DenisPBlondin
@denispblondin.bsky.social
Papa | Associate.Professor @USherbrooke 🇨🇦 | Researcher @_CRCHUS | Integrative Physiologist | Energy Metabolism in #Diabetes #Obesity
Pinned
DenisPBlondin
@denispblondin.bsky.social
· Nov 13
✅Love cold exposure❄️, heat exposure🔥, or exercise physiology🚴?
✅Looking to do an MSc/PhD/Postdoc🔬?
✅Interested in learning how to perform PET imaging, high-resolution respirometry, stable isotope methods or indirect calorimetry?
Come join us in Sherbrooke, Canada 🇨🇦!
✅Looking to do an MSc/PhD/Postdoc🔬?
✅Interested in learning how to perform PET imaging, high-resolution respirometry, stable isotope methods or indirect calorimetry?
Come join us in Sherbrooke, Canada 🇨🇦!
👀 Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism
Another outstanding contribution to our understanding of HSL, on adipose biology from the team of @dominiquelangin.bsky.social. Such a fascinating story!
www.sciencedirect.com/science/arti...
Another outstanding contribution to our understanding of HSL, on adipose biology from the team of @dominiquelangin.bsky.social. Such a fascinating story!
www.sciencedirect.com/science/arti...
Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism
In adipocytes, hormone-sensitive lipase (HSL) plays a key role in hydrolyzing triacylglycerols that are stored in lipid droplets. Contrary to the expe…
www.sciencedirect.com
October 25, 2025 at 3:39 PM
👀 Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism
Another outstanding contribution to our understanding of HSL, on adipose biology from the team of @dominiquelangin.bsky.social. Such a fascinating story!
www.sciencedirect.com/science/arti...
Another outstanding contribution to our understanding of HSL, on adipose biology from the team of @dominiquelangin.bsky.social. Such a fascinating story!
www.sciencedirect.com/science/arti...
Reposted by DenisPBlondin
New content online: Adipose tissue thermogenesis is not proportional to temperature
Adipose tissue thermogenesis is not proportional to temperature
Nature Reviews Endocrinology, Published online: 07 August 2025; doi:10.1038/s41574-025-01163-3Adipose tissue thermogenesis is not proportional to temperature
www.nature.com
August 7, 2025 at 6:32 PM
New content online: Adipose tissue thermogenesis is not proportional to temperature
Reposted by DenisPBlondin
Online now: Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temperature in cold-exposed men and women
Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temperature in cold-exposed men and women
Dumont et al. reveal that although heat generated by shivering muscles and by the heart increases based on the degree of cold exposure, heat-producing mechanisms present in adipose tissues like brown and white fat respond in an all-or-nothing fashion. In brown fat, the heat produced likely reflects its thermogenic capacity.
dlvr.it
July 16, 2025 at 3:42 PM
Online now: Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temperature in cold-exposed men and women
🧪📣Have you ever wondered how shivering and brown adipose tissue interact and respond to different degrees of cold stress in humans?❄️
Conclusion: Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temp in cold-exposed humans.
authors.elsevier.com/a/1lRgJ5WXUl...
Conclusion: Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temp in cold-exposed humans.
authors.elsevier.com/a/1lRgJ5WXUl...
authors.elsevier.com
July 16, 2025 at 4:09 PM
🧪📣Have you ever wondered how shivering and brown adipose tissue interact and respond to different degrees of cold stress in humans?❄️
Conclusion: Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temp in cold-exposed humans.
authors.elsevier.com/a/1lRgJ5WXUl...
Conclusion: Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temp in cold-exposed humans.
authors.elsevier.com/a/1lRgJ5WXUl...
🧪 Very pleased to have contributed to this important and very comprehensive review on a topic I have thought about for many years - it lays an important foundation to some original human data we hope to put out soon!
Excited to share our timely and comprehensive review published in Physiological Reviews, bringing together insights from multiple leading labs in metabolism: Marc Prentki and Murthy Madiraju, Shingo Kajimura, @denispblondin.bsky.social, and Christopher Nolan.
journals.physiology.org/doi/abs/10.1...
journals.physiology.org/doi/abs/10.1...
