Cris
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cristn.bsky.social
Cris
@cristn.bsky.social
110 followers 270 following 26 posts
Interesses nessa rede: Covid, Política, Ciências, Direito, Mudanças Climáticas e um pouco de Humor também.
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Reposted by Cris
erictopol.bsky.social
"The COVID-conscious people have not abandoned science, It’s the opposite: They’ve come to think that science has abandoned them."
People who are taking precautions, some of whom are immunocompromised, should not be mocked or discriminated against
www.theatlantic.com/health/archi...
The Evermaskers
The isolation of people who take precautions against COVID has only gotten more intense.
www.theatlantic.com
April 2, 2025 at 2:20 PM
Reposted by Cris
crisvector.com
Ontem na Unifesp foi lançado o Acervo da Pandemia de Covid 19 no Brasil. Um projeto imenso da SoU_Ciência, tanto em importância quanto em conteúdo.

acervopandemia-souciencia.unifesp.br
Acervo da Pandemia de Covid-19 – Evidências da Política da Morte na Pandemia da Covid-19 no Brasil
acervopandemia-souciencia.unifesp.br
March 13, 2025 at 1:12 PM
Reposted by Cris
sailorrooscout.bsky.social
against not just the original SARS-CoV-2 virus, but ALL variants of SARS-CoV-2 known to cause illness in humans. When tested in mouse models, the antibodies also SIGNIFICANTLY reduced the viral load in the lungs of mice exposed to Omicron variants.
Fig. 5. Deep mutational scanning of the SARS-CoV-2 XBB.1.5 spike protein for the C952-C1596 antibody cocktail or CoV2-biRN5 bsAb shows potential escape mutations. (A) The line plot shows the sum of escape for each amino acid residue in the SARS-CoV-2 XBB.1.5 S1 subunit (residues 1 to 600) as determined by a pseudovirus deep mutational scan with an equimolar cocktail of C952 and C1596 IgGs (top) or CoV2-biRN5 bsAb (bottom). Epitope residues for C952 and C1596 are highlighted with orange and purple shading, respectively. (B) BLI association and dissociation curves are shown, illustrating the effect of escape mutations in the SARS-CoV-2 XBB.1.5 S 6P on C1596 Fab binding. The concentrations of C1596 tested are indicated in each panel. The dissociation phase begins at time = 150 s and is depicted by a dotted vertical line. Fit curves are depicted as black solid lines. (C) Surface rendering of SARS-CoV-2 XBB.1.5 spike protein colored by the sum of escape scores, which is calculated as the sum of escape for all mutations at each site. Key residues of escape labeled along with their frequency across 5,240,975 sequences uploaded to GISAID CoVsurver as of 23 October 2024; frequency is denoted for the escape mutation with the greatest escape score (upper value) and for all amino acid mutations at that residue site (lower value). Fig. 6. Bispecific CoV2-biRN5 demonstrates prophylactic efficacy in a K18-hACE2 mouse model. (A) Shown is a schematic representation of the experimental timeline for assessing the efficacy of CoV2-biRN5 in vivo. K18-hACE2 mice received 5 mg kg−1 of either the cocktail of C952 and C1596 IgGs or the CoV2-biRN5 bsAb by intraperitoneal (ip) injection 24 hours before or 4 hours after intranasal (i.n.) inoculation with 2 × 104 PFU of the SARS-CoV-2 XBB.1.5 virus. Lungs were harvested at 3 days after infection. (B and C) Viral RNA load of SARS-CoV-2 XBB.1.5 in the lung was measured for each group (line indicates mean; n = 9 for untreated control and 5 for all other treatment groups) in the prophylaxis (B) and treatment (C) arms. Data were analyzed using one-way ANOVA, correcting for multiple comparisons with Dunnett’s test with comparison with the untreated control. ns, not significant, **P < 0.01, *P < 0.05. The dotted line indicates the lower limit of detection of the assay. The bispecific antibody’s design was specifically created to overcome challenges presented by SARS-CoV-2’s mutations. According to researchers, the antibody C1596, which targets the NTD, binds to a quaternary epitope, a region of the virus’s spike protein that doesn’t change frequently. This antibody, when paired with C952, an antibody targeting the RBD, resulted in increased neutralization efficacy in laboratory experiments, particularly against variants that have emerged after Omicron, such as XBB.1.5. In the study, the researchers found that the antibody pair was most effective when C1596 was placed at the N-terminal position, reinforcing the idea that the order in which the antibodies are combined matters for achieving the highest possible neutralization activity. This discovery will guide future research to further optimize bispecific antibodies for both efficacy and manufacturability.
