Badreddine Douzi
@badreddinedouzi.bsky.social
INRAe Researcher Scientist @ Nancy
Having fun to use microbiology, structural biology and biochemistry to understand mechanisms underlying proteins and DNA transport across bacterial envelope.
Having fun to use microbiology, structural biology and biochemistry to understand mechanisms underlying proteins and DNA transport across bacterial envelope.
Reposted by Badreddine Douzi
Coup de projecteur sur des projets en rupture et à haut risque du programme EXPLOR’AE
✔️39 idées exploration et 5 projets transformation déjà financés #France2030
Des hypothèses originales pour des innovations de rupture, des recherches qui sortent des sentiers battus !
url.inrae.fr/44ySyng
✔️39 idées exploration et 5 projets transformation déjà financés #France2030
Des hypothèses originales pour des innovations de rupture, des recherches qui sortent des sentiers battus !
url.inrae.fr/44ySyng
EXPLOR’AE : INRAE dévoile des projets de recherche en rupture et à haut risque
DOSSIER DE PRESSE - Le programme France 2030 « Accélération de la recherche à risque en Agriculture, Alimentation et Environnement » EXPLOR’AE offre un cadre inédit pour soutenir des projets de recher...
url.inrae.fr
April 16, 2025 at 9:08 AM
Coup de projecteur sur des projets en rupture et à haut risque du programme EXPLOR’AE
✔️39 idées exploration et 5 projets transformation déjà financés #France2030
Des hypothèses originales pour des innovations de rupture, des recherches qui sortent des sentiers battus !
url.inrae.fr/44ySyng
✔️39 idées exploration et 5 projets transformation déjà financés #France2030
Des hypothèses originales pour des innovations de rupture, des recherches qui sortent des sentiers battus !
url.inrae.fr/44ySyng
Reposted by Badreddine Douzi
#AMR Nice summary of the new hope www.thevermilion.com/why-could-a-...
Why could a new class of antibiotics really make a difference?
The discovery of penicillin dates back to 1928. And since then, antibiotics have contributed to saving millions of lives all over the world, extending the average duration of human life by 23 years. I...
www.thevermilion.com
March 29, 2025 at 6:23 AM
#AMR Nice summary of the new hope www.thevermilion.com/why-could-a-...
Reposted by Badreddine Douzi
New antibiotic class discovered by researchers at @mcmasteruniversity.bsky.social & @illinoispress.bsky.social
"A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome"
in @nature.com
Hope it can make it to market to help combat #AMR infections
www.nature.com/articles/s41...
"A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome"
in @nature.com
Hope it can make it to market to help combat #AMR infections
www.nature.com/articles/s41...
A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome - Nature
A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...
www.nature.com
March 28, 2025 at 10:27 AM
New antibiotic class discovered by researchers at @mcmasteruniversity.bsky.social & @illinoispress.bsky.social
"A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome"
in @nature.com
Hope it can make it to market to help combat #AMR infections
www.nature.com/articles/s41...
"A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome"
in @nature.com
Hope it can make it to market to help combat #AMR infections
www.nature.com/articles/s41...
Reposted by Badreddine Douzi
We are looking for a postdoc!
Join us to work in an exciting integrated structural biology project, focusing on understanding how Type 4 Secretion System facilitate horizontal gene transfer in bacteria!
Please share!
www.nature.com/naturecareer...
Join us to work in an exciting integrated structural biology project, focusing on understanding how Type 4 Secretion System facilitate horizontal gene transfer in bacteria!
Please share!
www.nature.com/naturecareer...
Postdoctoral position to study Gram-positive Type 4 Secretion Systems - Umeå, Sweden job with Umeå University | 12837918
A two-year Postdoctoral position for studies of Gram-positive Type 4 Secretion Systems that facilitate the spread of antibiotic resistance
www.nature.com
March 14, 2025 at 3:00 PM
We are looking for a postdoc!
Join us to work in an exciting integrated structural biology project, focusing on understanding how Type 4 Secretion System facilitate horizontal gene transfer in bacteria!
Please share!
www.nature.com/naturecareer...