Glycerolipid Cycling in Thermogenesis, Energy Homeostasis and Signaling | Physiological Reviews | American Physiological Society
Mammals maintain body heat by adaptive energy expenditure through different organ specific mechanisms. The glycerolipid/free fatty acid cycle (glycerolipid cycle), encompassing triglyceride lipolysis ...
journals.physiology.org
June 10, 2025 at 3:07 PM
🧪 Very pleased to have contributed to this important and very comprehensive review on a topic I have thought about for many years - it lays an important foundation to some original human data we hope to put out soon!
Reposted by DenisPBlondin
#FridayPhysiologyFact: APS member @denispblondin.bsky.social shares his thoughts with @gretchenxreynolds.bsky.social @washingtonpost.com about whether or not cold plunges are good for us: ow.ly/GEeN50W4oFC #ISpyPhysiology 🧪
June 6, 2025 at 4:00 PM
#FridayPhysiologyFact: APS member @denispblondin.bsky.social shares his thoughts with @gretchenxreynolds.bsky.social @washingtonpost.com about whether or not cold plunges are good for us: ow.ly/GEeN50W4oFC #ISpyPhysiology 🧪
🔊PSA:
If you are studying BAT in humans...👏Infrared👏Thermography👏of👏supraclavicular👏fossa👏is👏not👏BAT👏THERMOGENESIS!!!!!!!
🧪
Stop saying it is, it's not, and you are actively misleading the field!
If you are studying BAT in humans...👏Infrared👏Thermography👏of👏supraclavicular👏fossa👏is👏not👏BAT👏THERMOGENESIS!!!!!!!
🧪
Stop saying it is, it's not, and you are actively misleading the field!
April 2, 2025 at 12:54 AM
🔊PSA:
If you are studying BAT in humans...👏Infrared👏Thermography👏of👏supraclavicular👏fossa👏is👏not👏BAT👏THERMOGENESIS!!!!!!!
🧪
Stop saying it is, it's not, and you are actively misleading the field!
If you are studying BAT in humans...👏Infrared👏Thermography👏of👏supraclavicular👏fossa👏is👏not👏BAT👏THERMOGENESIS!!!!!!!
🧪
Stop saying it is, it's not, and you are actively misleading the field!
⏳Many years in the making, including collaborating with engineers to develop a new temperature control system.
This study provides the first ever dose-response of BAT, WAT and myocardial thermogenesis in cold-exposed humans ❄️.
We hope to receive some insightful feedback on our findings!
This study provides the first ever dose-response of BAT, WAT and myocardial thermogenesis in cold-exposed humans ❄️.
We hope to receive some insightful feedback on our findings!
Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temperature in cold-exposed men and women https://www.biorxiv.org/content/10.1101/2025.02.24.639578v1
February 27, 2025 at 8:49 PM
⏳Many years in the making, including collaborating with engineers to develop a new temperature control system.
This study provides the first ever dose-response of BAT, WAT and myocardial thermogenesis in cold-exposed humans ❄️.
We hope to receive some insightful feedback on our findings!
This study provides the first ever dose-response of BAT, WAT and myocardial thermogenesis in cold-exposed humans ❄️.
We hope to receive some insightful feedback on our findings!
Reposted by DenisPBlondin
After several decades, in a comorbidity-free U.S.-based population with #T2D the use of GLP-1 RAs did not increase their risk of pancreatitis. Their use was associated with a lower lifetime risk of #pancreatitis www.mdpi.com/2077-0383/14...
February 14, 2025 at 1:21 PM
After several decades, in a comorbidity-free U.S.-based population with #T2D the use of GLP-1 RAs did not increase their risk of pancreatitis. Their use was associated with a lower lifetime risk of #pancreatitis www.mdpi.com/2077-0383/14...
Since 2007, there's been a surge in studies investigating the function of BAT. Along the way, there's been much debate on various topics.
In this perspective, we highlight the importance of carefully considering your cooling protocol when studying BAT🔥in humans.❄️
www.cell.com/cell-metabol...
In this perspective, we highlight the importance of carefully considering your cooling protocol when studying BAT🔥in humans.❄️
www.cell.com/cell-metabol...
Emerging debates and resolutions in brown adipose tissue research
The explosive growth in the study of human BAT has led over time to lively debates over central physiological concepts. This perspective discusses six areas of current disagreement and proposes experiments to achieve resolutions and move the field forward.
www.cell.com
December 7, 2024 at 3:57 PM
Since 2007, there's been a surge in studies investigating the function of BAT. Along the way, there's been much debate on various topics.
