Explaining the origins of language is a key challenge in understanding ourselves as a species. We present an empirical framework that draws on synergies across fields to facilitate robust studies of l...

Lactase persistence (LP), the ability to digest lactose from milk into adulthood, is a classic example of natural selection in humans. Multiple mutations upstream of the LCT gene are associated with L...

Purpose: The aim of this tutorial is to show how the rise of molecular technologies and analytical methods in human genetics yields exciting new ...

YouTube video by Institut Pasteur EDUCATION

SimHumanity: Using SLiM 5.0 to run whole-genome simulations of human evolution

Abstract. Pigs are the most commercially important modern livestock animal in East Asia. Numerous aspects of their domestication history remain unclear, ho

The world at 18,000 BP, published by Gamble and Soffer (The world at 18,000 BP. Vol. 2: low latitude, Unwin Hyman, 1990), represents the first, and so far the only, attempt at characterising and discussing the impact of the Last Glacial Maximum (LGM) on human societies on a global scale. At the time, they highlighted that research and data on the LGM in southern latitudes and the tropics in particular were scant. Since 1990, however, many sites dated to the LGM and located in tropical latitudes have been published. Many paradigms have changed regarding the peopling of the Americas, which allows the archaeology of this continent to be integrated into global scale studies of the LGM. The development of Pleistocene archaeology in tropical contexts, in parallel with methodological advances in cultural, geosciences and palaeoenvironmental studies have strongly reshaped what we know of the antiquity of human occupation in tropical regions and specific human–environment interactions. This article provides for the first time a pan-tropical perspective on the impact of the LGM on human groups living within the tropical latitudes, drawing from case studies in Southeast Asia, Africa and South America, specifically regions which have up until now never been discussed together. To this end, we focus on six different tropical regions between 30 and 10 ka. We present the archaeological and paleoenvironmental data available in these areas, along with proposed relationships for variations in these two records. Finally, we discuss at the regional scale the presence or absence of human changes (site density and techno-cultural change or continuity) before, during and immediately after the LGM.

Abstract. Phantom epistasis arises when, in the course of testing for gene-by-gene interactions, the omission of a causal variant with a purely additive ef

Human populations differ in disease prevalences and in average values of phenotypes, but the extent to which differences are caused by genetic or environmental factors is unknown for most complex trai...

SINGER is a method for creating ancestral recombination graphs to understand the genealogical history of genomes. The method has increased speed, and thus scalability, without sacrificing accuracy.

The reconstruction of human evolutionary history has undergone repeated advances, each made possible by methodological innovations. In recent decades, genetic and genomic data played a central role in...

Human population contact leads to consistently similar rates of linguistic borrowing, but effects vary across linguistic features.

This Mooc aims to provide basic knowledge on population genetics and the help of genetics in the study of human migrations and human adaptation to extreme conditions.

Summary: Ancestral recombination graphs (ARGs) are a complete representation of the genetic relationships between recombining lineages and are of central importance in population genetics. Recent brea...