A pregnant woman's harrowing experience at Dallas Regional Medical Center is a stark reminder of the systemic issues in our healthcare system. The mother, left unattended for over 30 minutes, delivers...

Ethiopia has confirmed its first Marburg outbreak after nine cases were identified in the southern region of the country that borders South Sudan.

Background: All of the major antigenic changes in influenza A(H3N2) viruses since 1968 have involved mutations at just nine amino acid positions, called cluster transition sites, surrounding the receptor binding region of the hemagglutinin surface protein. During the northern hemisphere (NH) 2024–2025 influenza season, A(H3N2) variants emerged with multiple parallel substitutions affecting cluster transition sites 135, 145, 158 and/or 189, with implications for the 2025–2026 season. Methods: Using >24,000 global A(H3) sequences between September 2024 and August 2025, we assess the nature and frequency of amino acid mutations among emerging NH and southern hemisphere (SH) A(H3N2) variants relative to the 2024–2025 subclade J and updated 2025–2026 subclade J.2 vaccine reference strains. We contextualize based upon historic amino acid variation among >210,000 global A(H3) sequences since 1968 and publicly available antigenic characterization data relative to 2024–2025 and 2025–2026 vaccine reference strains Results: Virtually all circulating A(H3N2) viruses in 2024–2025 were subclade J.2. In Europe, about one-third had cluster transition site mutations, mostly T135A with S145N. In North America, more than two-thirds had cluster transition site mutations, including T135K or S145N, with late-season increase in doubly mutated J.2.3 (N158K + K189R) and J.2.5 (S145N + N158K) subclades. The SH 2025 season showed increase in J.2.3 and emergence of J.2.4 (T135K + K189R) including a further drifted J.2.4.1 variant with additional N158D and other mutations, recently renamed subclade K. A substantial proportion of J.2.3 and J.2.4 viruses are antigenically distinct from the 2025–2026 influenza vaccine. Conclusion: Influenza A(H3N2) variants with a combination of cluster transition site mutations emerged during the NH 2024–2025 season. A further drifted and vaccine-mismatched variant now called subclade K arose during the SH 2025 season and is projected to predominate among A(H3N2) viruses for the NH 2025–2026 season. While mismatched vaccines may still provide protection, enhanced genetic, antigenic and epidemiological (eg, vaccine effectiveness) monitoring are warranted to inform risk assessment and response.

ALT: a man is standing in a kitchen drinking from a cup and talking about flu season .

A pro-vaccine physician went to the anti-vaccine movement’s biggest gathering. He warns that public health must learn what it’s up against.

Because nothing says “festive” like avoiding an impromptu Norovirus outbreak.

The court turned away an appeal filed by Kim Davis, a former county clerk in Kentucky who was sued after refusing to issue a marriage license to a gay couple.

Because nothing says “festive” like avoiding an impromptu Norovirus outbreak.

Individuals previously infected with MPXV show strong and durable immunological memory lasting up to 2 years after infection, in contrast to the less robust and shorter-lived response observed after M...

Dr. Jamal Eltaeb of Sudan has been awarded the Aurora Prize for Awakening Humanity. He says, "Every day we work in the impossible conditions with barely enough to keep people alive."

James Watson, who co-discovered the structure of DNA has died at age 97. He was a scientific superstar until he made racist remarks that made him an outcast.

Elon Musk responded in kind to Tesla Inc. investors approving his $1 trillion compensation package, making a series of extravagant predictions about what the company will be capable of in the years to...

Paul Biya has been in power since 1982 - the opposition says the election was rigged.

Migrating wild birds are spreading the virus to domesticated flocks, increasing the risk of eventually seeing a human outbreak. Scientists are troubled by the muted federal response.

The short documentary “Rovina’s Choice” tells the story of what goes when aid goes.

Claudia Sheinbaum says she is pressing charges because "a line must be drawn" against the harassment of Mexican women.

No vaccine is currently available for Lassa fever, a viral hemorrhagic disease that is estimated to cause thousands of deaths each year in western Africa. A replication-competent recombinant vesicu...