Claudia Guimas Almeida
@cgalmeida.bsky.social
Neuroscience 🧠 Cell Biology 🧫 PI neuronal trafficking in aging laboratory 🥼 iNOVA4Health NOVA Medical School Lisbon 🇵🇹neuron cell biology 🧫 microscopy 🔬bio imaging 💻endosomes 😊synapses ⚡️Alzheimer’s Disease 🧠🧪
Pinned
The Alzheimer's Disease Risk Gene CD2AP Functions in Dendritic Spines by Remodeling F-Actin
CD2-associated protein (CD2AP) was identified as a genetic risk factor for late-onset Alzheimer's disease (LOAD). However, it is unclear how CD2AP contributes to LOAD synaptic dysfunction underlying A...
www.jneurosci.org
Yes! Our discovery that CD2AP loss of function might increase the risk of Alzheimer’s by disrupting dendritic spines directly via F-actin regulation and indirectly via beta-amyloid production is on the cover #jneurosci www.jneurosci.org/content/44/4...
🧠 What if Alzheimer’s risk starts at the synapse?
In our new study led by Mariana Barata, we show that BIN1, a key AD risk gene, regulates inhibitory synapses—loss of BIN1 → hyperexcitability before Aβ.
www.cell.com/cell-reports...
In our new study led by Mariana Barata, we show that BIN1, a key AD risk gene, regulates inhibitory synapses—loss of BIN1 → hyperexcitability before Aβ.
www.cell.com/cell-reports...
Alzheimer’s genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapses
Barata et al. show that the Alzheimer’s risk gene BIN1 is critical for the stability
of inhibitory synapses. BIN1 deficiency accelerates the synaptic vesicle endocytic
cycle, leading to synapse loss a...
www.cell.com
July 17, 2025 at 8:24 PM
🧠 What if Alzheimer’s risk starts at the synapse?
In our new study led by Mariana Barata, we show that BIN1, a key AD risk gene, regulates inhibitory synapses—loss of BIN1 → hyperexcitability before Aβ.
www.cell.com/cell-reports...
In our new study led by Mariana Barata, we show that BIN1, a key AD risk gene, regulates inhibitory synapses—loss of BIN1 → hyperexcitability before Aβ.
www.cell.com/cell-reports...
Reposted by Claudia Guimas Almeida
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
Homepage - openRxiv
openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.
openrxiv.org
March 11, 2025 at 1:20 PM
Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n
Reposted by Claudia Guimas Almeida
Sad times for science “For all this talk about free speech, this is direct censorship of scientific research.” www.nature.com/articles/d41...
Exclusive: NIH to terminate hundreds of active research grants
Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.
www.nature.com
March 6, 2025 at 7:44 AM
Sad times for science “For all this talk about free speech, this is direct censorship of scientific research.” www.nature.com/articles/d41...
Reposted by Claudia Guimas Almeida
If you're in the US, considering Europe for your PhD, and you identify as a minority, I will chat with you and review any application documents you need 🧪
Many US students don’t know how to seek opportunities outside the US. With some help from our colleagues in EU and Canada, we could put together a consolidated website of PhD opportunities and scholarships outside the US, organized by field. There might still be time for this year in some places.
I’m having similar conversations and sharing international opportunities a lot. I’m sure for a lot of US based trainees that feels overwhelming. I moved to Europe for my postdoc.Happy to chat with any trainees about my experience if it would be helpful.
March 1, 2025 at 12:53 PM
If you're in the US, considering Europe for your PhD, and you identify as a minority, I will chat with you and review any application documents you need 🧪
Reposted by Claudia Guimas Almeida
Há quase um ano que os cientistas aguardam pelos resultados das candidaturas ao principal concurso para financiamento de projectos de investigação. Alguns, no entanto, já tiveram resposta.
Ainda não há resultados dos projectos da FCT, mas alguns cientistas já receberam o “sim”
Há quase um ano que os cientistas aguardam pelos resultados das candidaturas ao principal concurso para financiamento de projectos de investigação. Alguns, no entanto, já tiveram resposta.
www.publico.pt
March 2, 2025 at 7:07 AM
Há quase um ano que os cientistas aguardam pelos resultados das candidaturas ao principal concurso para financiamento de projectos de investigação. Alguns, no entanto, já tiveram resposta.