March 9, 2025 at 4:09 PM
Reposted by Cris
sailorrooscout.bsky.social
The study has been published in Science. YES, it is PEER-REVIEWED.
• www.science.org/doi/10.1126/...
Abstract The ongoing emergence of severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants of concern (VOCs) that reduce the effectiveness of antibody therapeutics necessitates development of next-generation antibody modalities that are resilient to viral evolution. Here, we characterized amino-terminal domain (NTD)- and receptor binding domain (RBD) -specific monoclonal antibodies previously isolated from coronavirus disease 2019 (COVID-19) convalescent donors for their activity against emergent SARS-CoV-2 VOCs. Among these, the NTD-specific antibody C1596 displayed the greatest breadth of binding to VOCs, with cryo-electron microscopy structural analysis revealing recognition of a distinct NTD epitope outside of the site i antigenic supersite. Given C1596's favorable binding profile, we designed a series of bispecific antibodies (bsAbs), termed CoV2-biRNs, that featured both NTD and RBD specificities. Two of the C1596-inclusive bsAbs, CoV2-biRN5 and CoV2-biRN7, retained potent in vitro neutralization activity against all Omicron variants tested, including XBB.1.5, BA.2.86, and JN.1, contrasting the diminished potency of parental antibodies delivered as monotherapies or as a cocktail. Furthermore, prophylactic delivery of CoV2-biRN5 reduced the viral load within the lungs of K18-hACE2 mice after challenge with SARS-CoV-2 XBB.1.5. In conclusion, NTD-RBD bAbs offer promising potential for the design of resilient, next-generation antibody therapeutics against SARS-CoV-2 VOCs. An illustration of the bispecific antibodies the Stanford-led research team developed to neutralize the virus that causes COVID-19. Named “CoV2-biRN,” these two antibodies work together by attaching to different areas of the virus. Credit: Christopher O. Barnes/Adonis Rubi The bispecific antibodies target two areas of the virus: One attaches to the “NTD,” or Spike N-terminal domain, an area on the virus that does not change very much. This allows the second antibody to attach to the “RBD,” or receptor-binding domain, essentially preventing the virus from infecting human cells. Credit: Christopher O. Barnes/Adonis Rubio
March 9, 2025 at 4:01 PM
Reposted by Cris
sailorrooscout.bsky.social
THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable part of the virus. This breakthrough could lead to longer-lasting therapies that OUTPACE viral evolution. 🧪🧵⬇️
March 9, 2025 at 4:00 PM
Reposted by Cris
erictopol.bsky.social
Categorization of #LongCovid into 4 subtypes based on symptoms, with further evidence of the increased risk from multiple infections and reduced risk by vaccination and boosters.
www.thelancet.com/journals/ebi...
December 11, 2024 at 2:39 PM
Reposted by Cris
erictopol.bsky.social
With mild infection in healthy participants who received a SARS-CoV-2 challenge there was evidence of persistent cognitive and memory changes at least one year after Covid, compared with uninfected controls www.thelancet.com/journals/ecl...
September 22, 2024 at 8:13 PM
Reposted by Cris
lannaa.bsky.social
🎯
A COVID longa se manifesta com desregulação das células T, inflamação e uma resposta imune adaptativa descoordenada ao SARS-CoV-2
September 22, 2024 at 4:44 PM
Reposted by Cris
flabberghaster.bsky.social
There are plenty of studies saying that yes, it might cause immune system dysregulation. Here are some random examples:

- www.nature.com/articles/s41...
- www.nih.gov/news-events/...

