Andreas H. Laustsen-Kiel
@andreaslaustsen.bsky.social
Professor & Biotech Entrepreneur
Antibody discovery | Toxinology | Snakebite envenoming | Infectious diseases | Microbiome | Antimicrobial resistance
Website: http://antibody.dk/
Antibody discovery | Toxinology | Snakebite envenoming | Infectious diseases | Microbiome | Antimicrobial resistance
Website: http://antibody.dk/
New paper from the lab, where we sequenced the genome of Europe's most venomous snake, Western nose-horned viper (Vipera ammodytes ammodytes)!
Read paper in Genome Biology and Evolution: academic.oup.com/gbe/advance-...
Read paper in Genome Biology and Evolution: academic.oup.com/gbe/advance-...
November 11, 2025 at 2:33 PM
New paper from the lab, where we sequenced the genome of Europe's most venomous snake, Western nose-horned viper (Vipera ammodytes ammodytes)!
Read paper in Genome Biology and Evolution: academic.oup.com/gbe/advance-...
Read paper in Genome Biology and Evolution: academic.oup.com/gbe/advance-...
Reposted by Andreas H. Laustsen-Kiel
While a new, broad-spectrum 'nanobody' antivenom performed impressively in preclinical trials, the real significance is “showing this is possible,” @andreaslaustsen.bsky.social told me. That and more of the best from @science.org and science in #ScienceAdviser: www.science.org/content/arti... 🧪
October 30, 2025 at 4:07 PM
While a new, broad-spectrum 'nanobody' antivenom performed impressively in preclinical trials, the real significance is “showing this is possible,” @andreaslaustsen.bsky.social told me. That and more of the best from @science.org and science in #ScienceAdviser: www.science.org/content/arti... 🧪
Reposted by Andreas H. Laustsen-Kiel
Excited to share a new paper led by @andreaslaustsen.bsky.social, Anne Ljungars, @tpjenkins.bsky.social, Shirin Ahmadi and Nick Burlet. It was a privelege to be a part of this amazing team!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites - Nature
A recombinant antivenom composed of eight nanobodies provides broad protection against venom-induced lethality and dermonecrosis in mice challenged with venoms from cobras, mambas and rinkha...
www.nature.com
October 30, 2025 at 8:47 AM
Excited to share a new paper led by @andreaslaustsen.bsky.social, Anne Ljungars, @tpjenkins.bsky.social, Shirin Ahmadi and Nick Burlet. It was a privelege to be a part of this amazing team!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New article from the lab, where we describe how we developed a "Nanobody-based recombinant #antivenom for #cobra, #mamba, and #rinkhals bites" out in @nature.com!
October 29, 2025 at 7:25 PM
New article from the lab, where we describe how we developed a "Nanobody-based recombinant #antivenom for #cobra, #mamba, and #rinkhals bites" out in @nature.com!
New review article from the lab on "Advances in #antibody-based strategies for targeting #cancer-associated #glycopeptide antigens" just out in Drug Discovery Today, mainly written by my awesome PhD student, Edward Meier!
Read paper: sciencedirect.com/science/arti...
Read paper: sciencedirect.com/science/arti...
October 22, 2025 at 5:58 PM
New review article from the lab on "Advances in #antibody-based strategies for targeting #cancer-associated #glycopeptide antigens" just out in Drug Discovery Today, mainly written by my awesome PhD student, Edward Meier!
Read paper: sciencedirect.com/science/arti...
Read paper: sciencedirect.com/science/arti...
For those understanding German that are interested in getting up to date with the world of #snakebite #antivenoms and research in this field, Brigitte Osterath has written a great article for @gdch.de: gdch.app/article/wenn...
Full access: www.writingscience.de/artikel/schl...
Full access: www.writingscience.de/artikel/schl...
