ECM #Neurodevelopment #Preprint #metaanalysis
Deciphering Cell-Type and Temporal-Specific Matrisome Expression Signatures in Human Cortical Development and Neurodevelopmental Disorders via scRNA-Seq Meta-Analysis
Human cortical development is a complex process involving the proliferation, differentiation, and migration of progenitor cells, all coordinated within a dynamic extracellular matrix (ECM). ECM plays ...
www.biorxiv.org
February 26, 2025 at 11:47 AM
Interested in how expression patterns of extracellular matrix related genes evolve across early human cortical development! This recent preprint @biorxiv-neursci.bsky.social from our lab shows ECM signatures of diverse cell types of developing cortex and their link to neurodevelopmental disorders.
Reposted by Muhammad Zaman Assir
Proliferating neural stem cells in the P3 mouse dentate gyrus—capturing early postnatal neurogenesis in action. A glimpse into how the brain builds itself. #Neuroscience #Neurodevelopment #StemCells
February 25, 2025 at 3:36 PM
Proliferating neural stem cells in the P3 mouse dentate gyrus—capturing early postnatal neurogenesis in action. A glimpse into how the brain builds itself. #Neuroscience #Neurodevelopment #StemCells
Reposted by Muhammad Zaman Assir
Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social
rdcu.be/ebbZf
rdcu.be/ebbZf
Neuronal polyunsaturated fatty acids are protective in ALS/FTD
Nature Neuroscience - Lipidomics revealed that neurons of patients with ALS/FTD have reduced levels of polyunsaturated fatty acid (PUFA)-containing phospholipids. Increasing neuronal PUFA levels...
rdcu.be
February 25, 2025 at 1:31 PM
Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social
rdcu.be/ebbZf
rdcu.be/ebbZf
Reposted by Muhammad Zaman Assir
Reposted by Muhammad Zaman Assir
We are looking for a postdoc in #EvolutionarySystemsBiology.
Exciting science, amazing team, wonderful city!
landrylab.ibis.ulaval.ca/research-opp...
#evolution #synbio #systemsbiology #genomics
Exciting science, amazing team, wonderful city!
landrylab.ibis.ulaval.ca/research-opp...
#evolution #synbio #systemsbiology #genomics
Research opportunities | Landry Lab
landrylab.ibis.ulaval.ca
February 23, 2025 at 4:46 PM
We are looking for a postdoc in #EvolutionarySystemsBiology.
Exciting science, amazing team, wonderful city!
landrylab.ibis.ulaval.ca/research-opp...
#evolution #synbio #systemsbiology #genomics
Exciting science, amazing team, wonderful city!
landrylab.ibis.ulaval.ca/research-opp...
#evolution #synbio #systemsbiology #genomics
Reposted by Muhammad Zaman Assir
We are recruiting @ox.ac.uk @dunnschool.bsky.social for a joint project between Kevin Foster's group and mine! Cluster hire of two postdocs interested in:
1) Mucosal immunology and oral vaccine development
my.corehr.com/pls/uoxrecru...
2) Microbiology
my.corehr.com/pls/uoxrecru...
Please share!
1) Mucosal immunology and oral vaccine development
my.corehr.com/pls/uoxrecru...
2) Microbiology
my.corehr.com/pls/uoxrecru...
Please share!
'
my.corehr.com
February 22, 2025 at 8:07 PM
We are recruiting @ox.ac.uk @dunnschool.bsky.social for a joint project between Kevin Foster's group and mine! Cluster hire of two postdocs interested in:
1) Mucosal immunology and oral vaccine development
my.corehr.com/pls/uoxrecru...
2) Microbiology
my.corehr.com/pls/uoxrecru...
Please share!
1) Mucosal immunology and oral vaccine development
my.corehr.com/pls/uoxrecru...
2) Microbiology
my.corehr.com/pls/uoxrecru...
Please share!
Reposted by Muhammad Zaman Assir
We are hiring!
If you are curious to understand how the mechanical integrity of epithelia is maintained without the tissue tearing, apply now!
Phd and post-doctoral funding available
If you are curious to understand how the mechanical integrity of epithelia is maintained without the tissue tearing, apply now!
Phd and post-doctoral funding available
February 17, 2025 at 2:18 PM
We are hiring!
If you are curious to understand how the mechanical integrity of epithelia is maintained without the tissue tearing, apply now!
Phd and post-doctoral funding available
If you are curious to understand how the mechanical integrity of epithelia is maintained without the tissue tearing, apply now!
Phd and post-doctoral funding available