Sébastien Guizard
@bioinformaticus.bsky.social
Do some biology related stuff with computers
Reposted by Sébastien Guizard
@wytamma.bsky.social : so, it took a little bit of extra time (not the flight back from the CZI meeting), but I decided to just f#&$ing do it, and the basic code to build and parse with the auxiliary fastq index is working (github.com/COMBINE-lab/...). 1/2
GitHub - COMBINE-lab/mim: A small, auxiliary index to massively improve parallel fastq parsing
A small, auxiliary index to massively improve parallel fastq parsing - COMBINE-lab/mim
github.com
November 19, 2025 at 3:01 AM
@wytamma.bsky.social : so, it took a little bit of extra time (not the flight back from the CZI meeting), but I decided to just f#&$ing do it, and the basic code to build and parse with the auxiliary fastq index is working (github.com/COMBINE-lab/...). 1/2
Reposted by Sébastien Guizard
New Publication:
Structural variant landscape provides insights into genome organisation and domestication in European seabass
@roslininstitute.bsky.social @thedickvet.bsky.social
bmcbiol.biomedcentral.com/articles/10....
Structural variant landscape provides insights into genome organisation and domestication in European seabass
@roslininstitute.bsky.social @thedickvet.bsky.social
bmcbiol.biomedcentral.com/articles/10....
Structural variant landscape provides insights into genome organisation and domestication in European seabass - BMC Biology
Background Structural variants (SVs) are genetic polymorphisms including deletions, insertions, inversions, and duplications, with potential to influence traits through impacts on gene function and ex...
bmcbiol.biomedcentral.com
November 13, 2025 at 11:22 AM
New Publication:
Structural variant landscape provides insights into genome organisation and domestication in European seabass
@roslininstitute.bsky.social @thedickvet.bsky.social
bmcbiol.biomedcentral.com/articles/10....
Structural variant landscape provides insights into genome organisation and domestication in European seabass
@roslininstitute.bsky.social @thedickvet.bsky.social
bmcbiol.biomedcentral.com/articles/10....
Reposted by Sébastien Guizard
Les fantômes numériques, ou quand l'IA se mêle du deuil : ma nouvelle vidéo "Nos morts 2.0" est en ligne !
L'épisode est éprouvant mais les questions valent la peine d'être posées.
C'est ici ➡️ www.youtube.com/watch?v=FtJ_...
L'épisode est éprouvant mais les questions valent la peine d'être posées.
C'est ici ➡️ www.youtube.com/watch?v=FtJ_...
November 12, 2025 at 6:06 PM
Les fantômes numériques, ou quand l'IA se mêle du deuil : ma nouvelle vidéo "Nos morts 2.0" est en ligne !
L'épisode est éprouvant mais les questions valent la peine d'être posées.
C'est ici ➡️ www.youtube.com/watch?v=FtJ_...
L'épisode est éprouvant mais les questions valent la peine d'être posées.
C'est ici ➡️ www.youtube.com/watch?v=FtJ_...
Reposted by Sébastien Guizard
SC-Framework: A robust and FAIR semi-interactive environment for single-cell resolution datasets https://www.biorxiv.org/content/10.1101/2025.11.11.687874v1
November 13, 2025 at 3:31 PM
SC-Framework: A robust and FAIR semi-interactive environment for single-cell resolution datasets https://www.biorxiv.org/content/10.1101/2025.11.11.687874v1
Reposted by Sébastien Guizard
Our Springer Nature book is just published! Big thanks to the co-editor Chris Rinke
@chrisrinke.bsky.social and to all book contributors, coming from @i2sysbio.es, @jgi.doe.gov and many other institutes I couldn't find on BlueSky
link.springer.com/book/10.1007...
#microsky #singlecell #genomics 🧪🦠
@chrisrinke.bsky.social and to all book contributors, coming from @i2sysbio.es, @jgi.doe.gov and many other institutes I couldn't find on BlueSky
link.springer.com/book/10.1007...
#microsky #singlecell #genomics 🧪🦠
Single-Cell Omics in Microbiome Research
This volume introduces single-cell microbial (gen)omics as an innovative approach to study microbial diversity and symbiosis
link.springer.com
November 10, 2025 at 4:30 PM
Our Springer Nature book is just published! Big thanks to the co-editor Chris Rinke
@chrisrinke.bsky.social and to all book contributors, coming from @i2sysbio.es, @jgi.doe.gov and many other institutes I couldn't find on BlueSky
link.springer.com/book/10.1007...
#microsky #singlecell #genomics 🧪🦠
@chrisrinke.bsky.social and to all book contributors, coming from @i2sysbio.es, @jgi.doe.gov and many other institutes I couldn't find on BlueSky
link.springer.com/book/10.1007...
