Reposted by Phong Nguyen
Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lymph node environment drives FSP1 targetability in metastasizing melanoma | Nature
www.nature.com
November 5, 2025 at 4:11 PM
Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Phong Nguyen
ONLINE NOW in @science.org: @haozhulab.bsky.social discovers location matters for liver cancer's origins. 🧪
Read more ⬇️ cri.utsw.edu/zhu-lab-show...
🔖 @haozhulab.bsky.social's breakdown ➡️ x.com/Zhu_Lab/stat...
#relentlessdiscovery
Read more ⬇️ cri.utsw.edu/zhu-lab-show...
🔖 @haozhulab.bsky.social's breakdown ➡️ x.com/Zhu_Lab/stat...
#relentlessdiscovery
Zhu Lab shows location matters for liver cancer’s origins - Children's Medical Center Research Institute (CRI) | Dallas Texas
Hepatocellular carcinoma arises primarily in zone 3 due to glutathione transferase genes that help mutated cells avoid dying Scientists have discovered liver cancers arise in specific metabolic zones,...
cri.utsw.edu
November 6, 2025 at 8:48 PM
ONLINE NOW in @science.org: @haozhulab.bsky.social discovers location matters for liver cancer's origins. 🧪
Read more ⬇️ cri.utsw.edu/zhu-lab-show...
🔖 @haozhulab.bsky.social's breakdown ➡️ x.com/Zhu_Lab/stat...
#relentlessdiscovery
Read more ⬇️ cri.utsw.edu/zhu-lab-show...
🔖 @haozhulab.bsky.social's breakdown ➡️ x.com/Zhu_Lab/stat...
#relentlessdiscovery
Exciting news from the @rjdlab.bsky.social (with co-first author @zhengwu1.bsky.social)! We've uncovered a crucial new mechanism that controls the supply of purine nucleotides—a pathway essential for cancer growth.
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 7, 2025 at 11:52 AM
Exciting news from the @rjdlab.bsky.social (with co-first author @zhengwu1.bsky.social)! We've uncovered a crucial new mechanism that controls the supply of purine nucleotides—a pathway essential for cancer growth.
Reposted by Phong Nguyen
Super excited to share that my second project in the @rjdlab.bsky.social is now published in Science! Many thanks to all co-authors, especially @ptnguyen.bsky.social for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 6, 2025 at 11:37 PM
Super excited to share that my second project in the @rjdlab.bsky.social is now published in Science! Many thanks to all co-authors, especially @ptnguyen.bsky.social for his expertise in structural biology and enzymology! And big thanks to Ralph for his incredible mentorship and support!