I don't get why there's such a push to say "no, getting covid is fine, don't worry about it" from so many.
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2 - Nature Immunology
Roan et al. use Olink and single‐cell RNA sequencing (scRNA-seq) to show a dysregulated crosstalk between the cellular and humoral immune responses in individuals with long COVID 8 months postinfectio...
www.nature.com
September 21, 2024 at 11:01 PM
Reposted by Cris
laertecoutinho.bsky.social
saiu na Folha @folha.com :
Tira de Laerte, em 4 quadrinhos. 1) Imagem de um deus de Velho Testamento, isto é: um homem, velho, de barbas longas e ar severo, por trás de nuvens e com uma auréola triangular atrás da cabeça. Um título sob a imagem indica: “DEUS”. 2) Imagem de um soldado, de capacete, segurando ameaçador um rifle. Ele está atrás de uma trincheira de sacos de areia e com arames farpados. Um título indica: “PÁTRIA”. 3) Mesa de reunião com três homens de paletó e gravata. Um deles ergue um dedo e sugere: “Que tal algo pensando no público feminino?” - outro diz, pensativo: “Hm…” 4) Imagem de uma muralha de castelo medieval, atrás da qual se alinham soldados, com lanças e capacetes. Um título indica: “FAMÍLIA”.
September 22, 2024 at 10:34 AM
Reposted by Cris
mellziland.bsky.social
Dentro desse contexto das vacinas atualizadas, há uma movimentação da sociedade civil para levar essa demanda (da urgência da aquisição e disponibilidade) de vacinas atualizadas da Covid-19 para o @minsaude.bsky.social

Vou deixar o link abaixo:
Vacina atualizada contra covid19 nas versões para as variantes KP2 e JN1
Ao Excelentíssimo Sr. Luiz Inácio Lula da Silva, Presidente da RepúblicaÀ Excelentíssima Sra. Nísia Trindade Lima, Ministra da Saúde do BrasilAo Excelentíssimo Sr. Alexandre Padilha, Ministro das Rela...
secure.avaaz.org
September 19, 2024 at 2:30 PM
Reposted by Cris
lannaa.bsky.social
No momento a variante dominante é a KP.3. A OMS recomendou esse ano a vacinação com vacinas atualizadas mais adequadas a essas novas variantes. São as vacinas KP.2 da Pfizer e Moderna e a JN.1 da Novavax. Os EUA já começaram essa vacinação. No Brasil não temos doses suficientes nem da vacina XBB.
Uma nova subvariante do vírus da covid, mais contagiosa, começa a se espalhar nos EUA e Europa
As vacinas da Moderna e da Pfizer disponíveis hoje nos EUA, eficientes contra as variantes KP.2 e KP.3.1.1, não protegem adequadamente contra a nova variante XEC; Brasil só tem geração mais antiga de ...
epocanegocios.globo.com
September 15, 2024 at 10:18 PM
Reposted by Cris
folha.com
#OPINIÃO
📝Carlos Nobre | Crise climática: Mundo pode não ter mais volta e isso me apavora. A Terra só viu algo parecido no último período do interglacial, 120 mil anos atrás.
Crise climática: Mundo pode não ter mais volta - 14/09/2024 - Ambiente - Folha
A Terra só viu algo parecido no último período do interglacial, 120 mil anos atrás
mla.bs
September 14, 2024 at 12:20 PM
Reposted by Cris
broadwaybabyto.bsky.social
Austrian woman convicted of negligent homicide after infecting her neighbour with COVID (they died).

The woman had tested positive & told her doctor she wouldn’t isolate.

I always ask if people would change behaviour if they had to face a person they killed…is this a no? tinyurl.com/3ffnhph4
Austrian woman is found guilty of fatally infecting her neighbor with COVID-19
VIENNA (AP) — A woman in Austria was found guilty of fatally infecting her neighbor with COVID-19 in 2021, her second pandemic-related conviction in a year, according to local media.
www.thecanadianpressnews.ca
September 13, 2024 at 8:37 PM
Reposted by Cris
revistaforum.com.br
Não acabou: Casos de Covid-19 têm crescimento expressivo em apenas 1 mês

Por @lucasvasques1.bsky.social
Não acabou: Casos de Covid-19 têm crescimento expressivo em apenas 1 mês
Número de mortos também avançou no Brasil, de acordo com dados do Ministério da Saúde; confira
revistaforum.com.br
September 11, 2024 at 7:36 PM
Reposted by Cris
intercept.com.br
Ex-aluna de Direito relata que seu então professor, Silvio Almeida, insistiu para sair com ela pelo telefone para não ter trabalho ‘prejudicado’. Ele era um dos membros de sua banca de monografia.

