Matt Eldridge
@caspasekid.bsky.social
Post-doctoral fellow in Helaine Lab at Harvard Medical School. Working on antimicrobial recalcitrance and host-pathogen interactions.
Reposted by Matt Eldridge
Chan Lee @harperlabhms.bsky.social reports CASM-driven V-ATPase recruitment to lysosomes for acidification upon TRPML1 activation via DMXL1-RAVE loader. With Magdalene Moran(Caraway), Sophie Helaine lab, Joao Paulo, & HarperLab teams(HMS). Funds: Warren Alpert FND/NIH www.nature.com/articles/s41...
DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation - Nature Structural & Molecular Biology
Lee et al. show that DMXL1, a regulator of V-ATPase assembly, is recruited to lysosomes upon TRPML1 activation in a manner dependent on conjugation of ATG8 proteins on lysosomal membranes (CASM) and p...
www.nature.com
June 17, 2025 at 1:13 PM
Chan Lee @harperlabhms.bsky.social reports CASM-driven V-ATPase recruitment to lysosomes for acidification upon TRPML1 activation via DMXL1-RAVE loader. With Magdalene Moran(Caraway), Sophie Helaine lab, Joao Paulo, & HarperLab teams(HMS). Funds: Warren Alpert FND/NIH www.nature.com/articles/s41...
Reposted by Matt Eldridge
ICYMI: New online: DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation
DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation
Nature Structural & Molecular Biology, Published online: 17 June 2025; doi:10.1038/s41594-025-01581-xLee et al. show that DMXL1, a regulator of V-ATPase assembly, is recruited to lysosomes upon TRPML1 activation in a manner dependent on conjugation of ATG8 proteins on lysosomal membranes (CASM) and promotes lysosomal function.
go.nature.com
June 18, 2025 at 10:30 AM
ICYMI: New online: DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation
Reposted by Matt Eldridge
“Importantly, under long-standing law and practice, NIH does not have the authority to arbitrarily terminate grants. Its funding decisions must be guided by congressional mandates, regulatory requirements, and scientific expertise, not vague and undefined criteria.”
We're suing the Trump administration over its politically-motivated termination of research grants that has already harmed scientists and our communities.
Political ideology shouldn't dictate public health.
Political ideology shouldn't dictate public health.
‘Devastated’ and ‘Hopeless.’ Researchers Speak Out on Funding Cuts | ACLU
www.aclu.org
May 27, 2025 at 2:24 PM
“Importantly, under long-standing law and practice, NIH does not have the authority to arbitrarily terminate grants. Its funding decisions must be guided by congressional mandates, regulatory requirements, and scientific expertise, not vague and undefined criteria.”
Reposted by Matt Eldridge
These are extremely challenging times for early-career faculty. Here is my office's small contribution to make their hard and important work a bit easier:
Download our curated and comprehensive database of funding opportunities for early-career faculty.
Here: research.jhu.edu/rdt/funding-...
Download our curated and comprehensive database of funding opportunities for early-career faculty.
Here: research.jhu.edu/rdt/funding-...
March 6, 2025 at 8:28 PM
These are extremely challenging times for early-career faculty. Here is my office's small contribution to make their hard and important work a bit easier:
Download our curated and comprehensive database of funding opportunities for early-career faculty.
Here: research.jhu.edu/rdt/funding-...
Download our curated and comprehensive database of funding opportunities for early-career faculty.
Here: research.jhu.edu/rdt/funding-...
Reposted by Matt Eldridge
Highly multiplexed spatial transcriptomics in bacteria www.science.org/doi/abs/10.1... #jcampubs
Highly multiplexed spatial transcriptomics in bacteria
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...
www.science.org
January 24, 2025 at 2:39 PM
Highly multiplexed spatial transcriptomics in bacteria www.science.org/doi/abs/10.1... #jcampubs
Reposted by Matt Eldridge
Walgreens CEO says anti-shoplifting strategy backfired: ‘When you lock things up…you don’t sell as many of them’
Walgreens CEO says anti-shoplifting strategy backfired: 'When you lock things up…you don't sell as many of them’
Walgreens' CEO talked about the flip side of investing in increased security on a recent earnings call.
fortune.com
January 15, 2025 at 12:38 PM
Walgreens CEO says anti-shoplifting strategy backfired: ‘When you lock things up…you don’t sell as many of them’
Reposted by Matt Eldridge
Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
January 3, 2025 at 3:33 PM
Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
Details below 👇👇
Please Repost !!!
@ijmonod.bsky.social @cnrs.bsky.social
Reposted by Matt Eldridge
Getting closer to the reality of bacterial growth "in the wild".
Lab-adapted bugs are really like diabetic, force-fed versions of their wild parents. #MicroSky
Lab-adapted bugs are really like diabetic, force-fed versions of their wild parents. #MicroSky
Flow rapidly replenishes scarce nutrients to promote bacterial growth https://www.biorxiv.org/content/10.1101/2024.12.23.630146v1
December 24, 2024 at 12:29 PM
Getting closer to the reality of bacterial growth "in the wild".
