Coraline Mlynarczyk
@coraline-mly.bsky.social
Assistant Professor at Yale
interested in B cells, immunology, lymphoma & metabolism
she/her 🔈KO-rah-leen MLEE-nahr-zik
https://medicine.yale.edu/lab/mlynarczyk/
interested in B cells, immunology, lymphoma & metabolism
she/her 🔈KO-rah-leen MLEE-nahr-zik
https://medicine.yale.edu/lab/mlynarczyk/
Pinned
Immunology, Cancer, & Cell Metabolism - The Mlynarczyk Lab at Yale School of Medicine
YouTube video by Yale Medicine
youtu.be
What we are studying and how at the Mlynarczyk lab
youtu.be/YmmtdRcE3vQ?...
@yaleschoolofmed.bsky.social @yalecancer.bsky.social
youtu.be/YmmtdRcE3vQ?...
@yaleschoolofmed.bsky.social @yalecancer.bsky.social
What we are studying and how at the Mlynarczyk lab
youtu.be/YmmtdRcE3vQ?...
@yaleschoolofmed.bsky.social @yalecancer.bsky.social
youtu.be/YmmtdRcE3vQ?...
@yaleschoolofmed.bsky.social @yalecancer.bsky.social
Immunology, Cancer, & Cell Metabolism - The Mlynarczyk Lab at Yale School of Medicine
YouTube video by Yale Medicine
youtu.be
October 24, 2025 at 8:38 PM
What we are studying and how at the Mlynarczyk lab
youtu.be/YmmtdRcE3vQ?...
@yaleschoolofmed.bsky.social @yalecancer.bsky.social
youtu.be/YmmtdRcE3vQ?...
@yaleschoolofmed.bsky.social @yalecancer.bsky.social
the FLF wants to hear FL patients’ perspective, 👇quick survey, for anyone who has ever been diagnosed with FL, based anywhere in the world (available in English and Spanish). closes this Sunday 10/19
www.theflf.org/news/your-vo...
www.theflf.org/news/your-vo...
Make your voice heard: Join the Global Follicular Lymphoma 2025 Patient Survey
Your voice matters: Share your experience of living with follicular lymphoma and help shape the future of care, research, and patient support.
www.theflf.org
October 16, 2025 at 4:58 AM
the FLF wants to hear FL patients’ perspective, 👇quick survey, for anyone who has ever been diagnosed with FL, based anywhere in the world (available in English and Spanish). closes this Sunday 10/19
www.theflf.org/news/your-vo...
www.theflf.org/news/your-vo...
very inspiring ride! next year: 65 mi 💪
September 6, 2025 at 6:54 PM
very inspiring ride! next year: 65 mi 💪
first postdoctoral fellowship application of the lab is in! Congrats @yulaizhou.bsky.social 🎉 excited about the proposal you put together!!!
September 4, 2025 at 10:24 PM
first postdoctoral fellowship application of the lab is in! Congrats @yulaizhou.bsky.social 🎉 excited about the proposal you put together!!!
Please consider supporting cancer research and cancer patient care. We are riding our bikes on Sep 6. Even a few $$ can go a long way. Let’s end cancer!!
www.rideclosertofree.org/participants...
www.rideclosertofree.org/participants...
A fundraising page for Coraline Mlynarczyk
Join the Closer to Free Ride on Saturday, September 6th. Register or donate at RideCloserToFree.org.
www.rideclosertofree.org
August 16, 2025 at 3:59 PM
Please consider supporting cancer research and cancer patient care. We are riding our bikes on Sep 6. Even a few $$ can go a long way. Let’s end cancer!!
www.rideclosertofree.org/participants...
www.rideclosertofree.org/participants...
Reposted by Coraline Mlynarczyk
Fantastic to see two former IMP postdocs @thepenkpanther.bsky.social and @coraline-mly.bsky.social highlighted by JEM in this Viewpoint! #WomeninSTEM
In this Viewpoint, we asked women researchers across multiple research fields about their story of becoming an independent researcher and unique challenges they face as #WomenInSTEM in their respective scientific environments: rupress.org/jem/article/...