Obrigada @publico.pt por esta notícia desde Dezembro que os cientistas vivem num estado de ansiedade por causa da FCT, e desde que sairam para alguns a injustiça é imensurável porquê ? www.publico.pt/2025/03/02/c...
Ainda não há resultados dos projectos da FCT, mas alguns cientistas já receberam o “sim”
Há quase um ano que os cientistas aguardam pelos resultados das candidaturas ao principal concurso para financiamento de projectos de investigação. Alguns, no entanto, já tiveram resposta.
www.publico.pt
March 2, 2025 at 7:54 AM
Obrigada @publico.pt por esta notícia desde Dezembro que os cientistas vivem num estado de ansiedade por causa da FCT, e desde que sairam para alguns a injustiça é imensurável porquê ? www.publico.pt/2025/03/02/c...
Reposted by Claudia Guimas Almeida
O normal na ciência em Portugal! www.publico.pt/2025/02/13/c...
Apoio de 20 milhões de euros para contratar cientistas ainda não foi renovado: “Voltamos ao zero”
Verba de 20 milhões de euros para apoiar um terço das despesas com a contratação de cientistas foi aprovada em 2024. Instituições de ensino superior mostram-se preocupadas com falta de garantias.
www.publico.pt
February 13, 2025 at 11:43 AM
O normal na ciência em Portugal! www.publico.pt/2025/02/13/c...
Concordando com o acesso a todas as publicações científicas não vejo realmente implementar. O guia diz que posso publicar num jornal open access que tem um custo exorbitante apesar de a política de acesso aberto não permitir o pagamento duplo, pela ciência e pela publicação acessoaberto.fct.pt
Política de Acesso AbertoInfoFundação para a Ciência e a TecnologiaFundação para a Ciência e a TecnologiaLinkedInLinkedInLínguaInfoFundação para a Ciência e a TecnologiaLinkedInYouTubeTwitter
acessoaberto.fct.pt
February 7, 2025 at 7:46 AM
Concordando com o acesso a todas as publicações científicas não vejo realmente implementar. O guia diz que posso publicar num jornal open access que tem um custo exorbitante apesar de a política de acesso aberto não permitir o pagamento duplo, pela ciência e pela publicação acessoaberto.fct.pt
Reposted by Claudia Guimas Almeida
My NIH study section that was to meet tomorrow was one of those canceled. This represents many months of work by the applicants and by the NIH staff and reviewers. Devastating is the correct word.
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
January 22, 2025 at 11:52 PM
My NIH study section that was to meet tomorrow was one of those canceled. This represents many months of work by the applicants and by the NIH staff and reviewers. Devastating is the correct word.
Reposted by Claudia Guimas Almeida
Donate to Wikipedia.
Do it today, and every time one of the broligarchs has a tantrum because he can’t buy it
Do it today, and every time one of the broligarchs has a tantrum because he can’t buy it
January 21, 2025 at 10:49 PM
Donate to Wikipedia.
Do it today, and every time one of the broligarchs has a tantrum because he can’t buy it
Do it today, and every time one of the broligarchs has a tantrum because he can’t buy it
Reposted by Claudia Guimas Almeida
'The FDA’s Center for Drug Evaluation and Research approved 50 new small molecules, biologics and oligonucleotide therapeutics last year. The class of 2024 was a little smaller than that of 2023, which had 55 approvals and was the second largest in the past 30 years'
www.nature.com/articles/d41...
www.nature.com/articles/d41...
2024 FDA approvals
The FDA approved 50 new therapeutics in 2024, with green lights for a novel schizophrenia drug, a first NASH medicine and much more.
www.nature.com
January 7, 2025 at 11:58 AM
'The FDA’s Center for Drug Evaluation and Research approved 50 new small molecules, biologics and oligonucleotide therapeutics last year. The class of 2024 was a little smaller than that of 2023, which had 55 approvals and was the second largest in the past 30 years'
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Claudia Guimas Almeida
"If there is something you can technically do but that won’t answer your question, then don’t do it."
