Andy Chetwynd
@andychetwynd.bsky.social
Tenure Track Fellow, Kidney Research UK Senior Non-Clinical Fellow. Analytical Chemistry, biological/inorganic mass spectrometry. Proteomics, glycans, metabolomics.
Reposted by Andy Chetwynd
Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...
Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
This work challenges a major assumption in cell biology by showing that lipid bilayers
can have drastically different phospholipid abundances between their two leaflets.
This lipid abundance asymmetry...
www.cell.com
April 3, 2025 at 3:07 PM
Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...
Reposted by Andy Chetwynd
We are #hiring!
*Research Data Steward*
Support the work of Cystic Fibrosis Innovation Hubs by maintaining integrity & quality of datasets, optimising workflows, and supporting #FAIR. Work within the @cbflivuni.bsky.social. More information here: shorturl.at/v3P30
#datamanagement #jobs
*Research Data Steward*
Support the work of Cystic Fibrosis Innovation Hubs by maintaining integrity & quality of datasets, optimising workflows, and supporting #FAIR. Work within the @cbflivuni.bsky.social. More information here: shorturl.at/v3P30
#datamanagement #jobs
Job Specification
shorturl.at
March 12, 2025 at 6:02 PM
We are #hiring!
*Research Data Steward*
Support the work of Cystic Fibrosis Innovation Hubs by maintaining integrity & quality of datasets, optimising workflows, and supporting #FAIR. Work within the @cbflivuni.bsky.social. More information here: shorturl.at/v3P30
#datamanagement #jobs
*Research Data Steward*
Support the work of Cystic Fibrosis Innovation Hubs by maintaining integrity & quality of datasets, optimising workflows, and supporting #FAIR. Work within the @cbflivuni.bsky.social. More information here: shorturl.at/v3P30
#datamanagement #jobs
Reposted by Andy Chetwynd
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered
domains containing glycoRNAs.
www.cell.com
February 27, 2025 at 3:48 PM
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
Reposted by Andy Chetwynd
Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature
Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.
www.nature.com
February 26, 2025 at 9:58 PM
Happy to share this new #glycotime work with collaborator Tony Wyss-Coray, led by grad student Sophia Shi, mucin loss at the BBB is associated with aging and cognitive decline, can be reversed by restoration with with gene therapy. Aging is a mucinopathy!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Andy Chetwynd
The #WorldKidneyDay campaign and plans are now live!
This year, we're excited to launch a new campaign called 'Don't Kid Yourself.' It's all about challenging the myths about kidney disease and shedding light on the true facts.
Find out more and get involved: www.worldkidneyday.co.uk
This year, we're excited to launch a new campaign called 'Don't Kid Yourself.' It's all about challenging the myths about kidney disease and shedding light on the true facts.
Find out more and get involved: www.worldkidneyday.co.uk
February 25, 2025 at 9:43 AM
The #WorldKidneyDay campaign and plans are now live!
This year, we're excited to launch a new campaign called 'Don't Kid Yourself.' It's all about challenging the myths about kidney disease and shedding light on the true facts.
Find out more and get involved: www.worldkidneyday.co.uk
This year, we're excited to launch a new campaign called 'Don't Kid Yourself.' It's all about challenging the myths about kidney disease and shedding light on the true facts.
Find out more and get involved: www.worldkidneyday.co.uk
Reposted by Andy Chetwynd
For #WorldKidneyDay 2025, we have a new campaign, Don't Kid Yourself. It challenges the myths about kidney disease & highlights the facts.
Take this myth 👇 There are many reasons why someone gets kidney disease, it’s not just lifestyle. Read more here > worldkidney.day.co.uk
Take this myth 👇 There are many reasons why someone gets kidney disease, it’s not just lifestyle. Read more here > worldkidney.day.co.uk
February 24, 2025 at 7:43 PM
For #WorldKidneyDay 2025, we have a new campaign, Don't Kid Yourself. It challenges the myths about kidney disease & highlights the facts.