August 10, 2025 at 3:31 AM
Fantastic to see two former IMP postdocs @thepenkpanther.bsky.social and @coraline-mly.bsky.social highlighted by JEM in this Viewpoint! #WomeninSTEM
Reposted by Coraline Mlynarczyk
📢 We're now accepting applications for the JEM Early Career Travel Award, for grad students & early-career postdocs to participate in a scientific conference! This year, the award will support the attendance of #Cytokines2025 @cytokinesociety.bsky.social! Apply here 👉 rupress.org/jem/pages/ea...
July 29, 2025 at 2:15 PM
📢 We're now accepting applications for the JEM Early Career Travel Award, for grad students & early-career postdocs to participate in a scientific conference! This year, the award will support the attendance of #Cytokines2025 @cytokinesociety.bsky.social! Apply here 👉 rupress.org/jem/pages/ea...
Reposted by Coraline Mlynarczyk
Thrilled to share our lab’s first paper, just out in Blood Cancer Discovery @theaacr.bsky.social!
We uncovered an isoform-specific RUNX1C–BTG2 axis that drives chemoresistance in AML.
aacrjournals.org/bloodcancerd...
We uncovered an isoform-specific RUNX1C–BTG2 axis that drives chemoresistance in AML.
aacrjournals.org/bloodcancerd...
An isoform-specific RUNX1C–BTG2 axis governs AML quiescence and chemoresistance.
Abstract. Aberrant levels or structures of RNA isoforms are a hallmark of many cancers, including acute myeloid leukemia (AML), yet its role in AML chemoresistance remains unclear. We conducted a pair...
aacrjournals.org
July 10, 2025 at 2:26 PM
Thrilled to share our lab’s first paper, just out in Blood Cancer Discovery @theaacr.bsky.social!
We uncovered an isoform-specific RUNX1C–BTG2 axis that drives chemoresistance in AML.
aacrjournals.org/bloodcancerd...
We uncovered an isoform-specific RUNX1C–BTG2 axis that drives chemoresistance in AML.
aacrjournals.org/bloodcancerd...
Lunch outing with the lab*
to welcome Nina for the summer and celebrate the 1 year 🎂 of the lab - could not be more happy and proud of everything accomplished by the team already! And special thanks @s-j-aitken.bsky.social for the incredibly kind note ☺️
(*no research $$ were used)
to welcome Nina for the summer and celebrate the 1 year 🎂 of the lab - could not be more happy and proud of everything accomplished by the team already! And special thanks @s-j-aitken.bsky.social for the incredibly kind note ☺️
(*no research $$ were used)
July 3, 2025 at 2:01 AM
Lunch outing with the lab*
to welcome Nina for the summer and celebrate the 1 year 🎂 of the lab - could not be more happy and proud of everything accomplished by the team already! And special thanks @s-j-aitken.bsky.social for the incredibly kind note ☺️
(*no research $$ were used)
to welcome Nina for the summer and celebrate the 1 year 🎂 of the lab - could not be more happy and proud of everything accomplished by the team already! And special thanks @s-j-aitken.bsky.social for the incredibly kind note ☺️
(*no research $$ were used)
Reposted by Coraline Mlynarczyk
S1P is produced in the outer lymph follicle area and degraded by B cells resulting in a negative gradient towards to follicle center. S1PR2 signalling on GC B cells leads to migration arrest, keeping B cells within the follicle. (🐭 data)
Green et al 2011 🧪⑂
www.nature.com/articles/ni....
Green et al 2011 🧪⑂
www.nature.com/articles/ni....
July 1, 2025 at 9:14 PM
S1P is produced in the outer lymph follicle area and degraded by B cells resulting in a negative gradient towards to follicle center. S1PR2 signalling on GC B cells leads to migration arrest, keeping B cells within the follicle. (🐭 data)
Green et al 2011 🧪⑂
www.nature.com/articles/ni....
Green et al 2011 🧪⑂
www.nature.com/articles/ni....
On Sep 6 we are riding to raise funds for cancer research and patient care.
Join the #Cyclopaths team to ride with us! Can chose 10/25/40/65/100 miles 🚴
or support the effort with a donation :)
www.rideclosertofree.org/index.cfm?fu...
www.rideclosertofree.org/index.cfm?fu...
Join the #Cyclopaths team to ride with us! Can chose 10/25/40/65/100 miles 🚴
or support the effort with a donation :)
www.rideclosertofree.org/index.cfm?fu...
www.rideclosertofree.org/index.cfm?fu...
