Stephen Graham's Lab
@atomicvirology.bsky.social
Lab in the University of Cambridge 🇬🇧 studying the cell biology, biophysics and structural biology of virus infection. Blame Stephen 🇦🇺 for the content.
Just published in JBC @asbmbjournals.bsky.social - HSV-1 pUL21 teaches us that the universe of protein phosphatase 1 (PP1) binders may be much larger than previously recognised: www.jbc.org/article/S002...
Bluetorial at bsky.app/profile/atom...
Viruses - is there anything they can't do? 🦠💪
Bluetorial at bsky.app/profile/atom...
Viruses - is there anything they can't do? 🦠💪
November 15, 2025 at 10:17 AM
Just published in JBC @asbmbjournals.bsky.social - HSV-1 pUL21 teaches us that the universe of protein phosphatase 1 (PP1) binders may be much larger than previously recognised: www.jbc.org/article/S002...
Bluetorial at bsky.app/profile/atom...
Viruses - is there anything they can't do? 🦠💪
Bluetorial at bsky.app/profile/atom...
Viruses - is there anything they can't do? 🦠💪
Reposted by Stephen Graham's Lab
Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here.
www.cam.ac.uk/jobs/faculty...
www.cam.ac.uk/jobs/faculty...
Faculty Position in Computational Biology
Applications are invited for an Assistant/ Associate Professorship in Computational Biology to commence on 1 April 2026 or shortly thereafter. This is a joint post between the Department of Applied
www.cam.ac.uk
November 11, 2025 at 9:05 PM
Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here.
www.cam.ac.uk/jobs/faculty...
www.cam.ac.uk/jobs/faculty...
Reposted by Stephen Graham's Lab
I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.
October 24, 2025 at 5:44 PM
I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.
Reposted by Stephen Graham's Lab
Earlier this year we took our Escape Lab outreach activity on the road, funded by @microbiologysociety.org & @biochemsoc.bsky.social Outreach Grants. We had a blast teaching kids about viruses & the drug discovery process. Check out how Microbiology Society's Adam & Clare got on with Escape Lab!
Like Escape rooms? 🧐 What about Escape LABS! 🥳 Microbiology Society staff, Adam and Clare, travelled to De Montfort University, Leicester, UK, to take on an interactive lab-themed activity. @shivkumarlab.bsky.social Watch the video here: microb.io/4mbADZa
September 25, 2025 at 11:20 AM
Earlier this year we took our Escape Lab outreach activity on the road, funded by @microbiologysociety.org & @biochemsoc.bsky.social Outreach Grants. We had a blast teaching kids about viruses & the drug discovery process. Check out how Microbiology Society's Adam & Clare got on with Escape Lab!
Reposted by Stephen Graham's Lab
Our first post on here and it's a doozy 😍🤩. Our epic piece on #sarbecovirus host range. #virology #sars2 #covid #vaccines. Enjoy and please repost. www.biorxiv.org/content/10.1...
Understanding the future risk of bat coronavirus spillover into humans: correlating sarbecovirus receptor usage, host range, and antigenicity.
Sarbecoviruses interact with their receptor, angiotensin converting enzyme 2 (ACE2), via the receptor binding domain (RBD) of Spike, the immunodominant target for neutralising antibodies. Understandin...
www.biorxiv.org
September 9, 2025 at 3:02 PM
Our first post on here and it's a doozy 😍🤩. Our epic piece on #sarbecovirus host range. #virology #sars2 #covid #vaccines. Enjoy and please repost. www.biorxiv.org/content/10.1...
#Oropouche virus news!! @ukhsa.bsky.social has mapped the evidence for Oropouche virus epidemiology, vectors and ecology, virology, pathogenesis, medical countermeasures and public health:
www.gov.uk/government/p...
An incredibly useful resource to guide future research and funding
www.gov.uk/government/p...
