Nature Reviews Genetics - Multiplexed assays of variant effect (MAVEs) are highly scalable experimental approaches used to generate functional data for genetic variants. In this Review, McEwen et...

Dr Michael Mosley’s family, in partnership with the Chronic Disease Research Fund (CDRF), is proud to launch the Michael Mosley Memorial Research Fund. The fund will support urgent clinical research i...

Nature Reviews Genetics, Published online: 09 January 2025; doi:10.1038/s41576-024-00804-zRecent genomic approaches are providing unprecedented opportunity to disentangle how genotype and environment affect organismal traits. The authors review the role…

De Jonghe et al. present a comprehensive review of current commercial single-cell and spatial omic technologies, outlining key platforms, methodologies, and trends shaping the field—from microfluidics and plate-based approaches to combinatorial indexing, highlighting their applications in drug discovery. The authors discuss emerging engineering and computational advancements that are enabling more efficient data generation and interpretation. Finally, they explore new tools and techniques that promise to expand the scope of omic analyses, driving innovation and understanding in biomedical research.

A drug with a novel mechanism protects people against the AIDS virus for 6 months. It could speed the end of the epidemic—if those who need it most get access