Blaise Frederick
@blaisefrederick.bsky.social
A physicist who wandered into a psychiatry department and ended up obsessing about random fluctuations in cerebral circulation.
Director, Optomagnetic Group, McLean Hospital Brain Imaging Center/Assistant Professor of Psychiatry, Harvard Medical School.
Director, Optomagnetic Group, McLean Hospital Brain Imaging Center/Assistant Professor of Psychiatry, Harvard Medical School.
That’s seems pretty hard to dispute.
November 6, 2025 at 2:16 PM
That’s seems pretty hard to dispute.
I agree with the sentiment, but I don’t think anyone can legally do both 1 and 2.
November 1, 2025 at 12:12 PM
I agree with the sentiment, but I don’t think anyone can legally do both 1 and 2.
77 million people, apparently.
October 26, 2025 at 1:07 PM
77 million people, apparently.
An NYT reporter corrected a fabricated conservative talking point rather than just repeat it unchallenged? Haven’t seen that in a while.
October 10, 2025 at 11:56 PM
An NYT reporter corrected a fabricated conservative talking point rather than just repeat it unchallenged? Haven’t seen that in a while.
How is that inaccurate? The olives are literally directly below the sign.
August 31, 2025 at 1:53 AM
How is that inaccurate? The olives are literally directly below the sign.
Well, obviously yes, because it rains now.
August 5, 2025 at 2:14 PM
Well, obviously yes, because it rains now.
They have no interest in making their own lives better or more enjoyable. They are really only motivated by making other people’s lives worse.
July 17, 2025 at 3:40 PM
They have no interest in making their own lives better or more enjoyable. They are really only motivated by making other people’s lives worse.
Living systems are extremely complex. If you could fully model them to a sufficient level of detail that you could predict what they’d do in every situation, that would be great, but we’re nowhere near that.
July 16, 2025 at 11:52 PM
Living systems are extremely complex. If you could fully model them to a sufficient level of detail that you could predict what they’d do in every situation, that would be great, but we’re nowhere near that.
All of the things listed exist and are useful, but “alone, or in combination with animal models” is doing a LOT of heavy lifting.
“ChatGPT, alone or in combination with humans, can do anything humans can do”.
“ChatGPT, alone or in combination with humans, can do anything humans can do”.
July 16, 2025 at 11:48 PM
All of the things listed exist and are useful, but “alone, or in combination with animal models” is doing a LOT of heavy lifting.
“ChatGPT, alone or in combination with humans, can do anything humans can do”.
“ChatGPT, alone or in combination with humans, can do anything humans can do”.
I think it’s as simple as the fact that anybody still on Twitter at this point is fine with the way it is over there. Everybody who was bothered has left at this point.
July 11, 2025 at 12:14 PM
I think it’s as simple as the fact that anybody still on Twitter at this point is fine with the way it is over there. Everybody who was bothered has left at this point.
Repeal the Permanent Apportionment Act of 1929. That would uncap the size of the House and make the distribution of Representatives more closely match the actual population of the US. It would also make the electoral college vote better represent the actual population vote.
July 10, 2025 at 2:40 AM
Repeal the Permanent Apportionment Act of 1929. That would uncap the size of the House and make the distribution of Representatives more closely match the actual population of the US. It would also make the electoral college vote better represent the actual population vote.
It is a travesty that this bill is even coming to a vote. Thank you for being there to stand up for your constituents.
July 3, 2025 at 5:48 PM
It is a travesty that this bill is even coming to a vote. Thank you for being there to stand up for your constituents.
Oh but he does care. He’s trying to maximize the number of people he hurts.
June 27, 2025 at 1:54 AM
Oh but he does care. He’s trying to maximize the number of people he hurts.
And some don’t feel any need to obtain consent at all.
June 7, 2025 at 5:51 PM
And some don’t feel any need to obtain consent at all.
Because we're doing a data driven analysis using signals from within the brain, we don't have to make any assumptions about how the RRF or RV waveforms show up in the BOLD signal (the tacit assumption here is that the relationship is linear, which isn't a bad assumption though).
June 3, 2025 at 1:48 PM
Because we're doing a data driven analysis using signals from within the brain, we don't have to make any assumptions about how the RRF or RV waveforms show up in the BOLD signal (the tacit assumption here is that the relationship is linear, which isn't a bad assumption though).
+/-3-3.5 seconds will almost span the range of normal delays within the brain (assuming you've already delayed the RRF and RV regressors to account for transit time TO the brain), but if you have pathology, or even normal aging, that may not be broad enough.
June 3, 2025 at 1:47 PM
+/-3-3.5 seconds will almost span the range of normal delays within the brain (assuming you've already delayed the RRF and RV regressors to account for transit time TO the brain), but if you have pathology, or even normal aging, that may not be broad enough.
So I think the approach in the paper is pretty good, but I think voxel specific regressors are better because they are parsimonious and minimize the loss of degrees of freedom. They can also deal with arbitrary delay magnitudes.
June 3, 2025 at 1:45 PM
So I think the approach in the paper is pretty good, but I think voxel specific regressors are better because they are parsimonious and minimize the loss of degrees of freedom. They can also deal with arbitrary delay magnitudes.
Hey - I know I'm a bit late to this... Adding a temporal derivative deals with small delays (up to maybe 3-3.5 seconds in either direction for LFO signals). As far as I've been able to determine, blood flow through the brain is non-dispersive. So don't know if a dispersive derivative is needed.
June 3, 2025 at 1:44 PM
Hey - I know I'm a bit late to this... Adding a temporal derivative deals with small delays (up to maybe 3-3.5 seconds in either direction for LFO signals). As far as I've been able to determine, blood flow through the brain is non-dispersive. So don't know if a dispersive derivative is needed.
If you won't fight for yourself, why on earth would a client think you'd fight for them?
June 2, 2025 at 4:16 PM
If you won't fight for yourself, why on earth would a client think you'd fight for them?
_Everything_ pushes them further right.
May 9, 2025 at 12:43 AM
_Everything_ pushes them further right.
And John McCain
April 20, 2025 at 5:56 PM
And John McCain
How terrible for them. The terrible consequences were only supposed to affect 99% of the population, not the people who matter. So sad.
April 8, 2025 at 1:18 PM
How terrible for them. The terrible consequences were only supposed to affect 99% of the population, not the people who matter. So sad.
I think gemini.google.com appends "as drawn by Picasso" to the prompt.
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April 7, 2025 at 1:14 PM
I think gemini.google.com appends "as drawn by Picasso" to the prompt.