Alfredo Sciortino
@asciortino.bsky.social
Biophysicist / cytoskeleton in vitro
🏙 Paris @CytoMorphoLab
🏙 Paris @CytoMorphoLab
Pinned
Alfredo Sciortino
@asciortino.bsky.social
· Feb 26
New preprint out 🔥🔥 on my postdoc work with @manuelthery.bsky.social and @lblanchoin.bsky.social about how we can create sustained dynamic steady states of actin network inside microscopic wells that contract "forever" without collapsing! A thread 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Dress like your data like @timonnk.bsky.social does!
June 16, 2025 at 9:53 AM
Dress like your data like @timonnk.bsky.social does!
Thanks to @agudocanalejo.bsky.social and @raovutukuri.bsky.social [amongst the first ones to observe large fluctuations in GUVs!] for today's News and Views about our recent paper on active vesicle deformations - and I agree with the conclusion, it's just a beginning..! doi.org/10.1038/s415...
Synthetic cells get into shape - Nature Physics
Shape changes in biological cells are driven by an active network of biopolymers. Now, similar deformations are observed in synthetic cell membranes.
www.nature.com
May 5, 2025 at 5:21 PM
Thanks to @agudocanalejo.bsky.social and @raovutukuri.bsky.social [amongst the first ones to observe large fluctuations in GUVs!] for today's News and Views about our recent paper on active vesicle deformations - and I agree with the conclusion, it's just a beginning..! doi.org/10.1038/s415...
Grande Gianni!
Check out my interview on TGR Leonardo—the Italian science news program—about the research that I'll be starting at the Università della Calabria (subtitles generated with AI). ☀️
🔬more about my research and the project:
www.giannijacucci.com
🔬more about my research and the project:
www.giannijacucci.com
April 18, 2025 at 9:02 AM
Grande Gianni!
The Schaeffer magnum opus is out. 🔥
And it’s FINALLY OUT 🎉
The new work from Schaeffer, Théry and colleagues provides revolutionary insights into the processes underlying #centrosome positioning in adherent cells.
Check out the article @jcb.org to unlock the full story behind these new results: hubs.la/Q03hQjdn0!
@drs88.bsky.social
The new work from Schaeffer, Théry and colleagues provides revolutionary insights into the processes underlying #centrosome positioning in adherent cells.
Check out the article @jcb.org to unlock the full story behind these new results: hubs.la/Q03hQjdn0!
@drs88.bsky.social
Unlike eggs & mitotic cells, in adherent interphasic cells the centrosome is NOT positioned by a balance of forces along #microtubules, but by cell shape organization around the #centrosome: rupress.org/jcb/article/...
@lblanchoin.bsky.social
@manuelthery.bsky.social
@gelinmatthieu.bsky.social
@lblanchoin.bsky.social
@manuelthery.bsky.social
@gelinmatthieu.bsky.social
April 18, 2025 at 7:46 AM
The Schaeffer magnum opus is out. 🔥
As always with @lauraal.bsky.social , the pleasrue is all mine ☺️ - thanks @crpp-bordeaux.bsky.social for the nice hospitality
It was a pleasrue to have @asciortino.bsky.social with us last week at @crpp-bordeaux.bsky.social
Thanks for showing us the beauty of soft interface driven out-of-equilibrium :) - and the best explanation on nematic defects ever!
Thanks for showing us the beauty of soft interface driven out-of-equilibrium :) - and the best explanation on nematic defects ever!
Today we have a seminar by Alfredo Scortino from the CytoMorpholab, invited by @lauraal.bsky.social
Minimal cytoskeleton for Syn Cell !
@crpp-bordeaux.bsky.social
Minimal cytoskeleton for Syn Cell !
@crpp-bordeaux.bsky.social
April 14, 2025 at 1:11 PM
As always with @lauraal.bsky.social , the pleasrue is all mine ☺️ - thanks @crpp-bordeaux.bsky.social for the nice hospitality
Reposted by Alfredo Sciortino
Registration has started for the conference "Emerging Trends in the Physics of the Cell" in memoriam of Erich Sackmann at TU Munich from October 15-18 2025 www.cpa.tum.de/cpa/conferen...
March 31, 2025 at 4:32 PM
Registration has started for the conference "Emerging Trends in the Physics of the Cell" in memoriam of Erich Sackmann at TU Munich from October 15-18 2025 www.cpa.tum.de/cpa/conferen...
Interesting read. Some problems are just weirder than you'd say.
So, the DOGE kids intend to rewrite the social-security administration's COBOL code-base!
and they want to do it ...
