Cambridge Baker Systems Genomics Initiative
@cambridgebaker.bsky.social
A joint research initiative at the University of Cambridge and the Baker Heart & Diabetes Institute
Cambridge, UK | Melbourne, Australia
www.inouyelab.org
Cambridge, UK | Melbourne, Australia
www.inouyelab.org
Reposted by Cambridge Baker Systems Genomics Initiative
Wonderful contributions from many... tagging in bsky's I know @cfoguet.bsky.social @xilinjiang.bsky.social @yuxu.bsky.social @sritchie73.bsky.social @iamslambert.bsky.social @aidanbutty.bsky.social @stevesphd.bsky.social
November 22, 2025 at 11:47 AM
Wonderful contributions from many... tagging in bsky's I know @cfoguet.bsky.social @xilinjiang.bsky.social @yuxu.bsky.social @sritchie73.bsky.social @iamslambert.bsky.social @aidanbutty.bsky.social @stevesphd.bsky.social
Reposted by Cambridge Baker Systems Genomics Initiative
📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1...
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
November 22, 2025 at 11:42 AM
📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1...
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.
Reposted by Cambridge Baker Systems Genomics Initiative
🧬 PRSs in practice (5/5): Are healthcare professionals ready?
A concern about PRSs is that clinicians lack genomics knowledge or risk-communication skills.
The solution is not to avoid PRSs, but to invest in training & support.
Read my paper with @mikeinouye.bsky.social 👉 rdcu.be/eNeKN
#Genomics
A concern about PRSs is that clinicians lack genomics knowledge or risk-communication skills.
The solution is not to avoid PRSs, but to invest in training & support.
Read my paper with @mikeinouye.bsky.social 👉 rdcu.be/eNeKN
#Genomics
November 12, 2025 at 11:08 AM
🧬 PRSs in practice (5/5): Are healthcare professionals ready?
A concern about PRSs is that clinicians lack genomics knowledge or risk-communication skills.
The solution is not to avoid PRSs, but to invest in training & support.
Read my paper with @mikeinouye.bsky.social 👉 rdcu.be/eNeKN
#Genomics
A concern about PRSs is that clinicians lack genomics knowledge or risk-communication skills.
The solution is not to avoid PRSs, but to invest in training & support.
Read my paper with @mikeinouye.bsky.social 👉 rdcu.be/eNeKN
#Genomics
Reposted by Cambridge Baker Systems Genomics Initiative
✨ It was a real pleasure to host @mikeinouye.bsky.social today! A fantastic seminar connecting polygenic scores with multi-omic profiles — showing how integration can power next-generation disease prediction. #systemgenomics
On Monday 3 November, Prof Mike Inouye will join us to present 'Genetic prediction and multi-omics: Towards disease prevention'. Our External Seminars are open to any member of the University of Oxford. Don't miss it! talks.ox.ac.uk/talks/id/b6e...
November 3, 2025 at 1:43 PM
✨ It was a real pleasure to host @mikeinouye.bsky.social today! A fantastic seminar connecting polygenic scores with multi-omic profiles — showing how integration can power next-generation disease prediction. #systemgenomics
Reposted by Cambridge Baker Systems Genomics Initiative
🧬 PRSs in practice (1/5): Public understanding — are we underestimating the public?
A common claim: “The public won’t understand polygenic risk scores (PRSs)” — so using them in healthcare could be risky.
But is that really true? 🧵
A common claim: “The public won’t understand polygenic risk scores (PRSs)” — so using them in healthcare could be risky.
But is that really true? 🧵
November 3, 2025 at 9:40 AM
🧬 PRSs in practice (1/5): Public understanding — are we underestimating the public?
A common claim: “The public won’t understand polygenic risk scores (PRSs)” — so using them in healthcare could be risky.
But is that really true? 🧵
A common claim: “The public won’t understand polygenic risk scores (PRSs)” — so using them in healthcare could be risky.
But is that really true? 🧵
Reposted by Cambridge Baker Systems Genomics Initiative
🧬 PRSs in practice (2/5): Do higher-risk polygenic risk score (PRS) results really cause distress?
Evidence so far doesn’t suggest substantial or lasting psychological harm — though research remains limited.
👉 rdcu.be/eNeKN
#Genomics #PolygenicRiskScores #Risk #MentalHealth #Depression #Anxiety
Evidence so far doesn’t suggest substantial or lasting psychological harm — though research remains limited.
