Charles-Henri Buffet
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chbuffet.methysthen.fr
Charles-Henri Buffet
@chbuffet.methysthen.fr
28 followers 69 following 0 posts
Chemical Biologist, PhD
PostDoc at @mrclmb.bsky.social, Cambridge, UK
ᓚᘏᗢ
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Reposted by Charles-Henri Buffet
kjohnsson.bsky.social
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology
SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...
www.nature.com
July 3, 2025 at 7:45 PM
Reposted by Charles-Henri Buffet
cenmag.bsky.social
More proteins may be druggable with molecular glue degraders than initially thought, according to a new paper in Science from the biotech firm Monte Rosa Therapeutics. cen.acs.org/pharmaceutic... #chemsky 🧪
Molecular glue degraders are more versatile than previously thought
Study by biotech firm Monte Rosa finds that they can target a wider variety of proteins
cen.acs.org
July 4, 2025 at 7:44 PM
Reposted by Charles-Henri Buffet
cnrs.fr
#Communiqué 🗞️ Une étude démontre que la photosynthèse oxygénique existait déjà il y a au moins 2,87 milliards d’années. Cette avancée majeure a été rendue possible grâce à une nouvelle méthode de datation isotopique (La-Ce). 🍃

👉 www.cnrs.fr/fr/presse/la...
June 2, 2025 at 2:54 PM
Reposted by Charles-Henri Buffet
bugsinyourguts.bsky.social
I wouldn't be in the position I'm in now if I hadn't actively sought out and embraced change.

The only issues arise when people don't get that it's possible for a person to excel in more than one specialisation. The term "generalist" seems to be a dirty word in certain academic circles.
June 1, 2025 at 8:54 AM
Reposted by Charles-Henri Buffet
itaiyanai.bsky.social
90% of doing science is being open to new ideas.
May 31, 2025 at 6:14 PM
Reposted by Charles-Henri Buffet
mrclmb.bsky.social
How did life on Earth begin? 🌍🧬
New #LMBResearch from Phil Holliger’s group, including James Attwater (now @uclchemistry.bsky.social‬‬ @uclnews.bsky.social) shows how pH-freeze-thaw cycles enables RNA self-replication, overcoming a key evolutionary hurdle.‬
Read more: www.ucl.ac.uk/news/2025/ma...
Chemists recreate how RNA might have reproduced for first time
Chemists at UCL and the MRC Laboratory of Molecular Biology have demonstrated how RNA (ribonucleic acid) might have replicated itself on early Earth – a key process in the origin of life.
www.ucl.ac.uk
May 29, 2025 at 8:40 AM
Reposted by Charles-Henri Buffet
ebi.embl.org
Long-read sequencing can reveal hidden cancer mutations, but existing tools often produce false positives.

SAVANA is a machine learning algorithm trained on cancer genomes, built to make analysis faster and clinically reliable.

@isidrolauscher.bsky.social

www.ebi.ac.uk/about/news/r...

#oncosky
Machine learning algorithm brings long-read sequencing to the clinic
SAVANA is a new tool designed for accurate detection of structural variations in clinical samples.
www.ebi.ac.uk
May 29, 2025 at 8:54 AM