October 11, 2025 at 12:05 PM
For those understanding German that are interested in getting up to date with the world of #snakebite #antivenoms and research in this field, Brigitte Osterath has written a great article for @gdch.de: gdch.app/article/wenn...
Full access: www.writingscience.de/artikel/schl...
Full access: www.writingscience.de/artikel/schl...
I’m excited to share our new paper in mAbs!
We engineered pH-dependent antibodies without histidine “doping,” showing the light chain controls pH sensitivity by modulating water access.
Link: www.tandfonline.com/doi/full/10....
We engineered pH-dependent antibodies without histidine “doping,” showing the light chain controls pH sensitivity by modulating water access.
Link: www.tandfonline.com/doi/full/10....
September 12, 2025 at 7:22 AM
I’m excited to share our new paper in mAbs!
We engineered pH-dependent antibodies without histidine “doping,” showing the light chain controls pH sensitivity by modulating water access.
Link: www.tandfonline.com/doi/full/10....
We engineered pH-dependent antibodies without histidine “doping,” showing the light chain controls pH sensitivity by modulating water access.
Link: www.tandfonline.com/doi/full/10....
Excited to share the newest research paper from our lab, where we discover #nanobodies against #snake #neurotoxins using specially designed #consensus toxins and phage display technology. Link to paper in first comment.
July 19, 2025 at 5:31 AM
Excited to share the newest research paper from our lab, where we discover #nanobodies against #snake #neurotoxins using specially designed #consensus toxins and phage display technology. Link to paper in first comment.
New research article where we use consensus #toxins as #antigens for discovery of #nanobodies, showcasing this with short-chain alpha-neurotoxins from snakes - notoriously difficult to discover antibodies against.
Read article here:https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2522838
Read article here:https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2522838
June 29, 2025 at 12:44 PM
New research article where we use consensus #toxins as #antigens for discovery of #nanobodies, showcasing this with short-chain alpha-neurotoxins from snakes - notoriously difficult to discover antibodies against.
Read article here:https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2522838
Read article here:https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2522838
Thanks to Laura Tran for highlighting our work on Binding Proteins against cholera toxin: www.the-scientist.com/new-cholera-...
Original research article: www.nature.com/articles/s41...
Original research article: www.nature.com/articles/s41...
June 11, 2025 at 2:51 PM
Thanks to Laura Tran for highlighting our work on Binding Proteins against cholera toxin: www.the-scientist.com/new-cholera-...
Original research article: www.nature.com/articles/s41...
Original research article: www.nature.com/articles/s41...
Happy to share this "Ubegribeligt" podcast episode (in Danish) on venom and antivenom, which I had the pleasure of doing together with Huxi Bach from Danmarks Radio: www.dr.dk/lyd/p1/ubegr...
In the podcast, we discuss animal venoms, antivenom, and R&D, and spinout!
In the podcast, we discuss animal venoms, antivenom, and R&D, and spinout!
June 5, 2025 at 12:50 PM
Happy to share this "Ubegribeligt" podcast episode (in Danish) on venom and antivenom, which I had the pleasure of doing together with Huxi Bach from Danmarks Radio: www.dr.dk/lyd/p1/ubegr...
In the podcast, we discuss animal venoms, antivenom, and R&D, and spinout!
In the podcast, we discuss animal venoms, antivenom, and R&D, and spinout!
Pleased to share this new publication on the effects of Binding Proteins against virulence factors from enterotoxigenic E. coli: jasbsci.biomedcentral.com/articles/10....
As an #antibody engineer, I find it super interesting that we in this study show how stable #Binding #Proteins can be!
As an #antibody engineer, I find it super interesting that we in this study show how stable #Binding #Proteins can be!
June 2, 2025 at 9:47 AM
Pleased to share this new publication on the effects of Binding Proteins against virulence factors from enterotoxigenic E. coli: jasbsci.biomedcentral.com/articles/10....
As an #antibody engineer, I find it super interesting that we in this study show how stable #Binding #Proteins can be!
