Chloé Terwagne
@chloeterwagne.bsky.social
Computational Biology PhD Candidate - Genome Function lab @crick.ac.uk | 💻 🧬 Functional genomics | Genome-wide
Reposted by Chloé Terwagne
We're preparing an exciting series of master classes for 2026, come along, learn something new and chat with fellow early career bioinformaticians!
come along to our first event of 2026 to chat about bioinformatics data engineering & meet like-minded folks ! @londonomics.bsky.social www.ticketsource.co.uk/whats-on/lon...
www.ticketsource.co.uk
December 3, 2025 at 1:07 PM
We're preparing an exciting series of master classes for 2026, come along, learn something new and chat with fellow early career bioinformaticians!
Reposted by Chloé Terwagne
On Friday, @chloeterwagne.bsky.social will present:
“A scalable framework to link rare human variants to disease phenotypes using pooled prime editing”
Friday Oct 17th at 1:40pm, Rm205ABC
You can also catch up with Chloé at her poster, 5002T, Thursday 2:30-4:30
“A scalable framework to link rare human variants to disease phenotypes using pooled prime editing”
Friday Oct 17th at 1:40pm, Rm205ABC
You can also catch up with Chloé at her poster, 5002T, Thursday 2:30-4:30
October 15, 2025 at 3:34 PM
On Friday, @chloeterwagne.bsky.social will present:
“A scalable framework to link rare human variants to disease phenotypes using pooled prime editing”
Friday Oct 17th at 1:40pm, Rm205ABC
You can also catch up with Chloé at her poster, 5002T, Thursday 2:30-4:30
“A scalable framework to link rare human variants to disease phenotypes using pooled prime editing”
Friday Oct 17th at 1:40pm, Rm205ABC
You can also catch up with Chloé at her poster, 5002T, Thursday 2:30-4:30
Reposted by Chloé Terwagne
Hello Boston! The lab is delighted to be at #ASHG25🧬
Check out our talks over the next few days - all unpublished stories.
Kicking things off is @michaelherger.bsky.social presenting "Saturation mutagenesis of 37 human splicing factor genes with pooled prime editing". Today @2pm, Rm205abc
Also 👇
Check out our talks over the next few days - all unpublished stories.
Kicking things off is @michaelherger.bsky.social presenting "Saturation mutagenesis of 37 human splicing factor genes with pooled prime editing". Today @2pm, Rm205abc
Also 👇
October 15, 2025 at 2:42 PM
Hello Boston! The lab is delighted to be at #ASHG25🧬
Check out our talks over the next few days - all unpublished stories.
Kicking things off is @michaelherger.bsky.social presenting "Saturation mutagenesis of 37 human splicing factor genes with pooled prime editing". Today @2pm, Rm205abc
Also 👇
Check out our talks over the next few days - all unpublished stories.
Kicking things off is @michaelherger.bsky.social presenting "Saturation mutagenesis of 37 human splicing factor genes with pooled prime editing". Today @2pm, Rm205abc
Also 👇
Reposted by Chloé Terwagne
This was a great collaboration with @joachimdejonghe.bsky.social and @chloeterwagne.bsky.social
October 15, 2025 at 2:41 PM
This was a great collaboration with @joachimdejonghe.bsky.social and @chloeterwagne.bsky.social
Reposted by Chloé Terwagne
Excited to be presenting our work on "Saturation mutagenesis of 37 human splicing factor genes using pooled prime editing" later today at #ASHG2025 during the Platform Session "RNA Functions Beyond Coding Sequences" (1:30-2:30PM, Room 205ABC).
October 15, 2025 at 2:38 PM
Excited to be presenting our work on "Saturation mutagenesis of 37 human splicing factor genes using pooled prime editing" later today at #ASHG2025 during the Platform Session "RNA Functions Beyond Coding Sequences" (1:30-2:30PM, Room 205ABC).
Reposted by Chloé Terwagne
This year the lab is also participating in the Crick's Future Leaders in Biomedical Sciences scholarship programme, which has opened for candidates of Black or mixed Black heritage.
www.crick.ac.uk/careers-and-...
www.crick.ac.uk/careers-and-...
