Dr. Arun Sethuraman
@arunsethuraman.bsky.social
Computational evolutionary biologist. Associate Professor at @sandiegostate.bsky.social, athlete, insomniac, writer, singer, polyglot, polymath. He/him. 🏳️🌈🇮🇳🇺🇸🐞🌱🐢🧬🏋🏾♂️🎤✍🏾 www.sethuramanlab.com Views are mine and mine alone.
Reposted by Dr. Arun Sethuraman
Our latest story in preprint (www.biorxiv.org/content/10.1...) and one of my favorites so far. More detailed thread to come. Tldr we show that the distinctive collagen patterning we see in black breast cancer patients is caused by tumor intrinsic signaling and is critical for metastasis 1/3 🧪
November 11, 2025 at 12:49 AM
Our latest story in preprint (www.biorxiv.org/content/10.1...) and one of my favorites so far. More detailed thread to come. Tldr we show that the distinctive collagen patterning we see in black breast cancer patients is caused by tumor intrinsic signaling and is critical for metastasis 1/3 🧪
Reposted by Dr. Arun Sethuraman
New research from #ProcB: Confounding Fuels Misinterpretation in Human Genetics royalsocietypublishing.org/doi/10.1098/... | #Behaviour #Evolution #Genomics
November 9, 2025 at 2:01 PM
New research from #ProcB: Confounding Fuels Misinterpretation in Human Genetics royalsocietypublishing.org/doi/10.1098/... | #Behaviour #Evolution #Genomics
Reposted by Dr. Arun Sethuraman
Phylogeny of tinamous based on whole-genomes and fossils: academic.oup.com/sysbio/advan... 🪶🧪 (📷Musher et al.)
November 7, 2025 at 2:22 PM
Phylogeny of tinamous based on whole-genomes and fossils: academic.oup.com/sysbio/advan... 🪶🧪 (📷Musher et al.)
Reposted by Dr. Arun Sethuraman
Amy Angert and I are recruiting a #postdoc to participate in a collaborative NSF-funded study of demographic responses to climate across the geographic range of the scarlet monkeyflower. Please repost! jobs.ncsu.edu/postings/224...
November 7, 2025 at 3:10 PM
Amy Angert and I are recruiting a #postdoc to participate in a collaborative NSF-funded study of demographic responses to climate across the geographic range of the scarlet monkeyflower. Please repost! jobs.ncsu.edu/postings/224...
Reposted by Dr. Arun Sethuraman
On the cover of our #LatestIssue: Photo of a Joshua #tree (Yucca jaegeriana) at dawn in the Mojave #Desert. Image courtesy of Karolina Heyduk.
📖 See Heyduk et al. nph.onlinelibrary.wiley.com/doi/10.1111/...
📖 See Heyduk et al. nph.onlinelibrary.wiley.com/doi/10.1111/...
November 6, 2025 at 10:15 AM
On the cover of our #LatestIssue: Photo of a Joshua #tree (Yucca jaegeriana) at dawn in the Mojave #Desert. Image courtesy of Karolina Heyduk.
📖 See Heyduk et al. nph.onlinelibrary.wiley.com/doi/10.1111/...
📖 See Heyduk et al. nph.onlinelibrary.wiley.com/doi/10.1111/...
Lol @ Gayle King on CBS Mornings, commenting on this: ‘I’m glad that Dr. Oz was there - I’m sure he knew what to do’ 😹
This is officially one of the strangest pictures in American history, and I do not doubt that it will be considered iconic a hundred years from now.
100% serious here.
100% serious here.
November 7, 2025 at 3:32 PM
Lol @ Gayle King on CBS Mornings, commenting on this: ‘I’m glad that Dr. Oz was there - I’m sure he knew what to do’ 😹
Re-upping this! Do join us today at noon pacific!
Aaaahhh! Stoked to welcome and host the one and only Dr. Dunn this Friday (11/7/25) at noon PST in the @calstate.bsky.social bioinformatics webinar series! Do join us via Zoom: sdsu.zoom.us/j/88624423158
November 7, 2025 at 3:12 PM
Re-upping this! Do join us today at noon pacific!
