@brunogiotti.bsky.social
Trying to figure out the tumor microenvironment from single cell epigenomics as the world ends. Instructor at Icahn school of medicine.
Reposted
🔬Our paper from the @miriammerad.bsky.social lab is now online! This is a story shaped over years of cross-disciplinary endeavor at @sinaiimmuno.bsky.social and labs across the world. 🧵:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature
An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...
www.nature.com
September 22, 2025 at 12:41 PM
🔬Our paper from the @miriammerad.bsky.social lab is now online! This is a story shaped over years of cross-disciplinary endeavor at @sinaiimmuno.bsky.social and labs across the world. 🧵:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
Alex's highly complementary study and fantastic story here: www.nature.com/articles/s41...
Learning the cellular origins across cancers using single-cell chromatin landscapes - Nature Communications
Understanding the cellular origins of cancers is crucial for improving diagnosis and treatment. Here, the authors utilize single cell chromatin accessibility data, patient whole-genome sequencing muta...
www.nature.com
September 17, 2025 at 8:18 PM
Alex's highly complementary study and fantastic story here: www.nature.com/articles/s41...
Reposted
📝NEW STUDY📝 Cancer's first punch when battling the immune system may be rewiring myeloid progenitors in bone marrow so they become suppressive tumor macrophages blunting T-cell attacks. Find out how in @nature.com from @samhegde.bsky.social & @miriammerad.bsky.social 🧐 www.nature.com/articles/s41...
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature
An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...
www.nature.com
September 18, 2025 at 3:16 PM
📝NEW STUDY📝 Cancer's first punch when battling the immune system may be rewiring myeloid progenitors in bone marrow so they become suppressive tumor macrophages blunting T-cell attacks. Find out how in @nature.com from @samhegde.bsky.social & @miriammerad.bsky.social 🧐 www.nature.com/articles/s41...
Reposted
A targetable epigenetic node of myeloid progenitor dysregulation that sustains immunosuppressive lung tumor microenvironment, a target for improving immunotherapy outcomes @nature.com @miriammerad.bsky.social
@sinaiimmuno.bsky.social
www.nature.com/articles/s41...
@sinaiimmuno.bsky.social
www.nature.com/articles/s41...
September 10, 2025 at 4:55 PM
A targetable epigenetic node of myeloid progenitor dysregulation that sustains immunosuppressive lung tumor microenvironment, a target for improving immunotherapy outcomes @nature.com @miriammerad.bsky.social
@sinaiimmuno.bsky.social
www.nature.com/articles/s41...
@sinaiimmuno.bsky.social
www.nature.com/articles/s41...
Reposted
Jess and I share our thoughts on the assassination of Charlie Kirk.
@ragingmoderates.bsky.social
@jessicatarlov.bsky.social
youtu.be/Sz3SBK8PJik?...
@ragingmoderates.bsky.social
@jessicatarlov.bsky.social
youtu.be/Sz3SBK8PJik?...
The Fallout from Charlie Kirk's Death
YouTube video by Raging Moderates
youtu.be
September 11, 2025 at 6:43 PM
Jess and I share our thoughts on the assassination of Charlie Kirk.
@ragingmoderates.bsky.social
@jessicatarlov.bsky.social
youtu.be/Sz3SBK8PJik?...
@ragingmoderates.bsky.social
@jessicatarlov.bsky.social
youtu.be/Sz3SBK8PJik?...
Reposted
We need more Jon Ossoffs in the Democratic Party.
This is just fantastic.
This is just fantastic.
March 22, 2025 at 10:44 PM
We need more Jon Ossoffs in the Democratic Party.
This is just fantastic.
This is just fantastic.
Reposted
Devastating to hear of a child's death from measles—a completely preventable disease. Even more concerning is public health officials downplaying the outbreak. attached here is an important article on the lifesaving impact of measles vaccines. #FollowTheData academic.oup.com/jid/article/...
Measles in the 21st Century: Progress Toward Achieving and Sustaining Elimination
Abstract. The global measles vaccination program has been extraordinarily successful in reducing measles-related disease and deaths worldwide. Eradication
academic.oup.com
February 27, 2025 at 4:37 AM
Devastating to hear of a child's death from measles—a completely preventable disease. Even more concerning is public health officials downplaying the outbreak. attached here is an important article on the lifesaving impact of measles vaccines. #FollowTheData academic.oup.com/jid/article/...
Reposted
This is resistance.
Former NFL Kicker Arrested At City Council Meeting After Slamming 'Nazi' MAGA Movement
Now that's resistance.
www.comicsands.com
February 22, 2025 at 4:30 PM
This is resistance.
Reposted
New to bluesky, but I’m excited to share my work over the last few years with @jbuenrostro.bsky.social! Chronic inflammation creates an epigenetic memory in colonic stem cells, priming them for tumor growth: tinyurl.com/ColitisNagar.... Here’s a walkthrough of what we found (🧵)
February 18, 2025 at 3:01 AM
New to bluesky, but I’m excited to share my work over the last few years with @jbuenrostro.bsky.social! Chronic inflammation creates an epigenetic memory in colonic stem cells, priming them for tumor growth: tinyurl.com/ColitisNagar.... Here’s a walkthrough of what we found (🧵)
Reposted
This is the way.
