Objective To assess the quality, biases, and validity of evidence on maternal paracetamol (acetaminophen) use during pregnancy and the risk of autism spectrum disorder (referred to as autism) and atte...

Objective To compare the effect on health outcomes of continuing or discontinuing oral anticoagulants (OACs) among patients with unprovoked venous thromboembolism (VTE) after initial treatment for at ...

CKD is a major global health issue, with rising prevalence and increasing importance as a cause of death and as a risk factor for cardiovascular death. A better understating of aetiology, appropriate ...

Hypokalemia and even low-normal plasma potassium levels increase the risk of ventricular arrhythmias among patients with cardiovascular disease. An assessment of a strategy of actively increasing p...

Among older adults with frailty, evidence on the benefits and risks of discontinuing antihypertensive drugs is limited. In a multicenter, randomized, controlled trial conducted in France, we assign...

BACKGROUND: SGLT2 (sodium-glucose cotransporter-2) inhibitors reduce the risk of cardiovascular death or worsening heart failure (HF) in outpatients with HF. Data on initiation in patients hospitalize...

I have spent a lot of time summarizing the evidence and trying to dispel myths when it comes to contrast and kidney injury. (Bottom line: we have massive amounts of evidence, and in controlled studies with modern contrast agents, we cannot find even the smallest hint of harm from contrast.) However, there is another persistent aggravation when it comes to ordering contrast CTs: allergies and arcane allergy protocols.

Cefazolin constitutes an alternative to cloxacillin for the treatment of MSSA bacteraemia, offering non-inferior clinical efficacy and potentially enhanced tolerability.

In patients with shock, whether noninvasive blood-pressure monitoring is an effective alternative to the recommended use of an arterial catheter is uncertain. In this multicenter, open-label, nonin...

Patients with previously untreated, locally advanced, unresectable or metastatic triple-negative breast cancer who are not candidates for inhibitors of programmed cell death protein 1 (PD-1) or pro...

Current guideline recommendations for the use of beta-blockers after myocardial infarction without reduced ejection fraction are based on trials conducted before routine reperfusion, invasive care,...

Background Awareness has recently risen about the potential associated risks to the cardiovascular health of cannabis users. The objective was to evaluate the possible association between major advers...

Barrett’s esophagus (BE) is the only identifiable precursor to esophageal adenocarcinoma (EAC). Endoscopic surveillance has been proposed for early detection of BE-related neoplasia and reducing EAC m...

Guidelines evaluate and summarize available evidence with the aim of assisting health professionals in proposing the best diagnostic or therapeutic approac

This randomized clinical trial examines the effect of fractional flow reserve–guided complete coronary revascularization of nonculprit lesions vs culprit-only revascularization in patients with non–ST...