CowperKettle
@artyom-yekat.bsky.social
Freelance translator, now a food delivery cyclist in Yekaterinburg, Russia. Born in 1978.
A newly-published study I’ve just come across via a tweet by one of the authors:
# Plasma Glutathione Concentrations Are Associated with Leukocyte and Neutrophils’ Counts in Clozapine-Treated Patients (Martinez-Rodriguez et al.,2025) pubmed.ncbi.nlm.nih.gov/41011215/
# Plasma Glutathione Concentrations Are Associated with Leukocyte and Neutrophils’ Counts in Clozapine-Treated Patients (Martinez-Rodriguez et al.,2025) pubmed.ncbi.nlm.nih.gov/41011215/
Plasma Glutathione Concentrations Are Associated with Leukocyte and Neutrophils' Counts in Clozapine-Treated Patients - PubMed
Clozapine's potential hematological toxicity, particularly its effect on white blood cell counts, is well documented and routinely monitored in clinical practice. In this study, a significant associat...
pubmed.ncbi.nlm.nih.gov
October 8, 2025 at 7:10 AM
A newly-published study I’ve just come across via a tweet by one of the authors:
# Plasma Glutathione Concentrations Are Associated with Leukocyte and Neutrophils’ Counts in Clozapine-Treated Patients (Martinez-Rodriguez et al.,2025) pubmed.ncbi.nlm.nih.gov/41011215/
# Plasma Glutathione Concentrations Are Associated with Leukocyte and Neutrophils’ Counts in Clozapine-Treated Patients (Martinez-Rodriguez et al.,2025) pubmed.ncbi.nlm.nih.gov/41011215/
Reposted by CowperKettle
AGO1 in neural progenitor cells orchestrates brain development and sociability via LIN28A-REELIN axis #autism #reelin #ASD www.biorxiv.org/content/10.1...
AGO1 in neural progenitor cells orchestrates brain development and sociability via LIN28A-REELIN axis
AGO1, an essential RNA binding protein (RBP) in RNA interference, is associated with autism spectrum disorder (ASD). However, the precise functions of AGO1 in brain development and related disorders r...
www.biorxiv.org
October 8, 2025 at 5:11 AM
AGO1 in neural progenitor cells orchestrates brain development and sociability via LIN28A-REELIN axis #autism #reelin #ASD www.biorxiv.org/content/10.1...
Reposted by CowperKettle
Dr. Jane Goodall, 1934-2025
An exceptional scientist, and a singular woman in science
#WomeninScience 🐒
www.nytimes.com/2025/10/01/o...
An exceptional scientist, and a singular woman in science
#WomeninScience 🐒
www.nytimes.com/2025/10/01/o...
Jane Goodall, Eminent Primatologist Who Chronicled the Lives of Chimps, Dies at 91
www.nytimes.com
October 1, 2025 at 7:23 PM
Dr. Jane Goodall, 1934-2025
An exceptional scientist, and a singular woman in science
#WomeninScience 🐒
www.nytimes.com/2025/10/01/o...
An exceptional scientist, and a singular woman in science
#WomeninScience 🐒
www.nytimes.com/2025/10/01/o...
Reposted by CowperKettle
Here EPFL press release: actu.epfl.ch/news/a-molec...
A molecule repairs brain mitochondria and reverses anxiety in rats
A study led by EPFL shows that Urolithin A, a natural compound, can abolish high anxiety in rats by repairing mitochondrial function in their brain cells, specifically in the nucleus accumbens. The fi...
actu.epfl.ch
October 7, 2025 at 8:43 AM
Here EPFL press release: actu.epfl.ch/news/a-molec...
Reposted by CowperKettle
Very happy to share our new paper in Biological Psychiatry, showing that Urolithin A reverses high anxiety by repairing mitochondrial function in the nucleus accumbens.
Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!
🔗 Paper: doi.org/10.1016/j.bi...
Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!
🔗 Paper: doi.org/10.1016/j.bi...
Redirecting
doi.org
October 7, 2025 at 8:43 AM
Very happy to share our new paper in Biological Psychiatry, showing that Urolithin A reverses high anxiety by repairing mitochondrial function in the nucleus accumbens.
Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!
🔗 Paper: doi.org/10.1016/j.bi...
Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators!
🔗 Paper: doi.org/10.1016/j.bi...
