Bryan Mackowiak
@bryanmackowiak.bsky.social
NIAAA Postdoctoral Fellow in the Laboratory of Liver Diseases studying alcohol metabolism, alcohol-associated liver disease, and alcohol use disorder.
Reposted by Bryan Mackowiak
Check out a new paper coming out of our lab published in @acerjournal.bsky.social!!
Check out my new paper on how Cyp2e1 deletion results in increased sensitivity to ethanol-induced motor impairment and increased drinking escalation in a CIE model:
doi.org/10.1111/acer...
doi.org/10.1111/acer...
Cyp2e1 deletion in mice increases sensitivity to ethanol‐induced motor impairment and escalation of drinking behavior in the chronic intermittent ethanol model
This study investigates the impact of global Cyp2e1 knockout and wild-type mice to explore the effect of altered ethanol metabolism on behavior and gene expression. Knockout mice demonstrated altered...
doi.org
November 3, 2025 at 2:03 PM
Check out a new paper coming out of our lab published in @acerjournal.bsky.social!!
Reposted by Bryan Mackowiak
Check out my new paper on how Cyp2e1 deletion results in increased sensitivity to ethanol-induced motor impairment and increased drinking escalation in a CIE model:
doi.org/10.1111/acer...
doi.org/10.1111/acer...
Cyp2e1 deletion in mice increases sensitivity to ethanol‐induced motor impairment and escalation of drinking behavior in the chronic intermittent ethanol model
This study investigates the impact of global Cyp2e1 knockout and wild-type mice to explore the effect of altered ethanol metabolism on behavior and gene expression. Knockout mice demonstrated altered...
doi.org
November 3, 2025 at 1:54 PM
Check out my new paper on how Cyp2e1 deletion results in increased sensitivity to ethanol-induced motor impairment and increased drinking escalation in a CIE model:
doi.org/10.1111/acer...
doi.org/10.1111/acer...
Reposted by Bryan Mackowiak
for anyone interested in the amygdala and risky decision-making, check out our new preprint: biorxiv.org/content/10.1...
amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.
amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.
Risk reshapes amygdala representation of choice
Modifying behavior in response to changing environmental conditions is a crucial adaptive function. This capacity is exemplified when animals curtail pursuit of a valued outcome that risks being punis...
biorxiv.org
October 9, 2025 at 2:01 PM
for anyone interested in the amygdala and risky decision-making, check out our new preprint: biorxiv.org/content/10.1...
amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.
amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.
Reposted by Bryan Mackowiak
I'm deeply honored to share that I've been awarded a 2025 NARSAD Young Investigator Grant from @bbrfoundation.bsky.social .
I'm so grateful to my mentors & BBRF for continuing to support early career researchers during this tumultuous time. It will mean everything to scientists like me. 🥲
I'm so grateful to my mentors & BBRF for continuing to support early career researchers during this tumultuous time. It will mean everything to scientists like me. 🥲
August 6, 2025 at 12:34 PM
I'm deeply honored to share that I've been awarded a 2025 NARSAD Young Investigator Grant from @bbrfoundation.bsky.social .
I'm so grateful to my mentors & BBRF for continuing to support early career researchers during this tumultuous time. It will mean everything to scientists like me. 🥲
I'm so grateful to my mentors & BBRF for continuing to support early career researchers during this tumultuous time. It will mean everything to scientists like me. 🥲
Reposted by Bryan Mackowiak
Yup. Microsoft automatically switched me to the $99.99/year version with Spicy Autocomplete. You have to go all the way through "cancel subscription" to be presented these options and get the $69.99/year one you actually chose.
January 24, 2025 at 2:09 PM
Yup. Microsoft automatically switched me to the $99.99/year version with Spicy Autocomplete. You have to go all the way through "cancel subscription" to be presented these options and get the $69.99/year one you actually chose.
Reposted by Bryan Mackowiak
Microsoft is going to price gouge you by adding their genAI to your subscription without your consent, and they are not transparent about how to avoid this bullshit.
Here's how to change your subscription back to "Classic" for a lower charge without Copilot: answers.microsoft.com/en-us/msoffi...
Here's how to change your subscription back to "Classic" for a lower charge without Copilot: answers.microsoft.com/en-us/msoffi...
Redirecting
answers.microsoft.com
January 18, 2025 at 12:49 AM
Microsoft is going to price gouge you by adding their genAI to your subscription without your consent, and they are not transparent about how to avoid this bullshit.
Here's how to change your subscription back to "Classic" for a lower charge without Copilot: answers.microsoft.com/en-us/msoffi...
Here's how to change your subscription back to "Classic" for a lower charge without Copilot: answers.microsoft.com/en-us/msoffi...
Reposted by Bryan Mackowiak
Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice
Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice https://www.biorxiv.org/content/10.1101/2025.01.09.632203v1
January 14, 2025 at 2:59 AM
Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice
Reposted by Bryan Mackowiak
Wasps love alcohol. They seek out alcoholic drinks, and survive even after drinking the equivalent of 5 L of vodka, because they are incredibly efficient at metabolizing ethanol, helped by duplication of their alcohol dehydrogenase gene. www.pnas.org/doi/10.1073/... #BedtimeScience 🍺🐝 🧪
November 25, 2024 at 11:30 AM
Wasps love alcohol. They seek out alcoholic drinks, and survive even after drinking the equivalent of 5 L of vodka, because they are incredibly efficient at metabolizing ethanol, helped by duplication of their alcohol dehydrogenase gene. www.pnas.org/doi/10.1073/... #BedtimeScience 🍺🐝 🧪