An incredibly useful resource to guide future research and funding
Oropouche virus: a rapid evidence gap map
This rapid evidence gap map identifies and categorises the available evidence on Oropouche virus to inform research prioritisation.
www.gov.uk
August 14, 2025 at 11:17 AM
#Oropouche virus news!! @ukhsa.bsky.social has mapped the evidence for Oropouche virus epidemiology, vectors and ecology, virology, pathogenesis, medical countermeasures and public health:
www.gov.uk/government/p...
An incredibly useful resource to guide future research and funding
www.gov.uk/government/p...
An incredibly useful resource to guide future research and funding
Now published in @embomolmed.org 🥳🎉
Protein-based tools for detection and characterisation of #Oropouche virus infection...
See the final paper at doi.org/10.1038/s443... and read the bluetorial 👇
Protein-based tools for detection and characterisation of #Oropouche virus infection...
See the final paper at doi.org/10.1038/s443... and read the bluetorial 👇
August 11, 2025 at 6:02 PM
Now published in @embomolmed.org 🥳🎉
Protein-based tools for detection and characterisation of #Oropouche virus infection...
See the final paper at doi.org/10.1038/s443... and read the bluetorial 👇
Protein-based tools for detection and characterisation of #Oropouche virus infection...
See the final paper at doi.org/10.1038/s443... and read the bluetorial 👇
Fridge is stacked, marquee is up, house didn't need cleaning because it's always super tidy...😬🤥
I think we're ready for the lab summer garden party!
I think we're ready for the lab summer garden party!
August 9, 2025 at 11:42 AM
Fridge is stacked, marquee is up, house didn't need cleaning because it's always super tidy...😬🤥
I think we're ready for the lab summer garden party!
I think we're ready for the lab summer garden party!
Great job @danielacl.bsky.social presenting this work at #IHW2025. Missed the talk? You can still catch her at poster 3.14 this evening!
July 27, 2025 at 9:59 AM
Great job @danielacl.bsky.social presenting this work at #IHW2025. Missed the talk? You can still catch her at poster 3.14 this evening!
How does #herpes hijack a human phosphatase to promote virus replication? We have a new @biorxivpreprint.bsky.social preprint showing how #HSV and #VZV use a novel motif to compete with canonical cellular #PP1 adaptors.
www.biorxiv.org/content/10.1...
🧵👇
www.biorxiv.org/content/10.1...
🧵👇
Alphaherpesvirus pUL21 homologues use non-canonical motifs to compete with cellular adaptors for protein phosphatase 1 binding
Protein phosphatase 1 (PP1) is a key regulator of cellular phosphorylation and its activity is regulated via binding to cellular regulatory proteins via conserved short linear motifs (SLiMs). The herp...
www.biorxiv.org
July 27, 2025 at 8:12 AM
How does #herpes hijack a human phosphatase to promote virus replication? We have a new @biorxivpreprint.bsky.social preprint showing how #HSV and #VZV use a novel motif to compete with canonical cellular #PP1 adaptors.
www.biorxiv.org/content/10.1...
🧵👇
www.biorxiv.org/content/10.1...
🧵👇
Barnstorming talk by @danandviruses.bsky.social on his work looking at HSV infection is neurons and its ability to alter neuronal firing 💯👏
Missed the talk? You can still catch Dan at his poster tomorrow night (3.59). #IHW2025
Missed the talk? You can still catch Dan at his poster tomorrow night (3.59). #IHW2025
July 26, 2025 at 7:42 AM
Barnstorming talk by @danandviruses.bsky.social on his work looking at HSV infection is neurons and its ability to alter neuronal firing 💯👏
Missed the talk? You can still catch Dan at his poster tomorrow night (3.59). #IHW2025
Missed the talk? You can still catch Dan at his poster tomorrow night (3.59). #IHW2025
July 25, 2025 at 1:01 PM
Do viruses control protein translation using riboswitches? Via protein-mediated regulation of -1 programmed ribosomal frameshifting? We think the do. Very happy to have played a (small) part in this epic paper by @jemmabetts.bsky.social, @chillzaa.bsky.social and colleagues. See 👇for bluetorial.
