Nature Reviews Nephrology, Published online: 15 December 2025; doi:10.1038/s41581-025-01043-zIn this Tools of the Trade article, Nicholas Lucarelli (Computational Microscopy Imaging Lab, directed by Pinaki Sarder) describes the development of FUSION, a cloud-based platform for the integration of histology and spatial -omics data.

Nature Reviews Nephrology, Published online: 18 July 2025; doi:10.1038/s41581-025-00979-6Pregnancy-associated acute kidney injury is a risk factor for maternal and fetal morbidity and mortality and a driver of health inequity worldwide. This Consensus Statement from the Acute Disease Quality Initiative provides recommendations on the causes, diagnosis, management and follow-up of pregnancy-associated acute kidney injury.

ABSTRACT. Chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D) represents a major public health issue; it develops in about 30%–40% of pa

ABSTRACT. Peripheral artery disease (PAD) is a common and serious complication in people with chronic kidney disease (CKD) and end-stage kidney disease, oc

Nature Reviews Nephrology, Published online: 29 April 2025; doi:10.1038/s41581-025-00961-2Advances in biosensor technology have the potential to enable continuous, non-invasive monitoring of kidney health through wearable and implantable systems. Non-invasive microfluidic systems have demonstrated utility in the detection of kidney-relevant biomarkers in peripheral body fluids such as sweat, interstitial fluid, tears and saliva, whereas implantable systems permit the direct measurement of biophysical tissue properties including tissue oxygenation, perfusion and temperature.

Nature Reviews Nephrology, Published online: 25 April 2025; doi:10.1038/s41581-025-00963-0The prevalence of cognitive dysfunction among people with chronic kidney disease (CKD) is disproportionately high compared with that in the general population. This Review examines current evidence on key drivers of cognitive impairment in people with CKD, and highlights gaps in knowledge and potential therapeutic targets.

Nature Reviews Nephrology, Published online: 22 April 2025; doi:10.1038/s41581-025-00958-xHere, the authors describe the mechanisms by which innate immune cells contribute to acute kidney injury, the transition from acute kidney injury to chronic kidney disease, and the progression of chronic kidney disease. They also discuss potential therapeutic strategies that target the innate immune system.

Nature Reviews Nephrology, Published online: 22 April 2025; doi:10.1038/s41581-025-00964-zGalNAc-T14-associated defects in B cell homing in IgA nephropathy

Nature Reviews Nephrology, Published online: 07 April 2025; doi:10.1038/s41581-025-00962-1Artificial intelligence approaches that link patient data with chemical-induced kidney injury patterns are revolutionizing nephrotoxicity risk assessment. Substantial progress has been made in the development of integrated approaches that leverage big data, molecular profiles and toxicological understanding to identify at-risk patients, provide insights into molecular mechanisms and advance predictive nephrology.