Children's Research Institute at UT Southwestern
@cri-utsw.bsky.social
We are a community of researchers working together to answer fundamental questions about the biological basis of disease. #StemCells #CancerBiology #Metabolism
Reposted by Children's Research Institute at UT Southwestern
Exciting news from the @rjdlab.bsky.social (with co-first author @zhengwu1.bsky.social)! We've uncovered a crucial new mechanism that controls the supply of purine nucleotides—a pathway essential for cancer growth.
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 7, 2025 at 11:52 AM
Exciting news from the @rjdlab.bsky.social (with co-first author @zhengwu1.bsky.social)! We've uncovered a crucial new mechanism that controls the supply of purine nucleotides—a pathway essential for cancer growth.
Reposted by Children's Research Institute at UT Southwestern
Super excited to share that my second project in the @rjdlab.bsky.social is now published in Science! Many thanks to all co-authors, especially @ptnguyen.bsky.social for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 6, 2025 at 11:37 PM
Super excited to share that my second project in the @rjdlab.bsky.social is now published in Science! Many thanks to all co-authors, especially @ptnguyen.bsky.social for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!
ONLINE NOW in @science.org: @haozhulab.bsky.social discovers location matters for liver cancer's origins. 🧪
Read more ⬇️ cri.utsw.edu/zhu-lab-show...
🔖 @haozhulab.bsky.social's breakdown ➡️ x.com/Zhu_Lab/stat...
#relentlessdiscovery
Read more ⬇️ cri.utsw.edu/zhu-lab-show...
🔖 @haozhulab.bsky.social's breakdown ➡️ x.com/Zhu_Lab/stat...
#relentlessdiscovery
Zhu Lab shows location matters for liver cancer’s origins - Children's Medical Center Research Institute (CRI) | Dallas Texas
Hepatocellular carcinoma arises primarily in zone 3 due to glutathione transferase genes that help mutated cells avoid dying Scientists have discovered liver cancers arise in specific metabolic zones,...
cri.utsw.edu
November 6, 2025 at 8:48 PM
ONLINE NOW in @science.org: @haozhulab.bsky.social discovers location matters for liver cancer's origins. 🧪
Read more ⬇️ cri.utsw.edu/zhu-lab-show...
🔖 @haozhulab.bsky.social's breakdown ➡️ x.com/Zhu_Lab/stat...
#relentlessdiscovery
Read more ⬇️ cri.utsw.edu/zhu-lab-show...
🔖 @haozhulab.bsky.social's breakdown ➡️ x.com/Zhu_Lab/stat...
#relentlessdiscovery
ONLINE NOW in @science.org: DeBerardinis Lab discovers protein regulating balance between purine nucleotide production pathways. 🧪
Read more ➡️ cri.utsw.edu/deberardinis...
🔖 full breakdown ⬇️
Read more ➡️ cri.utsw.edu/deberardinis...
🔖 full breakdown ⬇️
November 6, 2025 at 7:15 PM
ONLINE NOW in @science.org: DeBerardinis Lab discovers protein regulating balance between purine nucleotide production pathways. 🧪
Read more ➡️ cri.utsw.edu/deberardinis...
🔖 full breakdown ⬇️
Read more ➡️ cri.utsw.edu/deberardinis...
🔖 full breakdown ⬇️
Reposted by Children's Research Institute at UT Southwestern
6 years ago, Lizz took a leap of faith by moving across the country to join our new and empty lab as a research tech. She then became our 1st grad student, playing a major role in shaping our research directions and lab culture. Today she defended her PhD, and I couldn’t be more proud.
Defended! 🍾 Introducing Elizabeth Maurais, Ph.D. 🎉 Congrats on your successful #dissertationdefense. Dr. Maurais was joined by her mentor @peterlylab.bsky.social & other Ly Lab mates. Next stop: #postdoc! 🧪
November 5, 2025 at 2:11 AM
6 years ago, Lizz took a leap of faith by moving across the country to join our new and empty lab as a research tech. She then became our 1st grad student, playing a major role in shaping our research directions and lab culture. Today she defended her PhD, and I couldn’t be more proud.