Reposted by Dr. Arun Sethuraman
How is functional variation at large-effect loci maintained in natural populations, even as environments change? In a paper led by @mkarag.bsky.social, we tracked known pesticide resistant alleles in outdoor 𝘋. 𝘮𝘦𝘭𝘢𝘯𝘰𝘨𝘢𝘴𝘵𝘦𝘳 cages & inferred selection and dominance from temporal sequencing data.
November 6, 2025 at 9:51 PM
How is functional variation at large-effect loci maintained in natural populations, even as environments change? In a paper led by @mkarag.bsky.social, we tracked known pesticide resistant alleles in outdoor 𝘋. 𝘮𝘦𝘭𝘢𝘯𝘰𝘨𝘢𝘴𝘵𝘦𝘳 cages & inferred selection and dominance from temporal sequencing data.
Reposted by Dr. Arun Sethuraman
On Oct 1, 2025, GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5
November 6, 2025 at 9:46 PM
On Oct 1, 2025, GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5
Reposted by Dr. Arun Sethuraman
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Specificity, length and luck drive gene rankings in association studies - Nature
Genetic association tests prioritize candidate genes based on different criteria.
www.nature.com
November 7, 2025 at 12:05 AM
How do GWAS and rare variant burden tests rank gene signals?
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
In new work @nature.com with @hakha.bsky.social, @jkpritch.bsky.social, and our wonderful coauthors we find that the key factors are what we call Specificity, Length, and Luck!
🧬🧪🧵
www.nature.com/articles/s41...
Congratulations to @doc-brock.bsky.social on advancing her first MS student to candidacy! Such cool work with introduced Italian wall lizards across native and invasive ranges - looking forward to seeing what Alyssa and Dr. Brock will discover!
a person is holding a lizard in their hands
ALT: a person is holding a lizard in their hands
media.tenor.com
November 7, 2025 at 1:49 AM
Congratulations to @doc-brock.bsky.social on advancing her first MS student to candidacy! Such cool work with introduced Italian wall lizards across native and invasive ranges - looking forward to seeing what Alyssa and Dr. Brock will discover!
Reposted by Dr. Arun Sethuraman
Oxygen limitation is considered a key mechanism of #ThermalTolerance. @dianasmadeira.bsky.social explores how a @plosbiology.org study challenges this idea, showing minimal protective effects of O2 supersaturation in heat-stressed #aquatic #ectotherms 🧪 Paper: plos.io/43hzMQa Primer: plos.io/3XeUtbS
November 6, 2025 at 5:30 PM
Oxygen limitation is considered a key mechanism of #ThermalTolerance. @dianasmadeira.bsky.social explores how a @plosbiology.org study challenges this idea, showing minimal protective effects of O2 supersaturation in heat-stressed #aquatic #ectotherms 🧪 Paper: plos.io/43hzMQa Primer: plos.io/3XeUtbS
Reposted by Dr. Arun Sethuraman
New and improved! (as of today, now with page numbers and an issue number ;)
"Evidence for ancient selective sweeps followed by differentiation among three species of Sphyrapicus sapsuckers"
Led by Dr. Libby Natola:
doi.org/10.1093/jeb/...
"Evidence for ancient selective sweeps followed by differentiation among three species of Sphyrapicus sapsuckers"
Led by Dr. Libby Natola:
doi.org/10.1093/jeb/...
Evidence for ancient selective sweeps followed by differentiation among three species of Sphyrapicus sapsuckers
Abstract. Genomic differentiation usually accompanies speciation, but that differentiation is often highly heterogeneous across the genome. Understanding w
doi.org
November 6, 2025 at 6:59 PM
New and improved! (as of today, now with page numbers and an issue number ;)
"Evidence for ancient selective sweeps followed by differentiation among three species of Sphyrapicus sapsuckers"
Led by Dr. Libby Natola:
doi.org/10.1093/jeb/...
"Evidence for ancient selective sweeps followed by differentiation among three species of Sphyrapicus sapsuckers"
Led by Dr. Libby Natola:
doi.org/10.1093/jeb/...
Reposted by Dr. Arun Sethuraman
#TEsky A comparative analysis of transposable element diversity and evolution across 75 bee genomes doi.org/10.1186/s128...
