Sebastian S. Cocioba
@atinygreencell.bsky.social
Amateur 🌿 Biologist • Aspiring 🌻 Designer
Independent Researcher at Binomica Labs
Degreeless Heathen • #diybio • #homelab
Open Lab Notebook: tinyurl.com/ATGCFFE
YouTube Channel: https://youtube.com/@atinygreencell
Independent Researcher at Binomica Labs
Degreeless Heathen • #diybio • #homelab
Open Lab Notebook: tinyurl.com/ATGCFFE
YouTube Channel: https://youtube.com/@atinygreencell
Since this would be the same exact result as through breeding the risk for alternative splicing would exist in both. After inserting a transgene you still need to breed it to be homozygous. Same for any crispr edits.
What is the difference in risk if identical?
What is the difference in risk if identical?
November 10, 2025 at 10:48 PM
Since this would be the same exact result as through breeding the risk for alternative splicing would exist in both. After inserting a transgene you still need to breed it to be homozygous. Same for any crispr edits.
What is the difference in risk if identical?
What is the difference in risk if identical?
What does "adjust things" mean in this context?
If I can make 100% the same exact plant genetically and epigenetically thru bioengineering as stepwise and can do it faster and cheaper, what is the downside? Markerless; no herbicide genes.
If I can make 100% the same exact plant genetically and epigenetically thru bioengineering as stepwise and can do it faster and cheaper, what is the downside? Markerless; no herbicide genes.
November 10, 2025 at 10:40 PM
What does "adjust things" mean in this context?
If I can make 100% the same exact plant genetically and epigenetically thru bioengineering as stepwise and can do it faster and cheaper, what is the downside? Markerless; no herbicide genes.
If I can make 100% the same exact plant genetically and epigenetically thru bioengineering as stepwise and can do it faster and cheaper, what is the downside? Markerless; no herbicide genes.
So we have demonstrable losses of crops in developing nations due to climate change, you can look this up, but there is no rush and no one is racing to make robust crops in time?
This feels very disconnected. Have you spoken with researchers in Nigeria or Zimbabwe?
This feels very disconnected. Have you spoken with researchers in Nigeria or Zimbabwe?
November 10, 2025 at 10:23 PM
So we have demonstrable losses of crops in developing nations due to climate change, you can look this up, but there is no rush and no one is racing to make robust crops in time?
This feels very disconnected. Have you spoken with researchers in Nigeria or Zimbabwe?
This feels very disconnected. Have you spoken with researchers in Nigeria or Zimbabwe?
Alice, please tell me what was the driving cause of the slow pace of development? Sincere request here. I know why but I want to know if you do or if this is uninformed presumption of incompetent researchers unable to make better GR.
November 10, 2025 at 10:10 PM
Alice, please tell me what was the driving cause of the slow pace of development? Sincere request here. I know why but I want to know if you do or if this is uninformed presumption of incompetent researchers unable to make better GR.
Why do you think plant breeding is safe? Why would the random shuffling of thousands of genes be safer than ONE gene added? Nature is not our friend. Nothing wants to die.
There is no such thing as natural crops, we made them all.
www.thedailymeal.com/heidelberg-g...
There is no such thing as natural crops, we made them all.
www.thedailymeal.com/heidelberg-g...
German Killed By Neighbor's Poison Zucchini - Daily Meal
To show your friends and guests you know what you're doing behind the bar, double strain your cocktails and give them the smoothest results possible.
www.thedailymeal.com
November 10, 2025 at 10:08 PM
Why do you think plant breeding is safe? Why would the random shuffling of thousands of genes be safer than ONE gene added? Nature is not our friend. Nothing wants to die.
There is no such thing as natural crops, we made them all.
www.thedailymeal.com/heidelberg-g...
There is no such thing as natural crops, we made them all.
www.thedailymeal.com/heidelberg-g...
We also have no control of how any gene recombines or mutates in the wild. You also just cited an activist organization as the source. How is this not a biased source with leading headlines? When you say study for 25yrs what do you mean by that?
November 10, 2025 at 10:06 PM
We also have no control of how any gene recombines or mutates in the wild. You also just cited an activist organization as the source. How is this not a biased source with leading headlines? When you say study for 25yrs what do you mean by that?
