David Morales-Alamo
@davidmoralesalamo.bsky.social
- Vice-Dean of Academic Planning FCAFD @ulpgc.es
- Associate Professor of Sport Sciences at @ulpgc.es
- Muscle Metabolism & Translational Physiology
- @ecssofficial.bsky.social Reviewing Panel Member & Fellow
- More about me: linktr.ee/drmoralesalamo
- Associate Professor of Sport Sciences at @ulpgc.es
- Muscle Metabolism & Translational Physiology
- @ecssofficial.bsky.social Reviewing Panel Member & Fellow
- More about me: linktr.ee/drmoralesalamo
Reposted by David Morales-Alamo
In vivo transcriptomic, functional, circuit-based, and translational analyses of enteric neurons @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
December 16, 2025 at 10:57 PM
In vivo transcriptomic, functional, circuit-based, and translational analyses of enteric neurons @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by David Morales-Alamo
A direct role for a mitochondrial targeting sequence in signalling stress @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 10, 2025 at 6:48 PM
A direct role for a mitochondrial targeting sequence in signalling stress @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New study in Redox Biology 🧬: MitoQ supplementation did not alter redox responses to acute exercise in skeletal muscle of older adults. Antioxidant hype doesn’t always match reality. #ExerciseScience #Aging #MitoQ
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
MitoQ supplementation does not impact redox responses to acute exercise in skeletal muscle of older individuals
Ageing is associated with attenuated exercise responses in skeletal muscle, which may be related to a failure of muscle redox signalling. The attenuat…
www.sciencedirect.com
December 10, 2025 at 11:30 AM
New study in Redox Biology 🧬: MitoQ supplementation did not alter redox responses to acute exercise in skeletal muscle of older adults. Antioxidant hype doesn’t always match reality. #ExerciseScience #Aging #MitoQ
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by David Morales-Alamo
Online now: Gut enteroendocrine cell activation using a combination of GPR119 and GPR40 agonists results in synergistic hormone secretion in mice and humans
Gut enteroendocrine cell activation using a combination of GPR119 and GPR40 agonists results in synergistic hormone secretion in mice and humans
Sebhat et al. present a strategy to mimic bariatric surgery by activating specialized intestinal cells that secrete satiety hormones, including GLP-1. Preclinically, a combination of gut-restricted agonists (K-833/K-757) induced synergistic hormone release that improved glucose tolerance and reduced body weight. In Ph1 trials, hormone levels surpassed those observed after surgery.
dlvr.it
December 2, 2025 at 4:42 PM
Online now: Gut enteroendocrine cell activation using a combination of GPR119 and GPR40 agonists results in synergistic hormone secretion in mice and humans
El sábado 13 de diciembre estaré en San Sebastián-Donostia en el "I Congreso de Entrenamiento Concurrente y Alta Intensidad" que organiza TC University
December 6, 2025 at 6:28 PM
El sábado 13 de diciembre estaré en San Sebastián-Donostia en el "I Congreso de Entrenamiento Concurrente y Alta Intensidad" que organiza TC University
Reposted by David Morales-Alamo
Reposted by David Morales-Alamo
Nasrin Dabirian & Chunyu Wang present this #JournalClub on the work of Sorensen et al. (2025) into ErbB2 as a therapeutic target for post-trauma muscle recovery ✍️
🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
December 3, 2025 at 6:02 PM
Nasrin Dabirian & Chunyu Wang present this #JournalClub on the work of Sorensen et al. (2025) into ErbB2 as a therapeutic target for post-trauma muscle recovery ✍️
🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
New in: Kurade et al. show that FGF21 isn’t just a metabolic hormone—it’s also regulated by mitochondrial and psychosocial stress in humans.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Mitochondrial and psychosocial stress-related regulation of FGF21 in humans - Nature Metabolism
FGF21 levels increase in response to acute mental stress in individuals with impaired mitochondrial OxPhos capacity, and correlate with stress-related neuroendocrine hormones and trait-level psychosoc...
www.nature.com
December 2, 2025 at 9:50 AM
New in: Kurade et al. show that FGF21 isn’t just a metabolic hormone—it’s also regulated by mitochondrial and psychosocial stress in humans.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
New @cp-cellreports.bsky.social : CMTR1 shapes T cell activation by controlling mitochondrial dynamics via epitranscriptomic regulation of splice isoforms. Its loss disrupts RNA capping/splicing, alters the fusion–fission balance, and impairs T cell metabolic function.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
CMTR1 directs mitochondrial dynamics during T cell activation through epitranscriptomic regulation of splice isoforms
T cell activation requires increased biosynthesis, which depends on mitochondrial
function. Galloway et al. demonstrate that mitochondrial function is regulated by
cap methyltransferase CMTR1 during T...
www.cell.com
December 2, 2025 at 8:26 AM
New @cp-cellreports.bsky.social : CMTR1 shapes T cell activation by controlling mitochondrial dynamics via epitranscriptomic regulation of splice isoforms. Its loss disrupts RNA capping/splicing, alters the fusion–fission balance, and impairs T cell metabolic function.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by David Morales-Alamo
Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling
www.nature.com/articles/s41...