Reposted by CowperKettle
New lab paper! We reveal a novel mitochondria–cilia interaction in neurons & #mitochondrial control of #ciliary molecular pathways & structure
Kudos to Dogukan Ulgen & Ale Chioino
🙏 O Zanoletti, A Quintana, E Sanz
@epfl-brainmind.bsky.social @jphysiol.bsky.social
Read doi.org/10.1113/JP28...
Kudos to Dogukan Ulgen & Ale Chioino
🙏 O Zanoletti, A Quintana, E Sanz
@epfl-brainmind.bsky.social @jphysiol.bsky.social
Read doi.org/10.1113/JP28...
Mitochondrial control of ciliary gene expression and structure in striatal neurons
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sens...
doi.org
February 19, 2025 at 7:53 AM
New lab paper! We reveal a novel mitochondria–cilia interaction in neurons & #mitochondrial control of #ciliary molecular pathways & structure
Kudos to Dogukan Ulgen & Ale Chioino
🙏 O Zanoletti, A Quintana, E Sanz
@epfl-brainmind.bsky.social @jphysiol.bsky.social
Read doi.org/10.1113/JP28...
Kudos to Dogukan Ulgen & Ale Chioino
🙏 O Zanoletti, A Quintana, E Sanz
@epfl-brainmind.bsky.social @jphysiol.bsky.social
Read doi.org/10.1113/JP28...
I'm sitting in a stupor and doing nothing. Had psychiatry existed, I would have run to the psychiatrist right away, because in November, a 6th year will start in a dysfunctional state, with no relationships, no proper work. Affect and ruminations.
September 4, 2025 at 3:22 AM
I'm sitting in a stupor and doing nothing. Had psychiatry existed, I would have run to the psychiatrist right away, because in November, a 6th year will start in a dysfunctional state, with no relationships, no proper work. Affect and ruminations.
During work, I see people holding hands, walking with their kids, and even hugging - and I feel like a steel hook is thrust into my abdomen and is being turned there. I feel like I'm in hell, and this feeling lingers, and ruminations start, and they don't stop.
August 8, 2025 at 4:38 PM
During work, I see people holding hands, walking with their kids, and even hugging - and I feel like a steel hook is thrust into my abdomen and is being turned there. I feel like I'm in hell, and this feeling lingers, and ruminations start, and they don't stop.
Reposted by CowperKettle
The public wants answers on WHAT ARE THE CAUSES OF #AUTISM. This lecture takes a deep dive on genes, environment and #vaccines and how it works. Video quality is poor in the beginning, but don't skip the first 5 slides or the segment at 20:00-25:00 www.youtube.com/watch?v=Jiy9...
The Causes of Autism
YouTube video by UC San Diego Autism Center of Excellence
www.youtube.com
March 19, 2025 at 12:37 AM
The public wants answers on WHAT ARE THE CAUSES OF #AUTISM. This lecture takes a deep dive on genes, environment and #vaccines and how it works. Video quality is poor in the beginning, but don't skip the first 5 slides or the segment at 20:00-25:00 www.youtube.com/watch?v=Jiy9...
Reposted by CowperKettle
As we have learned, genes have dose-dependent effects on psychiatric traits. DOSAGE, it turns out, is a key element that helps unravel mechanisms of gene → pathway → cell type → brain region → diagnosis. Here we developed a framework to characterize cellular processes that mediate genetic effects.
Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects https://www.medrxiv.org/content/10.1101/2025.07.11.25331381v1
July 16, 2025 at 9:23 PM
As we have learned, genes have dose-dependent effects on psychiatric traits. DOSAGE, it turns out, is a key element that helps unravel mechanisms of gene → pathway → cell type → brain region → diagnosis. Here we developed a framework to characterize cellular processes that mediate genetic effects.
Reposted by CowperKettle
The field of neuroscience views the goal of human genetics as "finding genes". This is an outdated view. In whole genome studies of rare variants, finding genes is the easy part. The more interesting and important goal is to map out the causal pathway from genes to brain function to cognitive traits
A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits https://www.medrxiv.org/content/10.1101/2025.07.11.25331310v1
July 16, 2025 at 2:47 PM
The field of neuroscience views the goal of human genetics as "finding genes". This is an outdated view. In whole genome studies of rare variants, finding genes is the easy part. The more interesting and important goal is to map out the causal pathway from genes to brain function to cognitive traits
Reposted by CowperKettle
Nice piece by the director of mental health at the Wellcome Trust on the need for innovation in brain-based therapies for psychiatric conditions.
www.ft.com/content/e9ec...
www.ft.com/content/e9ec...
