Brendon Neuen
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brendonneuen.bsky.social
Brendon Neuen
@brendonneuen.bsky.social
1.2K followers 710 following 99 posts
Nephrologist; Associate Professor; Program Lead, Renal & Metabolic, George Institute; Director, Kidney Trials, Royal North Shore Hospital; Secretariat, #SMART-C; Podcast host, #KidneyCompass

www.SMART-C.net
Posts Replies Media Videos
Reposted by Brendon Neuen
hswapnil.medsky.social
In the last #KidneyKompass @brendonneuen.bsky.social chats with Sophia Zoungas podcasts.apple.com/ca/podcast/k... on the SURPASS data

G-force FTW @christosargyrop.bsky.social @rnflex.bsky.social

Hey @brianrifkin.bsky.social if sema is captopril what would you call dulaglutide? 😏
Understanding Renal Outcomes in SURPASS-CVOT, With Sophia Zoungas, MBBS, PhD
Podcast Episode · Kidney Compass: Navigating Clinical Trials · 2025-11-13 · 17m
podcasts.apple.com
November 19, 2025 at 2:58 PM
Reposted by Brendon Neuen
nephjc.bsky.social
T0d: #NephJC

🛑Remission is defined an eGFR decline of ~1 ml/min/1.73 m²/year, closer to physiological rate

📉Vs 2-3 ml per year with only conservative therapy; hopefully, B-cell therapies will further flatten the slope

By @brendonneuen.bsky.social &Co

pubmed.ncbi.nlm.nih....
November 19, 2025 at 2:11 AM
Reposted by Brendon Neuen
hswapnil.medsky.social
16 is same as last year

someone check if I have missed anything

Read our blogs here www.nephjc.com/news/kidneyw...

#NephJC #KidneyWk

@nephroseeker.medsky.social @brendonneuen.bsky.social
Kidney Week in Houston: Day 1 — NephJC
in this edition: Atacicept in IgAN; Albuminuria as a surrogate outcome, Renal Remission and additional CONFIDENCE analysis
www.nephjc.com
November 9, 2025 at 11:31 PM
Reposted by Brendon Neuen
hswapnil.medsky.social
OK thread of all simulpubs at this year's #KidneyWk

ORIGIN-3: Atacicept pubmed.ncbi.nlm.nih.gov/41196369/

CKD as a curable dz? www.kidney-international.org/article/S008...

Albuminuria as a surrogate endpoint www.nature.com/articles/s41...
November 9, 2025 at 11:30 PM
Reposted by Brendon Neuen
hswapnil.medsky.social
Will we get more simultaneous publications this year than last year at #KidneyWk?

We had 16 last year

@brendonneuen.bsky.social
@nephroseeker.medsky.social

Will thread all later - but the #NephJC blog will have them all
Last year tally
November 8, 2025 at 11:19 PM
Reposted by Brendon Neuen
hswapnil.medsky.social
And @brendonneuen.bsky.social with another simultaneous pub in @jama.com

jamanetwork.com/journals/jam...

Flozination by GFR/albuminuria

#KidneyWk
SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria
This meta-analysis examines whether estimated glomerular filtration rate or degree of albuminuria, as measured by urinary albumin to creatinine ratio, modifies the effects of sodium-glucose cotranspor...
jamanetwork.com
November 8, 2025 at 12:05 AM
Reposted by Brendon Neuen
hswapnil.medsky.social
In the afternoon another late breaking oral session among other things at 4:30 pm

@brendonneuen.bsky.social
Lorundrostat
A new oral GLP1
REMODEL to understand sema mechanism
GBD kidney disease with @paddymark.bsky.social
And
@cervantes-lily1.bsky.social !

#KidneyWk
LBRO 2
November 7, 2025 at 10:39 AM
Reposted by Brendon Neuen
hswapnil.medsky.social
Is it not really TGF - and something else in the tubules?

Fascinating Biomarker study in @ajkd.bsky.social from the EMPA-KIDNEY group

www.ajkd.org/article/S027...

cc @pranavgarimella.bsky.social

#NephSky #RevengeOfTheTubules
Figure 1 Effect of empagliflozin versus placebo on study average concentration of urine biomarkers (indexed to urine creatinine). The MMRM model was adjusted for the prognostic variables specified in the minimized randomization algorithm (i.e., age, sex, prior diabetes, eGFR, uACR, and trial site region) in the same categories used in the minimization process, initial freezer storage temperature (-20°C versus below -20°C) and baseline log2-transformed urine biomarker-creatinine ratio. A weighted average of 2- and 18- month values proportional to the amount of time between visits was used to estimate the study average log2-transformed urine biomarker-to-creatinine ratio in each arm. Absolute values indicate geometric mean (approximate SE) creatinine-indexed urine biomarker concentration in the units specified. The size of the boxes represents the amount of information estimated.
October 31, 2025 at 10:36 PM
Reposted by Brendon Neuen
kidneyboy.bsky.social
New episode of Freely Filtered with @brendonneuen.bsky.social @hswapnil.medsky.social @captainchloride.bsky.social @sophia-kidney.bsky.social and author Muth Vaduganathan discussing the CONVINCE trial

www.nephjc.com/freelyfilter...