New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
A new protein-dependent riboswitch activates ribosomal frameshifting
Programmed -1 ribosomal frameshifting (PRF) is a ubiquitous translational control mechanism in RNA viruses, allowing them to change the relative abundance of proteins encoded in different reading fram...
www.biorxiv.org
July 20, 2025 at 9:04 AM
Do viruses control protein translation using riboswitches? Via protein-mediated regulation of -1 programmed ribosomal frameshifting? We think the do. Very happy to have played a (small) part in this epic paper by @jemmabetts.bsky.social, @chillzaa.bsky.social and colleagues. See 👇for bluetorial.
Reposted by Stephen Graham's Lab
New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
A new protein-dependent riboswitch activates ribosomal frameshifting
Programmed -1 ribosomal frameshifting (PRF) is a ubiquitous translational control mechanism in RNA viruses, allowing them to change the relative abundance of proteins encoded in different reading fram...
www.biorxiv.org
July 19, 2025 at 3:10 PM
New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨
www.biorxiv.org/content/10.1...
Reposted by Stephen Graham's Lab
It's Harrison Ford's birthday today, thus we are contractually obligated to point you to this ridiculous classic from our archives.
Back from Yet Another Globetrotting Adventure, Indiana Jones Checks His Mail and Discovers That His Bid for Tenure Has Been Denied
January 22, 1939 Assistant Professor Henry “Indiana” Jones Jr. Department of Anthropology Chapman Hall 227B Marshall College Dr. Jones: As chairman...
buff.ly
July 14, 2025 at 1:30 AM
It's Harrison Ford's birthday today, thus we are contractually obligated to point you to this ridiculous classic from our archives.
Reposted by Stephen Graham's Lab
Enteroviruses use two start sites to gain an edge 🦠🧬 #Enterovirus
Check out the latest @reviewcommons.org #preprintpeerreview of this study Lulla @valerialulla.bsky.social @cam.ac.uk
Reviews and author's reply here 👇
doi.org/10.1101/2025...
Check out the latest @reviewcommons.org #preprintpeerreview of this study Lulla @valerialulla.bsky.social @cam.ac.uk
Reviews and author's reply here 👇
doi.org/10.1101/2025...
June 27, 2025 at 9:16 AM
Enteroviruses use two start sites to gain an edge 🦠🧬 #Enterovirus
Check out the latest @reviewcommons.org #preprintpeerreview of this study Lulla @valerialulla.bsky.social @cam.ac.uk
Reviews and author's reply here 👇
doi.org/10.1101/2025...
Check out the latest @reviewcommons.org #preprintpeerreview of this study Lulla @valerialulla.bsky.social @cam.ac.uk
Reviews and author's reply here 👇
doi.org/10.1101/2025...
Reposted by Stephen Graham's Lab
I am recruiting - if you have a background in plant mol cell bio, a keen interest in sustainability and planetary health and are looking to move away from the bench, this may be for you!
Have a 👀 and please reach out if Qs
1yr FTC, remote in the UK
job-boards.eu.greenhouse.io/plos/jobs/46...
Have a 👀 and please reach out if Qs
1yr FTC, remote in the UK
job-boards.eu.greenhouse.io/plos/jobs/46...
PLOS Biology Associate Editor- FTC
UK-Remote
job-boards.eu.greenhouse.io
June 26, 2025 at 3:37 PM
I am recruiting - if you have a background in plant mol cell bio, a keen interest in sustainability and planetary health and are looking to move away from the bench, this may be for you!
Have a 👀 and please reach out if Qs
1yr FTC, remote in the UK
job-boards.eu.greenhouse.io/plos/jobs/46...
Have a 👀 and please reach out if Qs
1yr FTC, remote in the UK
job-boards.eu.greenhouse.io/plos/jobs/46...