O caso, que ocorreu em 2009, só foi relatado para as amigas próximas na época. tibr.in/ex-aluna-sil...
Ex-aluna de Silvio Almeida relata ter sido assediada antes da banca de monografia | Intercept Brasil
Ex-aluna afirma que Silvio Almeida, então seu professor e avaliador, a convidou para sair para não ter trabalho ‘prejudicado’. O caso, que ocorreu em 2009, só foi relatado para as amigas próximas na é...
tibr.in
September 10, 2024 at 6:43 PM
Reposted by Cris
fecampagnucci.com
É a monetização do debate político. A matéria reproduz esse comentário. Podia ser conversa de amigos discutindo voto, mas é apostador explicando a sua lógica de em quem apostar. Se o voto passa a valer dinheiro, como não considerar que a escolha de voto não vai ser influenciada por isso pra muitos?
September 10, 2024 at 8:10 AM
Reposted by Cris
lannaa.bsky.social
O SARS-CoV-2, o vírus que causa a COVID-19,afeta os pulmões, o coração, o cérebro,os rins e os vasos sanguíneos.Ele também pode desencadear complicações como a doença de Kawasaki (KD) em crianças.
As crianças merecem ter acesso às vacinas atualizadas contra COVID

www.frontiersin.org/journals/ped...
September 10, 2024 at 9:32 AM
Reposted by Cris
biaklimeck.bsky.social
Usem máscaras PFF2/PFF3 (mesmo dentro de casa), fechem as janelas e portas, mantenham-se muito hidratados, saiam de casa somente se for necessário, liguem a recirculação de ar nos carros.

Não minimizem essa quantidade de material particulado no ar, os danos à saúde podem ser muito graves.
September 9, 2024 at 3:24 PM
Reposted by Cris
anarcofino.bsky.social
60% do território brasileiro está coberto por fumaça de incêndios. 60% de uma país de proporções continentais está coberto por fumaça. A fumaça já se encaminha para países como Argentina e Uruguai.
September 9, 2024 at 1:07 PM
Reposted by Cris
mellziland.bsky.social
A fumaça das queimadas além de mudar cenários e rotinas do brasileiro, colocou três capitaias com a pior qualidade de ar DO MUNDO, recentemente. Mas hoje vou focar nos PREJUÍZOS SOBRE O SISTEMA NERVOSO

Ainda não sabemos todos os efeitos dessa exposição a longo prazo, mas temos dados preocupantes 🧵🔻
Imagem de satélite mostra densidade da fumaça de queimadas pelo país no início da manhã — Foto: Reprodução/Windy. Fonte: G1 https://g1.globo.com/meio-ambiente/noticia/2024/09/09/fumaca-de-incendios-na-amazonia-cobre-o-ceu-do-brasil-e-pode-chegar-a-argentina-e-ao-uruguai.ghtml Encoberta por fumaça, Porto Velho segue com a pior qualidade do ar do país — Foto: Tiago Frota/Rede Amazônica. Fonte: O Globo https://oglobo.globo.com/brasil/noticia/2024/09/07/fumaca-de-queimadas-da-amazonia-e-pantanal-atinge-estados-do-sul-e-do-sudeste-neste-sabado-cenario-de-guerra-diz-especialista.ghtml
September 9, 2024 at 3:08 PM
Reposted by Cris
luckytran.com
Air pollution kills millions of people a year. And over the last few years, airborne viruses spread by dirty indoor air have killed tens of millions of people. On this #WorldCleanAirDay, let's also speak up about the urgent need to clean indoor air too.
September 7, 2024 at 8:36 PM
Reposted by Cris
lolaescreva.bsky.social
Estarrecedor. O 1o assédio de Silvio a Anielle teria ocorrido em maio de 2023 durante reunião. Ele teria passado a mão entre as pernas dela. Ninguém viu, mas tds constataram q ela terminou a reunião abalada. Dps contou p/várias pessoas. Td sororidade à ministra www.metropoles.com/colunas/igor...
Silvio Almeida teria passado a mão entre as pernas de Anielle em reunião | Metrópoles
Ministra Anielle Franco relatou a colegas que Silvio Almeida teria passado a mão entre suas pernas durante reunião oficial em maio de 2023
www.metropoles.com
September 7, 2024 at 1:52 PM
Reposted by Cris
flasaad.bsky.social
Não. É certeza de que ninguém desconfia de sua reputação. O homem se acha intocável. O poder os protege e coloca a vítima sempre se questionando “mas fulano é tão legal/ativista/defensor dos direitos humanos”. Quem sofre o abuso acha que está doida, que não aconteceu
September 7, 2024 at 2:32 PM