Defended! 🍾 Introducing Elizabeth Maurais, Ph.D. 🎉 Congrats on your successful #dissertationdefense. Dr. Maurais was joined by her mentor @peterlylab.bsky.social & other Ly Lab mates. Next stop: #postdoc! 🧪
November 4, 2025 at 11:18 PM
Defended! 🍾 Introducing Elizabeth Maurais, Ph.D. 🎉 Congrats on your successful #dissertationdefense. Dr. Maurais was joined by her mentor @peterlylab.bsky.social & other Ly Lab mates. Next stop: #postdoc! 🧪
Reposted by Children's Research Institute at UT Southwestern
We moved the RJDLab potluck to Halloween this year. Thanks to Gaby Cano for organizing! (And decorating).
November 1, 2025 at 12:21 AM
We moved the RJDLab potluck to Halloween this year. Thanks to Gaby Cano for organizing! (And decorating).
Happy Halloween 🎃
Scary: food in the lab (👋 Harrison)
Sweet: problem-solving lab managers, like Jessica!
🎃🍬🤍🦇🕷️🕸️🐈⬛💀🧡🐦⬛🕯️🖤🍂🍁🔮🧪
@rjdlab.bsky.social
Scary: food in the lab (👋 Harrison)
Sweet: problem-solving lab managers, like Jessica!
🎃🍬🤍🦇🕷️🕸️🐈⬛💀🧡🐦⬛🕯️🖤🍂🍁🔮🧪
@rjdlab.bsky.social
October 31, 2025 at 3:19 PM
Happy Halloween 🎃
Scary: food in the lab (👋 Harrison)
Sweet: problem-solving lab managers, like Jessica!
🎃🍬🤍🦇🕷️🕸️🐈⬛💀🧡🐦⬛🕯️🖤🍂🍁🔮🧪
@rjdlab.bsky.social
Scary: food in the lab (👋 Harrison)
Sweet: problem-solving lab managers, like Jessica!
🎃🍬🤍🦇🕷️🕸️🐈⬛💀🧡🐦⬛🕯️🖤🍂🍁🔮🧪
@rjdlab.bsky.social
ONLINE NOW: CRI's Ohlstein Lab presents new research that reevaluates whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila, in @pnas.org. Read more ⬇️ www.pnas.org/doi/10.1073/...
#relentlessdiscovery 🧪
#relentlessdiscovery 🧪
Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila | PNAS
Recent work suggests that asymmetric segregation of preexisting and newly synthesized
canonical histone 3.1 (H3.1), but not variant histone 3.3A (H...
www.pnas.org
October 31, 2025 at 2:31 PM
ONLINE NOW: CRI's Ohlstein Lab presents new research that reevaluates whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila, in @pnas.org. Read more ⬇️ www.pnas.org/doi/10.1073/...
#relentlessdiscovery 🧪
#relentlessdiscovery 🧪
📍 #MotivationMonday:
"Resilience isn’t something that you are born with – it is a set of skills you have to cultivate.” -@seanjmorrison.bsky.social
Read more about pushing through adversity & #relentlessdiscovery with Sean & @rjdlab.bsky.social ⬇️
www.utsouthwestern.edu/ctplus/stori...
"Resilience isn’t something that you are born with – it is a set of skills you have to cultivate.” -@seanjmorrison.bsky.social
Read more about pushing through adversity & #relentlessdiscovery with Sean & @rjdlab.bsky.social ⬇️
www.utsouthwestern.edu/ctplus/stori...
From the trenches: Words of wisdom to postdocs from UTSW trailblazers - CT Plus - UT Southwestern
Four distinguished UT Southwestern scientists who are members of the National Academies inspired postdoctoral researchers by sharing their own experiences as postdocs recently, offering words of encou...
www.utsouthwestern.edu
October 27, 2025 at 1:32 PM
📍 #MotivationMonday:
"Resilience isn’t something that you are born with – it is a set of skills you have to cultivate.” -@seanjmorrison.bsky.social
Read more about pushing through adversity & #relentlessdiscovery with Sean & @rjdlab.bsky.social ⬇️
www.utsouthwestern.edu/ctplus/stori...