Join us to work in an exciting integrated structural biology project, focusing on understanding how Type 4 Secretion System facilitate horizontal gene transfer in bacteria!
Please share!
www.nature.com/naturecareer...
Reposted by Badreddine Douzi
www.nature.com/articles/s41...
In collaboration with Andrew Lang and Alison Buchan, we just published a review on the complex and sometimes convoluted interactions and evolutionary relationships among bacterial mobile genetic elements.
#phage #plasmid #evolution #bacteria #plasmidbiology #MGE
In collaboration with Andrew Lang and Alison Buchan, we just published a review on the complex and sometimes convoluted interactions and evolutionary relationships among bacterial mobile genetic elements.
#phage #plasmid #evolution #bacteria #plasmidbiology #MGE
Interactions and evolutionary relationships among bacterial mobile genetic elements - Nature Reviews Microbiology
In this Review, Lang and colleagues present an overview of the current knowledge landscape regarding mobile genetic elements in bacteria, with a focus on their evolutionary relationships and interacti...
www.nature.com
March 11, 2025 at 1:12 PM
www.nature.com/articles/s41...
In collaboration with Andrew Lang and Alison Buchan, we just published a review on the complex and sometimes convoluted interactions and evolutionary relationships among bacterial mobile genetic elements.
#phage #plasmid #evolution #bacteria #plasmidbiology #MGE
In collaboration with Andrew Lang and Alison Buchan, we just published a review on the complex and sometimes convoluted interactions and evolutionary relationships among bacterial mobile genetic elements.
#phage #plasmid #evolution #bacteria #plasmidbiology #MGE
Reposted by Badreddine Douzi
We organize the french EPR society meeting at the @iecb.bsky.social in Bordeaux. Registration are due soon! More info here : www.a-rpe.fr/spip.php?art...
Journées de l’ARPE 2025 - L’Association française de Résonance Paramagnétique Electronique (ARPE)
Cette année les journées de l'ARPE se délocalisent à Bordeaux ! Les journées de l'ARPE 2025 se délocalisent à Bordeaux, à l'EICB (Institut (…)
www.a-rpe.fr
January 31, 2025 at 8:24 AM
We organize the french EPR society meeting at the @iecb.bsky.social in Bordeaux. Registration are due soon! More info here : www.a-rpe.fr/spip.php?art...
Reposted by Badreddine Douzi
Exciting to see our paper now published 🙌
www.science.org/doi/10.1126/...
In this project co-led with @ostermanilya.bsky.social at @soreklab.bsky.social , we show that a bacterial immune system employs a TIR protein and a caspase-like protease, two typical immune components seen in eukaryotes. 🧵👇
www.science.org/doi/10.1126/...
In this project co-led with @ostermanilya.bsky.social at @soreklab.bsky.social , we show that a bacterial immune system employs a TIR protein and a caspase-like protease, two typical immune components seen in eukaryotes. 🧵👇
January 31, 2025 at 11:41 AM
Exciting to see our paper now published 🙌
www.science.org/doi/10.1126/...
In this project co-led with @ostermanilya.bsky.social at @soreklab.bsky.social , we show that a bacterial immune system employs a TIR protein and a caspase-like protease, two typical immune components seen in eukaryotes. 🧵👇
www.science.org/doi/10.1126/...
In this project co-led with @ostermanilya.bsky.social at @soreklab.bsky.social , we show that a bacterial immune system employs a TIR protein and a caspase-like protease, two typical immune components seen in eukaryotes. 🧵👇
Reposted by Badreddine Douzi
Exciting stuff! will be interesting to test this on our own favourite protein ensembles!
Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 6, 2024 at 12:14 PM
Exciting stuff! will be interesting to test this on our own favourite protein ensembles!
Reposted by Badreddine Douzi
Well, this is silly. Clarivate won’t give @elife.bsky.social an impact factor, citing quality concerns with their model, but happily does so for partially predatory journals like those within MDPI?
www.science.org/content/arti...
www.science.org/content/arti...
Open-access journal elife will lose its ‘impact factor’ over controversial publishing model
Web of Science index decides to strip key metric because elife’s unusual peer review doesn’t meet its criteria
www.science.org
December 7, 2024 at 2:06 PM
Well, this is silly. Clarivate won’t give @elife.bsky.social an impact factor, citing quality concerns with their model, but happily does so for partially predatory journals like those within MDPI?