Psychiatric medication is in dire need of innovation
There can be no either/or in mental health — we must rigorously examine pharmaceutical and social solutions
www.ft.com
July 12, 2025 at 8:36 AM
Nice piece by the director of mental health at the Wellcome Trust on the need for innovation in brain-based therapies for psychiatric conditions.
www.ft.com/content/e9ec...
www.ft.com/content/e9ec...
Reposted by CowperKettle
(buried in a reply, but) This is mind-blowing & deserves a post. Scroll to "video" in this article to watch what happens when the human hypothalamus is stimulated: it's a combo of embarrassment/shame and intense body sensations emanating from the heart. WOW.
www.brainstimjrnl.com/article/S193...
www.brainstimjrnl.com/article/S193...
Complex negative emotions induced by electrical stimulation of the human hypothalamus
Stimulation of the ventromedial hypothalamic region in animals has been reported to
cause attack behavior labeled as sham-rage without offering information about the
internal affective state of the an...
www.brainstimjrnl.com
July 13, 2025 at 8:50 AM
(buried in a reply, but) This is mind-blowing & deserves a post. Scroll to "video" in this article to watch what happens when the human hypothalamus is stimulated: it's a combo of embarrassment/shame and intense body sensations emanating from the heart. WOW.
www.brainstimjrnl.com/article/S193...
www.brainstimjrnl.com/article/S193...
Reposted by CowperKettle
Some good news! 😊
Solar is EU’s biggest power source for the first time ever | Ember https://ember-energy.org/latest-insights/solar-is-eus-biggest-power-source-for-the-first-time-ever #solar #energy #climate
July 13, 2025 at 3:29 PM
Some good news! 😊
Reposted by CowperKettle
Every day the world presents you with the wrong battles, designed to waste your energy so you don't fight the right ones.
July 12, 2025 at 11:20 PM
Every day the world presents you with the wrong battles, designed to waste your energy so you don't fight the right ones.
The oncologist told me that he does not think there might be a metastasis based on my intermittent mild pain in the nose. I wonder if there are good biomarkers of #HPV-associated #squamous cell #cancer of the nasal vestibule.
July 9, 2025 at 9:30 AM
The oncologist told me that he does not think there might be a metastasis based on my intermittent mild pain in the nose. I wonder if there are good biomarkers of #HPV-associated #squamous cell #cancer of the nasal vestibule.
Репост моей знакомой по Твиттеру
x.com/triki_tiki/s...
x.com/triki_tiki/s...
June 30, 2025 at 9:23 AM
Репост моей знакомой по Твиттеру
x.com/triki_tiki/s...
x.com/triki_tiki/s...
I feel myself dead because I see people in the streets who are holding hands and even kissing. If I were alive, I would have lived with a woman at least for some time over the last 47 years. I cannot go to a psychiatrist because I'm in Russia, we don't have them.
June 29, 2025 at 5:30 PM
I feel myself dead because I see people in the streets who are holding hands and even kissing. If I were alive, I would have lived with a woman at least for some time over the last 47 years. I cannot go to a psychiatrist because I'm in Russia, we don't have them.
Reposted by CowperKettle
Been taking folinic acid myself and been seeing much more stable energy levels so far, I’m not having a mid afternoon crash like I was. Promising results so far.
Methylfolate, folinic acid and sapropterin (synthetic BH4) might also work in a subset of patients. I felt better on methylfolate/folinic acid. I wish there was more research to replicate or refute this: www.cambridge.org/core/journal...
Metabolomic disorders: confirmed presence of potentially treatable abnormalities in patients with treatment refractory depression and suicidal behavior | Psychological Medicine | Cambridge Core
Metabolomic disorders: confirmed presence of potentially treatable abnormalities in patients with treatment refractory depression and suicidal behavior - Volume 53 Issue 13
www.cambridge.org
June 16, 2025 at 9:11 AM
Been taking folinic acid myself and been seeing much more stable energy levels so far, I’m not having a mid afternoon crash like I was. Promising results so far.
