Stephan Daetwyler
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daetwylerstephan.bsky.social
Stephan Daetwyler
@daetwylerstephan.bsky.social
Developing integrated technological platforms to study the molecular mechanisms that drive processes in development and disease.
@ Fiolka Lab, UT Southwestern
Reposted by Stephan Daetwyler
@daetwylerstephan.bsky.social will be giving a talk at #ZDM18 on “Imaging of cancer cell dynamics and interactions with self-driving, multi-scale microscopy.” We look forward to hearing about it on Weds 15th Oct! #zdmsECI #ZDMSociety
October 13, 2025 at 3:51 PM
Reposted by Stephan Daetwyler
We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...
October 6, 2025 at 5:52 PM
BLTP2 is often overexpressed in breast cancer, we were wondering why. Please check out the latest collaboration of the @retof.bsky.social lab with Subhrajit Banerjee and the Prinz lab:
www.nature.com/articles/s41...

Thank you Lab Katta for the YouTube summary
www.youtube.com/shorts/5Oih-...
Lab katta paperblitz 003 - Lipid transferring protein BLTP2 maintains flexibility of cell membrane
YouTube video by Lab katta
www.youtube.com
July 7, 2025 at 4:32 PM
Reposted by Stephan Daetwyler
I have seen lots of flavors of smart/event-driven microscopy, and this builds directly on the shoulders of existing works, but also takes this idea an important step further, both conceptually and in terms of accomplishments. www.nature.com/articles/s41...
Imaging of cellular dynamics from a whole organism to subcellular scale with self-driving, multiscale microscopy - Nature Methods
A self-driving multiresolution light-sheet microscope enables the simultaneous observation and quantification of cellular and subcellular dynamics in the context of intact and developing organisms ove...
www.nature.com
February 13, 2025 at 10:02 PM
Reposted by Stephan Daetwyler
I am thrilled to be posting about this paper that came out yesterday from @retof.bsky.social Reto's lab. The world sucks but amazing science will still prevail, and take my word for it this paper is special. (A thread)
February 13, 2025 at 10:02 PM
Reposted by Stephan Daetwyler
The self-driving multiscale microscope from @daetwylerstephan.bsky.social is out.

It can image an entire zebrafish embryo longitudinally and follow a volume of interest over time with high resolution.

We used it to study cancer-immune cell interactions.

www.nature.com/articles/s41...
Imaging of cellular dynamics from a whole organism to subcellular scale with self-driving, multiscale microscopy
Nature Methods - A self-driving multiresolution light-sheet microscope enables the simultaneous observation and quantification of cellular and subcellular dynamics in the context of intact and...
www.nature.com
February 12, 2025 at 1:45 PM
Reposted by Stephan Daetwyler
Faster 3D imaging in oblique plane microscopy through aliasing.

www.biorxiv.org/content/10.1...
December 26, 2024 at 4:56 PM
Reposted by Stephan Daetwyler
Relatively straightforward integration into an OPM, much better long term imaging stability.
December 2, 2024 at 7:30 PM
What a nice and easy way to generate your custom academic word cloud: shiny.rcg.sfu.ca/u/rdmorin/sc... by @morinryan.bsky.social
November 22, 2024 at 8:01 PM
Reposted by Stephan Daetwyler
Our debut here 🥰

Non-invasive intravital imaging of wound in skin epithelium of a juvenille zebrafish fed with a High-Cholesterol diet (HCD) versus a Normal Diet (ND)

Zebrafish is an outstanding model to study how diet and metabolic disease impact neutrophils

Keep following us, spread the word!
November 8, 2024 at 8:46 PM
Reposted by Stephan Daetwyler
Hello Bluesky-ers

Follow me for cell images and movies, stay for the shenanigans.

#Microscopy #Science
November 8, 2024 at 2:22 PM
Reposted by Stephan Daetwyler
Blood cells zooming through a #zebrafish embryo, imaged with @daetwylerstephan.bsky.social ‘s meso OPM.
November 8, 2024 at 2:54 PM
Reposted by Stephan Daetwyler
Sending out a #zebrafish signal 🚨 If you work with our favorite fish or similar fish models, we want to follow you! Help us connect 🙏
November 6, 2024 at 5:50 PM
Biological processes are inherently multi-scale in nature, however simultaneous observations of subcellular processes and entire organisms have remained challenging. Here, we introduce self-driving multi-scale microscopy to image processes in development and disease:
www.biorxiv.org/content/10.1...
Imaging of cellular dynamics in vitro and in situ: from a whole organism to sub-cellular imaging with self-driving, multi-scale microscopy
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
March 3, 2024 at 2:49 AM