Blaise Frederick
@blaisefrederick.bsky.social
A physicist who wandered into a psychiatry department and ended up obsessing about random fluctuations in cerebral circulation.
Director, Optomagnetic Group, McLean Hospital Brain Imaging Center/Assistant Professor of Psychiatry, Harvard Medical School.
Director, Optomagnetic Group, McLean Hospital Brain Imaging Center/Assistant Professor of Psychiatry, Harvard Medical School.
Check out this tour de force paper by @tsbolt.bsky.social showing the relationship between the autonomic nervous system and the global signal in fMRI!
First post on an exciting new manuscript online today @natneuro.nature.com - in collab with @lucinauddin.bsky.social and Catie Chang. We take a fresh look at the physiological dynamics associated with the global signal 🧠 ...
www.nature.com/articles/s41...
Read here:
rdcu.be/ek01F
www.nature.com/articles/s41...
Read here:
rdcu.be/ek01F
Autonomic physiological coupling of the global fMRI signal
Nature Neuroscience - The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.
rdcu.be
May 7, 2025 at 4:01 PM
Check out this tour de force paper by @tsbolt.bsky.social showing the relationship between the autonomic nervous system and the global signal in fMRI!
I'm happy to announce that rapidtide 3.0 has finally escaped from its development dungeon and has been released! rapidtide.readthedocs.io/en/stable/wh...
What's new — rapidtide 3.0 documentation
rapidtide.readthedocs.io
April 22, 2025 at 10:14 PM
I'm happy to announce that rapidtide 3.0 has finally escaped from its development dungeon and has been released! rapidtide.readthedocs.io/en/stable/wh...
If anybody hasn't seen this - this is a really cool method for looking at dopamine physiology using fMRI!
Interested in dopamine? Have fMRI data? We’ve identified a temporal BOLD feature that carries rich information about dopamine physiology. This measure, obtainable from resting-state and task fMRI, opens new ways to indirectly probe dopamine’s role in cognition and disease. 1/n tinyurl.com/bddyz67b
Temporal fMRI Dynamics Map Dopamine Physiology
Spatial variations in dopamine function are linked to cognition and substance use disorders but are challenging to characterize with current methods. Because dopamine influences blood vessel dilation,...
www.biorxiv.org
April 2, 2025 at 1:14 PM
If anybody hasn't seen this - this is a really cool method for looking at dopamine physiology using fMRI!
I think the average person doesn’t have any idea about this, which is why they aren’t more freaked out.
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
March 22, 2025 at 1:42 PM
I think the average person doesn’t have any idea about this, which is why they aren’t more freaked out.
Reposted by Blaise Frederick
I'm happy to share our paper in @npp-journal.bsky.social on rsFC, cue-reactivity, and craving in nicotine smoking AND vaping! Thanks to coauthors, @amy.janeslab.org @blaisefrederick.bsky.social @ckorponay.bsky.social @mariascavnicky.bsky.social Here's what we found 🧵 www.nature.com/articles/s41...
Brain reactivity to nicotine cues mediates the link between resting-state connectivity and cue-induced craving in individuals who smoke or vape nicotine - Neuropsychopharmacology
Neuropsychopharmacology - Brain reactivity to nicotine cues mediates the link between resting-state connectivity and cue-induced craving in individuals who smoke or vape nicotine
www.nature.com
March 13, 2025 at 7:10 PM
I'm happy to share our paper in @npp-journal.bsky.social on rsFC, cue-reactivity, and craving in nicotine smoking AND vaping! Thanks to coauthors, @amy.janeslab.org @blaisefrederick.bsky.social @ckorponay.bsky.social @mariascavnicky.bsky.social Here's what we found 🧵 www.nature.com/articles/s41...
This needs more visibility! While the general public is belatedly getting some sense of the catastrophe caused by not reviewing or funding external grants, DOGE is also completely wiping out the NIH intramural programs, which is just as bad, but is flying under the radar because NIH is gagged.
Compelling pushback from @jmgrohneuro.bsky.social and the Board of Scientific Counselors at the National Institute on Mental Health (NIMH) regarding termination of tenure-track investigators driven by DOGE.