👉 rdcu.be/eNeKN
#Genomics #PolygenicRiskScores #Risk #MentalHealth #Depression #Anxiety
November 5, 2025 at 10:05 AM
🧬 PRSs in practice (2/5): Do higher-risk polygenic risk score (PRS) results really cause distress?
Evidence so far doesn’t suggest substantial or lasting psychological harm — though research remains limited.
👉 rdcu.be/eNeKN
#Genomics #PolygenicRiskScores #Risk #MentalHealth #Depression #Anxiety
Evidence so far doesn’t suggest substantial or lasting psychological harm — though research remains limited.
👉 rdcu.be/eNeKN
#Genomics #PolygenicRiskScores #Risk #MentalHealth #Depression #Anxiety
Reposted by Cambridge Baker Systems Genomics Initiative
Gave a talk at the Cambridge Alumni Festival on the genetics of common diseases. It's high level but came off well I think. www.youtube.com/watch?v=xF_p...
Genetic risk of disease: Mike Inouye
YouTube video by Cambridge Development & Alumni Relations
www.youtube.com
October 26, 2025 at 8:19 AM
Gave a talk at the Cambridge Alumni Festival on the genetics of common diseases. It's high level but came off well I think. www.youtube.com/watch?v=xF_p...
Reposted by Cambridge Baker Systems Genomics Initiative
Not unrelated... I've recently updated the Research page on our lab's website (first time in nearly 10 years!) www.inouyelab.org/home/research
and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!
and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!
Inouye Lab - Research
Background
Technological advances have continued to drive the study of biology towards the statistical and computational sciences. We are now able to differentiate and quantify biomolecules at levels ...
www.inouyelab.org
October 3, 2025 at 7:54 PM
Not unrelated... I've recently updated the Research page on our lab's website (first time in nearly 10 years!) www.inouyelab.org/home/research
and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!
and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!
Reposted by Cambridge Baker Systems Genomics Initiative
On a personal note, it's great to have the first preprint out from my first PhD student! bsky.app/profile/clai...
I passed my PhD viva! 🎉 Thank you to everyone who has been a part of this incredible journey, especially my supervisors @iamslambert.bsky.social, Angela Wood, and @mikeinouye.bsky.social 😄
September 19, 2025 at 5:08 PM
On a personal note, it's great to have the first preprint out from my first PhD student! bsky.app/profile/clai...
Reposted by Cambridge Baker Systems Genomics Initiative
Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...
Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction
Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a…
www.medrxiv.org
September 19, 2025 at 5:06 PM
Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...
Reposted by Cambridge Baker Systems Genomics Initiative
Awesome work by @clairecoffey.bsky.social @iamslambert.bsky.social @sritchie73.bsky.social Lisa Pennells and Angela Wood
September 19, 2025 at 3:31 PM
Awesome work by @clairecoffey.bsky.social @iamslambert.bsky.social @sritchie73.bsky.social Lisa Pennells and Angela Wood
Reposted by Cambridge Baker Systems Genomics Initiative
PRS are well know to have variable performance across ancestries, frequently with a European bias. We looked closely at fairness of PRS for CVD risk prediction, both with PRS on it's own and in an integrated risk score...
Our results were surprising... 👉 www.medrxiv.org/content/10.1...
Our results were surprising... 👉 www.medrxiv.org/content/10.1...
Current polygenic risk scores are unlikely to exacerbate unfairness in cardiovascular disease risk prediction
Background: Current cardiovascular disease (CVD) risk prediction models place many individuals in an intermediate risk category where clinical decision-making remains uncertain, highlighting a critica...
www.medrxiv.org
September 19, 2025 at 3:29 PM
PRS are well know to have variable performance across ancestries, frequently with a European bias. We looked closely at fairness of PRS for CVD risk prediction, both with PRS on it's own and in an integrated risk score...
Our results were surprising... 👉 www.medrxiv.org/content/10.1...
Our results were surprising... 👉 www.medrxiv.org/content/10.1...
Reposted by Cambridge Baker Systems Genomics Initiative
📣Just out: Exposure accumulation drives age-dependent disease architectures and polygenic risk scores www.medrxiv.org/content/10.1...