A comparative analysis of transposable element diversity and evolution across 75 bee genomes - BMC Genomics
Transposable elements (TEs) are repetitive DNA sequences that can alter their position and abundance within genomes. While TEs are known to have various impacts on genome structure and function, our u...
doi.org
November 6, 2025 at 1:29 PM
#TEsky A comparative analysis of transposable element diversity and evolution across 75 bee genomes doi.org/10.1186/s128...
Reposted by Dr. Arun Sethuraman
With @aconga.bsky.social we wrote a short Dispatch to highlight two awesome companion papers in @currentbiology.bsky.social by @jeffgroh.bsky.social, @gcbias.bsky.social and by Liu et al. on how the control of heterodichogamy is going nuts in the Juglandaceae :
www.cell.com/current-biol...
www.cell.com/current-biol...
November 5, 2025 at 8:00 AM
With @aconga.bsky.social we wrote a short Dispatch to highlight two awesome companion papers in @currentbiology.bsky.social by @jeffgroh.bsky.social, @gcbias.bsky.social and by Liu et al. on how the control of heterodichogamy is going nuts in the Juglandaceae :
www.cell.com/current-biol...
www.cell.com/current-biol...
Reposted by Dr. Arun Sethuraman
I am so proud & happy to see our Potamo genome assembly finally out there in the world! The process ended up being way more challenging than expected, but for some really cool reasons. ❤️🐌🧬
TLDR: Surprise! A VERY recent WGD.
academic.oup.com/gbe/article/...
Photo: C. Böck, ILIM, Mondsee, Austria)
TLDR: Surprise! A VERY recent WGD.
academic.oup.com/gbe/article/...
Photo: C. Böck, ILIM, Mondsee, Austria)
November 5, 2025 at 4:50 PM
I am so proud & happy to see our Potamo genome assembly finally out there in the world! The process ended up being way more challenging than expected, but for some really cool reasons. ❤️🐌🧬
TLDR: Surprise! A VERY recent WGD.
academic.oup.com/gbe/article/...
Photo: C. Böck, ILIM, Mondsee, Austria)
TLDR: Surprise! A VERY recent WGD.
academic.oup.com/gbe/article/...
Photo: C. Böck, ILIM, Mondsee, Austria)
New preprint out today from us! Priyanshi built a pipeline to catalog telomeric content across the 1KGP phase 3 dataset, and we test for differences across populations, chromosomes, and sexes. Do check it out! Comments welcome.
A Comprehensive Catalog of Telomere Content Variation Across Human Populations https://www.biorxiv.org/content/10.1101/2025.11.03.686324v1
November 5, 2025 at 2:38 PM
New preprint out today from us! Priyanshi built a pipeline to catalog telomeric content across the 1KGP phase 3 dataset, and we test for differences across populations, chromosomes, and sexes. Do check it out! Comments welcome.
Reposted by Dr. Arun Sethuraman
We’re excited to expand our partnership with @reviewcommons.org in a new collaborative model reshaping scientific publishing to streamline peer review, reduce redundancy, and improve the author and reviewer experience. Read more: buff.ly/h6SfMXF
And meet our Editorial Board! 👋
And meet our Editorial Board! 👋
November 5, 2025 at 2:01 PM
We’re excited to expand our partnership with @reviewcommons.org in a new collaborative model reshaping scientific publishing to streamline peer review, reduce redundancy, and improve the author and reviewer experience. Read more: buff.ly/h6SfMXF
And meet our Editorial Board! 👋
And meet our Editorial Board! 👋
Go get ‘em, California!
JUST IN: California voters have approved a ballot measure to redraw the state's congressional map to favor Democrats, marking the party's biggest victory to date in a national battle over redistricting ahead of the 2026 midterms.
California voters OK new congressional lines, boosting Democrats ahead of midterms
California voters have approved a ballot measure to redraw the state's congressional map to favor Democrats, marking the party's biggest victory to date in a national battle over redistricting ahead of the 2026 midterms.
n.pr
November 5, 2025 at 4:10 AM
Go get ‘em, California!
Extra credit on your pop-gen exam today if you vote! Be a responsible citizen - this country needs it more than ever.
barack obama is giving a speech on a stage and saying `` do n't boo , vote ''
ALT: barack obama is giving a speech on a stage and saying `` do n't boo , vote ''
media.tenor.com
November 4, 2025 at 3:44 PM
Extra credit on your pop-gen exam today if you vote! Be a responsible citizen - this country needs it more than ever.