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March 6, 2025 at 6:06 PM
This needs more visibility! While the general public is belatedly getting some sense of the catastrophe caused by not reviewing or funding external grants, DOGE is also completely wiping out the NIH intramural programs, which is just as bad, but is flying under the radar because NIH is gagged.
Reposted by Blaise Frederick
Vermont understood the assignment.
Take notes, America.
Take notes, America.
March 2, 2025 at 3:04 AM
Vermont understood the assignment.
Take notes, America.
Take notes, America.
Reposted by Blaise Frederick
Kinda baffled too. Given the apparent zeal for whacking science, why hasn't Big Pharma been putting the squeeze on Senators to protect their turf (RFK, NIH, NSF, etc.)?
Are execs in denial? Too focused on short-term results? Or do they not understand their own scientific pipelines?
Are execs in denial? Too focused on short-term results? Or do they not understand their own scientific pipelines?
Did big pharma just forget that it has lobbyists? If a similar figure existed on the left that threatened pharma profits at even half the amount RFK will cause, then there would be a full court press against them
Most cooked of countries
February 8, 2025 at 9:04 PM
Kinda baffled too. Given the apparent zeal for whacking science, why hasn't Big Pharma been putting the squeeze on Senators to protect their turf (RFK, NIH, NSF, etc.)?
Are execs in denial? Too focused on short-term results? Or do they not understand their own scientific pipelines?
Are execs in denial? Too focused on short-term results? Or do they not understand their own scientific pipelines?
Reposted by Blaise Frederick
Corporate America just had to sit at the end of the scientific pipeline, plucking off the most promising results via the magic of "technology transfer", + then develop more advanced products to sell
All the risks of basic research were socialized, + the gains privatized
Capitalist utopia!
All the risks of basic research were socialized, + the gains privatized
Capitalist utopia!
February 8, 2025 at 11:35 PM
Corporate America just had to sit at the end of the scientific pipeline, plucking off the most promising results via the magic of "technology transfer", + then develop more advanced products to sell
All the risks of basic research were socialized, + the gains privatized
Capitalist utopia!
All the risks of basic research were socialized, + the gains privatized
Capitalist utopia!
Reposted by Blaise Frederick
Reposted by Blaise Frederick
The totality of this article seems to support the worst case reading of the memo. As far as I can tell, nearly all scientific research in the country is suspended.
January 28, 2025 at 2:50 AM
The totality of this article seems to support the worst case reading of the memo. As far as I can tell, nearly all scientific research in the country is suspended.
Does anybody know if any if the professional organizations in neuroscience/imaging like #ISMRM, #OHBM, #ACNP, or #SfN, etc. have any sort of organized effort to raise awareness of this? I’m not sure the general public has any idea this is going on.
Per an NIH source:
“Discussions with colleagues have suggested that if the universities all come together and raise hell about the delays to funding caused by not holding meetings, that might move the needle. From every state. There are well-funded universities in red states that will be impacted.”
“Discussions with colleagues have suggested that if the universities all come together and raise hell about the delays to funding caused by not holding meetings, that might move the needle. From every state. There are well-funded universities in red states that will be impacted.”
January 28, 2025 at 2:22 AM
Reposted by Blaise Frederick
OpenNeuro.org is now on Bluesky! Follow us for project updates and exciting new datasets.
OpenNeuro
OpenNeuro.org
November 18, 2024 at 7:11 PM
OpenNeuro.org is now on Bluesky! Follow us for project updates and exciting new datasets.
@ariellekeller.bsky.social - could you add me to the Human Neuroimaging starter pack? Thanks.
November 17, 2024 at 2:53 PM
@ariellekeller.bsky.social - could you add me to the Human Neuroimaging starter pack? Thanks.
Our (Dr. Cole Korponay, Dr. Amy Janes, and myself) functional connectivity inflation paper made the cover of Nature Human Behaviour!
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August 25, 2024 at 8:56 PM
Our (Dr. Cole Korponay, Dr. Amy Janes, and myself) functional connectivity inflation paper made the cover of Nature Human Behaviour!
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