@davidbersten.bsky.social
Transcription Factors, Synthetic Biology, forward and reverse genetic screens, mechanism rules! For the love of science!
Reposted
Great to be involved in this research on the Ghrelin receptor, out now in Molecular Cell - with potential for translation to improve quality of life for Parkinson's disease patients!
Download now for free via this link:
authors.elsevier.com/c/1lARg3vVUP...
www.uq.edu.au/news/article...
Download now for free via this link:
authors.elsevier.com/c/1lARg3vVUP...
www.uq.edu.au/news/article...
May 29, 2025 at 6:05 AM
Great to be involved in this research on the Ghrelin receptor, out now in Molecular Cell - with potential for translation to improve quality of life for Parkinson's disease patients!
Download now for free via this link:
authors.elsevier.com/c/1lARg3vVUP...
www.uq.edu.au/news/article...
Download now for free via this link:
authors.elsevier.com/c/1lARg3vVUP...
www.uq.edu.au/news/article...
Interested in drug or genetic screens? Have a look at our ‘new’ paper in @naturecomms.bsky.social special thanks to Tim and Ali and the labs groups that have supported me and this work. www.nature.com/articles/s41...
dFLASH; dual FLuorescent transcription factor activity sensor for histone integrated live-cell reporting and high-content screening - Nature Communications
Arrayed and pooled high-throughput screening is crucial for drug discovery and CRISPR functional genomics. Here, the authors present dFLASH; a dual FLuorescent transcription factor Activity Sensor for...
www.nature.com
April 7, 2025 at 10:42 AM
Interested in drug or genetic screens? Have a look at our ‘new’ paper in @naturecomms.bsky.social special thanks to Tim and Ali and the labs groups that have supported me and this work. www.nature.com/articles/s41...
Reposted
When you don't have new results to show in your lab meeting
March 22, 2025 at 4:57 AM
When you don't have new results to show in your lab meeting
Reposted
What it feels like revising a paper
March 5, 2025 at 5:14 AM
What it feels like revising a paper
This is pretty cool approach!
We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 16, 2025 at 12:58 AM
This is pretty cool approach!
Reposted
Engineering synthetic phosphorylation signaling networks in human cells
“in human T cells, such a circuit could sense tumor necrosis factor–α and maintain controlled cytokine secretion”
www.science.org/doi/10.1126/...
“in human T cells, such a circuit could sense tumor necrosis factor–α and maintain controlled cytokine secretion”
www.science.org/doi/10.1126/...
Engineering synthetic phosphorylation signaling networks in human cells
Protein phosphorylation signaling networks have a central role in how cells sense and respond to their environment. We engineered artificial phosphorylation networks in which reversible enzymatic phos...
www.science.org
January 3, 2025 at 4:07 AM
Engineering synthetic phosphorylation signaling networks in human cells
“in human T cells, such a circuit could sense tumor necrosis factor–α and maintain controlled cytokine secretion”
www.science.org/doi/10.1126/...
“in human T cells, such a circuit could sense tumor necrosis factor–α and maintain controlled cytokine secretion”
www.science.org/doi/10.1126/...
Reposted
Progress on the quest for a red mStayGold!
Just out: mScarlet3-S2, a new photostable red FP derived from mScarlet3: www.researchsquare.com/article/rs-5...
Just out: mScarlet3-S2, a new photostable red FP derived from mScarlet3: www.researchsquare.com/article/rs-5...
December 25, 2024 at 8:45 AM
Progress on the quest for a red mStayGold!
Just out: mScarlet3-S2, a new photostable red FP derived from mScarlet3: www.researchsquare.com/article/rs-5...
Just out: mScarlet3-S2, a new photostable red FP derived from mScarlet3: www.researchsquare.com/article/rs-5...
Reposted
New here and excited to share our new paper on transcriptional effectors! Interested to discuss context-specificity of gene regulation? Or how to get CRISPRi/a working in new contexts? 👋
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Development of compact transcriptional effectors using high-throughput measurements in diverse contexts - Nature Biotechnology
Improved effectors for CRISPRi/CRISPRa are developed following high-throughput screening of transcriptional domains.
www.nature.com
November 18, 2024 at 3:16 AM
New here and excited to share our new paper on transcriptional effectors! Interested to discuss context-specificity of gene regulation? Or how to get CRISPRi/a working in new contexts? 👋
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I scroll down and all I see is science and enthusiasm…. It’s great!!!
November 18, 2024 at 8:52 AM
I scroll down and all I see is science and enthusiasm…. It’s great!!!
Reposted
"malicious users could exploit a model like Evo to design a biological weapon, so the researchers banished from the training set any viruses that attack eukaryotes" 👀 www.science.org/content/arti...
Meet Evo, the DNA-trained AI that creates genomes from scratch
ChatGPT-like model learns on its own to devise new proteins and genetic sequences
www.science.org
November 15, 2024 at 1:44 PM
"malicious users could exploit a model like Evo to design a biological weapon, so the researchers banished from the training set any viruses that attack eukaryotes" 👀 www.science.org/content/arti...
Insect factory making plenty of mCherry!
November 15, 2024 at 8:54 AM
Insect factory making plenty of mCherry!
Reposted
Check out lab member Conor McClune's new preprint! He and Jack Liu in the Sattely lab at Stanford used single-cell transcriptomics from multiple plant tissues in the presence of perturbations to discover *8* new genes in the Taxol biosynthesis pathway!
biorxiv.org/content/10.1... (1/n)
biorxiv.org/content/10.1... (1/n)
Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors
Plants make complex and potent therapeutic molecules, but difficulties in sourcing from natural producers or chemical synthesis can challenge their use in the clinic. A prominent example is the anti-c...
biorxiv.org
November 13, 2024 at 7:25 AM
Check out lab member Conor McClune's new preprint! He and Jack Liu in the Sattely lab at Stanford used single-cell transcriptomics from multiple plant tissues in the presence of perturbations to discover *8* new genes in the Taxol biosynthesis pathway!
biorxiv.org/content/10.1... (1/n)
biorxiv.org/content/10.1... (1/n)