@natneuro.nature.com @usask.ca
www.nature.com/articles/s41...
@natneuro.nature.com @usask.ca
Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling - Nature Neuroscience
In this study, Yu et al. found that a positive feedback loop between oxidized phosphatidylcholine and IL-1β promotes chronic neurodegeneration in the central nervous system and could be a contributing...
www.nature.com
December 1, 2025 at 5:28 PM
Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling
www.nature.com/articles/s41...
@natneuro.nature.com @usask.ca
www.nature.com/articles/s41...
@natneuro.nature.com @usask.ca
Reposted by David Morales-Alamo
🎓 EDITOR'S CHOICE🎓
This study by Alexander R. Keeble et al. observed that CSF1-R inhibition attenuates posttraumatic #osteoarthritis and quadriceps atrophy following ligament injury 🔎
🔗 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
This study by Alexander R. Keeble et al. observed that CSF1-R inhibition attenuates posttraumatic #osteoarthritis and quadriceps atrophy following ligament injury 🔎
🔗 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
December 1, 2025 at 6:00 PM
🎓 EDITOR'S CHOICE🎓
This study by Alexander R. Keeble et al. observed that CSF1-R inhibition attenuates posttraumatic #osteoarthritis and quadriceps atrophy following ligament injury 🔎
🔗 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
This study by Alexander R. Keeble et al. observed that CSF1-R inhibition attenuates posttraumatic #osteoarthritis and quadriceps atrophy following ligament injury 🔎
🔗 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
New in @nature.com : “Multi-omic profiling reveals age-related immune dynamics in healthy adults”. Using multi-omics, the study maps how the immune system changes across adulthood, revealing coordinated age-linked shifts in immune cells & molecular pathways
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Multi-omic profiling reveals age-related immune dynamics in healthy adults - Nature
This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes w...
www.nature.com
December 1, 2025 at 7:11 AM
New in @nature.com : “Multi-omic profiling reveals age-related immune dynamics in healthy adults”. Using multi-omics, the study maps how the immune system changes across adulthood, revealing coordinated age-linked shifts in immune cells & molecular pathways
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Otro año más he tenido el privilegio de participar en el Máster Universitario en Patologías Crónicas y Poblaciones Especiales de la Universidad de Murcia 🙌 , un máster referente en la temática a nivel nacional y con el prestigioso sello de calidad del Consejo COLEF 🇪🇸
November 30, 2025 at 8:24 PM
Otro año más he tenido el privilegio de participar en el Máster Universitario en Patologías Crónicas y Poblaciones Especiales de la Universidad de Murcia 🙌 , un máster referente en la temática a nivel nacional y con el prestigioso sello de calidad del Consejo COLEF 🇪🇸
Reposted by David Morales-Alamo
"We thank the reviewers for their helpful suggestions"
November 23, 2025 at 11:19 AM
"We thank the reviewers for their helpful suggestions"
Reposted by David Morales-Alamo
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants @cellcellpress.bsky.social
www.cell.com/cell/fulltex... @ruizhideng.bsky.social
www.cell.com/cell/fulltex... @ruizhideng.bsky.social
November 20, 2025 at 3:39 AM
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants @cellcellpress.bsky.social
www.cell.com/cell/fulltex... @ruizhideng.bsky.social
www.cell.com/cell/fulltex... @ruizhideng.bsky.social
Reposted by David Morales-Alamo
Reposted by David Morales-Alamo
Online now: Gut microbiome-adipose crosstalk modulates soluble IL-6 receptor influencing exercise responsiveness in glycemic control and insulin sensitivity
Gut microbiome-adipose crosstalk modulates soluble IL-6 receptor influencing exercise responsiveness in glycemic control and insulin sensitivity
Wang and Wu et al. identify soluble interleukin-6 receptor (sIL-6R) as a key exerkine determining the efficacy of exercise in diabetes prevention, which is modulated by microbiome-dependent leucine through a gut-adipose tissue axis. Pharmacological or dietary interventions targeting adipocyte-secreted sIL-6R may help to improve the metabolic outcomes in those exercise non-responders.
dlvr.it
November 18, 2025 at 4:42 PM
Online now: Gut microbiome-adipose crosstalk modulates soluble IL-6 receptor influencing exercise responsiveness in glycemic control and insulin sensitivity
New study in @natmetabolism.nature.com : Cancer cachexia impairs cAMP–PKA–CREB1 in muscle, causing mitochondrial dysfunction. Restoring the pathway rescues bioenergetics—promising therapeutic target
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia - Nature Metabolism
Tumour-induced dysregulation of cAMP–PKA–CREB1 signalling in skeletal muscle is shown to be a driver of mitochondrial dysfunction, contributing to cancer cachexia in mice.
www.nature.com
November 18, 2025 at 8:10 AM
New study in @natmetabolism.nature.com : Cancer cachexia impairs cAMP–PKA–CREB1 in muscle, causing mitochondrial dysfunction. Restoring the pathway rescues bioenergetics—promising therapeutic target
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Este 28 de noviembre volveré a impartir clases en el "Máster Universitario en Entrenamiento en Patologías Crónicas y Poblaciones Especiales" de la FCAFD de @um.es
Todo un lujo de máster totalmente recomendable a los GCAFD por sus contenidos y profesorado.