June 29, 2025 at 5:07 PM
On Sep 6 we are riding to raise funds for cancer research and patient care.
Join the #Cyclopaths team to ride with us! Can chose 10/25/40/65/100 miles 🚴
or support the effort with a donation :)
www.rideclosertofree.org/index.cfm?fu...
www.rideclosertofree.org/index.cfm?fu...
Join the #Cyclopaths team to ride with us! Can chose 10/25/40/65/100 miles 🚴
or support the effort with a donation :)
www.rideclosertofree.org/index.cfm?fu...
www.rideclosertofree.org/index.cfm?fu...
and also, does it link to development of cancer from the immune system? B cell lymphoma incidence +++ with aging
Great to have the @jimmunol.bsky.social special collection, “Aging's impact on the immune system” out. academic.oup.com/jimmunol/pag...
Aging's impact on the immune system
Description
This 2025 collection of The Journal of Immunology features a special collection of articles curated by guest editor Patricia Gearhart. The collecti
academic.oup.com
June 7, 2025 at 12:24 AM
and also, does it link to development of cancer from the immune system? B cell lymphoma incidence +++ with aging
very cool findings from Andrew Wang, David Hafler and Noah Palm teams @yaleschoolofmed.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 2, 2025 at 4:42 AM
very cool findings from Andrew Wang, David Hafler and Noah Palm teams @yaleschoolofmed.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Coraline Mlynarczyk
"I research #cancer because… any cell in our body can become cancerous through a multitude of trajectories."
@coraline-mly.bsky.social
➡️https://yalecancercenter.org/news-article/national-cancer-research-month-with-dr-coraline-mlynarczyk/
@yale-hematology.bsky.social @theaacr.bsky.social
#NCRM25
@coraline-mly.bsky.social
➡️https://yalecancercenter.org/news-article/national-cancer-research-month-with-dr-coraline-mlynarczyk/
@yale-hematology.bsky.social @theaacr.bsky.social
#NCRM25
May 31, 2025 at 3:43 PM
"I research #cancer because… any cell in our body can become cancerous through a multitude of trajectories."
@coraline-mly.bsky.social
➡️https://yalecancercenter.org/news-article/national-cancer-research-month-with-dr-coraline-mlynarczyk/
@yale-hematology.bsky.social @theaacr.bsky.social
#NCRM25
@coraline-mly.bsky.social
➡️https://yalecancercenter.org/news-article/national-cancer-research-month-with-dr-coraline-mlynarczyk/
@yale-hematology.bsky.social @theaacr.bsky.social
#NCRM25
The MSK lymphoma symposium was a great opportunity to learn, discuss the future of lymphoma research and connect with a great group of people, looking forward to attending again! #MSKlymphomaCME
Excited to kick off the 9th MSK Symposium on #Lymphoma tomorrow with a plenary lecture from Dr. Christopher Flowers. Honored to welcome a distinguished faculty and look forward to a compelling program. Details: bit.ly/Lymphoma2025 #MSKlymphomaCME @mskcancercenter.bsky.social @gillessa.bsky.social
April 26, 2025 at 11:43 PM
The MSK lymphoma symposium was a great opportunity to learn, discuss the future of lymphoma research and connect with a great group of people, looking forward to attending again! #MSKlymphomaCME
Reposted by Coraline Mlynarczyk
Tissue-resident memory T cells have high levels of mRNA of proinflammatory cytokines but produce the proteins only upon stimulation. 🧪⑂
The integrated stress response inhibits mRNA translation in these cells, having these cells poised for rapid responses in 🐭 and 🧓. 1/2
The integrated stress response inhibits mRNA translation in these cells, having these cells poised for rapid responses in 🐭 and 🧓. 1/2
April 24, 2025 at 2:06 PM
Tissue-resident memory T cells have high levels of mRNA of proinflammatory cytokines but produce the proteins only upon stimulation. 🧪⑂
The integrated stress response inhibits mRNA translation in these cells, having these cells poised for rapid responses in 🐭 and 🧓. 1/2
The integrated stress response inhibits mRNA translation in these cells, having these cells poised for rapid responses in 🐭 and 🧓. 1/2
Reposted by Coraline Mlynarczyk
New imaging from @victora.bsky.social's lab reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations. #RockefellerScience
New mechanism behind adaptive immunity revealed. It could impact how we design vaccines. - News
Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted...
www.rockefeller.edu
March 19, 2025 at 6:40 PM
New imaging from @victora.bsky.social's lab reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations. #RockefellerScience
Sad to see you leave the US Ari but great new start!!! The @carrerasijc.bsky.social institute is lucky to have you join their mission!
