Chris Miller
@chrismiller.science
I study cancer at Washington University in St Louis. Cancer Genomics, Bioinformatics, Data Viz, Tumor Evolution, AML, Immunotherapy, Irreverent humor 🧬 🖥️ mostly @chrisamiller on other platforms
Reposted by Chris Miller
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January 1, 2026 at 12:00 AM
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Reposted by Chris Miller
New blog post: Spiritual Bypass, but with GPUs. The "Machinal Bypass," when AI becomes a shortcut around the work that makes us human, and why some tasks should feel a little hard. blog.stephenturner.us/p/machinal-b...
Spiritual Bypass, but with GPUs
The "Machinal Bypass," when AI becomes a shortcut around the work that makes us human, and why some tasks should feel a little hard.
blog.stephenturner.us
December 21, 2025 at 11:46 AM
New blog post: Spiritual Bypass, but with GPUs. The "Machinal Bypass," when AI becomes a shortcut around the work that makes us human, and why some tasks should feel a little hard. blog.stephenturner.us/p/machinal-b...
Reposted by Chris Miller
How are people dealing with AI use in their grad programs, specifically for thesis proposal, qualifying exam, dissertation? Banned completely? Allowed, but have to recognize its use? No guardrails at all? We have to develop a policy and I’m totally at a loss.
December 18, 2025 at 12:35 AM
How are people dealing with AI use in their grad programs, specifically for thesis proposal, qualifying exam, dissertation? Banned completely? Allowed, but have to recognize its use? No guardrails at all? We have to develop a policy and I’m totally at a loss.
Reposted by Chris Miller
SCOOP: American Academy of Pediatrics loses HHS funding after criticizing RFK Jr. Research included reducing sudden infant deaths and identifying autism early. Me and @Paigecunningham.Bsky.Social
www.washingtonpost.com/health/2025/...
www.washingtonpost.com/health/2025/...
American Academy of Pediatrics loses HHS funding after criticizing RFK Jr.
HHS cuts key AAP grants, citing concerns about “identity-based language” and insufficient focus on agency priorities. The organization said the cuts could harm child health.
www.washingtonpost.com
December 17, 2025 at 7:27 PM
SCOOP: American Academy of Pediatrics loses HHS funding after criticizing RFK Jr. Research included reducing sudden infant deaths and identifying autism early. Me and @Paigecunningham.Bsky.Social
www.washingtonpost.com/health/2025/...
www.washingtonpost.com/health/2025/...
I am once again struck by the unfair asymmetry between political philosophies here in the US. Tearing things down is easy. Building things is hard.
www.politico.com/news/2025/12...
www.politico.com/news/2025/12...
Vought says National Center for Atmospheric Research will be dismantled
Loss of the program would mean “public safety is at risk and science is being attacked,” Colorado Gov. Jared Polis (D) said in a statement Tuesday.
www.politico.com
December 17, 2025 at 4:59 PM
I am once again struck by the unfair asymmetry between political philosophies here in the US. Tearing things down is easy. Building things is hard.
www.politico.com/news/2025/12...
www.politico.com/news/2025/12...
Reposted by Chris Miller
Likewise. Video is useful to show how to reach in to replace a headlight bulb. But to transfer written information it’s an excruciating slow trickle. Just let me read it!
Yup. But I also HATE short form video with a passion. I hate that so many tutorials and reviews and stuff are now videos. Hate hate hate. Largely because video is such a slooooowwww medium. I can read so much faster than I can listen or watch.
December 15, 2025 at 10:19 PM
Likewise. Video is useful to show how to reach in to replace a headlight bulb. But to transfer written information it’s an excruciating slow trickle. Just let me read it!
Reposted by Chris Miller
"But ChatGPT said..." stopcitingai.com
Stop Citing AI
A response to ‘But ChatGPT said…’
stopcitingai.com
December 15, 2025 at 10:44 AM
"But ChatGPT said..." stopcitingai.com
Reposted by Chris Miller
absolutely losing it at my 14yo's biology homework
December 15, 2025 at 2:02 AM
absolutely losing it at my 14yo's biology homework
Reposted by Chris Miller
The devastation I feel about this attack on science in particular is hard to cope with. It’s like watching my dad die all over again. I would do anything to spare someone a death via pancreatic cancer.