... in *a few months*
I did a huge dive into COBOL a few years ago (www.wealthsimple.com/en-ca/magazi...) ...
... so let me explain why DOGE is *way* over its skis here
1/9
and they want to do it ...
... in *a few months*
I did a huge dive into COBOL a few years ago (www.wealthsimple.com/en-ca/magazi...) ...
... so let me explain why DOGE is *way* over its skis here
1/9
browse by category
www.wealthsimple.com
March 31, 2025 at 9:15 AM
Interesting read. Some problems are just weirder than you'd say.
Reposted by Alfredo Sciortino
So, the DOGE kids intend to rewrite the social-security administration's COBOL code-base!
and they want to do it ...
... in *a few months*
I did a huge dive into COBOL a few years ago (www.wealthsimple.com/en-ca/magazi...) ...
... so let me explain why DOGE is *way* over its skis here
1/9
and they want to do it ...
... in *a few months*
I did a huge dive into COBOL a few years ago (www.wealthsimple.com/en-ca/magazi...) ...
... so let me explain why DOGE is *way* over its skis here
1/9
browse by category
www.wealthsimple.com
March 30, 2025 at 6:41 PM
So, the DOGE kids intend to rewrite the social-security administration's COBOL code-base!
and they want to do it ...
... in *a few months*
I did a huge dive into COBOL a few years ago (www.wealthsimple.com/en-ca/magazi...) ...
... so let me explain why DOGE is *way* over its skis here
1/9
and they want to do it ...
... in *a few months*
I did a huge dive into COBOL a few years ago (www.wealthsimple.com/en-ca/magazi...) ...
... so let me explain why DOGE is *way* over its skis here
1/9
I am very happy to share that my work on active deformations of lipid vesicles is finally out in Nature Physics. A nicer thread+movies coming soon, in the meantime:
www.nature.com/articles/s41...
Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!
www.nature.com/articles/s41...
Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!
March 25, 2025 at 2:37 PM
I am very happy to share that my work on active deformations of lipid vesicles is finally out in Nature Physics. A nicer thread+movies coming soon, in the meantime:
www.nature.com/articles/s41...
Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!
www.nature.com/articles/s41...
Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!
Reposted by Alfredo Sciortino
We are organizing a conference for young researchers at the intersection between physics & biology: www.embl.org/about/info/c... @embl.org @events.embl.org @intcha.bsky.social
Please consider applying/registering -- the deadline is already in one week!
Please consider applying/registering -- the deadline is already in one week!
March 24, 2025 at 2:35 PM
We are organizing a conference for young researchers at the intersection between physics & biology: www.embl.org/about/info/c... @embl.org @events.embl.org @intcha.bsky.social
Please consider applying/registering -- the deadline is already in one week!
Please consider applying/registering -- the deadline is already in one week!
81% of Elon Musk thinks Elon Musk is a genius.
March 11, 2025 at 4:26 PM
81% of Elon Musk thinks Elon Musk is a genius.
New preprint out 🔥🔥 on my postdoc work with @manuelthery.bsky.social and @lblanchoin.bsky.social about how we can create sustained dynamic steady states of actin network inside microscopic wells that contract "forever" without collapsing! A thread 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 26, 2025 at 9:13 AM
New preprint out 🔥🔥 on my postdoc work with @manuelthery.bsky.social and @lblanchoin.bsky.social about how we can create sustained dynamic steady states of actin network inside microscopic wells that contract "forever" without collapsing! A thread 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
It's the time of the year when I make a Christmas themed experiment to celebrate another year gone by: this year, a micropatterned branched actin network with myosin, aka a Christmarp(2/3) tree, doing weird stuff. Happy holidays Bluesky! 🥳🥳🥳
December 23, 2024 at 10:36 AM
It's the time of the year when I make a Christmas themed experiment to celebrate another year gone by: this year, a micropatterned branched actin network with myosin, aka a Christmarp(2/3) tree, doing weird stuff. Happy holidays Bluesky! 🥳🥳🥳
😯
Visualizing Single V-ATPase Rotation Using Janus Nanoparticles
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Visualizing Single V-ATPase Rotation Using Janus Nanoparticles
Understanding the function of rotary molecular motors, such as rotary ATPases, relies on our ability to visualize single-molecule rotation. Traditional imaging methods often involve tagging those mot...
pubs.acs.org
December 15, 2024 at 9:36 AM
😯
Reposted by Alfredo Sciortino
What an end of the week! It is refreshing to catch up with friends and exchange exciting science! Thanks to @asciortino.bsky.social
and Sophie Marbach
for showing me around your labs #InstitutePierreGillesGennes
and @sorbonne-universite.fr
respectively! Gotta love Paris with this company!
and Sophie Marbach
for showing me around your labs #InstitutePierreGillesGennes
and @sorbonne-universite.fr
respectively! Gotta love Paris with this company!
