Dave Lawson
@davelawson101.bsky.social
Structural Biologist at the
John Innes Centre Norwich UK
Protein crystallography
Cryo-EM
John Innes Centre Norwich UK
Protein crystallography
Cryo-EM
Reposted by Dave Lawson
Thrilled to share our latest preprint! This work started during my PhD and was finished together with @jmadhuprakash.bsky.social. We found a Phytophthora infestans L-shaped effector that bridges a host TOL protein to activated NLRs to suppress immunity!
www.biorxiv.org/content/10.1...
1/15
www.biorxiv.org/content/10.1...
1/15
July 9, 2025 at 1:03 PM
Thrilled to share our latest preprint! This work started during my PhD and was finished together with @jmadhuprakash.bsky.social. We found a Phytophthora infestans L-shaped effector that bridges a host TOL protein to activated NLRs to suppress immunity!
www.biorxiv.org/content/10.1...
1/15
www.biorxiv.org/content/10.1...
1/15
Reposted by Dave Lawson
I am incredibly proud to share with you all my latest preprint on the structure of the NifL-NifA complex: doi.org/10.1101/2025...
Thanks to all my mentors and collaborators at the @johninnescentre.bsky.social and BBSRC for the funding.
Thanks to all my mentors and collaborators at the @johninnescentre.bsky.social and BBSRC for the funding.
Structural analysis of the NifL-NifA complex reveals the molecular basis of anti-activation of nitrogen fixation gene expression in Azotobacter vinelandii
Understanding the molecular basis of regulated nitrogen (N2) fixation is essential for engineering N2-fixing bacteria that fulfill the demand of crop plants for fixed nitrogen, reducing our reliance o...
doi.org
June 6, 2025 at 3:30 PM
I am incredibly proud to share with you all my latest preprint on the structure of the NifL-NifA complex: doi.org/10.1101/2025...
Thanks to all my mentors and collaborators at the @johninnescentre.bsky.social and BBSRC for the funding.
Thanks to all my mentors and collaborators at the @johninnescentre.bsky.social and BBSRC for the funding.
Same here!
It's done. I've deactivated my twitter account, good riddance.
March 12, 2025 at 1:12 PM
Same here!
If you want to explain AlphaFold to your grandmother, start here...
Ignore the click baity headline and opening - this is a *really* good description of the two parts of the 2024 Chemistry Nobel prize: predicting a protein structure from its sequence (AlphaFold) and designing a protein to have a function (Baker lab: RoseTTAFold diffusion); and their huge potential.
The Most Useful Thing AI Has Done
YouTube video by Veritasium
youtu.be
March 8, 2025 at 1:53 PM
If you want to explain AlphaFold to your grandmother, start here...
Reposted by Dave Lawson
OUT NOW: KorB is a DNA clamp which slides along DNA to mediate long-range gene silencing upon interaction with the clamp-locking KorA protein
by Tung Le & co @johninnescentre.bsky.social
www.nature.com/articles/s41...
by Tung Le & co @johninnescentre.bsky.social
www.nature.com/articles/s41...
KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid - Nature Microbiology
Structural and single-molecule analyses show the CTPase, KorB, is a sliding DNA clamp that interacts with a clamp-locking protein KorA to inhibit gene expression over distances of more than 1 kb in th...
www.nature.com
January 23, 2025 at 10:58 AM
OUT NOW: KorB is a DNA clamp which slides along DNA to mediate long-range gene silencing upon interaction with the clamp-locking KorA protein
by Tung Le & co @johninnescentre.bsky.social
www.nature.com/articles/s41...
by Tung Le & co @johninnescentre.bsky.social
www.nature.com/articles/s41...
Reposted by Dave Lawson
collecting Xray crystallography data tonight with our Structural Biology platform @johninnescentre.bsky.social !!! Amazing to feel a rush that I felt during my PhD again!!!
January 23, 2025 at 10:16 PM
collecting Xray crystallography data tonight with our Structural Biology platform @johninnescentre.bsky.social !!! Amazing to feel a rush that I felt during my PhD again!!!
Reposted by Dave Lawson
Watch the animation: youtu.be/_56P7eVpTBU
korB binding KorA mechanism
YouTube video by John Innes Centre
youtu.be
January 23, 2025 at 10:50 AM
Watch the animation: youtu.be/_56P7eVpTBU
Reposted by Dave Lawson
Super excited to share the peer-reviewed version of the KorAB paper. Amazing to work such talented collaborators and thanks to the reviewers for making the work even better!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid - Nature Microbiology
Structural and single-molecule analyses show the CTPase, KorB, is a sliding DNA clamp that interacts with a clamp-locking protein KorA to inhibit gene expression over distances of more than 1 kb in th...
www.nature.com
January 23, 2025 at 11:08 AM
Super excited to share the peer-reviewed version of the KorAB paper. Amazing to work such talented collaborators and thanks to the reviewers for making the work even better!
www.nature.com/articles/s41...
www.nature.com/articles/s41...