We're pleased to announce that Dr Ari Melnick has been appointed new Director of the Josep Carreras Institute.
Dr Melnick will lead IJC in our mission to advance #research in #leukaemia and other malignant blood diseases.
Read the full release here: www.carrerasresearch.org/en/news/dr-a...
Dr Melnick will lead IJC in our mission to advance #research in #leukaemia and other malignant blood diseases.
Read the full release here: www.carrerasresearch.org/en/news/dr-a...
April 23, 2025 at 12:37 AM
Sad to see you leave the US Ari but great new start!!! The @carrerasijc.bsky.social institute is lucky to have you join their mission!
sharing the joy of this week 😁 with our first lab presentations by Mahid and Divyeksha, at the Yale HTI (human & translational immunology program) retreat. so proud of them, they did wonderful!
April 12, 2025 at 11:07 PM
sharing the joy of this week 😁 with our first lab presentations by Mahid and Divyeksha, at the Yale HTI (human & translational immunology program) retreat. so proud of them, they did wonderful!
Reposted by Coraline Mlynarczyk
One of our obsessions in the Crotty lab is to better understand B-cell immunology in the context of vaccines. Rare B cells can have antibody specificities particularly important for protection against some diseases. In our most recent paper…
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
Diverse priming outcomes under conditions of very rare precursor B cells
B cells that give rise to neutralizing antibody responses can be extremely rare in
the naive B cell repertoire. Madden et al. show that delivery strategy and adjuvant
selection affect the recruitment ...
www.cell.com
April 7, 2025 at 1:50 PM
One of our obsessions in the Crotty lab is to better understand B-cell immunology in the context of vaccines. Rare B cells can have antibody specificities particularly important for protection against some diseases. In our most recent paper…
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
@cp-immunity.bsky.social
www.cell.com/immunity/ful...
Thank you The Mark Foundation @themarkfdn.bsky.social & The Follicular Lymphoma Foundation for supporting this important research. Honored to work on this project with Rong Fan @rongfan8.bsky.social & Mina Xu
Another ASPIRE Award supports Rong Fan, Mina Xu, & Coraline Mlynarczyk at @yaleschoolofmed.bsky.social. Their research will use advanced spatial omics to map genetic changes & the microenvironment of FL tumors, predicting progression & treatment responses.
themarkfoundation.org/portfolio/en...
themarkfoundation.org/portfolio/en...
March 31, 2025 at 2:40 AM
Thank you The Mark Foundation @themarkfdn.bsky.social & The Follicular Lymphoma Foundation for supporting this important research. Honored to work on this project with Rong Fan @rongfan8.bsky.social & Mina Xu
Reposted by Coraline Mlynarczyk
Announcing two new ASPIRE Awards! The Follicular Lymphoma Foundation & The Mark Foundation are partnering to fund two teams working to identify biomarkers to predict #FollicularLymphoma disease progression & transformation. #CureFL
themarkfoundation.org/2025/03/driv...
themarkfoundation.org/2025/03/driv...
March 27, 2025 at 9:35 PM
Announcing two new ASPIRE Awards! The Follicular Lymphoma Foundation & The Mark Foundation are partnering to fund two teams working to identify biomarkers to predict #FollicularLymphoma disease progression & transformation. #CureFL
themarkfoundation.org/2025/03/driv...
themarkfoundation.org/2025/03/driv...
Reposted by Coraline Mlynarczyk
Reposted by Coraline Mlynarczyk
As a reminder, early discounted rates for the 9th annual #MSKlymphomaCME expire in two weeks. Join leading experts and colleagues from around the world to explore the latest advancements in this rapidly evolving field. Early rates end February 28—register at: bit.ly/Lymphoma2025
February 14, 2025 at 6:35 PM
As a reminder, early discounted rates for the 9th annual #MSKlymphomaCME expire in two weeks. Join leading experts and colleagues from around the world to explore the latest advancements in this rapidly evolving field. Early rates end February 28—register at: bit.ly/Lymphoma2025