As an #antibody engineer, I find it super interesting that we in this study show how stable #Binding #Proteins can be!
Reposted by Andreas H. Laustsen-Kiel
🚨 We’re hiring a PhD student! 🚨
Join us at DTU Bioengineering + collaborators Messoud & Håkan Ashina + Esperanza Rivera de Torre to bring preventative migraine therapeutics from 💻 to 🧠
🔗 Apply: lnkd.in/dCRU_EN3
🔍 Project: lnkd.in/dbpi8MwX
Join us at DTU Bioengineering + collaborators Messoud & Håkan Ashina + Esperanza Rivera de Torre to bring preventative migraine therapeutics from 💻 to 🧠
🔗 Apply: lnkd.in/dCRU_EN3
🔍 Project: lnkd.in/dbpi8MwX
May 14, 2025 at 9:33 PM
🚨 We’re hiring a PhD student! 🚨
Join us at DTU Bioengineering + collaborators Messoud & Håkan Ashina + Esperanza Rivera de Torre to bring preventative migraine therapeutics from 💻 to 🧠
🔗 Apply: lnkd.in/dCRU_EN3
🔍 Project: lnkd.in/dbpi8MwX
Join us at DTU Bioengineering + collaborators Messoud & Håkan Ashina + Esperanza Rivera de Torre to bring preventative migraine therapeutics from 💻 to 🧠
🔗 Apply: lnkd.in/dCRU_EN3
🔍 Project: lnkd.in/dbpi8MwX
Reposted by Andreas H. Laustsen-Kiel
I co-wrote an opinion piece in a Danish newspaper. There are a few EU initiatives focused on recruiting american scientist. These ignore that the developments in the US the past years have spread here as well. We need a strategy and stronger political will, if we are to be a safe haven for science.
Sammen med @kristinabsimonsen.bsky.social & @aaaautzen.bsky.social fra @theyoungacademydk.bsky.social har jeg en kronik i Weekendavisen om problemet i at byde sig til over for amerikanske forskere på jagt efter grønnere græsgange uden først at feje for egen dør.
www.weekendavisen.dk/2025-19/opin...
www.weekendavisen.dk/2025-19/opin...
Krigen mod forskning
Kronik. Hvis vi vil være tilflugtssted for USAs forskere, må vi feje for egen dør først.
www.weekendavisen.dk
May 11, 2025 at 6:55 PM
I co-wrote an opinion piece in a Danish newspaper. There are a few EU initiatives focused on recruiting american scientist. These ignore that the developments in the US the past years have spread here as well. We need a strategy and stronger political will, if we are to be a safe haven for science.
Reposted by Andreas H. Laustsen-Kiel
🚨 Big news! We’ve received a NovoNordisk Foundation Tandem Grant for #MIGRAINE — designing #AI-powered #GPCR-targeting biologics for chronic migraine. From computer to human in 4 years. Proud to team up with Messoud and Hakan Ashina, as well as Esperanza Rivera de Torre!
🧠 + 💊 + 🧬 = new hope.
🧠 + 💊 + 🧬 = new hope.
May 12, 2025 at 11:39 AM
🚨 Big news! We’ve received a NovoNordisk Foundation Tandem Grant for #MIGRAINE — designing #AI-powered #GPCR-targeting biologics for chronic migraine. From computer to human in 4 years. Proud to team up with Messoud and Hakan Ashina, as well as Esperanza Rivera de Torre!
🧠 + 💊 + 🧬 = new hope.
🧠 + 💊 + 🧬 = new hope.
I am grateful to the Technical University of Denmark (DTU) who kindly awarded me with the university's Innovation Award 2025 for my contributions to innovation, entrepreneurship, and spinout of companies.
www.dtu.dk/nyheder/alle...
www.dtu.dk/nyheder/alle...