Reposted by Dr. Arun Sethuraman
Janaki Ammal was born 128 years ago today! A legend of botanical genetics, she studied how polyploidy plays into the resilience of agricultural crops, compiled a sprawling chromosomal atlas of plants, and fought for the preservation of India's natural legacy.
tinyurl.com/2j9hxmjb
#WomenInSTEM
tinyurl.com/2j9hxmjb
#WomenInSTEM
Janaki Ammal And the Fight for India’s Botanical Future.
Caste. Race. Gender. These were the three categories that, in early twentieth century Madras, combined to determine the boundaries of an individual’s potential. Being of an undesirable categorizat...
tinyurl.com
November 4, 2025 at 3:13 PM
Janaki Ammal was born 128 years ago today! A legend of botanical genetics, she studied how polyploidy plays into the resilience of agricultural crops, compiled a sprawling chromosomal atlas of plants, and fought for the preservation of India's natural legacy.
tinyurl.com/2j9hxmjb
#WomenInSTEM
tinyurl.com/2j9hxmjb
#WomenInSTEM
Aaaahhh! Stoked to welcome and host the one and only Dr. Dunn this Friday (11/7/25) at noon PST in the @calstate.bsky.social bioinformatics webinar series! Do join us via Zoom: sdsu.zoom.us/j/88624423158
November 3, 2025 at 10:41 PM
Aaaahhh! Stoked to welcome and host the one and only Dr. Dunn this Friday (11/7/25) at noon PST in the @calstate.bsky.social bioinformatics webinar series! Do join us via Zoom: sdsu.zoom.us/j/88624423158
Reposted by Dr. Arun Sethuraman
NEW Publication🥳
Rapid #evolution is thought to be disadvantageous due to the accumulation of deleterious #mutations. We identify multiple lineages of rapidly evolving and stable #yeast that are many millions of years old
🔗: academic.oup.com/mbe/advance-...
Rapid #evolution is thought to be disadvantageous due to the accumulation of deleterious #mutations. We identify multiple lineages of rapidly evolving and stable #yeast that are many millions of years old
🔗: academic.oup.com/mbe/advance-...
November 3, 2025 at 6:29 PM
NEW Publication🥳
Rapid #evolution is thought to be disadvantageous due to the accumulation of deleterious #mutations. We identify multiple lineages of rapidly evolving and stable #yeast that are many millions of years old
🔗: academic.oup.com/mbe/advance-...
Rapid #evolution is thought to be disadvantageous due to the accumulation of deleterious #mutations. We identify multiple lineages of rapidly evolving and stable #yeast that are many millions of years old
🔗: academic.oup.com/mbe/advance-...
Even though I don't live in NYC, I can't wait for the purported "exodus of millions of New Yorkers" to whatever xenophobic holes they crawled out of, when a fellow immigrant of Indian origin, Zohran, becomes Mayor.
a man in a suit and tie stands in front of an elevator that says truly you need to stop
ALT: a man in a suit and tie stands in front of an elevator that says truly you need to stop
media.tenor.com
November 3, 2025 at 5:37 PM
Even though I don't live in NYC, I can't wait for the purported "exodus of millions of New Yorkers" to whatever xenophobic holes they crawled out of, when a fellow immigrant of Indian origin, Zohran, becomes Mayor.
Reposted by Dr. Arun Sethuraman
Gower et al. present an extension to the stdpopsim framework, which enables simulation of various modes of selection, providing a resource for the popgen community to explore the interplay between selection and other evolutionary forces.
🔗 doi.org/10.1093/molbev/msaf236
#evobio #molbio #compbio
🔗 doi.org/10.1093/molbev/msaf236
#evobio #molbio #compbio
Accessible, Realistic Genome Simulation with Selection Using stdpopsim
Abstract. Selection is a fundamental evolutionary force that shapes patterns of genetic variation across species. However, simulations incorporating realis
doi.org
November 3, 2025 at 10:07 AM
Gower et al. present an extension to the stdpopsim framework, which enables simulation of various modes of selection, providing a resource for the popgen community to explore the interplay between selection and other evolutionary forces.
🔗 doi.org/10.1093/molbev/msaf236
#evobio #molbio #compbio
🔗 doi.org/10.1093/molbev/msaf236
#evobio #molbio #compbio