Very cool results: Accumulating E with age reduces heritability & PGS effects
Led by Xilin Jiang (Wellcome ECR joint w/Alkes Price) + @arundurvasula.bsky.social
Very cool results: Accumulating E with age reduces heritability & PGS effects
Led by Xilin Jiang (Wellcome ECR joint w/Alkes Price) + @arundurvasula.bsky.social
September 3, 2025 at 9:39 AM
📣Just out: Exposure accumulation drives age-dependent disease architectures and polygenic risk scores www.medrxiv.org/content/10.1...
Very cool results: Accumulating E with age reduces heritability & PGS effects
Led by Xilin Jiang (Wellcome ECR joint w/Alkes Price) + @arundurvasula.bsky.social
Very cool results: Accumulating E with age reduces heritability & PGS effects
Led by Xilin Jiang (Wellcome ECR joint w/Alkes Price) + @arundurvasula.bsky.social
Reposted by Cambridge Baker Systems Genomics Initiative
Come join the Baker Heart and Diabetes Institute @bakerresearchau.bsky.social as a Lab Head in Biomedical Data Science 📣 www.baker.edu.au/career/head-...
There's never been a more exciting time to lead a research program in this area... and have work-life balance to boot!
There's never been a more exciting time to lead a research program in this area... and have work-life balance to boot!
Career opportunities at the Baker Heart and Diabetes Institute
The Baker Heart and Diabetes Institute is an independent, internationally renowned medical research facility. We have a long and distinguished history, spanning more than 97 years with our work critic...
www.baker.edu.au
August 30, 2025 at 2:41 PM
Come join the Baker Heart and Diabetes Institute @bakerresearchau.bsky.social as a Lab Head in Biomedical Data Science 📣 www.baker.edu.au/career/head-...
There's never been a more exciting time to lead a research program in this area... and have work-life balance to boot!
There's never been a more exciting time to lead a research program in this area... and have work-life balance to boot!
Reposted by Cambridge Baker Systems Genomics Initiative
New episode of the Health Data Science Insights podcast has dropped! This one with Prof Tim Chico on his beginnings in research and now on using smartphone and wearable data to improve cardiovascular care. open.spotify.com/episode/045Y...
Insights from Professor Tim Chico
Health Data Science Insights - Cambridge · Episode
open.spotify.com
August 21, 2025 at 9:32 AM
New episode of the Health Data Science Insights podcast has dropped! This one with Prof Tim Chico on his beginnings in research and now on using smartphone and wearable data to improve cardiovascular care. open.spotify.com/episode/045Y...
Reposted by Cambridge Baker Systems Genomics Initiative
ICYMI it's not a Max Planck directorship but still a great opportunity to join an exciting research environment down under 😁 bsky.app/profile/mike...
📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
August 3, 2025 at 6:18 PM
ICYMI it's not a Max Planck directorship but still a great opportunity to join an exciting research environment down under 😁 bsky.app/profile/mike...
Reposted by Cambridge Baker Systems Genomics Initiative
📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
July 25, 2025 at 7:24 AM
📣📣 Cool job alert! The @bakerresearchau.bsky.social is recruiting up to 2 new PIs in Biomedical Data Science 👉 www.seek.com.au/job/85989791...
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
You’d join an awesome institute in an incredible city (Melbourne, Australia) as well as partnerships like with @cam.ac.uk… you’ll also get to work with me 😁
Reposted by Cambridge Baker Systems Genomics Initiative
Published last month @nathumbehav.nature.com from Saskia Sanderson and me: "Psychological and behavioural considerations for integrating polygenic risk scores for disease into clinical practice" www.nature.com/articles/s41...
July 20, 2025 at 8:18 PM
Published last month @nathumbehav.nature.com from Saskia Sanderson and me: "Psychological and behavioural considerations for integrating polygenic risk scores for disease into clinical practice" www.nature.com/articles/s41...
Reposted by Cambridge Baker Systems Genomics Initiative
Wrote a short blog on personalised health for the Public Health Genomics Foundation. Believe it or not I actually wrote it before the NHS 10 Year Plan came out... www.phgfoundation.org/blog/making-...
Making personalised health work for population health - PHG Foundation
The concept of personalised health is at the centre of a renewed NHS and its 10 Year Health Plan. PHG Trustee, says Prof Mike Inouye as we put 'Making personalised health work for population health' i...
www.phgfoundation.org
July 14, 2025 at 4:14 PM
Wrote a short blog on personalised health for the Public Health Genomics Foundation. Believe it or not I actually wrote it before the NHS 10 Year Plan came out... www.phgfoundation.org/blog/making-...