@victora.bsky.social
www.cell.com/news-do/50-i...
@victora.bsky.social
www.cell.com/news-do/50-i...
December 22, 2024 at 8:05 AM
"If there is something you can technically do but that won’t answer your question, then don’t do it."
@victora.bsky.social
www.cell.com/news-do/50-i...
@victora.bsky.social
www.cell.com/news-do/50-i...
December 16, 2024 at 10:55 AM
Reposted by Claudia Guimas Almeida
Highly-respected non-profit journals like @dev-journal.bsky.social support scientific communities
But after rejection at glam journals, it is tempting to avoid re-review by sliding through commercial ecosystems
BUT WAIT! LOOK! “We will consider papers with reviewer reports from other journals” 😍
But after rejection at glam journals, it is tempting to avoid re-review by sliding through commercial ecosystems
BUT WAIT! LOOK! “We will consider papers with reviewer reports from other journals” 😍
December 3, 2024 at 9:33 AM
Highly-respected non-profit journals like @dev-journal.bsky.social support scientific communities
But after rejection at glam journals, it is tempting to avoid re-review by sliding through commercial ecosystems
BUT WAIT! LOOK! “We will consider papers with reviewer reports from other journals” 😍
But after rejection at glam journals, it is tempting to avoid re-review by sliding through commercial ecosystems
BUT WAIT! LOOK! “We will consider papers with reviewer reports from other journals” 😍
Reposted by Claudia Guimas Almeida
Cytoskeleton rules!!!
November 30, 2024 at 7:03 PM
Cytoskeleton rules!!!
Reposted by Claudia Guimas Almeida
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
A panoramic view of cell population dynamics in mammalian aging
To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...
tinyurl.com
November 29, 2024 at 4:17 PM
Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!
Yes! Our discovery that CD2AP loss of function might increase the risk of Alzheimer’s by disrupting dendritic spines directly via F-actin regulation and indirectly via beta-amyloid production is on the cover #jneurosci www.jneurosci.org/content/44/4...
The Alzheimer's Disease Risk Gene CD2AP Functions in Dendritic Spines by Remodeling F-Actin
CD2-associated protein (CD2AP) was identified as a genetic risk factor for late-onset Alzheimer's disease (LOAD). However, it is unclear how CD2AP contributes to LOAD synaptic dysfunction underlying A...
www.jneurosci.org
November 28, 2024 at 8:18 AM
Yes! Our discovery that CD2AP loss of function might increase the risk of Alzheimer’s by disrupting dendritic spines directly via F-actin regulation and indirectly via beta-amyloid production is on the cover #jneurosci www.jneurosci.org/content/44/4...
www.publico.pt/2024/11/27/c...
Apesar do alerta de muitos investigadores com posições de liderança na ciência que se faz neste país o partido socialista absteve-se ao reforço do orçamento que visava não aumentar mas apenas não diminuir face ao ano passado. @ciencia_pt 🧪
Apesar do alerta de muitos investigadores com posições de liderança na ciência que se faz neste país o partido socialista absteve-se ao reforço do orçamento que visava não aumentar mas apenas não diminuir face ao ano passado. @ciencia_pt 🧪
Proposta para aumento do orçamento da FCT chumbada no Parlamento
O partido Livre tinha apresentado uma proposta para transferir 70 milhões de euros para o orçamento da FCT – colmatando o corte de 68 milhões de euros no Orçamento do Estado.
www.publico.pt
November 28, 2024 at 8:07 AM
www.publico.pt/2024/11/27/c...
Apesar do alerta de muitos investigadores com posições de liderança na ciência que se faz neste país o partido socialista absteve-se ao reforço do orçamento que visava não aumentar mas apenas não diminuir face ao ano passado. @ciencia_pt 🧪
Apesar do alerta de muitos investigadores com posições de liderança na ciência que se faz neste país o partido socialista absteve-se ao reforço do orçamento que visava não aumentar mas apenas não diminuir face ao ano passado. @ciencia_pt 🧪
Reposted by Claudia Guimas Almeida
Happy #MicroscopyMonday!