Take this myth 👇 There are many reasons why someone gets kidney disease, it’s not just lifestyle. Read more here > worldkidney.day.co.uk
Take this myth 👇 There are many reasons why someone gets kidney disease, it’s not just lifestyle. Read more here > worldkidney.day.co.uk
Reposted by Andy Chetwynd
🧵 Earlier this month, the LifeArc-KRUK Centre for Rare Diseases held a successful international workshop at the Child Health Institute in the Park campus to design a clinical trial for patients with the inflammatory disease, IgA vasculitis (1/2)
February 24, 2025 at 3:22 PM
🧵 Earlier this month, the LifeArc-KRUK Centre for Rare Diseases held a successful international workshop at the Child Health Institute in the Park campus to design a clinical trial for patients with the inflammatory disease, IgA vasculitis (1/2)
Reposted by Andy Chetwynd
An #NIH-funded research team has developed an mRNA vaccine to treat pancreatic cancer. Results from the clinical trial were published this week in Nature.
#pancreas #cancer #mRNA #vaccine #medsky #science #medicine #bluesky
#pancreas #cancer #mRNA #vaccine #medsky #science #medicine #bluesky
In Early-Phase Pancreatic Cancer Clinical Trial, Investigational mRNA Vaccine Induces Sustained Immune Activity in Small Patient Group
Learn how MSK researchers are deploying mRNA vaccines against pancreatic cancer.
www.mskcc.org
February 23, 2025 at 8:00 AM
Reposted by Andy Chetwynd
Our new paper in print describes a new approach: release and analysis of N-glycans in less than 24 hours. A perfect approach for those that are glycan-curious as it does not require changing any of your proteomics buffers! 1/5
#glycotime #teammassspec
pubs.acs.org/doi/10.1021/...
#glycotime #teammassspec
pubs.acs.org/doi/10.1021/...
Swift Universal Glycan Acquisition (SUGA) Enables Quantitative Glycan Profiling across Diverse Sample Types
The ability to rapidly analyze complex mixtures of glycans derived from glycoproteins is important, but techniques are often laborious and require multiple glycan derivatization steps. Here, we descri...
pubs.acs.org
February 21, 2025 at 6:55 AM
Our new paper in print describes a new approach: release and analysis of N-glycans in less than 24 hours. A perfect approach for those that are glycan-curious as it does not require changing any of your proteomics buffers! 1/5
#glycotime #teammassspec
pubs.acs.org/doi/10.1021/...
#glycotime #teammassspec
pubs.acs.org/doi/10.1021/...
Reposted by Andy Chetwynd
Event alert! Join us for our Showcase Event at the Institute in the Park, Alder Hey Children’s Hospital on the 22nd March 2025!
9:30 AM - 4:00 PM
Details below!
#EATCShowcase #PaediatricResearch #MakingADifference #JoinUs
@alderhey.nhs.uk
@livunihls.bsky.social
@livuniresearch.bsky.social
9:30 AM - 4:00 PM
Details below!
#EATCShowcase #PaediatricResearch #MakingADifference #JoinUs
@alderhey.nhs.uk
@livunihls.bsky.social
@livuniresearch.bsky.social
January 27, 2025 at 1:56 PM
Event alert! Join us for our Showcase Event at the Institute in the Park, Alder Hey Children’s Hospital on the 22nd March 2025!
9:30 AM - 4:00 PM
Details below!
#EATCShowcase #PaediatricResearch #MakingADifference #JoinUs
@alderhey.nhs.uk
@livunihls.bsky.social
@livuniresearch.bsky.social
9:30 AM - 4:00 PM
Details below!
#EATCShowcase #PaediatricResearch #MakingADifference #JoinUs
@alderhey.nhs.uk
@livunihls.bsky.social
@livuniresearch.bsky.social