Briggs Group
@briggsgroup.bsky.social
Briggs group at MPI Biochemistry
Department of Cell and Virus Structure
Cryo-EM, tomography, CLEM, coated vesicles, enveloped viruses.
Department of Cell and Virus Structure
Cryo-EM, tomography, CLEM, coated vesicles, enveloped viruses.
An amazing study from @chlandalab.bsky.social - a lot of new insights from these beautiful tomograms!
Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET!
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
October 25, 2025 at 1:07 PM
An amazing study from @chlandalab.bsky.social - a lot of new insights from these beautiful tomograms!
Reposted by Briggs Group
Providing order amongst constant traffic: #LMBResearch from Sean Munro (@cellbiol-mrclmb.bsky.social) with John Briggs (@mpibiochem.bsky.social) reveals how GOLPH3 allows COPI vesicles to distinguish between Golgi residents & ER-bound proteins.
Read more: www2.mrc-lmb.cam.ac.uk/protein-sort...
Read more: www2.mrc-lmb.cam.ac.uk/protein-sort...
October 6, 2025 at 8:07 AM
Providing order amongst constant traffic: #LMBResearch from Sean Munro (@cellbiol-mrclmb.bsky.social) with John Briggs (@mpibiochem.bsky.social) reveals how GOLPH3 allows COPI vesicles to distinguish between Golgi residents & ER-bound proteins.
Read more: www2.mrc-lmb.cam.ac.uk/protein-sort...
Read more: www2.mrc-lmb.cam.ac.uk/protein-sort...
The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...
The mechanistic basis of cargo selection during Golgi maturation
Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.
www.science.org
October 6, 2025 at 11:39 AM
The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...
Do you want to start your own research group? The current call for Max Planck Research Group Leaders is open until October 14th.
www.mpg.de/career/max-p...
www.mpg.de/career/max-p...
Apply now!
Apply to become a Max Planck Research Group Leader. Max Planck Research Groups - Announcement 2024.
www.mpg.de
September 26, 2025 at 1:23 PM
Do you want to start your own research group? The current call for Max Planck Research Group Leaders is open until October 14th.
www.mpg.de/career/max-p...
www.mpg.de/career/max-p...
Reposted by Briggs Group
Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.
August 1, 2025 at 9:06 AM
Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.
Reposted by Briggs Group
How did a brain gene end up behaving like a virus? Research has shown that there is an evolutionary connection between Arc, retroviruses, and virus-like genetic elements called retrotransposons.
More at Molecule of the Month: pdb101.rcsb.org/motm...
More at Molecule of the Month: pdb101.rcsb.org/motm...
August 19, 2025 at 4:56 PM
How did a brain gene end up behaving like a virus? Research has shown that there is an evolutionary connection between Arc, retroviruses, and virus-like genetic elements called retrotransposons.
More at Molecule of the Month: pdb101.rcsb.org/motm...
More at Molecule of the Month: pdb101.rcsb.org/motm...
Congratulations @tbharat-lab.bsky.social !
Congratulations to @tbharat-lab.bsky.social, Group Leader in the LMB’s Structural Studies Division, who has received the Gold Medal from @embo.org for his research on prokaryotic surface molecules.
Read more here: www2.mrc-lmb.cam.ac.uk/tanmay-bhara...
#LMBNews
Read more here: www2.mrc-lmb.cam.ac.uk/tanmay-bhara...
#LMBNews
June 5, 2025 at 2:53 PM
Congratulations @tbharat-lab.bsky.social !
Reposted by Briggs Group
We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM
May 26, 2025 at 4:56 PM
We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM
Reposted by Briggs Group
Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...
April 9, 2025 at 1:07 PM
Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...
Our work on HIV-1 matrix, led by James Stacey and @dhrebik.bsky.social, is in this week's @nature.com. Extended explanatory video from @margotriggi.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 4, 2025 at 1:03 PM
Our work on HIV-1 matrix, led by James Stacey and @dhrebik.bsky.social, is in this week's @nature.com. Extended explanatory video from @margotriggi.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Briggs Group
New #Review 🥳
@dr-downes.bsky.social and @giuliazanetti.bsky.social discuss recent findings on how #COPII particles assemble and recognise their cargo as part of the #SecretoryPathway
🔗 go.nature.com/3XJHHmy
@dr-downes.bsky.social and @giuliazanetti.bsky.social discuss recent findings on how #COPII particles assemble and recognise their cargo as part of the #SecretoryPathway
🔗 go.nature.com/3XJHHmy
Mechanisms of COPII coat assembly and cargo recognition in the secretory pathway - Nature Reviews Molecular Cell Biology
Coat protein complex II (COPII) subunits assemble to form membrane transport carriers at ER exit sites, thereby concentrating secretory cargoes and facilitating their transport to the Golgi. This Revi...
go.nature.com
April 2, 2025 at 5:38 AM
New #Review 🥳
@dr-downes.bsky.social and @giuliazanetti.bsky.social discuss recent findings on how #COPII particles assemble and recognise their cargo as part of the #SecretoryPathway
🔗 go.nature.com/3XJHHmy
@dr-downes.bsky.social and @giuliazanetti.bsky.social discuss recent findings on how #COPII particles assemble and recognise their cargo as part of the #SecretoryPathway
🔗 go.nature.com/3XJHHmy
Reposted by Briggs Group
Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET combined with #virology, #cellbiology, and #biophysics.
Deadline 4 May. More info: www.carlsonlab.se/join/
Open #PhDposition in structural virology in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET combined with #virology, #cellbiology, and #biophysics.
Deadline 4 May. More info: www.carlsonlab.se/join/
April 4, 2025 at 8:06 AM
Repost appreciated:
Open #PhDposition in structural virology in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET combined with #virology, #cellbiology, and #biophysics.
Deadline 4 May. More info: www.carlsonlab.se/join/
Open #PhDposition in structural virology in my group! Join us in Umeå, 🇸🇪 to uncover how arboviruses remodel the cellular interior. In situ #cryoET combined with #virology, #cellbiology, and #biophysics.
Deadline 4 May. More info: www.carlsonlab.se/join/
Reposted by Briggs Group
Our #cryoEM technology group with scientists from @mpibp.bsky.social and @viennabiocenter.bsky.social, used #cryoET to capture retrotransposons in action, resolving copia in #fruitflies at sub-nanometer resolution inside cells.
❕Publication @cellpress.bsky.social: www.cell.com/cell/fulltex...
❕Publication @cellpress.bsky.social: www.cell.com/cell/fulltex...
March 5, 2025 at 4:53 PM
Our #cryoEM technology group with scientists from @mpibp.bsky.social and @viennabiocenter.bsky.social, used #cryoET to capture retrotransposons in action, resolving copia in #fruitflies at sub-nanometer resolution inside cells.
❕Publication @cellpress.bsky.social: www.cell.com/cell/fulltex...
❕Publication @cellpress.bsky.social: www.cell.com/cell/fulltex...
Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social
February 28, 2025 at 2:04 PM
Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social