#microsky #singlecell #genomics 🧪🦠
Reposted by Sébastien Guizard
It's important to remember that while the degree to which James Watson deliberately stole from Rosalind Franklin is still in dispute, he also shit on her in his memoir for no apparent reason other than to save face and then spent the last two decades of his life pushing bullshit race science.
November 8, 2025 at 12:31 AM
It's important to remember that while the degree to which James Watson deliberately stole from Rosalind Franklin is still in dispute, he also shit on her in his memoir for no apparent reason other than to save face and then spent the last two decades of his life pushing bullshit race science.
Reposted by Sébastien Guizard
Have you mastered the art of stacking your panes in your favorite terminal environment? 🥞 🇵🇦
Check out this tutorial on stacked panes, stacked resize and floating panes - so that your zellij is organized just the way you like it. Text tutorial is in the description!
www.youtube.com/watch?v=cQYl...
Check out this tutorial on stacked panes, stacked resize and floating panes - so that your zellij is organized just the way you like it. Text tutorial is in the description!
www.youtube.com/watch?v=cQYl...
Zellij Stacked Resize and Pinned Floating Panes Tutorial
YouTube video by Zellij_dev
www.youtube.com
November 6, 2025 at 4:31 PM
Have you mastered the art of stacking your panes in your favorite terminal environment? 🥞 🇵🇦
Check out this tutorial on stacked panes, stacked resize and floating panes - so that your zellij is organized just the way you like it. Text tutorial is in the description!
www.youtube.com/watch?v=cQYl...
Check out this tutorial on stacked panes, stacked resize and floating panes - so that your zellij is organized just the way you like it. Text tutorial is in the description!
www.youtube.com/watch?v=cQYl...
Reposted by Sébastien Guizard
QIAGEN to acquire Parse Biosciences corporate.qiagen.com/English/news...
QIAGEN to acquire Parse Biosciences, expanding its Sample technologies portfolio into highly scalable single-cell solutions
Parse Biosciences is a fast-growing innovator in single-cell sample preparation, with technologies used in more than 3,000 labs across over 40 countries Acquisition strengthens QIAGEN’s presence in th...
corporate.qiagen.com
November 4, 2025 at 9:32 PM
QIAGEN to acquire Parse Biosciences corporate.qiagen.com/English/news...
Reposted by Sébastien Guizard
Grokipedia a-t-il une assise solide ? Tibo InShape fait-il réellement des expériences sociales avec Sora ? La revue du fake d'hier soir est dispo en replay.
📰 Revue du fake - 03/11/25
YouTube video by Defakator [Replays Twitch]
youtu.be
November 4, 2025 at 10:10 PM
Grokipedia a-t-il une assise solide ? Tibo InShape fait-il réellement des expériences sociales avec Sora ? La revue du fake d'hier soir est dispo en replay.
Reposted by Sébastien Guizard
For when your old windows machine catches fire?
November 4, 2025 at 10:22 PM
For when your old windows machine catches fire?
Reposted by Sébastien Guizard
💙 "Python Foundation goes ride or DEI, rejects government grant with strings attached"
www.theregister.com/2025/10/27/p...
www.theregister.com/2025/10/27/p...
Python Foundation rejects $1.5M grant with no-DEI strings
: Foundation says it won't compromise policy of inclusivity even if that cash would've really helped
www.theregister.com
November 3, 2025 at 7:01 AM
💙 "Python Foundation goes ride or DEI, rejects government grant with strings attached"
www.theregister.com/2025/10/27/p...
www.theregister.com/2025/10/27/p...
Reposted by Sébastien Guizard
15 million Americans are going to lose their health care.
October 31, 2025 at 10:04 PM
15 million Americans are going to lose their health care.
Reposted by Sébastien Guizard
Monty Python understood p-hacking
October 23, 2025 at 8:43 AM
Monty Python understood p-hacking
Reposted by Sébastien Guizard
This is very good
October 22, 2025 at 11:52 PM
This is very good
Reposted by Sébastien Guizard
mRNA vaccines seem to work synergistically w/ cancer immunotherapy.
In patients, the vaccine acts like a siren that triggers the release of immune signaling proteins, instructing the immune system to attack tumors.
We need to funding for mRNA based therapeutics.
🧪 www.science.org/content/arti...
In patients, the vaccine acts like a siren that triggers the release of immune signaling proteins, instructing the immune system to attack tumors.
We need to funding for mRNA based therapeutics.
🧪 www.science.org/content/arti...
A surprise bonus from COVID-19 vaccines: bolstering cancer treatment
Patients who got shots of mRNA before starting a type of cancer immunotherapy lived much longer
www.science.org
October 22, 2025 at 3:14 PM
mRNA vaccines seem to work synergistically w/ cancer immunotherapy.