May 6, 2025 at 4:44 AM
I am grateful to the Technical University of Denmark (DTU) who kindly awarded me with the university's Innovation Award 2025 for my contributions to innovation, entrepreneurship, and spinout of companies.
www.dtu.dk/nyheder/alle...
www.dtu.dk/nyheder/alle...
I shared thoughts with @statnews.com on new research aiming to develop a universal antivenom, using antibodies from Tim Friede’s decades of self-immunization. Thanks to @usha.bsky.social for including me in the scientific discussion. 🐍👇 www.statnews.com/2025/05/02/d...
Snake enthusiast survived hundreds of bites. Now his blood is aiding the search for a universal antivenom
Blood from a snake enthusiast who's been bitten hundreds of times aided the search for a universal snakebite treatment
www.statnews.com
May 3, 2025 at 5:24 AM
I shared thoughts with @statnews.com on new research aiming to develop a universal antivenom, using antibodies from Tim Friede’s decades of self-immunization. Thanks to @usha.bsky.social for including me in the scientific discussion. 🐍👇 www.statnews.com/2025/05/02/d...
I had the chance to comment on a new study in Cell about the development of human monoclonal antibodies for #snakebite treatments. Grateful to @nerdychristie.bsky.social & @science.org for including me in the scientific discussion! Fascinating work. 🐍👇 www.science.org/content/arti...
He injected himself with venom for decades. Can his antibodies help snakebite victims?
A cocktail of antibodies from snake enthusiast Tim Friede protected mice from many deadly venoms—but some say the study has ethical issues
www.science.org
May 3, 2025 at 5:19 AM
I had the chance to comment on a new study in Cell about the development of human monoclonal antibodies for #snakebite treatments. Grateful to @nerdychristie.bsky.social & @science.org for including me in the scientific discussion! Fascinating work. 🐍👇 www.science.org/content/arti...
Reposted by Andreas H. Laustsen-Kiel
Our review article on progress towards #recombinant #antivenoms for #snakebite is now published at www.tandfonline.com/doi/full/10....
We cover snakebite, methods for #mAb discovery, do a deep dive on mAbs for neurotoxins, and discuss what is needed next to get this from concept to clinic.
We cover snakebite, methods for #mAb discovery, do a deep dive on mAbs for neurotoxins, and discuss what is needed next to get this from concept to clinic.
Practical progress towards the development of recombinant antivenoms for snakebite envenoming
Snakebite envenoming is a neglected tropical disease that affects millions globally each year. In recent years, research into the potential production of recombinant antivenoms, formulated using mi...
www.tandfonline.com
April 30, 2025 at 10:20 AM
Our review article on progress towards #recombinant #antivenoms for #snakebite is now published at www.tandfonline.com/doi/full/10....
We cover snakebite, methods for #mAb discovery, do a deep dive on mAbs for neurotoxins, and discuss what is needed next to get this from concept to clinic.
We cover snakebite, methods for #mAb discovery, do a deep dive on mAbs for neurotoxins, and discuss what is needed next to get this from concept to clinic.
New scientific article from the VenomAid Diagnostics in collaboration with the Center for Antibody Technologies at Danmarks Tekniske Universitet - DTU and Bactolife, led by our fantastic PhD student Selma Blom Belfakir!
Read the article here: www.sciencedirect.com/science/arti...
Read the article here: www.sciencedirect.com/science/arti...
April 23, 2025 at 4:43 AM
New scientific article from the VenomAid Diagnostics in collaboration with the Center for Antibody Technologies at Danmarks Tekniske Universitet - DTU and Bactolife, led by our fantastic PhD student Selma Blom Belfakir!
Read the article here: www.sciencedirect.com/science/arti...
Read the article here: www.sciencedirect.com/science/arti...
Thanks to Henrik Reinberg Simonsen from Sundhedspolitisk Tidsskrift for the fun interview on what cultural experiences I enjoy and for putting a bit of focus on YATSI's competition Denmark's Best Science Meme: sundhedskultur.dk/kultur/905-v...