February 15, 2025 at 8:18 PM
This is the way.
Reposted
Incompetence in Washington puts every American at risk, no matter how you voted. No one should be happy that the DOGE team - the same folks who randomly published classified U.S. security information online today - wants access to your bank account & Social Security numbers.
February 15, 2025 at 3:26 AM
Incompetence in Washington puts every American at risk, no matter how you voted. No one should be happy that the DOGE team - the same folks who randomly published classified U.S. security information online today - wants access to your bank account & Social Security numbers.
Reposted
Unsafe at any speed www.reuters.com/business/aut...
Cybertruck crash raises alarm bells about Tesla's self-driving software
A crash involving a Tesla Cybertruck in self-driving mode this week has sparked worries about the reliability of the company's software that powers the feature, days after CEO Elon Musk said he would roll out a paid robotaxi service this year.
www.reuters.com
February 14, 2025 at 6:07 AM
Unsafe at any speed www.reuters.com/business/aut...
Reposted
NIH-supported research saves lives: here are two "poster" human beings to prove it.
Emily Whitehead: cured of her leukemia by CAR-T developed at Penn.
Victoria Gray: major symptoms of her sickle cell disease resolved following CRISPR gene editing - path paved at Boston Childrens, UW, UC Berkeley.
Emily Whitehead: cured of her leukemia by CAR-T developed at Penn.
Victoria Gray: major symptoms of her sickle cell disease resolved following CRISPR gene editing - path paved at Boston Childrens, UW, UC Berkeley.
February 10, 2025 at 4:51 PM
NIH-supported research saves lives: here are two "poster" human beings to prove it.
Emily Whitehead: cured of her leukemia by CAR-T developed at Penn.
Victoria Gray: major symptoms of her sickle cell disease resolved following CRISPR gene editing - path paved at Boston Childrens, UW, UC Berkeley.
Emily Whitehead: cured of her leukemia by CAR-T developed at Penn.
Victoria Gray: major symptoms of her sickle cell disease resolved following CRISPR gene editing - path paved at Boston Childrens, UW, UC Berkeley.
Reposted
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
February 9, 2025 at 9:58 PM
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Reposted
Trump & Musk are making massive cuts to the National Institutes of Health.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
February 8, 2025 at 11:16 PM
Trump & Musk are making massive cuts to the National Institutes of Health.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
I know there is a lot going on right now, but this is one of worst things they have done so far, will affect cancer research and trials, the search for cures, innovation and competitiveness, our universities. Your lives.
Reposted
Rep. LaMonica McIver: "We are at war!"
February 4, 2025 at 10:50 PM
Rep. LaMonica McIver: "We are at war!"
Reposted
Jasmine is on FIRE 🔥 🔥🔥
"...we are going to be in your face, we are going to be on your asses, and we are going to make sure you understand what democracy looks like...
...and this ain't it!"
"...we are going to be in your face, we are going to be on your asses, and we are going to make sure you understand what democracy looks like...
...and this ain't it!"
February 4, 2025 at 11:38 PM
Jasmine is on FIRE 🔥 🔥🔥
"...we are going to be in your face, we are going to be on your asses, and we are going to make sure you understand what democracy looks like...
...and this ain't it!"
"...we are going to be in your face, we are going to be on your asses, and we are going to make sure you understand what democracy looks like...
...and this ain't it!"
Reposted
Mark Cuban on Running for Prez, Diddy Parties, & Destroying Big Pharma
YouTube video by FLAGRANT
youtu.be
January 23, 2025 at 5:29 AM
Reposted
Bishop Mariann Edgar Budde
Hero.
Hero.
January 22, 2025 at 1:54 AM
Bishop Mariann Edgar Budde
Hero.
Hero.
Reposted
Kudos to whoever did this one. Perfect.
January 16, 2025 at 3:38 AM
Kudos to whoever did this one. Perfect.
Reposted
Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/
www.encodeproject.org/single-cell/...
www.encodeproject.org/single-cell/...
Single cell – ENCODEHomo sapiens clickable body map
www.encodeproject.org
January 7, 2025 at 9:29 PM
Very excited to announce that the single cell/nuc. RNA/ATAC/multi-ome resource from ENCODE4 is now officially public. This includes raw data, processed data, annotations and pseudobulk products. Covers many human & mouse tissues. 1/
www.encodeproject.org/single-cell/...
www.encodeproject.org/single-cell/...
Reposted
Some thoughts about what I am looking forward this year from my vantage point of computational molecular biology. One mega-trend for me; we will definitely see more AI methods of all sorts emerge.
January 3, 2025 at 6:46 PM
Some thoughts about what I am looking forward this year from my vantage point of computational molecular biology. One mega-trend for me; we will definitely see more AI methods of all sorts emerge.
Reposted
Our ChromBPNet preprint out!
www.biorxiv.org/content/10.1...
Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/
www.biorxiv.org/content/10.1...
Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/
December 25, 2024 at 11:48 PM
Our ChromBPNet preprint out!
www.biorxiv.org/content/10.1...
Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/
www.biorxiv.org/content/10.1...
Huge congrats to Anusri! This was quite a slog (for both of us) but we r very proud of this one! It is a long read but worth it IMHO. Methods r in the supp. materials. Bluetorial coming soon below 1/