Future Leaders in Biomedical Sciences: How to Apply
How to apply for a Future Leaders in Biomedical Sciences Scholarship. Open to candidates of Black or mixed Black heritage only.
www.crick.ac.uk
October 1, 2025 at 1:24 PM
This year the lab is also participating in the Crick's Future Leaders in Biomedical Sciences scholarship programme, which has opened for candidates of Black or mixed Black heritage.
www.crick.ac.uk/careers-and-...
www.crick.ac.uk/careers-and-...
Can’t believe it’s been 3 years since I started my PhD in the Genome Function Lab at The Crick! It’s been an amazing journey in a really ambitious and supportive lab, with a fantastic Supervisor.
Feel free to reach out if you’d like to hear more about my experience in the group!
Feel free to reach out if you’d like to hear more about my experience in the group!
🚨 Applications to the Crick PhD programme are now open!
We are pleased to be recruiting this year. 👇
www.crick.ac.uk/careers-stud...
We are pleased to be recruiting this year. 👇
www.crick.ac.uk/careers-stud...
Findlay Lab | Developing novel genome editing methods to test human genetic variants at scale
www.crick.ac.uk
October 2, 2025 at 11:36 AM
Can’t believe it’s been 3 years since I started my PhD in the Genome Function Lab at The Crick! It’s been an amazing journey in a really ambitious and supportive lab, with a fantastic Supervisor.
Feel free to reach out if you’d like to hear more about my experience in the group!
Feel free to reach out if you’d like to hear more about my experience in the group!
Heading into my 4th year in this lab, it continues to be an inspiring and rewarding place to grow every day. Can’t recommend the team, PI, and science enough 🧬✨
We now have an open post-doc position in the lab:
crick.wd3.myworkdayjobs.com/External/job...
Please apply if you have a background in functional genomics or a related field and are eager to develop methods to map variant effects at scale.
crick.wd3.myworkdayjobs.com/External/job...
Please apply if you have a background in functional genomics or a related field and are eager to develop methods to map variant effects at scale.
crick.wd3.myworkdayjobs.com
September 8, 2025 at 4:03 PM
Heading into my 4th year in this lab, it continues to be an inspiring and rewarding place to grow every day. Can’t recommend the team, PI, and science enough 🧬✨
Thanks to everyone for joining and sharing science & advice. This year was, once again, a lot of fun! 🎉
Big kudos to my co-organisers for making it all possible 🌟
👉 Come and join our amazing community: londonomics.co.uk
Big kudos to my co-organisers for making it all possible 🌟
👉 Come and join our amazing community: londonomics.co.uk
September 4, 2025 at 5:03 PM
Thanks to everyone for joining and sharing science & advice. This year was, once again, a lot of fun! 🎉
Big kudos to my co-organisers for making it all possible 🌟
👉 Come and join our amazing community: londonomics.co.uk
Big kudos to my co-organisers for making it all possible 🌟
👉 Come and join our amazing community: londonomics.co.uk
Massive congrats to my fantastic PI, @gregfindlay.bsky.social! 🎉 Our lab is on its way to explore the non-coding region - exciting times ahead! 🚀
Read more about it👇
Read more about it👇
Congratulations to @gregfindlay.bsky.social on being awarded a €1.5 million Starting Grant from the @erc.europa.eu to take a closer look at possible disease variants hiding in the dark genome.
www.crick.ac.uk/news/2025-09...
www.crick.ac.uk/news/2025-09...
€1.5 million to uncover disease risk hiding in non-coding DNA
Greg Findlay, Group Leader of the Genome Function Laboratory at the Francis Crick Institute, has been awarded a Starting Grant from the European Research Council for €1.5 million to take a deep dive i...
www.crick.ac.uk
September 4, 2025 at 4:58 PM
Massive congrats to my fantastic PI, @gregfindlay.bsky.social! 🎉 Our lab is on its way to explore the non-coding region - exciting times ahead! 🚀
Read more about it👇
Read more about it👇
Reposted by Chloé Terwagne
Thrilled to have been selected as a speaker at #ASHG2025 🧬 Annual Meeting in Boston.
If you are interested in the development of high-throughput assays to test non-coding variant effects come join us at Session 53 on Thursday, October 16th!
If you are interested in the development of high-throughput assays to test non-coding variant effects come join us at Session 53 on Thursday, October 16th!