April 11, 2025 at 10:43 AM
Thanks to Henrik Reinberg Simonsen from Sundhedspolitisk Tidsskrift for the fun interview on what cultural experiences I enjoy and for putting a bit of focus on YATSI's competition Denmark's Best Science Meme: sundhedskultur.dk/kultur/905-v...
Thanks to Videnskab.dk for putting a bit of spotlight on our competition Denmark's Best Science Meme, which we have the pleasure of organizing in YATSI: videnskab.dk/kultur-samfu...
If you like science and memes, make sure to submit your best science meme asap!
If you like science and memes, make sure to submit your best science meme asap!
April 11, 2025 at 10:39 AM
Thanks to Videnskab.dk for putting a bit of spotlight on our competition Denmark's Best Science Meme, which we have the pleasure of organizing in YATSI: videnskab.dk/kultur-samfu...
If you like science and memes, make sure to submit your best science meme asap!
If you like science and memes, make sure to submit your best science meme asap!
Reposted by Andreas H. Laustsen-Kiel
🎉 Big news! Our paper is out in Nature Machine Intelligence!
"InstaNovo enables diffusion-powered de novo peptide sequencing in large-scale proteomics experiments"
🔗 www.nature.com/articles/s42...
👇 Thread 🧵
"InstaNovo enables diffusion-powered de novo peptide sequencing in large-scale proteomics experiments"
🔗 www.nature.com/articles/s42...
👇 Thread 🧵
InstaNovo enables diffusion-powered de novo peptide sequencing in large-scale proteomics experiments - Nature Machine Intelligence
InstaNovo, a transformer-based model, and InstaNovo+, a multinomial diffusion model, enhance de novo peptide sequencing, enabling discovery of novel peptides, improved therapeutics sequencing coverage...
www.nature.com
April 1, 2025 at 7:30 AM
🎉 Big news! Our paper is out in Nature Machine Intelligence!
"InstaNovo enables diffusion-powered de novo peptide sequencing in large-scale proteomics experiments"
🔗 www.nature.com/articles/s42...
👇 Thread 🧵
"InstaNovo enables diffusion-powered de novo peptide sequencing in large-scale proteomics experiments"
🔗 www.nature.com/articles/s42...
👇 Thread 🧵
Reposted by Andreas H. Laustsen-Kiel
New AI tools InstaNovo and InstaNovo+ can now detect proteins previously beyond reach, opening doors in cancer research and disease biology. Early results are promising, though 5% may be false positives. 🧬💻
AI is helping scientists decode previously inscrutable proteins
A new set of artificial intelligence models could make protein sequencing even more powerful for better understanding cell biology and diseases.
www.sciencenews.org
March 31, 2025 at 3:27 PM
New AI tools InstaNovo and InstaNovo+ can now detect proteins previously beyond reach, opening doors in cancer research and disease biology. Early results are promising, though 5% may be false positives. 🧬💻
Reposted by Andreas H. Laustsen-Kiel
Eloff et al.’s InstaNovo uses transformers plus a diffusion refinement to perform high-throughput de novo peptide sequencing. It recovers more novel peptides at low FDR, outperforms current tools, and extends proteomics beyond database limits. www.nature.com/articles/s42...
InstaNovo enables diffusion-powered de novo peptide sequencing in large-scale proteomics experiments - Nature Machine Intelligence
InstaNovo, a transformer-based model, and InstaNovo+, a multinomial diffusion model, enhance de novo peptide sequencing, enabling discovery of novel peptides, improved therapeutics sequencing coverage...
www.nature.com
March 31, 2025 at 2:06 PM
Eloff et al.’s InstaNovo uses transformers plus a diffusion refinement to perform high-throughput de novo peptide sequencing. It recovers more novel peptides at low FDR, outperforms current tools, and extends proteomics beyond database limits. www.nature.com/articles/s42...