"Resilience isn’t something that you are born with – it is a set of skills you have to cultivate.” -@seanjmorrison.bsky.social
Read more about pushing through adversity & #relentlessdiscovery with Sean & @rjdlab.bsky.social ⬇️
www.utsouthwestern.edu/ctplus/stori...
Reposted by Children's Research Institute at UT Southwestern
Interested in organellar metabolomics? Check out my talk tomorrow on how the Rapid Organellar IP technology has enabled discoveries in organellar biology over the past 10 years! Ty Tech Networks for the invite! @cri-utsw.bsky.social @rjdlab.bsky.social www.technologynetworks.com/proteomics/o...
Advances in Proteomics & Metabolomics 2025
Proteomics and metabolomics are unlocking new dimensions in our understanding of biology and disease. This event will highlight the latest developments in mass spectrometry, single-cell proteomics and...
www.technologynetworks.com
October 23, 2025 at 3:41 AM
Interested in organellar metabolomics? Check out my talk tomorrow on how the Rapid Organellar IP technology has enabled discoveries in organellar biology over the past 10 years! Ty Tech Networks for the invite! @cri-utsw.bsky.social @rjdlab.bsky.social www.technologynetworks.com/proteomics/o...
Reposted by Children's Research Institute at UT Southwestern
Many thanks also to @cri-utsw.bsky.social for providing such an excellent environment for training and discovery.
October 21, 2025 at 2:59 PM
Many thanks also to @cri-utsw.bsky.social for providing such an excellent environment for training and discovery.
Reposted by Children's Research Institute at UT Southwestern
Congrats to all Damon Runyon's SPARK Scholars, including our own scholar Imani Williams who is studying cancer metabolism. Thank you Damon Runyon Cancer Research Foundation @damonrunyon.org for supporting this great initiative.
www.damonrunyon.org/news/entries...
www.damonrunyon.org/news/entries...
Damon Runyon announces newest class of SPARK Scholars
www.damonrunyon.org
October 21, 2025 at 2:43 PM
Congrats to all Damon Runyon's SPARK Scholars, including our own scholar Imani Williams who is studying cancer metabolism. Thank you Damon Runyon Cancer Research Foundation @damonrunyon.org for supporting this great initiative.
www.damonrunyon.org/news/entries...
www.damonrunyon.org/news/entries...
Reposted by Children's Research Institute at UT Southwestern
Thrilled to announce the launch of my lab
@cri-utsw.bsky.social at UTSW this January!
We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.
@cri-utsw.bsky.social at UTSW this January!
We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.
We're growing! Our newest Investigator @henrydebelly.bsky.social will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ cri.utsw.edu/faculty/henr... and 📌apply to research in his lab cri.utsw.edu/careers
October 16, 2025 at 10:00 PM
Thrilled to announce the launch of my lab
@cri-utsw.bsky.social at UTSW this January!
We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.
@cri-utsw.bsky.social at UTSW this January!
We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.
We're growing! Our newest Investigator @henrydebelly.bsky.social will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ cri.utsw.edu/faculty/henr... and 📌apply to research in his lab cri.utsw.edu/careers
October 16, 2025 at 7:24 PM
We're growing! Our newest Investigator @henrydebelly.bsky.social will join the CRI Tissue #Regeneration Program in January 2026. Learn more about Henry ➡️ cri.utsw.edu/faculty/henr... and 📌apply to research in his lab cri.utsw.edu/careers
Reposted by Children's Research Institute at UT Southwestern
One week left to apply!
🔬 APPLY NOW: Seeking faculty scientists in #stemcells #TissueRegeneration #metabolism & #cancerbiology.
You ready for #relentlessdiscovery at our collaborative Institute? Learn more at cri.utsw.edu/careers & apply before Oct. 15. 🤜💥🤛
#jobs #faculty #facultyjobs #ScienceJobs 🧪
You ready for #relentlessdiscovery at our collaborative Institute? Learn more at cri.utsw.edu/careers & apply before Oct. 15. 🤜💥🤛
#jobs #faculty #facultyjobs #ScienceJobs 🧪
October 8, 2025 at 12:37 PM
One week left to apply!