August 23, 2025 at 6:57 PM
Thrilled to have been selected as a speaker at #ASHG2025 🧬 Annual Meeting in Boston.
If you are interested in the development of high-throughput assays to test non-coding variant effects come join us at Session 53 on Thursday, October 16th!
If you are interested in the development of high-throughput assays to test non-coding variant effects come join us at Session 53 on Thursday, October 16th!
Reposted by Chloé Terwagne
What is the future of fertility?
Meet the panellists for one of the upcoming live episode recordings of our podcast, A Question of Science:
@profjoyceharper.bsky.social, @lucyvandewiel.bsky.social,
@nmoris.bsky.social and @gunes-taylor.bsky.social.
🎟️ Book now ⬇️
🔗 lostintv.com/tv-show?id=1...
Meet the panellists for one of the upcoming live episode recordings of our podcast, A Question of Science:
@profjoyceharper.bsky.social, @lucyvandewiel.bsky.social,
@nmoris.bsky.social and @gunes-taylor.bsky.social.
🎟️ Book now ⬇️
🔗 lostintv.com/tv-show?id=1...
August 21, 2025 at 12:21 PM
What is the future of fertility?
Meet the panellists for one of the upcoming live episode recordings of our podcast, A Question of Science:
@profjoyceharper.bsky.social, @lucyvandewiel.bsky.social,
@nmoris.bsky.social and @gunes-taylor.bsky.social.
🎟️ Book now ⬇️
🔗 lostintv.com/tv-show?id=1...
Meet the panellists for one of the upcoming live episode recordings of our podcast, A Question of Science:
@profjoyceharper.bsky.social, @lucyvandewiel.bsky.social,
@nmoris.bsky.social and @gunes-taylor.bsky.social.
🎟️ Book now ⬇️
🔗 lostintv.com/tv-show?id=1...
Congratulations to Anjali and the team on this fantastic work!! I was fortunate to contribute in the very early stages during my internship in @davidaknowles.bsky.social lab. Wonderful to see how far it’s come.
Shiny new probabilistic model, gruyere 🧀, for powering up rare variant associations w/ DL effect prediction! We find novel associations for Alzheimer's disease, e.g. nuclear pore protein NUP93 in microglia. Big thanks to NIH/NIA/ADSP and Anjali for the hard work! authors.elsevier.com/a/1ldzwgeXDzHj
authors.elsevier.com
August 22, 2025 at 9:20 AM
Congratulations to Anjali and the team on this fantastic work!! I was fortunate to contribute in the very early stages during my internship in @davidaknowles.bsky.social lab. Wonderful to see how far it’s come.
Reposted by Chloé Terwagne
We recently performed SGE of RNU4-2 and identified functionally impactful variants underlying a new recessive disease. Today, the team led by @rociorius.bsky.social @alexblakes.bsky.social @cassimons.bsky.social & @nickywhiffin.bsky.social provide in-depth analysis of its clinical presentation. 🧵⬇️
I am absolutely delighted to share our work describing a new *recessive* condition caused by variants in #RNU4-2. Yes, that #RNU4-2!
tinyurl.com/3j9r56s8
@rociorius.bsky.social @yuyangchen.bsky.social @gregfindlay.bsky.social @dgmacarthur.bsky.social @cassimons.bsky.social @nickywhiffin.bsky.social
tinyurl.com/3j9r56s8
@rociorius.bsky.social @yuyangchen.bsky.social @gregfindlay.bsky.social @dgmacarthur.bsky.social @cassimons.bsky.social @nickywhiffin.bsky.social
Biallelic variants in the non-coding RNA gene RNU4-2 cause a recessive neurodevelopmental syndrome with distinct white matter changes
Genetic variants in RNU4-2, which encodes U4, a key non-coding small nuclear RNA (snRNA) component of the major spliceosome, were recently shown to cause a prevalent neurodevelopmental disorder (NDD) ...