Q for the hive-mind 🧠: What transfection reagents do people like for big constructs these days? (I am thinking #HSV encoding BACs, ~170 kb). We've recently had poor performance with Trans-IT LT1 and Lipofectamine 2000, our two go-tos. Target cells are U2OS. Suggestions or RTs greatly appreciated 🙏
June 19, 2025 at 11:09 AM
Q for the hive-mind 🧠: What transfection reagents do people like for big constructs these days? (I am thinking #HSV encoding BACs, ~170 kb). We've recently had poor performance with Trans-IT LT1 and Lipofectamine 2000, our two go-tos. Target cells are U2OS. Suggestions or RTs greatly appreciated 🙏
Reposted by Stephen Graham's Lab
Exciting job opportunities!
Two postdoc positions are available in the Fodor Lab at
@dunnschool.bsky.social to study influenza virus transcription, genome replication, nuclear export and assembly.
More info: my.corehr.com/pls/uoxrecru...
Two postdoc positions are available in the Fodor Lab at
@dunnschool.bsky.social to study influenza virus transcription, genome replication, nuclear export and assembly.
More info: my.corehr.com/pls/uoxrecru...
May 7, 2025 at 8:26 AM
Exciting job opportunities!
Two postdoc positions are available in the Fodor Lab at
@dunnschool.bsky.social to study influenza virus transcription, genome replication, nuclear export and assembly.
More info: my.corehr.com/pls/uoxrecru...
Two postdoc positions are available in the Fodor Lab at
@dunnschool.bsky.social to study influenza virus transcription, genome replication, nuclear export and assembly.
More info: my.corehr.com/pls/uoxrecru...
Reposted by Stephen Graham's Lab
Great opportunity to work on influenza virus-host factor interactions in a brand new lab at Imperial (led by a friend and collaborator, Carol Sheppard)
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
May 22, 2025 at 4:26 PM
Great opportunity to work on influenza virus-host factor interactions in a brand new lab at Imperial (led by a friend and collaborator, Carol Sheppard)
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
It's time 🚀 Very happy to launch our CL2 cryo-imaging facility PaCIFiC @cambridgebiosci.bsky.social We're excited to welcome both local and external users (academic and industry) for plunge freezing and cryo confocal imaging infected (or uninfected) samples. ❄️🔬🦠
www.path.cam.ac.uk/research/fac...
www.path.cam.ac.uk/research/fac...
Pathogen Cryo-Imaging Facility in Cambridge (PaCIFiC) | Department of Pathology
PaCIFiC Launch Event Wednesday 14th May, 2025, 12:00 PM-14:00 PM at the Pathology Dept Lecture Theatre We are delighted to invite you to a lunchtime launch event to hear about our recently launched cr...
www.path.cam.ac.uk
May 14, 2025 at 12:55 PM
It's time 🚀 Very happy to launch our CL2 cryo-imaging facility PaCIFiC @cambridgebiosci.bsky.social We're excited to welcome both local and external users (academic and industry) for plunge freezing and cryo confocal imaging infected (or uninfected) samples. ❄️🔬🦠
www.path.cam.ac.uk/research/fac...
www.path.cam.ac.uk/research/fac...
Gearing up with a 🍕 lunch before the PaCIFiC imaging facility launch at @campathology.bsky.social
www.path.cam.ac.uk/research/fac...
www.path.cam.ac.uk/research/fac...
May 14, 2025 at 11:21 AM
Gearing up with a 🍕 lunch before the PaCIFiC imaging facility launch at @campathology.bsky.social
www.path.cam.ac.uk/research/fac...
www.path.cam.ac.uk/research/fac...
Newspapers: This has been both the wettest and driest March on record, with drought and floods in Europe, and temperatures 1.6C above pre-industrial levels
Also newspapers:
Also newspapers:
April 8, 2025 at 6:59 AM
Newspapers: This has been both the wettest and driest March on record, with drought and floods in Europe, and temperatures 1.6C above pre-industrial levels
Also newspapers:
Also newspapers:
April 6, 2025 at 7:34 AM