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Badreddine Douzi
New review from our C. Lesterlin/TacC lab ! 🌟 The potential and limitations of conjugation-based antibacterial strategies. doi.org/10.1111/1751...
Design, potential and limitations of conjugation‐based antibacterial strategies
Highlighting of innovative non-antibiotic strategies, specifically CRISPR-based systems delivered via bacterial conjugation.
doi.org
November 19, 2024 at 8:22 AM
New review from our C. Lesterlin/TacC lab ! 🌟 The potential and limitations of conjugation-based antibacterial strategies. doi.org/10.1111/1751...
Reposted by Badreddine Douzi
Re-sharing our last paper on the effect of restriction-modification systems on conjugative plasmids: doi.org/10.1093/nar/... #MicroSky
Various plasmid strategies limit the effect of bacterial restriction–modification systems against conjugation
Abstract. In bacteria, genes conferring antibiotic resistance are mostly carried on conjugative plasmids, mobile genetic elements that spread horizontally
doi.org
November 18, 2024 at 5:32 PM
Re-sharing our last paper on the effect of restriction-modification systems on conjugative plasmids: doi.org/10.1093/nar/... #MicroSky
Reposted by Badreddine Douzi
And finally, a recent review we wrote speculating on the evolutionary aspects of MGEs mobilising chromosomal DNA
New review paper led by Mick Vos (currently not on social media)
Why do mobile genetic elements transfer DNA of their hosts?: Trends in Genetics www.cell.com/trends/genet...
Why do mobile genetic elements transfer DNA of their hosts?: Trends in Genetics www.cell.com/trends/genet...
Why do mobile genetic elements transfer DNA of their hosts?
The prokaryote world is replete with mobile genetic elements (MGEs) – self-replicating
entities that can move within and between their hosts. Many MGEs not only transfer
their own DNA to new hosts but...
www.cell.com
November 18, 2024 at 6:45 PM
And finally, a recent review we wrote speculating on the evolutionary aspects of MGEs mobilising chromosomal DNA
Reposted by Badreddine Douzi
The contribution of natural transformation for the acquisition of novel genes has been notoriously difficult to quantify because it relies on recombination (which is affected by other processes). Here's a first estimate : doi.org/10.1101/2025... (for the very busy: 1-6% of gene gains) #MicroSky
January 27, 2025 at 1:11 PM
The contribution of natural transformation for the acquisition of novel genes has been notoriously difficult to quantify because it relies on recombination (which is affected by other processes). Here's a first estimate : doi.org/10.1101/2025... (for the very busy: 1-6% of gene gains) #MicroSky
Happy to see this story out!
Elucidating assembly and function of VirB8 cell wall subunits refines the DNA translocation model in Gram-positive T4SSs | Science Advances www.science.org/doi/10.1126/...
Thanks to all colleagues and collaborators!
With support of INRAe, Université de Lorraine and ANR.
Elucidating assembly and function of VirB8 cell wall subunits refines the DNA translocation model in Gram-positive T4SSs | Science Advances www.science.org/doi/10.1126/...
Thanks to all colleagues and collaborators!
With support of INRAe, Université de Lorraine and ANR.
Elucidating assembly and function of VirB8 cell wall subunits refines the DNA translocation model in Gram-positive T4SSs
Structure-function exploration of VirB8-like subunits paves the way to better understand T4SSs in Gram-positive bacteria.
www.science.org
January 26, 2025 at 10:01 PM
Happy to see this story out!
Elucidating assembly and function of VirB8 cell wall subunits refines the DNA translocation model in Gram-positive T4SSs | Science Advances www.science.org/doi/10.1126/...
Thanks to all colleagues and collaborators!
With support of INRAe, Université de Lorraine and ANR.
Elucidating assembly and function of VirB8 cell wall subunits refines the DNA translocation model in Gram-positive T4SSs | Science Advances www.science.org/doi/10.1126/...
Thanks to all colleagues and collaborators!
With support of INRAe, Université de Lorraine and ANR.