Then 100% you have proven that you are against the principle of it. You would rather watch someone struggle and waste literal decade on the *same exact* modification to get to the same plant than a fast alternative.
Why fly when we can walk?
No GM study or result could convince you otherwise.
Why fly when we can walk?
No GM study or result could convince you otherwise.
November 10, 2025 at 10:02 PM
Then 100% you have proven that you are against the principle of it. You would rather watch someone struggle and waste literal decade on the *same exact* modification to get to the same plant than a fast alternative.
Why fly when we can walk?
No GM study or result could convince you otherwise.
Why fly when we can walk?
No GM study or result could convince you otherwise.
If I make the same exact modifications to rice via none GE breeding would you accept it?
November 10, 2025 at 9:55 PM
If I make the same exact modifications to rice via none GE breeding would you accept it?
...
Okay this is clearly argument in bad faith and an insult to the african farmers who you seem to think have never considered growing food for their people.
A carrot is perishable. Rice stores long term. Staple of human civilization and zero cold chain.
This was genuinely disappointing. Im out.
Okay this is clearly argument in bad faith and an insult to the african farmers who you seem to think have never considered growing food for their people.
A carrot is perishable. Rice stores long term. Staple of human civilization and zero cold chain.
This was genuinely disappointing. Im out.
November 10, 2025 at 9:49 PM
...
Okay this is clearly argument in bad faith and an insult to the african farmers who you seem to think have never considered growing food for their people.
A carrot is perishable. Rice stores long term. Staple of human civilization and zero cold chain.
This was genuinely disappointing. Im out.
Okay this is clearly argument in bad faith and an insult to the african farmers who you seem to think have never considered growing food for their people.
A carrot is perishable. Rice stores long term. Staple of human civilization and zero cold chain.
This was genuinely disappointing. Im out.
You do know that it took 25yrs just to get field trials and the ones in bangladesh were conveniently burned down. Nothing works if not tested. Cant test if endless baseless hate for non commercial tech
November 10, 2025 at 9:43 PM
You do know that it took 25yrs just to get field trials and the ones in bangladesh were conveniently burned down. Nothing works if not tested. Cant test if endless baseless hate for non commercial tech
Imagine a world where BOTH are offered?
I see the antagonism to a FREE GM crop with NO ROYALTY is not aligned with the interests of anyone but the personal opinioms of antigm ppl. What harm comes of carrot gene in rice for free? What ecological ruin? Why not golden sorghum? Golden sadza? GR Fufu?
I see the antagonism to a FREE GM crop with NO ROYALTY is not aligned with the interests of anyone but the personal opinioms of antigm ppl. What harm comes of carrot gene in rice for free? What ecological ruin? Why not golden sorghum? Golden sadza? GR Fufu?
November 10, 2025 at 9:42 PM
Imagine a world where BOTH are offered?
I see the antagonism to a FREE GM crop with NO ROYALTY is not aligned with the interests of anyone but the personal opinioms of antigm ppl. What harm comes of carrot gene in rice for free? What ecological ruin? Why not golden sorghum? Golden sadza? GR Fufu?
I see the antagonism to a FREE GM crop with NO ROYALTY is not aligned with the interests of anyone but the personal opinioms of antigm ppl. What harm comes of carrot gene in rice for free? What ecological ruin? Why not golden sorghum? Golden sadza? GR Fufu?
Yes the vitA rich foods they dont have access to bc they are malnourished? You would suggest they grow the crops they dont have to grow? Very few starch crops are rich in vitA. Cassava is an empty starch too.
November 10, 2025 at 9:40 PM
Yes the vitA rich foods they dont have access to bc they are malnourished? You would suggest they grow the crops they dont have to grow? Very few starch crops are rich in vitA. Cassava is an empty starch too.
Hellen keller gives 2 capsules yearly. Golden rice is zero capital in places that grow rice. Every nation grows landcrops. You can easily make an endemic line wirh carrot genes and uplift people out of reliance on charities. Seems like can be synergy but we seem adamantly against on principle. Why?