www.medrxiv.org
August 18, 2025 at 12:20 PM
We recently performed SGE of RNU4-2 and identified functionally impactful variants underlying a new recessive disease. Today, the team led by @rociorius.bsky.social @alexblakes.bsky.social @cassimons.bsky.social & @nickywhiffin.bsky.social provide in-depth analysis of its clinical presentation. 🧵⬇️
Reposted by Chloé Terwagne
This story is the PhD work of Phoebe Dace, who has done remarkably well to bring this all together. Congrats, Phoebe! 👏
Thanks to the lab, Nicole, @lcubes.bsky.social @chloeterwagne.bsky.social and Megan), our great collaborators, and @crick.ac.uk & @cancerresearchuk.org for vital funding. 🙏 END/16
Thanks to the lab, Nicole, @lcubes.bsky.social @chloeterwagne.bsky.social and Megan), our great collaborators, and @crick.ac.uk & @cancerresearchuk.org for vital funding. 🙏 END/16
August 18, 2025 at 7:33 AM
This story is the PhD work of Phoebe Dace, who has done remarkably well to bring this all together. Congrats, Phoebe! 👏
Thanks to the lab, Nicole, @lcubes.bsky.social @chloeterwagne.bsky.social and Megan), our great collaborators, and @crick.ac.uk & @cancerresearchuk.org for vital funding. 🙏 END/16
Thanks to the lab, Nicole, @lcubes.bsky.social @chloeterwagne.bsky.social and Megan), our great collaborators, and @crick.ac.uk & @cancerresearchuk.org for vital funding. 🙏 END/16
Thrilled to see Phoebe's fantastic work out today on @medrxivpreprint.bsky.social
Saturation genome editing of BRCA1 across cell types, packed with insights 👇
Saturation genome editing of BRCA1 across cell types, packed with insights 👇
Our latest research is out today on @medrxivpreprint.bsky.social:
www.medrxiv.org/content/10.1...
Saturation genome editing of BRCA1 across cell types accurately resolves cancer risk.
Led by the amazing Phoebe Dace. This one’s packed full of data, so check out the paper. Quick highlights… 🧵 1/n
www.medrxiv.org/content/10.1...
Saturation genome editing of BRCA1 across cell types accurately resolves cancer risk.
Led by the amazing Phoebe Dace. This one’s packed full of data, so check out the paper. Quick highlights… 🧵 1/n
Saturation genome editing of BRCA1 across cell types accurately resolves cancer risk
Germline pathogenic BRCA1 variants predispose women to breast and ovarian cancer. Despite accumulation of functional evidence for variants in BRCA1 , over half of reported single-nucleotide variants (...
www.medrxiv.org
August 18, 2025 at 8:23 AM
Thrilled to see Phoebe's fantastic work out today on @medrxivpreprint.bsky.social
Saturation genome editing of BRCA1 across cell types, packed with insights 👇
Saturation genome editing of BRCA1 across cell types, packed with insights 👇
Reposted by Chloé Terwagne
Coming up in September!
➡️Christina Kajba @ckajba.bsky.social & Michael Herger @michaelherger.bsky.social — pooled prime editing screens in haploid human cells
➡️Jon Acosta — multiplexed in vivo base editing screens
#GeneticVariants #PrimeEditing
ℹ️https://www.varianteffect.org/seminar-series/
➡️Christina Kajba @ckajba.bsky.social & Michael Herger @michaelherger.bsky.social — pooled prime editing screens in haploid human cells
➡️Jon Acosta — multiplexed in vivo base editing screens
#GeneticVariants #PrimeEditing
ℹ️https://www.varianteffect.org/seminar-series/
August 7, 2025 at 2:26 PM
Coming up in September!
➡️Christina Kajba @ckajba.bsky.social & Michael Herger @michaelherger.bsky.social — pooled prime editing screens in haploid human cells
➡️Jon Acosta — multiplexed in vivo base editing screens
#GeneticVariants #PrimeEditing
ℹ️https://www.varianteffect.org/seminar-series/
➡️Christina Kajba @ckajba.bsky.social & Michael Herger @michaelherger.bsky.social — pooled prime editing screens in haploid human cells
➡️Jon Acosta — multiplexed in vivo base editing screens
#GeneticVariants #PrimeEditing
ℹ️https://www.varianteffect.org/seminar-series/
Reposted by Chloé Terwagne
Excited for this to be out officially! It was a great team effort and has a lot of useful tidbits for studying isoform function. www.nature.com/articles/s41...
Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox - Nature Communications
The majority of human genes can produce multiple isoforms, but studying their functional relevance requires tools to target specific isoforms. Here, the authors develop a CRISPR-based exon-exon juncti...
www.nature.com
July 29, 2025 at 4:35 PM
Excited for this to be out officially! It was a great team effort and has a lot of useful tidbits for studying isoform function. www.nature.com/articles/s41...
London computational biologist, mark your calendars and sign up: Londonomics symposium is back this September! ✨
🧬 Join us: londonomics.co.uk/index.php/ev...
Abstract deadline: August 12
👩💻 Don’t miss your chance to present your work and connect with the community!
See you there!
🧬 Join us: londonomics.co.uk/index.php/ev...
Abstract deadline: August 12
👩💻 Don’t miss your chance to present your work and connect with the community!
See you there!
July 29, 2025 at 11:39 AM
London computational biologist, mark your calendars and sign up: Londonomics symposium is back this September! ✨
🧬 Join us: londonomics.co.uk/index.php/ev...
Abstract deadline: August 12
👩💻 Don’t miss your chance to present your work and connect with the community!
See you there!
🧬 Join us: londonomics.co.uk/index.php/ev...
Abstract deadline: August 12
👩💻 Don’t miss your chance to present your work and connect with the community!
See you there!
Super grateful for the opportunity to share recent project progress last week at the @crick.ac.uk and Partner Universities PhD Student Symposium! A big thanks to all the PhD volunteers whose time, care, and effort made this event such a supportive and engaging space for students ✨
July 16, 2025 at 8:48 AM
Super grateful for the opportunity to share recent project progress last week at the @crick.ac.uk and Partner Universities PhD Student Symposium! A big thanks to all the PhD volunteers whose time, care, and effort made this event such a supportive and engaging space for students ✨
Reposted by Chloé Terwagne
New work from the lab trying to wrap our heads around the massive complexity of the human transcriptome revealed by long-read RNA-seq! Fun collab with Gloria Sheynkman. www.biorxiv.org/content/10.1...
Perplexity as a Metric for Isoform Diversity in the Human Transcriptome
Long-read sequencing (LRS) has revealed a far greater diversity of RNA isoforms than earlier technologies, increasing the critical need to determine which, and how many, isoforms per gene are biologic...
www.biorxiv.org
July 2, 2025 at 11:46 PM
New work from the lab trying to wrap our heads around the massive complexity of the human transcriptome revealed by long-read RNA-seq! Fun collab with Gloria Sheynkman. www.biorxiv.org/content/10.1...
Reposted by Chloé Terwagne
Check out @ckajba.bsky.social and Michael Herger's concise description of their recent work. Thanks to Nature Reviews Genetics for featuring this.
rdcu.be/eraxZ
rdcu.be/eraxZ
Determining variant effects with pooled prime editing
Nature Reviews Genetics - In this Tools of the Trade article, Christina Kajba and Michael Herger describe their screening platform, based on pooled prime editing, for large-scale functional...
rdcu.be
June 16, 2025 at 6:30 PM
Check out @ckajba.bsky.social and Michael Herger's concise description of their recent work. Thanks to Nature Reviews Genetics for featuring this.
rdcu.be/eraxZ
rdcu.be/eraxZ
Looking forward to speaking at the @genomicsengland.bsky.social Summit tomorrow!
I'll be sharing insights from my current project on the Discovery Stage at 2 pm.
Come say hi if you're around!
I'll be sharing insights from my current project on the Discovery Stage at 2 pm.
Come say hi if you're around!
June 16, 2025 at 1:29 PM
Looking forward to speaking at the @genomicsengland.bsky.social Summit tomorrow!
I'll be sharing insights from my current project on the Discovery Stage at 2 pm.
Come say hi if you're around!
I'll be sharing insights from my current project on the Discovery Stage at 2 pm.
Come say hi if you're around!
Reposted by Chloé Terwagne
Big congratulations to our very own Christina Kajba for winning a presentation award at #ESHG25.
You can read all about her work here:
www.cell.com/cell-genomic...
You can read all about her work here:
www.cell.com/cell-genomic...
June 4, 2025 at 5:02 PM
Big congratulations to our very own Christina Kajba for winning a presentation award at #ESHG25.
You can read all about her work here:
www.cell.com/cell-genomic...
You can read all about her work here:
www.cell.com/cell-genomic...