With chapters, refs, and pictures
October 21, 2025 at 12:11 PM
Reposted by Brendon Neuen
hswapnil.medsky.social
And three ‘late breaking research’ orals each evening Thursday - Saturday

#KidneyWk
LBRO 1 LBRO 2 LBRO 3
October 17, 2025 at 9:49 PM
Reposted by Brendon Neuen
hswapnil.medsky.social
A second High Impact trial session in plenary hall on Saturday AM

#KidneyWk
HICT 2
October 17, 2025 at 9:49 PM
Reposted by Brendon Neuen
hswapnil.medsky.social
It’s all live now!

Apart from the two trials mentioned above

We have 5 more sessions at #KidneyWk + posters

High Impact Trials 1 on Friday AM in plenary hall
HICT 1
October 17, 2025 at 9:49 PM
Reposted by Brendon Neuen
hswapnil.medsky.social
The opening plenary at #KidneyWk looks phenomenal

Renal RCT Renaissance is upon us

(LBCT list drops tomorrow)

www.asn-online.org/education/ki...
program for thursday at kidney wk including 2 LBCTs and Vlado P talking on RCTs and curing kidney disease
October 16, 2025 at 1:10 PM
Reposted by Brendon Neuen
jwaitz.bsky.social
In this house we drink liquids and support #nephjc

(Maybe I should get a backpack next time)

Donate at: www.nephjc.com/news/2025/9/...
October 13, 2025 at 3:53 PM
Reposted by Brendon Neuen
cvctforum.bsky.social
Take the ultimate deep dive in major recent clinical trials with the largest global gathering of clinical trials key stakeholders at #CVCT2025, December 8-10, 2025 in Washington DC ! Discover the scientific program here: www.globalcvctforum.com/scientific-p...
#clinicaltrials #clinicalresearch #CVCT
July 31, 2025 at 10:43 AM
Reposted by Brendon Neuen
cvctforum.bsky.social
Join us December 8-10, Washington DC! Full programme here: www.globalcvctforum.com/scientific-p...
CVCT Global Forum Scientific Program 2025
Discover the unique high science & discussion program for CVCT 2025 (Global CardioVascular Trialists Forum), December 8-10, at the Mayflower Hotel, Washington DC
www.globalcvctforum.com
September 2, 2025 at 1:26 PM
Reposted by Brendon Neuen
kidneyboy.bsky.social
Interesting slide #BucketOfColdWater
September 23, 2025 at 7:41 PM
brendonneuen.bsky.social
📢 New in CJASN: pooled analysis of all completed phase 2/3 RCTs in #IgAN

🔹 4 drug classes (steroids, B-cell, complement, non-immunological)
🔹 All ↓ proteinuria ≥30%
🔹 All improved GFR slope
🔹 Biggest benefit: B-cell therapies

journals.lww.com/cjasn/abstra...
September 12, 2025 at 2:24 AM
Reposted by Brendon Neuen
nephjc.bsky.social
If you want to support #NephJC and get some cool merch, check out
www.nephjc.com/merch...
September 3, 2025 at 1:56 AM
Reposted by Brendon Neuen
nephtimes.bsky.social
Attending Kidney Week 2025? Check out details about the plenaries. We'll be there, at Booth 2234! #kidneywk #nephrology #nephsky @asnkidney.bsky.social www.docwirenews.com/post/asn-rev...
ASN Reveals Kidney Week Plenary Details | Docwire News
The American Society of Nephrology announced details of the plenary sessions scheduled to take place at Kidney Week 2025, which will take place November 6-9, in Houston, Texas.
www.docwirenews.com
August 22, 2025 at 6:24 PM
Reposted by Brendon Neuen
theisn.org
Your abstract could be next to inspire change in kidney care. When you share your research at #ISNWCN, the benefits go far beyond the presentation.
• Global visibility
• Peer recognition
• Publication opportunity

Submit your abstract today ➡️ http://lite.spr.ly/6...
August 21, 2025 at 12:00 PM
Reposted by Brendon Neuen
nephjc.bsky.social
😎Check out the VA for HiLO by @sejalplakhani.bsky.social
🆒 This should be quite the discussion, don't miss it!
#NephJC #NephSky
www.nephjc.com/news/2025/8/4/the-hilo-trial-visual-abstract
The HiLo Trial - Visual Abstract — NephJC
Is a lower versus higher phosphate target beneficial to patients undergoing hemodialysis? Check out this crisp VA by Dr Sejal Lakhani
www.nephjc.com
August 5, 2025 at 1:16 AM
Reposted by Brendon Neuen
theisn.org
🌏 Join us at WCN'26 in Yokohama!
🧠 Learn from global experts
📈 Share your research
👥 Connect with peers
📅 Abstracts due Oct 22
🎬 #ISNFilmEvent submissions by Nov 5
✈️ Travel grants & registration open Sept 16
🔗 http://lite.spr.ly/6... #ISNWCN
July 15, 2025 at 12:01 PM
brendonneuen.bsky.social
SGLT2i in CKD: impact beyond kidneys

🔻 15% all-cause hospitalizations
✅ Consistent regardless of eGFR, UACR & diabetes
🏥 ~36 fewer hospitalizations per 1000 pt-years

Large absolute gains for patients & health systems

Meta-analysis in @asnpublications.bsky.social

journals.lww.com/cjasn/pages/...
July 15, 2025 at 3:40 AM
Reposted by Brendon Neuen
christosargyrop.bsky.social
Only reason to sequence the RASi first is that they are good antihypertensives (but note the BP effect in the combo arm of #confidence) #nephjc

But no matter the sequence, the goal should be to have someone on the four pillars in less than 6 months
July 9, 2025 at 1:26 AM