Reposted by Cambridge Baker Systems Genomics Initiative
The UK Govt just released its 10 year plan for the NHS and it is legitimately ambitious and exciting. Genomic population health features heavily... on the cover even! assets.publishing.service.gov.uk/media/686638...
July 4, 2025 at 2:45 AM
The UK Govt just released its 10 year plan for the NHS and it is legitimately ambitious and exciting. Genomic population health features heavily... on the cover even! assets.publishing.service.gov.uk/media/686638...
Reposted by Cambridge Baker Systems Genomics Initiative
Mike’s on his next trip after we were lucky enough to host him in Geneva for a few hours . It was great to hear his measured and inspiring take on polygenic risk scores .
Heading to Shanghai tomorrow for a few days for a meeting (and first time to China). If you had 24 hours free there, what would you do? Any once in a lifetime / only in Shanghai experiences?
June 19, 2025 at 1:21 PM
Mike’s on his next trip after we were lucky enough to host him in Geneva for a few hours . It was great to hear his measured and inspiring take on polygenic risk scores .
Reposted by Cambridge Baker Systems Genomics Initiative
Super excited to see beginning integration of PredictDB into OmicsPred!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
June 16, 2025 at 10:33 AM
Super excited to see beginning integration of PredictDB into OmicsPred!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
We've annotated/deposited the GTExV8 gene expression predictors so they are now available alongside all the other multi-omic predictors at www.omicspred.org
More on its way... a wonderful collab with @hakyim.bsky.social & co!
Reposted by Cambridge Baker Systems Genomics Initiative
Can deep-learning be used for polygenic risk scores?
New paper out in @natcomms.nature.com!
To find out more read here: www.nature.com/articles/s41...
@mikeinouye.bsky.social @aidanbutty.bsky.social @yuxu.bsky.social
New paper out in @natcomms.nature.com!
To find out more read here: www.nature.com/articles/s41...
@mikeinouye.bsky.social @aidanbutty.bsky.social @yuxu.bsky.social
Performance of deep-learning-based approaches to improve polygenic scores - Nature Communications
Polygenic scores aim to capture genetic risk but may miss nonlinear genetic and environmental interactions. Here, the authors show that neural networks detect limited nonlinearity and do not outperfor...
www.nature.com
June 13, 2025 at 10:07 AM
Can deep-learning be used for polygenic risk scores?
New paper out in @natcomms.nature.com!
To find out more read here: www.nature.com/articles/s41...
@mikeinouye.bsky.social @aidanbutty.bsky.social @yuxu.bsky.social
New paper out in @natcomms.nature.com!
To find out more read here: www.nature.com/articles/s41...
@mikeinouye.bsky.social @aidanbutty.bsky.social @yuxu.bsky.social
Reposted by Cambridge Baker Systems Genomics Initiative
📣📣 Preprint just out from the awesome Xilin Jiang, Yujie Zhao & co!
Pleiotropic heritability quantifies the shared genetic variance of common diseases www.medrxiv.org/content/10.1...
The overlap of disease aetiologies is surprisingly pervasive... ~50% of common disease heritability is pleiotropic!
Pleiotropic heritability quantifies the shared genetic variance of common diseases www.medrxiv.org/content/10.1...
The overlap of disease aetiologies is surprisingly pervasive... ~50% of common disease heritability is pleiotropic!
June 12, 2025 at 6:00 AM
📣📣 Preprint just out from the awesome Xilin Jiang, Yujie Zhao & co!
Pleiotropic heritability quantifies the shared genetic variance of common diseases www.medrxiv.org/content/10.1...
The overlap of disease aetiologies is surprisingly pervasive... ~50% of common disease heritability is pleiotropic!
Pleiotropic heritability quantifies the shared genetic variance of common diseases www.medrxiv.org/content/10.1...
The overlap of disease aetiologies is surprisingly pervasive... ~50% of common disease heritability is pleiotropic!
Reposted by Cambridge Baker Systems Genomics Initiative
Another great article from @mikeinouye.bsky.social and his team
📖Read more here www.nature.com/articles/s41...
📖Read more here www.nature.com/articles/s41...
June 5, 2025 at 2:07 PM
Another great article from @mikeinouye.bsky.social and his team
📖Read more here www.nature.com/articles/s41...
📖Read more here www.nature.com/articles/s41...