In this perspective, we highlight the importance of carefully considering your cooling protocol when studying BAT🔥in humans.❄️
www.cell.com/cell-metabol...
In this perspective, we highlight the importance of carefully considering your cooling protocol when studying BAT🔥in humans.❄️
www.cell.com/cell-metabol...
Reposted by DenisPBlondin
Our latest review in NJP Metabolic Health and Disease: eur02.safelinks.protection.outlook.com?url=https%3A...
Human adipose depots’ diverse functions and dysregulations during cardiometabolic disease - npj Metabolic Health and Disease
npj Metabolic Health and Disease - Human adipose depots’ diverse functions and dysregulations during cardiometabolic disease
eur02.safelinks.protection.outlook.com
November 30, 2024 at 9:36 AM
Our latest review in NJP Metabolic Health and Disease: eur02.safelinks.protection.outlook.com?url=https%3A...
Reposted by DenisPBlondin
#Tirzepatide for Obesity Treatment & Diabetes Prevention
SURMOUNT-1 Trial
✅ Reduced progression to T2DM by 93%
#CardioSky #EndoSky #MedSky #NEJM
www.nejm.org/doi/full/10....
SURMOUNT-1 Trial
✅ Reduced progression to T2DM by 93%
#CardioSky #EndoSky #MedSky #NEJM
www.nejm.org/doi/full/10....
Tirzepatide for Obesity Treatment and Diabetes Prevention | NEJM
Obesity is chronic disease and causal precursor to myriad other conditions, including
type 2 diabetes. In an earlier analysis of the SURMOUNT-1 trial, tirzepatide was shown
to provide substantial a...
www.nejm.org
November 14, 2024 at 3:44 AM
#Tirzepatide for Obesity Treatment & Diabetes Prevention
SURMOUNT-1 Trial
✅ Reduced progression to T2DM by 93%
#CardioSky #EndoSky #MedSky #NEJM
www.nejm.org/doi/full/10....
SURMOUNT-1 Trial
✅ Reduced progression to T2DM by 93%
#CardioSky #EndoSky #MedSky #NEJM
www.nejm.org/doi/full/10....
Reposted by DenisPBlondin
Created a NeuroMetabolism starter pack. It’s just beginning…who to add?? #neurometabolism #metabolism #brain #peripheralnerve go.bsky.app/4nbSbNR
November 16, 2024 at 12:24 AM
Created a NeuroMetabolism starter pack. It’s just beginning…who to add?? #neurometabolism #metabolism #brain #peripheralnerve go.bsky.app/4nbSbNR
Reposted by DenisPBlondin
In our recent paper in @Cell_Metabolism @jananerahbani and no-twitter Jakub Bunk demonstrate that thermogenic adipocytes utilize non-paralogous protein redundancy—through UCP1 and CKB—to promote cold-induced energy dissipation. www.cell.com/cell-metabol...
www.cell.com
November 11, 2024 at 4:34 PM
In our recent paper in @Cell_Metabolism @jananerahbani and no-twitter Jakub Bunk demonstrate that thermogenic adipocytes utilize non-paralogous protein redundancy—through UCP1 and CKB—to promote cold-induced energy dissipation. www.cell.com/cell-metabol...
✅Love cold exposure❄️, heat exposure🔥, or exercise physiology🚴?
✅Looking to do an MSc/PhD/Postdoc🔬?
✅Interested in learning how to perform PET imaging, high-resolution respirometry, stable isotope methods or indirect calorimetry?
Come join us in Sherbrooke, Canada 🇨🇦!
✅Looking to do an MSc/PhD/Postdoc🔬?
✅Interested in learning how to perform PET imaging, high-resolution respirometry, stable isotope methods or indirect calorimetry?
Come join us in Sherbrooke, Canada 🇨🇦!
November 13, 2024 at 11:51 PM
✅Love cold exposure❄️, heat exposure🔥, or exercise physiology🚴?
✅Looking to do an MSc/PhD/Postdoc🔬?
✅Interested in learning how to perform PET imaging, high-resolution respirometry, stable isotope methods or indirect calorimetry?
Come join us in Sherbrooke, Canada 🇨🇦!
✅Looking to do an MSc/PhD/Postdoc🔬?
✅Interested in learning how to perform PET imaging, high-resolution respirometry, stable isotope methods or indirect calorimetry?
Come join us in Sherbrooke, Canada 🇨🇦!