A tiny trial in New York has shown that personalized mRNA vaccines can provoke massive, lasting immune responses against pancreatic cancer, even as sweeping federal cuts now threaten the fragile labs required to produce them.
theintellectualistofficial.substack.com/p/a-breakthr...
theintellectualistofficial.substack.com/p/a-breakthr...
December 12, 2025 at 6:03 PM
The devastation I feel about this attack on science in particular is hard to cope with. It’s like watching my dad die all over again. I would do anything to spare someone a death via pancreatic cancer.
Reposted by Chris Miller
Ungodly sums of money being spent on Workday -- hundreds of millions of $ per higher ed institution (!!). And everyone seems to hate it. What gives? This article has some answers. The summary: "Customer service is Workday's goal. It's just that the customer isn't you."
December 12, 2025 at 4:57 PM
Ungodly sums of money being spent on Workday -- hundreds of millions of $ per higher ed institution (!!). And everyone seems to hate it. What gives? This article has some answers. The summary: "Customer service is Workday's goal. It's just that the customer isn't you."
Reposted by Chris Miller
Reposting @stephenturner.us’s response to the article from Current Affairs on how AI is turning universities into businesses. As he points out, students expecting measurable returns on their investment in college are not the problems here. I couldn’t agree more.
However, I don't accept the premise of the broader critique that treating students as customers and asking for accountability in what universities deliver is somehow a corruption of higher education’s noble purpose. More thoughts: doi.org/10.59350/4md...
The False Choice Between Meaning and Accountability in Higher Education
Thoughts on Ronald Purser's December 2025 essay in Current Affairs, "AI is Destroying the University and Learning Itself"
doi.org
December 8, 2025 at 1:48 PM
Reposting @stephenturner.us’s response to the article from Current Affairs on how AI is turning universities into businesses. As he points out, students expecting measurable returns on their investment in college are not the problems here. I couldn’t agree more.
Reposted by Chris Miller
"are you enjoying duo mobile" does a hamburger enjoy being made of quarks. does a fish enjoy linear time. does the mountain enjoy the first taste of a cup of hot chocolate when you get back to the ski lodge. your question means nothing to me. i couldn't enjoy duo mobile even if i tried
December 3, 2025 at 7:36 PM
"are you enjoying duo mobile" does a hamburger enjoy being made of quarks. does a fish enjoy linear time. does the mountain enjoy the first taste of a cup of hot chocolate when you get back to the ski lodge. your question means nothing to me. i couldn't enjoy duo mobile even if i tried
Reposted by Chris Miller
We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen.
1/n
1/n
Intro to Bedder – The Quinlan Lab
quinlanlab.org
December 2, 2025 at 2:28 AM
Reposted by Chris Miller
I have never understood why organizations don't recognize & value these people. In academic medical centers, they are often informaticians.... #informatics #bioinformatics #glue
November 29, 2025 at 6:57 PM
I have never understood why organizations don't recognize & value these people. In academic medical centers, they are often informaticians.... #informatics #bioinformatics #glue
Reposted by Chris Miller
Does anyone want a survivorship bias shortbread
November 29, 2025 at 4:50 AM
Does anyone want a survivorship bias shortbread
Reposted by Chris Miller
For the first time in my career, I can’t tell people to trust what the CDC website says. And that is an incredibly sad and devastating place for this country to be.
CDC has overhauled its website to assert that “the claim ‘vaccines do not cause autism’ is not an evidence-based claim”
November 20, 2025 at 4:22 AM
For the first time in my career, I can’t tell people to trust what the CDC website says. And that is an incredibly sad and devastating place for this country to be.