Todo un lujo de máster totalmente recomendable a los GCAFD por sus contenidos y profesorado.
November 17, 2025 at 4:00 PM
Este 28 de noviembre volveré a impartir clases en el "Máster Universitario en Entrenamiento en Patologías Crónicas y Poblaciones Especiales" de la FCAFD de @um.es
Todo un lujo de máster totalmente recomendable a los GCAFD por sus contenidos y profesorado.
Todo un lujo de máster totalmente recomendable a los GCAFD por sus contenidos y profesorado.
New @pnas.org : Denervated skeletal muscle mounts a multimodal transcriptional program, pinpointing Gramd1 gene regulation as a key driver of muscle size changes. Highlights: coordinated lipid/cholesterol signaling shifts, fiber-type–specific responses, atrophy...
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
The multimodal transcriptional response of denervated skeletal muscle involves regulation of Gramd1 genes impacting muscle size | PNAS
The development and maintenance of the neuromuscular junction (NMJ) requires reciprocal
signals between the nerve terminals and multinucleated skel...
www.pnas.org
November 16, 2025 at 10:44 AM
New @pnas.org : Denervated skeletal muscle mounts a multimodal transcriptional program, pinpointing Gramd1 gene regulation as a key driver of muscle size changes. Highlights: coordinated lipid/cholesterol signaling shifts, fiber-type–specific responses, atrophy...
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Nice perspective published in in @cp-cellmetabolism.bsky.social !!!!
Online now: From microbiome to metabolism: Bridging a two-decade translational gap
From microbiome to metabolism: Bridging a two-decade translational gap
Despite their initial promise, microbiome-based therapies face translational challenges. This perspective examines the limitations of correlative studies; the mechanistic insights from animal models; and the need for precision, functional profiling, and AI-driven multi-omics to realize personalized, systems-level interventions in metabolic disease.
dlvr.it
November 14, 2025 at 10:53 AM
Nice perspective published in in @cp-cellmetabolism.bsky.social !!!!
New study in @natmetabolism.nature.com : In cancer cachexia, disrupted cAMP–PKA–CREB1 signaling impairs mitochondrial function in skeletal muscle. Restoring this pathway improves muscle performance—a promising therapeutic target
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia - Nature Metabolism
Tumour-induced dysregulation of cAMP–PKA–CREB1 signalling in skeletal muscle is shown to be a driver of mitochondrial dysfunction, contributing to cancer cachexia in mice.
www.nature.com
November 13, 2025 at 10:11 AM
New study in @natmetabolism.nature.com : In cancer cachexia, disrupted cAMP–PKA–CREB1 signaling impairs mitochondrial function in skeletal muscle. Restoring this pathway improves muscle performance—a promising therapeutic target
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Adipocyte EVs restore central leptin sensitivity, enhance hypothalamic signaling, and improve energy balance. Altered in obesity—potential therapy target. Published in @cp-cellmetabolism.bsky.social . #Leptin #Obesity #Metabolism
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis
The exact mechanisms underlying leptin resistance remain elusive. Here, Wang et al.
report that adipocyte-derived EVs and their miRNA cargo are key regulators of central
leptin sensitivity and that th...
www.cell.com
November 13, 2025 at 9:43 AM
Adipocyte EVs restore central leptin sensitivity, enhance hypothalamic signaling, and improve energy balance. Altered in obesity—potential therapy target. Published in @cp-cellmetabolism.bsky.social . #Leptin #Obesity #Metabolism
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
High-fat diets disrupt a host–microbiome lipid network that supports metabolic health. Klag et al. ( @cp-cellmetabolism.bsky.social ) show altered commensal lipids and host signaling impair glucose/lipid homeostasis—highlighting microbiome–lipid crosstalk as a target.
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Dietary fat disrupts a commensal-host lipid network that promotes metabolic health
Klag et al. identified that Turicibacter, a spore-forming bacteria, promotes leanness
by producing unique lipids that suppress host ceramides and reduce fat uptake. High-fat
diets lower Turicibacter l...
www.cell.com
November 12, 2025 at 8:32 AM
High-fat diets disrupt a host–microbiome lipid network that supports metabolic health. Klag et al. ( @cp-cellmetabolism.bsky.social ) show altered commensal lipids and host signaling impair glucose/lipid homeostasis—highlighting microbiome–lipid crosstalk as a target.
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...