Michael Lustgarten, PhD
@conquer-aging-123y.bsky.social
Scientist
Reposted by Michael Lustgarten, PhD
Physical activity decreases cancer burden by alleviating immunosenescence-related inflammation and improving overall immunity
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Physical activity decreases cancer burden by alleviating immunosenescence-related inflammation and improving overall immunity
Jin Y. et al. report that physical activity decreases the risks of inflammation-related
cancer and cancer-related mortality at least partially by alleviating aging-associated
systemic inflammation and...
www.cell.com
December 21, 2025 at 12:53 AM
Physical activity decreases cancer burden by alleviating immunosenescence-related inflammation and improving overall immunity
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Michael Lustgarten, PhD
The antiviral Interferon pathway drives astrocyte aging and motor decline
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
December 16, 2025 at 11:55 PM
The antiviral Interferon pathway drives astrocyte aging and motor decline
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Michael Lustgarten, PhD
The inflammation-aging axis: Shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging
www.jstage.jst.go.jp/article/bst/...
www.jstage.jst.go.jp/article/bst/...
The inflammation-aging axis: Shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging
Inflammatory bowel disease (IBD) and physiological gut aging present with overlapping clinical features, including impaired barrier functioning, decre …
www.jstage.jst.go.jp
December 8, 2025 at 7:54 PM
The inflammation-aging axis: Shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging
www.jstage.jst.go.jp/article/bst/...
www.jstage.jst.go.jp/article/bst/...
Reposted by Michael Lustgarten, PhD
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
Arif et al. show that lysosomes in aged HSCs are hyperacidic and dysfunctional, and
that lysosomal alterations are central to HSCs’ decline with age. cGAS-STING signaling,
driven by misprocessed mtDNA...
www.cell.com
December 7, 2025 at 11:37 PM
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Reposted by Michael Lustgarten, PhD
Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice
Mitochondrial respiratory supercomplex assembly factor COX7RP improves metabolic homeostasis and contributes to lifespan extension in mice. The overexpression of COX7RP reduces white adipose tissue m...
onlinelibrary.wiley.com
December 3, 2025 at 1:18 PM
Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Michael Lustgarten, PhD
How a mattress sensor and smartwatch confirmation led to a patient's diagnosis of complete heart block and need for a pacemaker @nejm.org www.nejm.org/doi/full/10....
November 29, 2025 at 4:02 PM
How a mattress sensor and smartwatch confirmation led to a patient's diagnosis of complete heart block and need for a pacemaker @nejm.org www.nejm.org/doi/full/10....
Reposted by Michael Lustgarten, PhD
As I've said before, the distinction drawn between acute infectious diseases and chronic diseases is, in many cases, artificial. This is the huge flaw in MAHA: infections can and often do cause chronic disease; vaccines can thus prevent some chronic diseases.
stanmed.stanford.edu/infections-l...
stanmed.stanford.edu/infections-l...
Why acute infections can lead to neurodegeneration
Researchers are uncovering the mysteries of why early-in-life acute infections can lead to neurodegenerative diseases in later years.
stanmed.stanford.edu
November 21, 2025 at 4:52 PM
As I've said before, the distinction drawn between acute infectious diseases and chronic diseases is, in many cases, artificial. This is the huge flaw in MAHA: infections can and often do cause chronic disease; vaccines can thus prevent some chronic diseases.
stanmed.stanford.edu/infections-l...
stanmed.stanford.edu/infections-l...
Tracking Every Biomarker: Inside Dr. Lustgarten’s Data-Driven Blueprint for Longevity
youtube.com/watch?v=agwn...
youtube.com/watch?v=agwn...
youtube.com
October 31, 2025 at 2:19 PM
Tracking Every Biomarker: Inside Dr. Lustgarten’s Data-Driven Blueprint for Longevity
youtube.com/watch?v=agwn...
youtube.com/watch?v=agwn...
Reposted by Michael Lustgarten, PhD
Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice - GeroScience
Obesity and type 2 diabetes mellitus accelerate aging, shortening the duration of healthspan. Conversely, chronic calorie restriction (CR) extends healthspan. Research aimed at understanding the mecha...
link.springer.com
October 31, 2025 at 12:44 PM
Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Michael Lustgarten, PhD
Roles of plasminogen activator inhibitor-1 in aging-related muscle and bone loss in mice
www.aging-us.com/article/2063...
www.aging-us.com/article/2063...
Roles of plasminogen activator inhibitor-1 in aging-related muscle and bone loss in mice | Aging
Aging | doi:10.18632/aging.206318. Takashi Ohira, Naoyuki Kawao, Yuya Mizukami, Kiyotaka Okada, Akihito Nishikawa, Hisatoshi Yamao, Ayaka Yamada, Hiroshi Kaji
www.aging-us.com
October 5, 2025 at 2:42 PM
Roles of plasminogen activator inhibitor-1 in aging-related muscle and bone loss in mice
www.aging-us.com/article/2063...
www.aging-us.com/article/2063...