Reposted by Children's Research Institute at UT Southwestern
Excited to present my research at the upcoming University of Utah Rising Stars Symposium and meet fellow scientists who love metabolism! @cri-utsw.bsky.social @rjdlab.bsky.social
Please join us for the Diabetes and Metabolism Research Center (DMRC) 2025 Rising Stars in partnership with the Mountain West Prevention Center (MW-PRC). This is a multi-departmental effort, aligned with the University of Utah’s synergistic approach to amplify voices and foster connections
October 3, 2025 at 2:36 PM
Excited to present my research at the upcoming University of Utah Rising Stars Symposium and meet fellow scientists who love metabolism! @cri-utsw.bsky.social @rjdlab.bsky.social
Reposted by Children's Research Institute at UT Southwestern
Thank you @cri-utsw.bsky.social postdocs!
We have the best postdocs! We appreciate you being a critical part of our CRI team to help discover the treatments of tomorrow. #npaw2025 #npaw #relentlessdiscovery 🧪
September 19, 2025 at 7:40 PM
Thank you @cri-utsw.bsky.social postdocs!
We have the best postdocs! We appreciate you being a critical part of our CRI team to help discover the treatments of tomorrow. #npaw2025 #npaw #relentlessdiscovery 🧪
September 19, 2025 at 5:30 PM
We have the best postdocs! We appreciate you being a critical part of our CRI team to help discover the treatments of tomorrow. #npaw2025 #npaw #relentlessdiscovery 🧪
🎉 JUST ANNOUNCED: @haozhulab.bsky.social named project co-leader for UTSW liver cancer SPORE. His project will study how to prevent hepatocellular carcinoma — which accounts for >85% of liver cancer cases across the nation.
Read more ⬇️ cri.utsw.edu/zhu-named-co...
#relentlessdiscovery 🧪
Read more ⬇️ cri.utsw.edu/zhu-named-co...
#relentlessdiscovery 🧪
UTSW named Specialized Program of Research Excellence for liver cancer
The Liver Tumor Program at UT Southwestern Medical Center’s Harold C. Simmons Comprehensive Cancer Center has been selected by the National Cancer Institute as a Specialized Program of Research Excell...
cri.utsw.edu
September 17, 2025 at 4:41 PM
🎉 JUST ANNOUNCED: @haozhulab.bsky.social named project co-leader for UTSW liver cancer SPORE. His project will study how to prevent hepatocellular carcinoma — which accounts for >85% of liver cancer cases across the nation.
Read more ⬇️ cri.utsw.edu/zhu-named-co...
#relentlessdiscovery 🧪
Read more ⬇️ cri.utsw.edu/zhu-named-co...
#relentlessdiscovery 🧪
🔬 APPLY NOW: Seeking faculty scientists in #stemcells #TissueRegeneration #metabolism & #cancerbiology.
You ready for #relentlessdiscovery at our collaborative Institute? Learn more at cri.utsw.edu/careers & apply before Oct. 15. 🤜💥🤛
#jobs #faculty #facultyjobs #ScienceJobs 🧪
You ready for #relentlessdiscovery at our collaborative Institute? Learn more at cri.utsw.edu/careers & apply before Oct. 15. 🤜💥🤛
#jobs #faculty #facultyjobs #ScienceJobs 🧪
September 15, 2025 at 3:57 PM
🔬 APPLY NOW: Seeking faculty scientists in #stemcells #TissueRegeneration #metabolism & #cancerbiology.
You ready for #relentlessdiscovery at our collaborative Institute? Learn more at cri.utsw.edu/careers & apply before Oct. 15. 🤜💥🤛
#jobs #faculty #facultyjobs #ScienceJobs 🧪
You ready for #relentlessdiscovery at our collaborative Institute? Learn more at cri.utsw.edu/careers & apply before Oct. 15. 🤜💥🤛
#jobs #faculty #facultyjobs #ScienceJobs 🧪
Reposted by Children's Research Institute at UT Southwestern
Excited to join the @cri-utsw.bsky.social community to advance discoveries in genome instability. We are grateful to UTSW Pathology for 6 wonderful years.
🚨 We are also recruiting motivated postdocs to study how mitotic errors and aberrant nuclear structures drive cancer genome evolution—join us!