December 13, 2024 at 3:06 PM
What an end of the week! It is refreshing to catch up with friends and exchange exciting science! Thanks to @asciortino.bsky.social
and Sophie Marbach
for showing me around your labs #InstitutePierreGillesGennes
and @sorbonne-universite.fr
respectively! Gotta love Paris with this company!
and Sophie Marbach
for showing me around your labs #InstitutePierreGillesGennes
and @sorbonne-universite.fr
respectively! Gotta love Paris with this company!
I met Taeyoon a long time ago and his simulations are so life-like.. happy I could contribute a very very little bit to this work now on biorxiv, on gliding assays with mobile motors. Kudos to him & Brandon.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Cluster Formation and Phase Separation Driven by Mobile Myosin Motors in the Motility Assay
Interactions between F-actin and myosin are critically important for a wide range of biological processes, including cell migration, cytokinesis, and morphogenesis. The motility assay with myosin moto...
www.biorxiv.org
December 6, 2024 at 11:03 AM
I met Taeyoon a long time ago and his simulations are so life-like.. happy I could contribute a very very little bit to this work now on biorxiv, on gliding assays with mobile motors. Kudos to him & Brandon.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
How does protein charge distribution influence the force exerted by biomolecular condensates? We tried to answer this question in our first Bluesky 🦋 #preprint! tinyurl.com/3fzuufy3 1/8
December 3, 2024 at 4:19 PM
There you go, the full story by @manuelthery.bsky.social and remember "life is fluid on lipids"!
Stay tuned, this system has many more surprises ready for you! 🤗🤗🤗
🙏🙏 thx to @lblanchoin.bsky.social @bhagyanaths.bsky.social and to afaik Bsky-less clo, sudipta, JF, alex and jerem!
Stay tuned, this system has many more surprises ready for you! 🤗🤗🤗
🙏🙏 thx to @lblanchoin.bsky.social @bhagyanaths.bsky.social and to afaik Bsky-less clo, sudipta, JF, alex and jerem!
Mix two motors of opposite polarity with microtubules and they will partition space !
Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns.
#morphogenesis
doi.org/10.1073/pnas...
(1/n)
Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns.
#morphogenesis
doi.org/10.1073/pnas...
(1/n)
November 27, 2024 at 2:03 PM
There you go, the full story by @manuelthery.bsky.social and remember "life is fluid on lipids"!
Stay tuned, this system has many more surprises ready for you! 🤗🤗🤗
🙏🙏 thx to @lblanchoin.bsky.social @bhagyanaths.bsky.social and to afaik Bsky-less clo, sudipta, JF, alex and jerem!
Stay tuned, this system has many more surprises ready for you! 🤗🤗🤗
🙏🙏 thx to @lblanchoin.bsky.social @bhagyanaths.bsky.social and to afaik Bsky-less clo, sudipta, JF, alex and jerem!
Inaugurating my Bsky experience by sharing my favorite project so far, on which I had the big chance to collaborate, out now on @pnas.org .
I am sure @manuelthery.bsky.social has a lot to say about it, so let me just congratulate Clo, @bhagyanaths.bsky.social et al. for it! bit.ly/49aE6Cz More soon!
I am sure @manuelthery.bsky.social has a lot to say about it, so let me just congratulate Clo, @bhagyanaths.bsky.social et al. for it! bit.ly/49aE6Cz More soon!
November 26, 2024 at 9:45 PM
Inaugurating my Bsky experience by sharing my favorite project so far, on which I had the big chance to collaborate, out now on @pnas.org .
I am sure @manuelthery.bsky.social has a lot to say about it, so let me just congratulate Clo, @bhagyanaths.bsky.social et al. for it! bit.ly/49aE6Cz More soon!
I am sure @manuelthery.bsky.social has a lot to say about it, so let me just congratulate Clo, @bhagyanaths.bsky.social et al. for it! bit.ly/49aE6Cz More soon!
Reposted by Alfredo Sciortino
Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN
November 13, 2024 at 8:28 PM
Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN
I am here since 5 minutes and I already miss all the Elon tweets 🙃
November 14, 2024 at 4:34 PM
I am here since 5 minutes and I already miss all the Elon tweets 🙃