The recordings of the #Virtual #I2K2024 workshops are available now
tinyurl.com/VirtualI2K20...
Thanks to all who presented!
Please re-share! 2022 and 2023 content available too:
www.youtube.com/@I2KConference
The recordings of the #Virtual #I2K2024 workshops are available now
tinyurl.com/VirtualI2K20...
Thanks to all who presented!
Please re-share! 2022 and 2023 content available too:
www.youtube.com/@I2KConference
November 25, 2024 at 6:44 PM
Happy #MicroscopyMonday!
The recordings of the #Virtual #I2K2024 workshops are available now
tinyurl.com/VirtualI2K20...
Thanks to all who presented!
Please re-share! 2022 and 2023 content available too:
www.youtube.com/@I2KConference
The recordings of the #Virtual #I2K2024 workshops are available now
tinyurl.com/VirtualI2K20...
Thanks to all who presented!
Please re-share! 2022 and 2023 content available too:
www.youtube.com/@I2KConference
Reposted by Claudia Guimas Almeida
Who should you nominate as reviewers for your manuscript? After a long chat with a post-grad it appears that there's a lot of misguided advice out there. Thread 👇
November 22, 2024 at 11:05 AM
Who should you nominate as reviewers for your manuscript? After a long chat with a post-grad it appears that there's a lot of misguided advice out there. Thread 👇
Reposted by Claudia Guimas Almeida
As an academic, when you're so busy with your service, teaching, and administrative commitments, you often don't make time to write. 😮💨
That's why writing retreats can be SO valuable: https://buff.ly/48vtfmg
#PhDchat #NewPI #ECRchat
That's why writing retreats can be SO valuable: https://buff.ly/48vtfmg
#PhDchat #NewPI #ECRchat
Academic Writing Retreats
Academic writing retreats are either hosted off-campus or virtually and can last from a day up to a whole week. Find out how attending writing retreats can boost your productivity (and joy!) writing…
buff.ly
November 19, 2024 at 5:05 PM
As an academic, when you're so busy with your service, teaching, and administrative commitments, you often don't make time to write. 😮💨
That's why writing retreats can be SO valuable: https://buff.ly/48vtfmg
#PhDchat #NewPI #ECRchat
That's why writing retreats can be SO valuable: https://buff.ly/48vtfmg
#PhDchat #NewPI #ECRchat
Reposted by Claudia Guimas Almeida
Are you an #ECR who would like to attend a #microscopy or #bioimageanalysis training course in the next ~6 months but don't have sufficient funding, check to see if you are eligible for our JCS-FocalPlane Training Grant.
Next deadline: 22 November 2024
www.biologists.com/grants/jcs-f...
Next deadline: 22 November 2024
www.biologists.com/grants/jcs-f...
November 19, 2024 at 2:02 PM
Are you an #ECR who would like to attend a #microscopy or #bioimageanalysis training course in the next ~6 months but don't have sufficient funding, check to see if you are eligible for our JCS-FocalPlane Training Grant.
Next deadline: 22 November 2024
www.biologists.com/grants/jcs-f...
Next deadline: 22 November 2024
www.biologists.com/grants/jcs-f...
Reposted by Claudia Guimas Almeida
Apply to the Neurobiology course, that’s where the cool kids hang out. It’s one of the few opportunities you’ll get to truly explore the “fucking around” phase of science, where you try out creative projects and wild ideas, while surrounded with a ton of excellent faculty and students and resources.
Excited to announce that our 2025 Advanced Research Training Course schedule is up and applications are open! 🎉🎉🎉
See you in Woods Hole! mbl.edu/courses
🧪🐙🦑🧠🐟
See you in Woods Hole! mbl.edu/courses
🧪🐙🦑🧠🐟
October 30, 2024 at 8:50 PM
Apply to the Neurobiology course, that’s where the cool kids hang out. It’s one of the few opportunities you’ll get to truly explore the “fucking around” phase of science, where you try out creative projects and wild ideas, while surrounded with a ton of excellent faculty and students and resources.