November 10, 2025 at 9:37 PM
Hellen keller gives 2 capsules yearly. Golden rice is zero capital in places that grow rice. Every nation grows landcrops. You can easily make an endemic line wirh carrot genes and uplift people out of reliance on charities. Seems like can be synergy but we seem adamantly against on principle. Why?
This is moving a goal post without any offering of a solution. This could be easily ported to local land races of literally any crop. Any.
I ask again, what is your solution?
I can add phyotene desaturase to a ground crop endemic to that nation. What do you suggest? Subsistence to West?
I ask again, what is your solution?
I can add phyotene desaturase to a ground crop endemic to that nation. What do you suggest? Subsistence to West?
November 10, 2025 at 9:32 PM
This is moving a goal post without any offering of a solution. This could be easily ported to local land races of literally any crop. Any.
I ask again, what is your solution?
I can add phyotene desaturase to a ground crop endemic to that nation. What do you suggest? Subsistence to West?
I ask again, what is your solution?
I can add phyotene desaturase to a ground crop endemic to that nation. What do you suggest? Subsistence to West?
The core gripe here is that there is an imperfect solution that is non-commercial and we are arguing against it bc its imperfect. Meanwhile what is done for VAD as cheaply as free rice seed? Synthetic VitA is way more expensive than free rice and no reliance on West for supply...
November 10, 2025 at 9:29 PM
The core gripe here is that there is an imperfect solution that is non-commercial and we are arguing against it bc its imperfect. Meanwhile what is done for VAD as cheaply as free rice seed? Synthetic VitA is way more expensive than free rice and no reliance on West for supply...
So the logic here is we have an ultra cheap means of vitA in rice but we should refuse it bc there is no way for say cooking oil to appear in any dish made?
What is the solution?
What is the basis of the argument against GR release? Carrot genes in the wild?
Not concincing tbh
What is the solution?
What is the basis of the argument against GR release? Carrot genes in the wild?
Not concincing tbh
November 10, 2025 at 9:26 PM
So the logic here is we have an ultra cheap means of vitA in rice but we should refuse it bc there is no way for say cooking oil to appear in any dish made?
What is the solution?
What is the basis of the argument against GR release? Carrot genes in the wild?
Not concincing tbh
What is the solution?
What is the basis of the argument against GR release? Carrot genes in the wild?
Not concincing tbh
Please link that claim in primary literature as I have from the biochemical availability of betacarotene in rice
November 10, 2025 at 9:14 PM
Please link that claim in primary literature as I have from the biochemical availability of betacarotene in rice
Study 1:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Review:
pubmed.ncbi.nlm.nih.gov/40609688/
Study 2:
pubmed.ncbi.nlm.nih.gov/15793573/
A plea from the National Academies:
www.pnas.org/doi/10.1073/...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Review:
pubmed.ncbi.nlm.nih.gov/40609688/
Study 2:
pubmed.ncbi.nlm.nih.gov/15793573/
A plea from the National Academies:
www.pnas.org/doi/10.1073/...
November 10, 2025 at 9:13 PM
Study 1:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Review:
pubmed.ncbi.nlm.nih.gov/40609688/
Study 2:
pubmed.ncbi.nlm.nih.gov/15793573/
A plea from the National Academies:
www.pnas.org/doi/10.1073/...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Review:
pubmed.ncbi.nlm.nih.gov/40609688/
Study 2:
pubmed.ncbi.nlm.nih.gov/15793573/
A plea from the National Academies:
www.pnas.org/doi/10.1073/...
My core gripe is there are peer reviewed biochemical publications provind countless times the benefits of GM tech, esp golden rice so not sure how to wade through propaganda on both sides. Each side exaggerates. Both think other is wrong. Truth is always nuanced!
November 10, 2025 at 8:48 PM
My core gripe is there are peer reviewed biochemical publications provind countless times the benefits of GM tech, esp golden rice so not sure how to wade through propaganda on both sides. Each side exaggerates. Both think other is wrong. Truth is always nuanced!
Yeah everyone I know is so disappointed when the see one in action. May it always be boring and uneventful lol.
November 10, 2025 at 5:14 AM
Yeah everyone I know is so disappointed when the see one in action. May it always be boring and uneventful lol.