🚨 We are also recruiting motivated postdocs to study how mitotic errors and aberrant nuclear structures drive cancer genome evolution—join us!
WELCOME to the Institute, @peterlylab.bsky.social! Dr. Ly studies how cells maintain genomic integrity and how dysregulation of these processes impacts human health. 🧪Learn more about his research 👉 cri.utsw.edu/faculty/pete... #relentlessdiscovery
September 10, 2025 at 4:31 PM
Excited to join the @cri-utsw.bsky.social community to advance discoveries in genome instability. We are grateful to UTSW Pathology for 6 wonderful years.
🚨 We are also recruiting motivated postdocs to study how mitotic errors and aberrant nuclear structures drive cancer genome evolution—join us!
🚨 We are also recruiting motivated postdocs to study how mitotic errors and aberrant nuclear structures drive cancer genome evolution—join us!
WELCOME to the Institute, @peterlylab.bsky.social! Dr. Ly studies how cells maintain genomic integrity and how dysregulation of these processes impacts human health. 🧪Learn more about his research 👉 cri.utsw.edu/faculty/pete... #relentlessdiscovery
September 10, 2025 at 2:52 PM
WELCOME to the Institute, @peterlylab.bsky.social! Dr. Ly studies how cells maintain genomic integrity and how dysregulation of these processes impacts human health. 🧪Learn more about his research 👉 cri.utsw.edu/faculty/pete... #relentlessdiscovery
👉New article in @newscientist.com features a #relentlessdiscovery 🧪 from CRI's Agathocleous Lab ⬇️
According to the textbooks, we lost the ability to make vitamin C because our diet meant that we didn't need it. But studies in animals suggest it had an unexpected benefit.
The real reason why we lost the ability to make vitamin C
The textbooks say our ancestors lost the ability to make vitamin C because we didn't need it, but the loss may have protected us from some parasites
www.newscientist.com
August 21, 2025 at 9:20 PM
👉New article in @newscientist.com features a #relentlessdiscovery 🧪 from CRI's Agathocleous Lab ⬇️
Reposted by Children's Research Institute at UT Southwestern
Thrilled and deeply honored to be named a 2025 Pew Biomedical Scholar!
Huge congrats to my friend and colleague
@cri-utsw.bsky.social Javi, who’s also joining the Pew family as a Pew-Stewart Scholar.
CRI is on fire—let’s go make some bold, groundbreaking science happen! 🔥🧪✨
Huge congrats to my friend and colleague
@cri-utsw.bsky.social Javi, who’s also joining the Pew family as a Pew-Stewart Scholar.
CRI is on fire—let’s go make some bold, groundbreaking science happen! 🔥🧪✨
Congrats! 👏👏👏 Two CRI scientists named 2025 Pew-Stewart & Pew Scholars — Javier Garcia-Bermudez, Ph.D. &
@hrshin.bsky.social — to advance cancer, biomedical research 🧪 Read more about their #relentlessdiscovery ⬇️ cri.utsw.edu/two-children... @pewtrusts.org
@hrshin.bsky.social — to advance cancer, biomedical research 🧪 Read more about their #relentlessdiscovery ⬇️ cri.utsw.edu/two-children... @pewtrusts.org
Two Children’s Research Institute scientists named 2025 Pew Scholars - Children's Medical Center Research Institute (CRI) | Dallas Texas
Javier Garcia-Bermudez, Ph.D., Hijai Regina Shin, Ph.D., selected to advance cancer, biomedical research DALLAS – Aug. 12, 2025 – Two Children’s Medical Center Research Institute at UT Southwestern fa...
cri.utsw.edu
August 13, 2025 at 2:59 AM
Thrilled and deeply honored to be named a 2025 Pew Biomedical Scholar!
Huge congrats to my friend and colleague
@cri-utsw.bsky.social Javi, who’s also joining the Pew family as a Pew-Stewart Scholar.
CRI is on fire—let’s go make some bold, groundbreaking science happen! 🔥🧪✨
Huge congrats to my friend and colleague
@cri-utsw.bsky.social Javi, who’s also joining the Pew family as a Pew-Stewart Scholar.
CRI is on fire—let’s go make some bold, groundbreaking science happen! 🔥🧪✨