Lab-adapted bugs are really like diabetic, force-fed versions of their wild parents. #MicroSky
Lab-adapted bugs are really like diabetic, force-fed versions of their wild parents. #MicroSky
Reposted by Matt Eldridge
Predicting the subcellular location of prokaryotic proteins with DeepLocPro academic.oup.com/bioinformati... #jcampubs
Predicting the subcellular location of prokaryotic proteins with DeepLocPro
AbstractMotivation. Protein subcellular location prediction is a widely explored task in bioinformatics because of its importance in proteomics research. W
academic.oup.com
December 9, 2024 at 6:33 PM
Reposted by Matt Eldridge
🚨 Call for Applications 🚨
The Institut Pasteur is recruiting junior research group leaders!
Focus on:
💉 Vaccinology & immunotherapies
🦠 Infectious diseases
🧠 Neuro-immunology and neurodevelopment
🤰 Maternal & child health
📅 research.pasteur.fr/en/call/call...
#ResearchOpportunity #ScienceJobs
The Institut Pasteur is recruiting junior research group leaders!
Focus on:
💉 Vaccinology & immunotherapies
🦠 Infectious diseases
🧠 Neuro-immunology and neurodevelopment
🤰 Maternal & child health
📅 research.pasteur.fr/en/call/call...
#ResearchOpportunity #ScienceJobs
Call for applications 2025 – Creation of new research groups at the Institut Pasteur | Research - Institut Pasteur
research.pasteur.fr
December 9, 2024 at 11:05 AM
🚨 Call for Applications 🚨
The Institut Pasteur is recruiting junior research group leaders!
Focus on:
💉 Vaccinology & immunotherapies
🦠 Infectious diseases
🧠 Neuro-immunology and neurodevelopment
🤰 Maternal & child health
📅 research.pasteur.fr/en/call/call...
#ResearchOpportunity #ScienceJobs
The Institut Pasteur is recruiting junior research group leaders!
Focus on:
💉 Vaccinology & immunotherapies
🦠 Infectious diseases
🧠 Neuro-immunology and neurodevelopment
🤰 Maternal & child health
📅 research.pasteur.fr/en/call/call...
#ResearchOpportunity #ScienceJobs
Reposted by Matt Eldridge
Just did my first Starter Pack, I think it can be useful. Let me know if you miss any journal and I will add it. Enjoy!! go.bsky.app/QPFZpj9
November 25, 2024 at 8:26 PM
Just did my first Starter Pack, I think it can be useful. Let me know if you miss any journal and I will add it. Enjoy!! go.bsky.app/QPFZpj9
Another paper from the Helaine lab! This time a review! Great work from Rachel outlining definitions and concepts in studying antibiotic recalcitrance (it can be very tough to do!)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Antibiotic-recalcitrant Salmonella during infection - Nature Reviews Microbiology
In this Review, Giorgio and Helaine provide an overview of the physiology of antibiotic-recalcitrant Salmonella enterica during infection, discuss recent insights into the clinical implications of ant...
www.nature.com
November 20, 2024 at 5:49 PM
Another paper from the Helaine lab! This time a review! Great work from Rachel outlining definitions and concepts in studying antibiotic recalcitrance (it can be very tough to do!)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Matt Eldridge
Join us!
4 Assistant/ Associate Professor posts available at University of Warwick School of Life Sciences, 2 in Host-Pathogen interactions and 2 in Plant Sciences:
warwick-careers.tal.net/vx/lang-en-G...
warwick-careers.tal.net/vx/lang-en-G...
#microsky
4 Assistant/ Associate Professor posts available at University of Warwick School of Life Sciences, 2 in Host-Pathogen interactions and 2 in Plant Sciences:
warwick-careers.tal.net/vx/lang-en-G...
warwick-careers.tal.net/vx/lang-en-G...
#microsky
Assistant or Associate Professor (Host-Pathogen Interactions) (109794-1024) - University of Warwick
Title: Assistant or Associate Professor (Host-Pathogen Interactions) (109794-1024). Application Deadline:
warwick-careers.tal.net
November 8, 2024 at 11:06 AM
Join us!
4 Assistant/ Associate Professor posts available at University of Warwick School of Life Sciences, 2 in Host-Pathogen interactions and 2 in Plant Sciences:
warwick-careers.tal.net/vx/lang-en-G...
warwick-careers.tal.net/vx/lang-en-G...
#microsky
4 Assistant/ Associate Professor posts available at University of Warwick School of Life Sciences, 2 in Host-Pathogen interactions and 2 in Plant Sciences:
warwick-careers.tal.net/vx/lang-en-G...
warwick-careers.tal.net/vx/lang-en-G...
#microsky