Reposted by Chris Miller
AI tells you what you want to hear, statisticians usually tell you what you don't want to hear
The advances we've made in statistics, experimental study design, and causal inference over the past century are remarkably useful for understanding our world. But there is never been a push to make people use them like we are seeing with generative AI. Perhaps take a moment to consider why.
November 7, 2025 at 9:13 AM
AI tells you what you want to hear, statisticians usually tell you what you don't want to hear
I am adding this to my bioinformatics course immediately.
mtcars |>
yeet(mpg > 20) |>
vibe_check(mpg, cyl, hp) |>
glow_up(kpg = mpg * 1.6) |>
slay(desc(mpg))
mtcars |>
yeet(mpg > 20) |>
vibe_check(mpg, cyl, hp) |>
glow_up(kpg = mpg * 1.6) |>
slay(desc(mpg))
Do you teach #rstats? Do your students complain about how lame and old-fashioned dplyr is? Don't worry: I have the solution for you: github.com/hadley/genzp....
genzplyr is dplyr, but bussin fr fr no cap.
genzplyr is dplyr, but bussin fr fr no cap.
GitHub - hadley/genzplyr: dplyr but make it bussin fr fr no cap
dplyr but make it bussin fr fr no cap. Contribute to hadley/genzplyr development by creating an account on GitHub.
github.com
November 7, 2025 at 4:19 AM
I am adding this to my bioinformatics course immediately.
mtcars |>
yeet(mpg > 20) |>
vibe_check(mpg, cyl, hp) |>
glow_up(kpg = mpg * 1.6) |>
slay(desc(mpg))
mtcars |>
yeet(mpg > 20) |>
vibe_check(mpg, cyl, hp) |>
glow_up(kpg = mpg * 1.6) |>
slay(desc(mpg))
Reposted by Chris Miller
I will support any New York mayoral candidate who admits bodegas are just convenience stores and everywhere in the world has them
November 4, 2025 at 2:05 AM
I will support any New York mayoral candidate who admits bodegas are just convenience stores and everywhere in the world has them
Reposted by Chris Miller
This is from Autocracy, Inc, about how modern autocratic propaganda works.
I consider this every time I decide what to share and how to frame it.
I consider this every time I decide what to share and how to frame it.
November 2, 2025 at 12:04 PM
This is from Autocracy, Inc, about how modern autocratic propaganda works.
I consider this every time I decide what to share and how to frame it.
I consider this every time I decide what to share and how to frame it.
Reposted by Chris Miller
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
November 3, 2025 at 1:55 PM
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
😱😱😱😱😱
October 31, 2025 at 1:48 PM
😱😱😱😱😱
Reposted by Chris Miller
I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it.
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
www.nature.com
October 30, 2025 at 3:35 PM
I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it.
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
Interviewer: Oh, nice! I see you've published in Nature Cell and Science. You should really proofread your CV, though - you forgot some commas.
Interviewee: Errrr...
Interviewee: Errrr...
October 24, 2025 at 6:34 PM
Interviewer: Oh, nice! I see you've published in Nature Cell and Science. You should really proofread your CV, though - you forgot some commas.
Interviewee: Errrr...
Interviewee: Errrr...
Reposted by Chris Miller
WashU in STL just announced, in a university-wide email, that we will NOT be signing The Compact.
This statement, I believe, exists thanks to the tremendous energy generated w/in our community by, among others, the Faculty Senate, the revived AAUP, and student journalists. I'm proud of everybody.
This statement, I believe, exists thanks to the tremendous energy generated w/in our community by, among others, the Faculty Senate, the revived AAUP, and student journalists. I'm proud of everybody.
October 22, 2025 at 4:35 PM
WashU in STL just announced, in a university-wide email, that we will NOT be signing The Compact.
This statement, I believe, exists thanks to the tremendous energy generated w/in our community by, among others, the Faculty Senate, the revived AAUP, and student journalists. I'm proud of everybody.
This statement, I believe, exists thanks to the tremendous energy generated w/in our community by, among others, the Faculty Senate, the revived AAUP, and student journalists. I'm proud of everybody.