In patients, the vaccine acts like a siren that triggers the release of immune signaling proteins, instructing the immune system to attack tumors.
We need to funding for mRNA based therapeutics.
🧪 www.science.org/content/arti...
In patients, the vaccine acts like a siren that triggers the release of immune signaling proteins, instructing the immune system to attack tumors.
We need to funding for mRNA based therapeutics.
🧪 www.science.org/content/arti...
Reposted by Sébastien Guizard
📣 A new fellowship launched by @biofair.bsky.social will build a skilled community of technical professionals to embed #FAIRdata practices across the UK #lifesciences.
@nsoranzo.bsky.social @elixiruknode.org
@nsoranzo.bsky.social @elixiruknode.org
New fellowship launched to embed FAIR data across the UK life sciences
The Fellowship brings together a diverse group of individuals from across the UK life sciences ecosystem to drive sustainable cultural change in data management.
buff.ly
October 20, 2025 at 9:01 AM
📣 A new fellowship launched by @biofair.bsky.social will build a skilled community of technical professionals to embed #FAIRdata practices across the UK #lifesciences.
@nsoranzo.bsky.social @elixiruknode.org
@nsoranzo.bsky.social @elixiruknode.org
Reposted by Sébastien Guizard
Edinburgh castle failing to render, likely thanks to the AWS outage
October 20, 2025 at 8:35 AM
Edinburgh castle failing to render, likely thanks to the AWS outage
Reposted by Sébastien Guizard
I wasn’t exaggerating it rules so hard
October 19, 2025 at 12:53 AM
I wasn’t exaggerating it rules so hard
Reposted by Sébastien Guizard
Le pouvoir américain en est au stade où le président poste une vidéo générée par IA de lui-même portant une couronne royale et pilotant un avion de chasse qui déverse de la diarrhée sur les manifestants du mouvement No King
Je pense que c’est inutile de commenter davantage, tout est dit
Je pense que c’est inutile de commenter davantage, tout est dit
Trump posts AI video showing him literally dumping shit on America
October 19, 2025 at 6:52 AM
Le pouvoir américain en est au stade où le président poste une vidéo générée par IA de lui-même portant une couronne royale et pilotant un avion de chasse qui déverse de la diarrhée sur les manifestants du mouvement No King
Je pense que c’est inutile de commenter davantage, tout est dit
Je pense que c’est inutile de commenter davantage, tout est dit
Reposted by Sébastien Guizard
This makes so much sense. Never call a plumber of electrician to fix things at your house: just do your own research
RFK Jr: We need to stop trusting the experts... Trusting the experts is not a feature of science or democracy, it's a feature of religion and totalitarianism.
October 16, 2025 at 11:22 AM
This makes so much sense. Never call a plumber of electrician to fix things at your house: just do your own research
Reposted by Sébastien Guizard
The Nobel verdict! 💯🤣
October 10, 2025 at 11:28 AM
The Nobel verdict! 💯🤣
Reposted by Sébastien Guizard
"Une solution majeure à une arnaque"... qui elle-même est une arnaque. C'est littéralement une promesse impossible à tenir. Mathématiquement, baisser de 300% ça veut dire rendre de l'argent à ceux qui achètent. Est-ce qu'il reste quelqu'un qui réfléchisse à ce que cette administration raconte ?
October 8, 2025 at 6:05 AM
"Une solution majeure à une arnaque"... qui elle-même est une arnaque. C'est littéralement une promesse impossible à tenir. Mathématiquement, baisser de 300% ça veut dire rendre de l'argent à ceux qui achètent. Est-ce qu'il reste quelqu'un qui réfléchisse à ce que cette administration raconte ?
Reposted by Sébastien Guizard
Meta open-sources OpenZL
A new data compression library and training tools to generator specialized compressors for structured data, achieving performance levels inaccessible to classic generic algorithms.
github.com/facebook/ope...
A new data compression library and training tools to generator specialized compressors for structured data, achieving performance levels inaccessible to classic generic algorithms.
github.com/facebook/ope...
GitHub - facebook/openzl: A novel data compression framework
A novel data compression framework. Contribute to facebook/openzl development by creating an account on GitHub.
github.com
October 7, 2025 at 1:03 AM
Meta open-sources OpenZL
A new data compression library and training tools to generator specialized compressors for structured data, achieving performance levels inaccessible to classic generic algorithms.
github.com/facebook/ope...
A new data compression library and training tools to generator specialized compressors for structured data, achieving performance levels inaccessible to classic generic algorithms.
github.com/facebook/ope...
Reposted by Sébastien Guizard
🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq - Nature Genetics
This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TFs and cellular heterogeneity by mapping TF dose-dependent transcriptomic changes during the reprogramming of mouse embryonic multipotent stromal cells.
www.nature.com
October 6, 2025 at 6:57 AM
🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China